The bioactivity of saponins: Triterpenoid and steroidal glycosides

Drug Metabolism and Drug Interactions

Volumn 17, Issue 1-4, 2000, Pages 211-235

  Rao, A V ^a   Gurfinkel, D M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Anti coagulation; Anti inflammatory activity; Anti oxidant activity; Anticarcinogen; Hepatoprotection; Hypocholesterolemic activity; Hypoglycemic activity; Immunomodulation; Neuroprotection; Saponins; Steroidal glycosides; Triterpenoid glycosides

Indexed keywords

AFROMOSIN; BILE ACID; CASPASE; CELLOBIOSIDE; CYTOCHROME P450; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RG 2; GLEDITSIASAPONIN C; GLYCYRRHIZA EXTRACT; GLYCYRRHIZIC ACID; GYMNOCLADUSSAPONIN G; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MAJONOSIDE R2; PAMAQUESIDE; PLANT GLYCOSIDE; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN KINASE C; SAPONIN DERIVATIVE; SOYASAPONIN I; TIQUESIDE; TRITERPENOID; TUBEIMOSIDE 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; CANCER INHIBITION; CANCER PREVENTION; COLON CANCER; DRUG METABOLISM; GLUCOSE HOMEOSTASIS; HUMAN; HYPERLIPIDEMIA; IMMUNOMODULATION; INFLAMMATION; LIVER INJURY; LIVER PROTECTION; MELANOMA; METASTASIS INHIBITION; NEUROPROTECTION; NONHUMAN; OVARY CANCER; REVIEW; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

EID: 0034521898     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.2000.17.1-4.211     Document Type: Review

References (161)

1. Dietary saponins and human health
2. U.K. mean daily intake of saponins: Intestine-permeabilizing factors in legumes
3. Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek
4. Studies in absorption, distribution, excretion, and metabolism of ginseng saponins. V. The decomposition products of geinsenoside Rb2 in the large intestine of rats
5. Main ginseng saponin metabolites formed by intestinal bacteria
6. Phytotherapeutic aspects of diseases of the cardiovascular system. 5. Saponins and possibilities of their use in prevention and therapy
7. Hypocholesterolemic effects of saponins
8. Nutritional and biological significance of saponins
9. Steroid saponins from fenugreek seeds: Extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol
10. Hypocholesterolemic activity of saponin on cholesterol added Bengalgram (Cicer arietinurn) diet in rats
11. Effects of dietary saponins on fecal bile acids and neutral sterols and availability of vitamins A and E in the chick
12. Fecal steroid excretion is increased in rats by oral administration of gymnemic acids contained in Gymnema sylvestre leaves
13. Pharmacologic consequences of cholesterol absorption inhibition: Alteration in cholesterol concentration induced by the synthetic saponin beta-tigogenin cellobioside (CP-88818; tiqueside)
14. Inhibiting cholesterol absorption with CP-88,818 (beta-tigogenin cellobioside; tiqueside): Studies in normal and hyperlipidemic subjects
15. Steroidal glycoside cholesterol absorption inhibitors
16. Comparison of synthetic saponin cholesterol absorption inhibitors in rabbits: Evidence for a nonstoichiometric, intestinal mechanism of action
17. Inhibitiory effects of Acanthopanax gracilistylus saponins in human platelet aggregation and platelet factor 4 liberation in vitro
18. 19 new steroidal saponins from Allium plants: Isolation, structural elucidation and effect on blood coagulability
19. Effect of notoginsenoside R1 on the synthesis of components of the fibrinolytic system in cultured smooth muscle cells of human pulmonary artery
20. Platelet activating factor antagonist activity of ginsenosides
21. Hypotensive effect of tenuifolic saponin and its mechanism
22. Effect of tea-leaf saponin on blood pressure of spontaneously hypertensive rats
23. Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta
24. + channels
25. Effects of panaxadiol and panaxatriol saponins on action of normal and xanthine-xanthine oxidase damaged cultured myocardial cells
26. Effect of Panax notoginseng saponins on increased proliferation of cultured aortic smooth muscle cells stimulated by hypercholesterolemic serum
27. Effects of Panax notoginseng saponin Rg1 on cardiac electrophysiological properties and ventricular fibrillation threshold in dogs
28. Effects of Panax notoginseng saponins on monophasic action potentials of heart and automaticity and contractility of isolated atria
29. Panax quinquefolium saponins protects low density lipoproteins from oxidation
30. Anticarcinogenic effects of saponins and phytosterols
31. Antiproliferative triterpene saponins from Trevesia palmata
32. Anti-tumor-promoting activity of majonoside-R2 from Vietnamese ginseng, Panax vienamensis Ha et Grushv
33. Anti-tumor-promoting activities of triterpenoid glycosides; cancer chemoprevention by saponins
34. Effect of soybean saponins and Gypsophila saponin on growth and viability of colon carcinoma cells in culture
35. Effect of soybean saponins and Gypsophila saponin on morphology of colon carcinoma cells in culture
36. Effect of soy bean saponin on azoxymethane-induced preneoplastic lesions in the colon of mice
37. Cytotoxic activity of some triterpenoid saponins
38. Cytotoxicity of triterpenoid saponins. Part 1: Activities against tumor cells in vitro and hemolytical index
39. Antitumor-promoting activity of glycyrrhetinic acid and its related compounds
40. A new bioactive steroidal saponin, furcreastatin, from the plant Furcraea foetida
41. Antineoplastic agents; I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca
42. Steroidal saponins from the rhizomes of Hosta sieboldii and their cytostatic activity on HL-60 cells
43. Steroidal saponins from the underground parts of Rucus aculeatus and their cytostatic activity on HL-60 cells
44. Steroidal saponins from Asparagus officinalis and their cytotoxic activity
45. Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by Tubeimoside 1
46. Steroidal saponins from Hosta longipes and their inhibitory activity on tumour promoter-induced phospholipid metabolism of HeLa cells
47. Steroidal saponins from the underground parts of Chlorophytum comosum and their inhibitory activity on tumour promoter-induced phospholipids metabolism of HeLa cells
48. Structures of steroidal saponins from the tubers of Brodiaea californica and their inhibitory activity on tumor promoter-induced phospholipid metabolism
49. Steroidal saponins from the bulbs of Lilium longiflorum and their antitumour-promoter activity
50. Steroidal glycosides from Allium Macleanii and A. senescens, and their inhibitory activity on tumour promoter-induced phospholipid metabolism of HeLa cells
51. 32P-incorporation into phospholipids of HeLa cells and proliferation of human malignant tumor cells
52. Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells
53. In vivo antimetastatic action of ginseng protopanaxdiol saponins is based on their intestinal bacterial metabolites after oral administration
54. Antitumour activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin
55. Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng
56. Involvement of glucocorticoid receptor in the induction of differentiation by ginsenosides in F9 teratocarcinoma cells
57. Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: Modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2
58. Ginsenoside-Rg5 suppresses cyclin E-dependent protein kinase activity via up-regulating p21Cip/WAF1 and down-regulating cyclin E in SK-HEP-1 cells
59. Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells as the G1/S boundary by selectively inducing the protein expression of p27kip1
60. Anti-proliferating effects ofginsenoside Rh2 on MCF-7 human breast cancer cells
61. G1 phase-specific suppression of the Cdk2 activity by ginsenoside Rh2 in cultured murine cells
62. Ginsenoside-Rs4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma SK-HEP-1 cells
63. Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells
64. Activation of caspase-3 protease via a Bcl-2insensitive pathway during the process of ginsenoside Rh-2-induced apoptosis
65. Ginsenoside Rh-2 induces apoptotic cell death in rat C6 glioma via a reactive oxygen- and caspase-dependent but Bcl-X(L)-independent pathway
66. Inhibitory effect of tumour metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)ginsenoside-Rg3, of red ginseng
67. Inhibition of in vitro tumor cell invasion by ginsenoside Rg3
68. Inhibition by ginsenoside Rg3 of bombesinenhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats
69. Antimetastatic efficacy of orally administered ginsenoside Rb1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite
70. Protective effects of alpha-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin cultured human lymphocytes
71. In vitro antigenotoxic activity of novel ginseng saponin metabolites formed in intestinal bacteria
72. Effects of nine active ingredients in Chinese herbal medicine sho-saiko-to on 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide mutagenicity
73. Characterization and antimutagenic activity of soybean saponins
74. Protective effects of red ginseng saponins against carbon tetrachloride-induced hepatotoxicity in Sprague Dawley rats
75. Anti-hepatic activity of ginsenoside Ro
76. Preventive effects of saponins from puerariae radix (the root of Pueraria lobata Ohwi) on in vitro immunological injury of rat primary hepatocyte cultures
77. Kaikasaponin III and soyasaponin I, major triterpene saponins of Abrus cantoniensis, act on GOT and GPT: Influence on transaminase elevation of rat liver cells concomitantly exposed to carbon tetrachloride for one hour
78. Bioactive saponins and glycosides. XI. Structures of new dammarane-type triterpene oligoglycosides, quinquenosides I, II, III, IV, and V, from American ginseng, the roots of Panax quinquefolium L
79. Bioactive saponins and glycosides. VIII. Notoginseng (1): New dammarane-type triterpene oligoglycosides, notoginsenosides -A, -B, -C, and -D, from dried root of Panax notoginseng (Burk.) F.H. Chen
80. HPLC profile analysis of hepatoprotective oleanene-glucuronides in Puerariae Flos
81. Study of structure-hepatoprotective relationships of oleanene-type triterpenoidal glucuronides obtained from several fabaceous plants on rat primary hepatocyte cultures
82. Structures of three new oleanene glucuronides isolated from Lathyrus palustris var. pilosus and hepatoprotective activity
83. Structure-hepatoprotective relationships study of soyasaponins I-IV having soyasapogenol B as aglycone
84. Partial hydrolysis of soyasaponin I and the hepatoprotective effects of the hydrolytic products. Study of the structurehepatoprotective relationship of soyasapogenol B analogs
85. Effect of alpha-hederin on hepatic detoxifying systems in mice
86. Suppression of constitutive and inducible cytochrome P450 gene expression by alpha-hederin in mice
87. The prevention of carbon tetrachloride-induced hepatotoxicity in mice by alpha-hederin: Inhibition of cytochrome P450 2E1 expression
88. Suppression of liver cytochrome P450 by alpha-hederin: Relevance to hepatoprotection
89. Effect of alpha-hederin and sapindoside B on hepatic microsomal cytochrome P-450 in mice
90. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity
91. Induction of cytochrome P-450 by triterpensaponins in Vietnamese ginseng
92. Metabolism of kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites
93. Medicinal foodstuffs. VII. On the saponin constituents with glucose and alcohol absorption-inhibitory activity from a food garnish "Tonburi," the fruit of Japanese Kochia scoparia (L.) Schrad.: Structures of scoparianosides A, B. and C
94. New hypoglycemic constituents in "gymnemic acid" from Gymnema sylvestre
95. Medicinal foodstuffs. X. Structures of new triterpene glycosides, gymnemosides-c, -d, -e, and -f, from the leaves of Gymnema sylvestre R. Br.: Influence of gymnema glycosides on glucose uptake in rat small intestinal fragments
96. Suppression of glucose absorption by extracts from the leaves of Gymnema inodorum
97. Medicinal foodstuffs. III. Sugar beet. (1): Hypoglycemic oleanolic acid oligoglycosides, betavulgarosides I, II, III, and IV, from the root of Beta vulgaris L. (Chenopodiaceae)
98. Bioactive saponins and glycosides. I. Senegae radix. (1): E-senegasaponins a and b and Z-senegasaponins a and b, their inhibitory effect on alcohol absorption and hypoglycemic activity
99. Bioactive saponins and glycosides. II. Senegae Radix. (2): Chemical structures, hypoglycemic activity, and ethanol absorption-inhibitory effect of E-senegasaponin c, Z-senegasaponin c, and Z-senegins II, III, and IV
100. Medicinal foodstuffs. I. Hypoglycemic constituents from a garnish foodstuff "taranome," the young shoot of Aralia elata Seem.: Elatosides G, H, I, J, and K
101. Elatoside E, a new hypoglycemic principle from the root cortex of Aralia elata Seem.: Structure-related hypoglycemic activity of oleanolic acid glycosides
102. Bioactive saponins and glycosides. VII. On the hypoglycemic principles from the root cortex of Aralia elata Seem.: Structure related hypoglycemic activity of oleanolic acid oligoglycoside
103. Hypoglycemic effect of saponin isolated from leaves of Acanthopanax senticosus (Rupr. et Maxin.) Harms
104. Effects of steroidal glycosides on blood glucose in normal and diabetic mice
105. Escins-Ia, Ib, IIa, IIb, and IIIa, bioactive triterpene oligoglycosides from the seeds of Aesculus hippocastanum L.: Their inhibitory effects on ethanol absorption and hypoglycemic activity on glucose tolerance test
106. Bioactive saponins and glycosides, III. Horse chestnut. (1): The structures, inhibitory effects on ethanol absorption, and hypoglycemic activity of escins Ia, Ib, IIa, IIb, and IIIa from the seeds of Aesculus hippocastanum L
107. Hypoglycemic and antihyperglycemic effects of Zizyphus spinachrisri in rats
108. Isolation of pseudoprototimosaponin AIII from rhizomes of Anemarrhena asphodeloides and its hypoglycemic activity in streptozotocin-induced diabetic mice
109. Interactions of ginseng extract, ginseng separated fractions, and some triterpenoid saponins with glucose transporters in sheep erythrocytes
110. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities
111. Mode of action of escins Ia and IIa and E,Z-senegin II on glucose absorption in gastrointestinal tract
112. Roles of endogenous prostaglandins and nitric oxide in inhibitions of gastric emptying and accelerations of gastrointestinal transit by escins Ia, Ib, IIa, and IIb in mice
113. Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats
114. ISCOMs: An adjuvant with multiple functions
115. QS-21 and QS-7: Purified saponin adjuvants
116. Quillaja saponin formulations that stimulate proinflammatory cytokines elicit a potent acquired cell-mediated immunity
117. Inhibitory activity of soyasaponin II on virus replication in vitro
118. Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro
119. Anti-AIDS agents, 21. Triterpenoid saponins as anti-HIV principles from fruits of Gleditsia japonica and Gymnocladus chinensis, and structure-activity correlation
120. Structure and in vitro antiviral activity of triterpenoid saponins from Calendula arvensis
121. Inactivation of human type A and B influenza viruses by tea-seed saponins
122. Activation of retinoic acid (RA)differentiated HL-60 cells by saponins
123. Effect of timosaponin E1 and E2 on superoxide generation induced by various stimuli in human neutrophils and on platelet aggregation in human blood
124. Bioactive saponins and glycosides: IV. Four methyl-migrated 16,17-seco-dammarane triterpene glycosides from Chinese natural medicine, hoveniae semen seu fructus, the seeds and fruit of Hovenia dulcis Thunb.: Absolute stereostructures and inhibitory activity on histamine release of hovenidulciosides A1, A2, B1, and B2
125. Bioactive saponins and glycosides. X. On the constituents of zizyphi spinosi semen, seeds of Zizyphus jujuba Mill. var. spinosa Hu (1): Structures and histamine release-inhibitory effect of jujubosides A1 and C and acetyljujuboside B
126. Medicinal foodstuffs. VI. Histamine release inhibitors from kidney bean, the seeds of Phaseolus vulgaaris L.: Chemical structures of sandosaponins A and B
127. Anti-allergic effect of tea-leaf saponin (TLS) from tea leaves (Camellia sinensis var. sinensis)
128. Effects of ginsenosides on maze performance and brain choline acetyltransferase activity in scopolaminetreated young rats and aged rats
129. Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice
130. Effects of ginsenoside Rb1 on central cholinergic metabolism
131. Majonoside-R2, a major constituent of Vietnamese ginseng, attenuates opioid-induced antinociception
132. The anti-stress effect of majonoside-R2, a major saponin component of Vietnamese ginseng: Neuronal mechanisms of action
133. Effects of the ginsenosides Rg1 and Rb1 on morphine-induced hyperactivity and reinforcement in mice
134. Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice
135. Inhibitory effects of ginseng total saponin on nicotine-induced hyperactivity, reverse tolerance and dopamine receptor supersensitivity
136. Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats
137. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia
138. Inhibition of apoptosis by ginsenoside Rg1 in cultured cortical neurons
139. Protective effect of ginseng saponins against impaired brain growth in neonatal rats exposed to ethanol
140. Relationship between chemical structures and biological activities of triterpenoid saponins from soybean
141. Prevention of hydrogen peroxide damage by soybean saponins to mouse fibroblasts
142. Antioxidative action of soyasaponin monomers I, A1, A2, and their inhibitory effects on action potential and beating of myocardiocytes in culture
143. The protective activity of alpha-hederine against hydrogen peroxide genotoxicity in HepG2 cells by alkaline comet assay
144. Protective effects of ginsenosides on oxygen free radical induced damages of cultured vascular endothelial cells in vitro
145. Calcium channel blockade and anti-freeradical actions of panaxatriol saponins in cultured myocardiocytes
146. Protective effects of panaxadiol saponins on cardiac functions in burned rats
147. Experimental study on the scavenging effects of ginsenosides on oxygen free radicals using model of heterotopic heart transplantation in rats
148. Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng
149. Transcriptional activation of the Cu,Znsuperoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng
150. Anti-lipid peroxidative effect of ginsenoside Rb1 and Rg1
151. Anti-inflammatory actions of pentacyclic triterpenes
152. Inhibition of mouse ear edema by steroidal and triterpenoid saponins
153. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals
154. Analgesic and anti-inflammatory activity of saponins of Argania spinoza
155. In vivo and in vitro anti-inflammatory activity of saikosaponins
156. Antimicrobial and anti-inflammatory actions of tea-leaf saponin
157. Anti-inflammatory effects of total saponins of Panax notoginseng
158. Two novel oleanolic acid saponins having a sialyl Lewis X mimetic structure from Achyranthes fauriei root
159. Anticomplementary activity of ginseng saponins and their degradation products
160. Anticomplement activities of oleanolic acid monodesmosides and bisdesmosides isolated from Tiarella polyphylla