Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on extrahepatic sulfhydryl levels in mice treated with acetaminophen

Biochemical Pharmacology

Volumn 61, Issue 7, 2001, Pages 925-931

  Srinivasan, Chandrika ^a   Williams, Walter M ^a   Nagasawa, Herbert T ^b   Chen, Theresa S ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

2(RS) n propylthiazolidine 4(R) carboxylic acid (PTCA); Acetaminophen (APAP); Blood; Brain; Glutathione; Kidney

Indexed keywords

2 N PROPYLTHIAZOLIDINE 4 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; CYSTEINE; GLUTATHIONE; PARACETAMOL; UNCLASSIFIED DRUG;

AMINO ACID BLOOD LEVEL; AMINO ACID BRAIN LEVEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; KIDNEY CORTEX; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TISSUE LEVEL;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BRAIN; CYSTEINE; DRUG INTERACTIONS; GLUTATHIONE; HEPATOCYTES; KIDNEY CORTEX; MALE; MICE; MICE, INBRED C57BL; PRODRUGS; SULFHYDRYL COMPOUNDS; THIAZOLES; TISSUE DISTRIBUTION;

EID: 0035313679     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00539-1     Document Type: Article

References (36)

1. Liver necrosis from paracetamol
2. Acute paracetamol poisoning
3. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione
4. N-Acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen
5. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism
6. Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice
7. Glutathione metabolism
8. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine
9. Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo
10. Prodrugs of L-cysteine as liver-protective agents. 2(RS)-Methylthiazolidine-4-(R)-carboxylic acid, a latent cysteine
11. 2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity
12. Acetaminophen-induced hepatic necrosis and renal failure
13. Paracetamol (acetaminophen) poisoning resulting in acute renal failure without hepatic coma
14. Evidence against deacetylation and for cytochrome P450-mediated activation in acetaminophen-induced nephrotoxicity in the CD-1 mouse
15. Sex-related differences in mouse renal metabolism and toxicity of acetaminophen
16. Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis
17. Acetaminophen nephrotoxicity in the CD-1 mouse. II. Protection by probenecid and AT-125 without diminution of renal covalent binding
18. Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione
19. Nephrotoxicity of acetaminophen in male Wistar rats: Role of hepatically derived metabolites
20. Acute renal failure due to acetaminophen ingestion: A case report and review of the literature
21. Effects of exogenous factors on the cerebral glutathione in rodents
22. Life-span profiles of glutathione and acetaminophen detoxification
23. Compounds of thiol acids with aldehydes
24. The determination of glutathione, cyst(e)ine, and other thiols and disulfides in biological samples using high-performance liquid chromatography with dual electrochemical detection
25. Detoxification reactions in isolated hepatocytes. Role of glutathone peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system
26. Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney
27. Differential distribution of free and bound glutathione and cyst(e)ine in human blood
28. Active transport of glutathione disulfide from erythrocytes
29. Levels of acetaminophen and its metabolites in mouse tissues after a toxic dose
30. Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: Correspondence of covalent binding with toxicity
31. Extrahepatic microsomal forms: Brain cytochrome P450
32. Role of membrane transport in metabolism and function of glutathione in mammals
33. Glutathione turnover in the kidney; considerations relating to the γ-glutamyl cycle and the transport of amino acids
34. Apparent rates of glutathione turnover in rat tissues
35. Marked increase of cysteine levels in many regions of the brain after administration of 2-oxothiazolidine-4-carboxylate
36. Increase in rat brain glutathione following intracerebroventricular administration of γ-glutamylcysteine