Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione

Journal of Biochemical and Molecular Toxicology

Volumn 17, Issue 2, 2003, Pages 95-97

  Berkeley, Lorelle I ^a   Cohen, Jonathan F ^b   Crankshaw, Daune L ^a   Shirota, Frances N ^a   Nagasawa, Herbert T ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Acetaminophen hepatotoxicity; L Cysteine glutathione disulfide; Prodrugs

Indexed keywords

(2 HYDROXYMETHYLMERCAPTO) CYSTEINE; ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; CYSTEINE; CYSTEINE DERIVATIVE; DRUG VEHICLE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE ETHYL ESTER; GLUTATHIONE REDUCTASE; PARACETAMOL; PRODRUG; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISULFIDE BOND; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME DEGRADATION; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER PROTECTION; LIVER TOXICITY; MALE; MAMMAL CELL; MOUSE; NONHUMAN;

ACETAMINOPHEN; ACETYLCYSTEINE; ANALGESICS, NON-NARCOTIC; ANIMALS; CYSTEINE; FREE RADICAL SCAVENGERS; GLUTATHIONE; HEPATITIS, TOXIC; MICE; PRODRUGS;

MAMMALIA;

EID: 0038324477     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.10069     Document Type: Article

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