Differential regulation of IKKα-mediated activation of IRF3/7 by NIK

Molecular Immunology

Volumn 45, Issue 7, 2008, Pages 1926-1934

  Wang, Rui Peng ^a   Zhang, Min ^a   Li, Ying ^b   Diao, Fei Ci ^a   Chen, Danying ^a   Zhai, Zhonghe ^a   Shu, Hong Bing ^b  

^a PEKING UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

IKK ; IRF3; IRF7; NIK; TLR7; Type I interferon induction

Indexed keywords

GLUTAMIC ACID; I KAPPA B KINASE ALPHA; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; SERINE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOREGULATION; INNATE IMMUNITY; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VIRUS INFECTION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; INTERFERON TYPE I; MICE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYLATION; PHOSPHOSERINE; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 39149089328     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.10.034     Document Type: Article

References (34)

1. Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
2. Balachandran S., Thomas E., and Barber G.N. A FADD-dependent innate immune mechanism in mammalian cells. Nature 432 (2004) 401-405
3. Bin L.H., Xu L.G., and Shu H.B. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J. Biol. Chem. 278 (2003) 24526-24532
4. Claudio E., Brown K., Park S., Wang H., and Siebenlist U. BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat. Immunol. 3 (2002) 958-965
5. Coope H.J., Atkinson P.G., Huhse B., Belich M., Janzen J., Holman M.J., Klaus G.G., Johnston L.H., and Ley S.C. CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J. 21 (2002) 5375-5385
6. Dejardin E., Droin N.M., Delhase M., Haas E., Cao Y., Makris C., Li Z.W., Karin M., Ware C.F., and Green D.R. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity 17 (2002) 525-535
7. Diebold S.S., Kaisho T., Hemmi H., Akira S., and Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303 (2004) 1529-1531
8. Fitzgerald K.A., McWhirter S.M., Faia K.L., Rowe D.C., Latz E., Golenbock D.T., Coyle A.J., Liao S.M., and Maniatis T. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4 (2003) 491-496
9. Hacker H., and Karin M. Regulation and function of IKK and IKK-related kinases. Sci. STKE 2006 (2006) re13
10. Hacker H., Vabulas R.M., Takeuchi O., Hoshino K., Akira S., and Wagner H. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192 (2000) 595-600
11. Han K.J., Su X., Xu L.G., Bin L.H., Zhang J., and Shu H.B. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. J. Biol. Chem. 279 (2004) 15652-15661
12. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., and Bauer S. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303 (2004) 1526-1529
13. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., and Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
14. Honda K., Ohba Y., Yanai H., Negishi H., Mizutani T., Takaoka A., Taya C., and Taniguchi T. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040
15. Honda K., Yanai H., Mizutani T., Negishi H., Shimada N., Suzuki N., Ohba Y., Takaoka A., Yeh W.C., and Taniguchi T. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 15416-15421
16. Honda K., Yanai H., Negishi H., Asagiri M., Sato M., Mizutani T., Shimada N., Ohba Y., Takaoka A., Yoshida N., and Taniguchi T. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434 (2005) 772-777
17. Hoshino K., Sugiyama T., Matsumoto M., Tanaka T., Saito M., Hemmi H., Ohara O., Akira S., and Kaisho T. IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 440 (2006) 949-953
18. Hu W.H., Johnson H., and Shu H.B. Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. J. Biol. Chem. 274 (1999) 30603-30610
19. Iwamura T., Yoneyama M., Yamaguchi K., Suhara W., Mori W., Shiota K., Okabe Y., Namiki H., and Fujita T. Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells 6 (2001) 375-388
20. Kawai T., Sato S., Ishii K.J., Coban C., Hemmi H., Yamamoto M., Terai K., Matsuda M., Inoue J., Uematsu S., Takeuchi O., and Akira S. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5 (2004) 1061-1068
21. Kayagaki N., Yan M., Seshasayee D., Wang H., Lee W., French D.M., Grewal I.S., Cochran A.G., Gordon N.C., Yin J., Starovasnik M.A., and Dixit V.M. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity 17 (2002) 515-524
22. Lin X., Mu Y., Cunningham Jr. E.T., Marcu K.B., Geleziunas R., and Greene W.C. Molecular determinants of NF-kappaB-inducing kinase action. Mol. Cell. Biol. 18 (1998) 5899-5907
23. Ling L., Cao Z., and Goeddel D.V. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 3792-3797
24. McWhirter S.M., Fitzgerald K.A., Rosains J., Rowe D.C., Golenbock D.T., and Maniatis T. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 233-238
25. Mercurio F., Zhu H., Murray B.W., Shevchenko A., Bennett B.L., Li J., Young D.B., Barbosa M., Mann M., Manning A., and Rao A. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278 (1997) 860-866
26. Sato M., Suemori H., Hata N., Asagiri M., Ogasawara K., Nakao K., Nakaya T., Katsuki M., Noguchi S., Tanaka N., and Taniguchi T. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity 13 (2000) 539-548
27. Senftleben U., Cao Y., Xiao G., Greten F.R., Krahn G., Bonizzi G., Chen Y., Hu Y., Fong A., Sun S.C., and Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293 (2001) 1495-1499
28. Sharma S., tenOever B.R., Grandvaux N., Zhou G.P., Lin R., and Hiscott J. Triggering the interferon antiviral response through an IKK-related pathway. Science 300 (2003) 1148-1151
29. Shinkura R., Kitada K., Matsuda F., Tashiro K., Ikuta K., Suzuki M., Kogishi K., Serikawa T., and Honjo T. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. Nat. Genet. 22 (1999) 74-77
30. Smith C., Andreakos E., Crawley J.B., Brennan F.M., Feldmann M., and Foxwell B.M. NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts. J. Immunol. 167 (2001) 5895-5903
31. Uematsu S., Sato S., Yamamoto M., Hirotani T., Kato H., Takeshita F., Matsuda M., Coban C., Ishii K.J., Kawai T., Takeuchi O., and Akira S. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J. Exp. Med. 201 (2005) 915-923
32. Xu L.G., Wang Y.Y., Han K.J., Li L.Y., Zhai Z., and Shu H.B. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell. 19 (2005) 727-740
33. Yang K., Puel A., Zhang S., Eidenschenk C., Ku C.L., Casrouge A., Picard C., von Bernuth H., Senechal B., Plancoulaine S., Al-Hajjar S., Al-Ghonaium A., Marodi L., Davidson D., Speert D., Roifman C., Garty B.Z., Ozinsky A., Barrat F.J., Coffman R.L., Miller R.L., Li X., Lebon P., Rodriguez-Gallego C., Chapel H., Geissmann F., Jouanguy E., and Casanova J.L. Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity 23 (2005) 465-478
34. Yin L., Wu L., Wesche H., Arthur C.D., White J.M., Goeddel D.V., and Schreiber R.D. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 291 (2001) 2162-2165