The anti-hyperlipidemic effect and constituents of the 19α- hydroxyursane-type triterpenoid fraction obtained from the leaves of Rubus crataegifolius

Natural Product Sciences

Volumn 13, Issue 2, 2007, Pages 152-159

  Nam, Jung Hwan ^a   Jung, Hyun Ju ^b   Tapondjou, Leon Azefack ^c   Lee, Kyung Tae ^d   Choi, Jongwon ^e   Kim, Won Bae ^f   Park, Hee Juhn ^a  

^a Sangji University   (South Korea)

^b Wonkwang University   (South Korea)

^c UNIVERSITY OF DSCHANG   (Cameroon)

^d Kyung Hee University   (South Korea)

^e Kyungsung University   (South Korea)

^f National Institute of Animal Science   (South Korea)

Author keywords

19 hydroxyursane type triterpenoid; Anti hyperlipidemic; NMR; Pomolic acid ester; Rosaceae; Rubus crataegifolius

Indexed keywords

19ALPHA HYDROXYURSANE; 23 HYDROXYTORMENTIC ACID; COREANOSIDE F1; KAJI ICHIGOSIDE F1; NIGA ICHIGOSIDE F1; NIGA ICHIGOSIDE F2; POMOLIC ACID ESTER; ROSAMULTIN; SEPHADEX; SILICON DIOXIDE; SUAVISSIMOSIDE F1; TORMENTIC ACID; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LIPID DIET; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT LEAF; RAT; ROSACEAE; RUBUS CRATAEGIFOLIUS;

EID: 34447518599     PISSN: 12263907     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Arimoto, K., Yoshikawa, K., and Arihara, S., Triterpenoid saponins of Aquifoliaceous plants. XI. Ilexosides XVI-XIV from the leaves of Ilex rotunda Thunb. Chem. Pharm. Bull. 41, 39-42 (1993a).
2. Arimoto, K., Yoshikawa, K., and Arihara, S., Triterpenoid saponins of Aquifoliaceous plants. XII. Ilexosides XLVI-LI from the leaves of Ilex rotunda Thunb. Chem. Pharm. Bull. 41, 77-80 (1993b).
3. Bagniski, E. and Zak., B., Micro-determination of serum phosphate and phospholipids. Clinica. Chimica. Acta. 5, 834-838 (1960).
4. Cheng, D.-L. and Cao, X.-R., Pomolic acid derivatives from the root of Sanguisorba officinalis. Phytochemistry 31, 1317-1320 (1992).
5. Choi, J., Lee, K.T., Ha, J., Yun, S.Y., Ko, C.D., Jung, H.J., and Park, H.J., Antinociceptive and anti-inflammatory effects of niga-ichigoside F1 and 23-hydroxytormentic acid obtained from Rubus coreanus. Biol. Pharm. Bull. 26, 1436-1441 (2003).
6. Chou, W.H., Oinaka, T., Kanamaru, F., Mizutani, K., Chen, F.H., and Osamu, T., Diterpene glycosides from leaves of Chinese Rubus chingii and fruits of R. suavissimus and identification of the source plant of the Chinese folk medicine "Fu-pen-zi". Chem. Pharm. Bull. 35, 3021-3024 (1987).
7. Friedewald, W.T., Levy, R.I., and Fredrickson, D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 24, 499-502 (1972).
8. Gao, F.G., Chen, F.H., Tanaka, T., Kasai, R., Seto, T., and Tanaka, O., 19α-Hydroxyursane-type triterpene glucosyl esters from the roots of Rubus suavissimus S. Lee. Chem. Pharm. Bull. 33, 37-40 (1985).
9. Gudej, J., Kaempferol and quercetin glycosides from Rubus idaeus L. leaves. Acta Pol. Pharm. 60, 313-315 (2003).
10. Hirai, N., Suige, M., Wada, M., Lahlou, E.H., Kamo, T., Yoshida, R., Tsuda, M., and Ohigashi, H., Triterpene phytoalexins from strawberry fruit. Biosci. Biotechnol. Biochem. 64, 1707-1712 (2000).
11. Houghton, P.J. and Lian, L.M., Ttritrpenoids from Sesfontania spinosa. Phytochemistry 25, 1939-1944 (1986).
12. Ito, K. and Lai, J., Study on the constituents of Marsdenia tinctoria var. tomentosa Masamune. Yakugaku Zasshi 98, 249 (1978).
13. Jung, S.W., Shin, M.H., Jung, J.H., Kim, N.D., and Im, K.S., A triterpene glucosyl from the roots of Rubus crataegifolius. Arch. Pharm. Res., 24, 412-415 (2001).
14. Kim, Y.H. and Kang, S.S., Triterpenoids from Rubi Fructus (Bogbunja). Arch. Pharm. Res. 16, 109-113 (1993).
15. Kim, Y.K., Yoon, S.K., and Ryu, S.Y., Cytotoxic triterpenes from stem bark of physocarpus intermedins. Planta Med. 66, 485-486 (2000).
16. Kuang, H.-X., Kasai, R., Ohtani, K., Liu, Z.-S., Yuan, C.-S., and Tanaka, O., Chemical constituents of pericarps of Rosa davurica Pall., a traditional Chinese medicine. Chem. Pharm. Bull. 37, 2232-2233 (1989).
17. McGowan, M.W. and Artiss, J.D., Strandbergh, D. R., Zak, B., A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin. Chem. 29, 538-542 (1983).
18. Moon, K.S., Constituents and Uses of Medicinal Herbs, Ilweolseogak. Seoul, pp. 310-311, 1964.
19. Murakami, C., Ishijima, K., Hirota, M., Sakaguchi, K., Yoshida, H., and Mizushina, Y., Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases. Biochim. Biophys. Acta 1596, 193-200 (2002).
20. Nakanishi, T., Terai, H., Nasu, M., Miura, I., and Yoneda, K., Two triterpenoid glycosides from leaves of Ilex cornuta. Phytochemistry 21, 1373-1377 (1982).
21. 1, and 23-hydroxytormentic acid isolated from the unripe fruits of Rubus coreanus in a rat model. Biol. Pharm. Bull. 29, 967-970 (2006).
22. 2+, and an anion-exchange resin. Clin. Chem. 24, 1504-1508 (1978).
23. Numata, A., Yang, P., Takahashi, C., Fujiki, R., Nabae, M., and Fujita, E., Cytotoxic triterpenes from a Chinese medicine, Goreishi.Chem. Pharm. Bull. 37, 648-651 (1989).
24. Ohtani, K., Miyajima, C., Takahashi, T., Kasai, R., Tanaka, R., and Hahn, D.R., Naruhashi N, A dimeric triterpene-glycoside from Rubus coreanus. Phytochemistry 29, 3275-3280 (1990).
25. Park, H.J., Nam, J.H., Jung, H.J., Lee, M.S., Lee, K.T., Jung, M.H., and Choi, J.W., Inhibitory Effect of Euscaphic Acid and Tormentic acid from the Roots of Rosa rugosa on High Fat Diet-Induced Obesity in the Rat. Kor. J. Pharmacogn. 36, 324-331 (2005).
26. Richmond, W., Use of cholesterol oxidase for assay of total and free cholesterol in serum by continuous flow analysis. Clin. Chem. 22, 1579-1588 (1976).
27. Seto, T., Tanaka, T., Tanaka, O., and Naruhashi, N., β-Glucosyl esters of 19α-hydroxyursolic acid derivatives in leaves of Rubus species. Phytochemistry 23, 2829-2834 (1984).
28. Tanaka, T., Tachibana, H., Nonaka, G., Nishioka, I., Hsu, F.L., Kohda, H., and Tanaka, O., Tannins and related compounds. CXXII. New dimeric, trimeric and terameric ellagitanins, labertianins A-D, from Rubus lambertianus Seringe. Chem. Pharm. Bull. 41, 1214-1220 (1993).
29. Wang, S.Y and Lin, H.S., Antioxidant activity and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J. agric. Food Chem. 48, 140-146 (2000).
30. Wang, J.S., Qiu, Z.Y., Xia, Y.P., Li, H.J., Ren, L.Y., and Zhang, L., The protective effects of total glycosides Rubus parviflolius on cerebral ischemic in rat. Zhongguo Zhong Yao Za Zhi 31, 138-141 (2006).
31. Yamagishi, T., Zhang, D.-C., Chang, J.-J., McPhail, D.R., McPhail, A.T., and Lee, K.-H., The cytotoxic principles of Hyptis capitata and the structures of the new triterpenes hyptatic acid-A and -B. Phytochemistry 27, 3213-3216 (1988).