Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain

Brain, Behavior, and Immunity

Volumn 22, Issue 3, 2008, Pages 285-298

  Strauss, Kenneth I ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Arachidonic acid; Brain injuries; Cyclooxygenase 2; CYP genes; Eicosanoids; Epoxygenase; Gene regulation and expression; Neuroinflammation; Neuroprotection; Prostaglandins

Indexed keywords

ARACHIDONIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME; CYTOCHROME P450; ICOSANOID; LIPOXYGENASE;

ANTIINFLAMMATORY ACTIVITY; BRAIN INJURY; DRUG INHIBITION; DRUG MECHANISM; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARACHIDONIC ACID; BRAIN; BRAIN INJURIES; CYCLOOXYGENASE 2 INHIBITORS; EICOSANOIDS; FREE RADICALS; HUMANS; NEUROPROTECTIVE AGENTS; PROSTAGLANDINS;

EID: 38849198682     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2007.09.011     Document Type: Review

References (198)

1. Abramovitz M., Adam M., Boie Y., Carriere M., Denis D., Godbout C., Lamontagne S., Rochette C., Sawyer N., Tremblay N.M., Belley M., Gallant M., Dufresne C., Gareau Y., Ruel R., Juteau H., Labelle M., Ouimet N., and Metters K.M. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim. Biophys. Acta 1483 (2000) 285-293
2. Acarin L., Gonzalez B., and Castellano B. Triflusal posttreatment inhibits glial nuclear factor-kappaB, downregulates the glial response, and is neuroprotective in an excitotoxic injury model in postnatal brain. Stroke 32 (2001) 2394-2402
3. Acarin L.G.B.C.B. Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage. Stroke 33 (2002) 2499-2505
4. Adams J., Collaco-Moraes Y., and de Belleroche J. Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation. J. Neurochem. 66 (1996) 6-13
5. Alkayed N.J., Goyagi T., Joh H.D., Klaus J., Harder D.R., Traystman R.J., and Hurn P.D. Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. Stroke 33 (2002) 1677-1684
6. Alkayed N.J., Narayanan J., Gebremedhin D., Medhora M., Roman R.J., and Harder D.R. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke 27 (1996) 971-979
7. Almeida T., Cunha R.A., and Ribeiro J.A. Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus. Brain Res. 826 (1999) 104-111
8. Amruthesh S.C., Boerschel M.F., McKinney J.S., Willoughby K.A., and Ellis E.F. Metabolism of arachidonic acid to epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and prostaglandins in cultured rat hippocampal astrocytes. J. Neurochem. 61 (1993) 150-159
9. Bank U., Reinhold D., Schneemilch C., Kunz D., Synowitz H.J., and Ansorge S. Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation. J. Interferon Cytokine Res. 19 (1999) 1277-1287
10. Barr J., Sharma C.S., Sarkar S., Wise K., Dong L., Periyakaruppan A., and Ramesh G.T. Nicotine induces oxidative stress and activates nuclear transcription factor kappa B in rat mesencephalic cells. Mol. Cell. Biochem. 297 (2007) 93-99
11. Bertrand V., Guimbaud R., Tulliez M., Mauprivez C., Sogni P., Couturier D., Giroud J.P., Chaussade S., and Chauvelot-Moachon L. Increase in tumor necrosis factor-alpha production linked to the toxicity of indomethacin for the rat small intestine. Br. J. Pharmacol. 124 (1998) 1385-1394
12. Bezzi P., Carmignoto G., Pasti L., Vesce S., Rossi D., Rizzini B.L., Pozzan T., and Volterra A. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature 391 (1998) 281-285
13. Blom M.A., van Twillert M.G., de Vries S.C., Engels F., Finch C.E., Veerhuis R., and Eikelenboom P. NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2. Brain Res. 777 (1997) 210-218
14. Breder C.D., Smith W.L., Raz A., Masferrer J., Seibert K., Needleman P., and Saper C.B. Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain. J. Comp. Neurol. 322 (1992) 409-438
15. Brezinski M.E., and Serhan C.N. Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids. Proc. Natl. Acad. Sci. USA 87 (1990) 6248-6252
16. Caggiano A.O., Breder C.D., and Kraig R.P. Long-term elevation of cyclooxygenase-2, but not lipoxygenase, in regions synaptically distant from spreading depression. J. Comparative Neurol. 376 (1996) 447-462
17. Campbell W.B. New role for epoxyeicosatrienoic acids as anti-inflammatory mediators. Trends Pharmacolog. Sci. 21 (2000) 125-127
18. Candelario-Jalil E., Alvarez D., Castaneda J.M., Al-Dalain S.M., Martinez-Sanchez G., Merino N., and Leon O.S. The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. Brain Res. 927 (2002) 212-215
19. Candelario-Jalil E., Alvarez D., Merino N., and Leon O.S. Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. Neurosci. Res. 47 (2003) 245-253
20. Candelario-Jalil E., González-Falcón A., García-Cabrera M., León O.S., and Fiebich B.L. Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. Brain Res. 1007 (2004) 98-108
21. Candelario-Jalil E., Mhadu N.H., Gonzalez-Falcon A., Garcia-Cabrera M., Munoz E., Leon O.S., and Fiebich B.L. Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. J. Neuroinflamm. 2 (2005) 3
22. Cao C., Matsumura K., Shirakawa N., Maeda M., Jikihara I., Kobayashi S., and Watanabe Y. Pyrogenic cytokines injected into the rat cerebral ventricle induce cyclooxygenase-2 in brain endothelial cells and also upregulate their receptors. Eur. J. Neurosci. 13 (2001) 1781-1790
23. Cao C., Matsumura K., Yamagata K., and Watanabe Y. Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response. Brain Res. 697 (1995) 187-196
24. Capdevila J., Gil L., Orellana M., Marnett L.J., Mason J.I., Yadagiri P., and Falck J.R. Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. Arch. Biochem. Biophys. 261 (1988) 257-263
25. Capdevila J., Marnett L.J., Chacos N., Prough R.A., and Estabrook R.W. Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids. Proc. Natl. Acad. Sci. USA 79 (1982) 767-770
26. Capdevila J.H., Kishore V., Dishman E., Blair I.A., and Falck J.R. A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs). Biochem. Biophys. Res. Commun. 146 (1987) 638-644
27. Casolini P., Catalani A., Zuena A.R., and Angelucci L. Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat. J. Neurosci. Res. 68 (2002) 337-343
28. Cernak I., O'Connor C., and Vink R. Activation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats. Clin. Exp. Pharmacol. Physiol. 28 (2001) 922-925
29. Cernak I., O'Connor C., and Vink R. Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats. Exp. Brain Res. 147 (2002) 193-199
30. Chacos N., Capdevila J., Falck J.R., Manna S., Martin-Wixtrom C., Gill S.S., Hammock B.D., and Estabrook R.W. The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase. Arch. Biochem. Biophys. 223 (1983) 639-648
31. Chacos N., Falck J.R., Wixtrom C., and Capdevila J. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem. Biophys. Res. Commun. 104 (1982) 916-922
32. Chen J., Marsh T., Zhang J.S., and Graham S.H. Expression of cyclo-oxygenase 2 in rat brain following kainate treatment. Neuroreport 6 (1995) 245-248
33. Chen J.K., Capdevila J., and Harris R.C. Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Mol. Biol. 21 (2001) 6322-6331
34. Christie M.J., Vaughan C.W., and Ingram S.L. Opioids, NSAIDs and 5-lipoxygenase inhibitors act synergistically in brain via arachidonic acid metabolism. Inflamm. Res. 48 (1999) 1-4
35. Collaco-Moraes Y., Aspey B., Harrison M., and de Belleroche J. Cyclo-oxygenase-2 messenger RNA induction in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16 (1996) 1366-1372
36. Csuka E., Hans V.H., Ammann E., Trentz O., Kossmann T., and Morganti-Kossmann M.C. Cell activation and inflammatory response following traumatic axonal injury in the rat. Neuroreport 11 (2000) 2587-2590
37. Dash P., Mach S., and Moore A. Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury. J. Neurotrauma 17 (2000) 69-81
38. Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., Gibson D., Mandelbaum A., Etinger A., and Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor[comment]. Science 258 (1992) 1946-1949
39. Dewitt D., Kong D., Lyeth B., Jenkins L., Hayes R., Wooten E., and Prough D. Experimental traumatic brain injury elevates brain prostaglandin E2 and thromboxane B2 levels in rats. J. Neurotrauma 5 (1988) 303-313
40. Dhillon H.S., Dose J.M., Scheff S.W., and Prasad M.R. Time course of changes in lactate and free fatty acids after experimental brain injury and relationship to morphologic damage. Exp. Neurol. 146 (1997) 240-249
41. Dumuis A., Sebben M., Haynes L., Pin J., and Bockaert J. NMDA receptors activate the arachidonic acid cascade system in striatal neurons. Nature 336 (1988) 68-70
42. Ellis E.F., Amruthesh S.C., Police R.J., and Yancey L.M. Brain synthesis and cerebrovascular action of cytochrome P-450/monooxygenase metabolites of arachidonic acid. Adv. Prostaglanandin. Thromb. Leukot. Res. 21A (1991) 201-204
43. Ellis E.F., Police R.J., Rice L.Y., Grabeel M., and Holt S. Increased plasma PGE2, 6-keto-PGF1 alpha, and 12-HETE levels following experimental concussive brain injury. J. Neurotrauma 6 (1989) 31-37
44. Ellis E.F., Wei E.P., and Kontos H.A. Vasodilation of cat cerebral arterioles by prostaglandins D2, E2, G2, and I2. Am. J. Physiol. 237 (1979) H381-H385
45. Ellis E.F., Wright K.F., Wei E.P., and Kontos H.A. Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury. J. Neurochem. 37 (1981) 892-896
46. Ericsson A., Ek M., and Lindefors N. Distribution of prostaglandin E2 receptor (EP3 subtype) mRNA containing cells in the rat central nervous system. Soc. Neurosci. Abs. 21 (1995) 98
47. Feng L., Sun W., Xia Y., Tang W.W., Chanmugam P., Soyoola E., Wilson C.B., and Hwang D. Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Arch. Biochem. Biophys. 307 (1993) 361-368
48. Feng L., Xia Y., Garcia G., Hwang D., and Wilson C. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide. J. Clin. Invest. 95 (1995) 1669-1675
49. Fennekohl A., Sugimoto Y., Segi E., Maruyama T., Ichikawa A., and Puschel G.P. Contribution of the two Gs-coupled PGE2-receptors EP2-receptor and EP4-receptor to the inhibition by PGE2 of the LPS-induced TNFalpha-formation in Kupffer cells from EP2-or EP4-receptor-deficient mice. Pivotal role for the EP4-receptor in wild type Kupffer cells. J. Hepatol. 36 (2002) 328-334
50. Fitch M.T., Doller C., Combs C.K., Landreth G.E., and Silver J. Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J. Neurosci. 19 (1999) 8182-8198
51. Fitch M.T., and Silver J. Activated macrophages and the blood-brain barrier: inflammation after CNS injury leads to increases in putative inhibitory molecules. Exp. Neurol. 148 (1997) 587-603
52. Fitzpatrick F.A., and Murphy R.C. Cytochrome P-450 metabolism of arachidonic acid: formation and biological actions of "epoxygenase"-derived eicosanoids. Pharmacol. Rev. 40 (1988) 229-241
53. Flohe S., Ackermann M., Reuter M., Nast-Kolb D., and Schade F.U. Sublethal hemorrhagic shock reduces tumor necrosis factor-alpha-producing capacity in different cell compartments. Eur. Cytokine Network 11 (2000) 420-426
54. +, K(+)-ATPase activity. Biochem. Biophys. Res. Commun. 235 (1997) 374-376
55. Gardiner M., Nilsson B., Rehncrona S., and Siesjo B.K. Free fatty acids in the rat brain in moderate and severe hypoxia. J. Neurochem. 36 (1981) 1500-1505
56. Goncalves de Moraes V.L., Boris Vargaftig B., Lefort J., Meager A., and Chignard M. Effect of cyclo-oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide-induced neutrophil infiltration in mouse lung. Br. J. Pharmacol. 117 (1996) 1792-1796
57. Gopez J.J., Yue H., Vasudevan R., Malik A.S., Fogelsanger L.N., Lewis S., Panikashvili D., Shohami E., Jansen S.A., Narayan R.K., and Strauss K.I. Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. Neurosurgery 56 (2005) 590-604
58. Graham S., Nakayama M., Zhu R., and Chen J. Cyclooxygenase 2 and the pathogenesis of delayed neuronal death after global ischemia. Neurology 46 (1996) 406
59. Grilli M., and Memo M. Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway. Cell Death Differ. 6 (1999) 22-27
60. Grilli M., Pizzi M., Memo M., and Spano P. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 274 (1996) 1383-1385
61. Hampson A.J., and Grimaldi M. 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J. Neurosci. 22 (2002) 257-264
62. Harder D.R., Campbell W.B., and Roman R.J. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J. Vascular Res. 32 (1995) 79-92
63. Heck S., Lezoualc'h F., Engert S., and Behl C. Insulin-like growth factor-1-mediated neuroprotection against oxidative stress is associated with activation of nuclear factor kappaB. J. Biol. Chem. 274 (1999) 9828-9835
64. Hernandez M., de Arriba A.F., Merlos M., Fuentes L., Crespo M.S., and Nieto M.L. Effect of 4-trifluoromethyl derivatives of salicylate on nuclear factor kappaB-dependent transcription in human astrocytoma cells. Br. J. Pharmacol. 132 (2001) 547-555
65. Herschman H.R., Xie W., and Reddy S. Inflammation, reproduction, cancer and all that. The regulation and role of the inducible prostaglandin synthase. Bioessays 17 (1995) 1031-1037
66. Hewett S., Uliasz T., Vidwans A., and Hewett J. Cyclooxygenase-2 contributes to N-methyl-d-aspartate-mediated neuronal cell death in primary cortical cell culture. J. Pharm. Exp. Ther. 293 2 (2000) 417-425
67. Hirst W.D., Young K.A., Newton R., Allport V.C., Marriott D.R., and Wilkin G.P. Expression of COX-2 by normal and reactive astrocytes in the adult rat central nervous system. Mol. Cell. Neurosci. 13 (1999) 57-68
68. Ho L., Pieroni C., Winger D., Purohit D.P., Aisen P.S., and Pasinetti G.M. Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease. J. Neurosci. Res. 57 (1999) 295-303
69. Holmin S., and Mathiesen T. Intracerebral administration of interleukin-1beta and induction of inflammation, apoptosis, and vasogenic edema. J. Neurosurgery 92 (2000) 108-120
70. Iadecola C., Niwa K., Nogawa S., Zhao X., Nagayama M., Araki E., Morham S., and Ross M.E. Reduced susceptibility to ischemic brain injury and N-methyl-d-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc. Natl Acad. Sci. USA 98 (2001) 1294-1299
71. Iliff J.J., Close L.N., Selden N.R., and Alkayed N.J. A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat. Exp. Physiol. 92 (2007) 653-658
72. Ishaque A., Dunn M.J., and Sorokin A. Cyclooxygenase-2 inhibits tumor necrosis factor alpha-mediated apoptosis in renal glomerular mesangial cells. J. Biol. Chem. 278 (2003) 10629-10640
73. Jantzen P.T., Connor K.E., DiCarlo G., Wenk G.L., Wallace J.L., Rojiani A.M., Coppola D., Morgan D., and Gordon M.N. Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J. Neurosci. 22 (2002) 2246-2254
74. Jellinger K.A. Head injury and dementia. Curr. Opin. Neurol. 17 (2004) 719-723
75. Kaltschmidt B., Linker R.A., Deng J., and Kaltschmidt C. Cyclooxygenase-2 is a neuronal target gene of NF-kappaB. BMC Mol. Biol. 3 (2002) 16
76. Karara A., Dishman E., Falck J.R., and Capdevila J.H. Endogenous epoxyeicosatrienoyl-phospholipids A novel class of cellular glycerolipids containing epoxidized arachidonate moieties. J. Biol. Chem. 266 (1991) 7561-7569
77. Kaufmann W., Worley P., Pegg J., Bremer M., and Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. USA 93 (1996) 2317-2321
78. Kim E., Raval A.P., Defazio R.A., and Perez-Pinzon M.A. Ischemic preconditioning via epsilon protein kinase C activation requires cyclooxygenase-2 activation in vitro. Neuroscience 145 (2007) 931-941
79. Kiriyama M., Ushikubi F., Kobayashi T., Hirata M., Sugimoto Y., and Narumiya S. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 122 (1997) 217-224
80. Kjome J.R., Swenson K.A., Johnson M.N., Bordayo E.Z., Anderson L.E., Klevan L.C., Fraticelli A.I., Aldrich S.L., Fawcett J.R., Venters Jr. H.D., Ala T.A., and Frey II W.H. Inhibition of antagonist and agonist binding to the human brain muscarinic receptor by arachidonic acid. J. Mol. Neurosci. 10 (1998) 209-217
81. Knoblach S.M., and Faden A.I. Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp. Neurol. 153 (1998) 143-151
82. Koerner, I.P., Zhang, W., Hurn, P.D., Alkayed, N.J., 2005. Neuroprotective effect of 14,15-epoxyeicosatrienoic acid. Society for Neuroscience Meeting Abstracts. AbstractViewer/ItineraryPlanner, Washington, D.C.
83. Koistinaho J., Koponen S., and Chan P.H. Expression of cyclooxygenase-2 mRNA after global ischemia is regulated by AMPA receptors and glucocorticoids. Stroke 30 (1999) 1900-1905
84. Kontos H.A., Dietrich W.D., Wei E.P., Ellis E.F., and Povlishock J.T. Abnormalities of the cerebral microcirculation after traumatic injury: the relationship of hypertension and prostaglandins. Adv. Exp. Med. Biol. 131 (1980) 243-256
85. Kontos H.A., Wei E.P., Povlishock J.T., Dietrich W.D., Magiera C.J., and Ellis E.F. Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. Science 209 (1980) 1242-1245
86. Kozak K.R., Prusakiewicz J.J., and Marnett L.J. Oxidative metabolism of endocannabinoids by COX-2. Curr. Pharm. Des. 10 (2004) 659-667
87. Kozak K.R., Rowlinson S.W., and Marnett L.J. Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. J. Biol. Chem. 275 (2000) 33744-33749
88. Kozak W., Kluger M.J., Kozak A., Wachulec M., and Dokladny K. Role of cytochrome P-450 in endogenous antipyresis. Am. J. Physiol. Regul. Integ. Comparative Physiol. 279 (2000) R455-R460
89. Kubo Y., Suzuki M., Kudo A., Yoshida K., Suzuki T., Ogasawara K., Ogawa A., Kurose A., and Sawai T. Thrombin inhibitor ameliorates secondary damage in rat brain injury: suppression of inflammatory cells and vimentin-positive astrocytes. J. Neurotrauma 17 (2000) 163-172
90. Kunz T., and Oliw E. The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus. Eur. J. Neurosci. 13 (2001) 569-575
91. Lazarewicz J., Salinska E., Stafiej A., Ziembowicz A., and Zieminska E. NMDA receptors and nitric oxide regulate prostaglandin D2 synthesis in the rabbit hippocampus in vivo. Acta Neurobiol. Exp. 60 (2000) 427-435
92. Lazarewicz J., Wroblewski J., and Costa E. N-Methyl-d-aspartate-sensitive glutamate receptors induce calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells. J. Neurochem. 55 (1990) 1875-1881
93. Lazarewicz J.W., Wroblewski J.T., Palmer M.E., and Costa E. Activation of N-methyl-d-aspartate-sensitive glutamate receptors stimulates arachidonic acid release in primary cultures of cerebellar granule cells. Neuropharmacology 27 (1988) 765-770
94. Lewen A., and Hillered L. Involvement of reactive oxygen species in membrane phospholipid breakdown and energy perturbation after traumatic brain injury in the rat. J. Neurotrauma 15 (1998) 521-530
95. Li D.Y., Varma D.R., Chatterjee T.K., Fernandez H., Abran D., and Chemtob S. Fewer PGE2 and PGF2 alpha receptors in brain synaptosomes of newborn than of adult pigs. J. Pharmacol. Exp. Ther. 267 (1993) 1292-1297
96. Li S.R., Wu K.K., Anggard E., and Ferns G. Localization of prostaglandin G/H synthase gene expression in rat brain by in situ hybridization. Biol. Signals 2 (1993) 77-83
97. Lipsky R.H., Xu K., Zhu D., Kelly C., Terhakopian A., Novelli A., and Marini A.M. Nuclear factor kappaB is a critical determinant in N-methyl-d-aspartate receptor-mediated neuroprotection. J. Neurochem. 78 (2001) 254-264
98. Liu D., Wu L., Breyer R., Mattson M.P., and Andreasson K. Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia. Ann. Neurol. 57 (2005) 758-761
99. Liu M., and Alkayed N.J. Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes. J. Cereb. Blood Flow Metab. 25 (2005) 939-948
100. Lukiw W.J., and Bazan N.G. Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J. Neurosci. Res. 53 (1998) 583-592
101. Makita K., Falck J.R., and Capdevila J.H. Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system. FASEB J. 10 (1996) 1456-1463
102. Makita K., Takahashi K., Karara A., Jacobson H.R., Falck J.R., and Capdevila J.H. Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. J. Clin. Invest. 94 (1994) 2414-2420
103. Malik A.S., Narayan R.K., Cole R.W., Schwartz A.G., Pashko L.L., and Strauss K.I. A novel dehydroepiandrosterone analog improves functional recovery in a rat traumatic brain injury model. J. Neurotrauma 20 (2003) 463-475
104. Manabe Y., Anrather J., Kawano T., Niwa K., Zhou P., Ross M.E., and Iadecola C. Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. Ann. Neurol. 55 (2004) 668-675
105. Manev H., Uz T., and Qu T. 5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus:early response to glutamate receptor activation by kainate. Exp. Gerontol. 35 (2000) 1201-1209
106. Marcheselli V.L., and Bazan N.G. Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus Inhibition by a platelet-activating factor antagonist. J. Biol. Chem. 271 (1996) 24794-24799
107. Marini A., and Paul S. N-Methyl-d-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis. Proc. Natl. Acad. Sci. USA 89 (1992) 6555-6559
108. Marklund N., Salci K., Lewen A., and Hillered L. Glycerol as a marker for post-traumatic membrane phospholipid degradation in rat brain. Neuroreport 8 (1997) 1457-1461
109. Matsumoto Y., Yamaguchi T., Watanabe S., and Yamamoto T. Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta. Neuropharmacology 46 (2004) 1195-1200
110. Mayhan W.G. Leukocyte adherence contributes to disruption of the blood-brain barrier during activation of mast cells. Brain Res. 869 (2000) 112-120
111. McCullough L., Wu L., Haughey N., Liang X., Hand T., Wang Q., Breyer R.M., and Andreasson K. Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J. Neurosci. 24 (2004) 257-268
112. McGiff J.C., and Carroll M.A. Cytochrome P450-dependent arachidonate metabolites, renal function and blood pressure regulation. Adv. Prostaglandin Thromb. Leukot. Res. 21B (1991) 675-682
113. Mechoulam R., Ben-Shabat S., Hanus L., Ligumsky M., Kaminski N.E., Schatz A.R., Gopher A., Almog S., Martin B.R., and Compton D.R. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50 (1995) 83-90
114. Mechoulam R., Fride E., and Di Marzo V. Endocannabinoids. Eur. J. Pharmacol. 359 (1998) 1-18
115. Medhora M., and Harder D. Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review). Int. J. Mol. Med. 2 (1998) 661-669
116. Medhora M., Narayanan J., and Harder D. Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids. Trends Cardiovasc. Med. 11 (2001) 38-42
117. Miettinen S., Fusco F.R., Yrjanheikki J., Keinanen R., Hirovonen T., Roivainen R., Narhi M., Hokfelt T., and Koistinaho J. Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-d-aspartic acid-receptors and phospholipase A(2). Proc. Natl. Acad. Sci. USA 94 (1997) 6500-6505
118. Minghetti L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J. Neuropathol. Exp. Neurol. 63 (2004) 901-910
119. Morganti-Kossmann M.C., Lenzlinger P.M., Hans V., Stahel P., Csuka E., Ammann E., Stocker R., Trentz O., and Kossmann T. Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Mol. Psychiatry 2 (1997) 133-136
120. Nadjar A., Tridon V., May M.J., Ghosh S., Dantzer R., Amedee T., and Parnet P. NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain. J. Cereb. Blood Flow Metab. 25 (2005) 1047-1059
121. Nagayama M., Niwa K., Nagayama T., Ross M.E., and Iadecola C. The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene. J. Cereb. Blood Flow Metab. 19 (1999) 1213-1219
122. Nakai M., Qin Z., Wang Y., and Chase T.N. NMDA and non-NMDA receptor-stimulated IkappaB-alpha degradation: differential effects of the caspase-3 inhibitor DEVD. CHO, ethanol and free radical scavenger OPC-14117. Brain Res. 859 (2000) 207-216
123. Nakayama M., Imamura S., Miyanohara O., Kawaguchi K., Chen J., and Graham S. Cyclooxygenase-2 inhibition decreases infarction after temporary focal ischemia in rats. Soc. Neurosci. Abs. 23 (1997) 849
124. Nakayama M., Uchimura K., Zhu R.L., Nagayama T., Rose M.E., Stetler R.A., Isakson P.C., Chen J., and Graham S.H. Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proc. Natl. Acad. Sci. USA 95 (1998) 10954-10959
125. Nishizaki T., Nomura T., Matsuoka T., Enikolopov G., and Sumikawa K. Arachidonic acid induces a long-lasting facilitation of hippocampal synaptic transmission by modulating PKC activity and nicotinic ACh receptors. Mol. Brain Res. 69 (1999) 263-272
126. Nishizaki T., Nomura T., Matsuoka T., and Tsujishita Y. Arachidonic acid as a messenger for the expression of long-term potentiation. Biochem. Biophys. Res. Comm. 254 (1999) 446-449
127. Node K., Huo Y.Q., Ruan X.L., Yang B.C., Spiecker M., Ley K., Zeldin D.C., and Liao J.K. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 285 (1999) 1276-1279
128. Nogawa S., Fangyi Z., Ross M.E., and Iadecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J. Neurosci. Res. 17 (1997) 2746-2755
129. Novelli A., Reilly J., Lysko P., and Henneberry R. Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced. Brain Res. 451 (1988) 205-212
130. Nurmi A., Lindsberg P.J., Koistinaho M., Zhang W., Juettler E., Karjalainen-Lindsberg M.L., Weih F., Frank N., Schwaninger M., and Koistinaho J. Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke 35 (2004) 987-991
131. O'Neill G.P., and Ford-Hutchinson A.W. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett. 330 (1993) 156-160
132. Ogorochi T., Narumiya S., Mizuno N., Yamashita K., Miyazaki H., and Hayaishi O. Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. J. Neurochem. 43 (1984) 71-82
133. Oka A., and Takashima S. Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons. Neuroreport 8 (1997) 1161-1164
134. Oliw E.H., Guengerich F.P., and Oates J.A. Oxygenation of arachidonic acid by hepatic monooxygenases Isolation and metabolism of four epoxide intermediates. J. Biol. Chem. 257 (1982) 3771-3781
135. Panikashvili D., Simeonidou C., Ben-Shabat S., Hanus L., Breuer A., Mechoulam R., and Shohami E. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature 413 (2001) 527-531
136. Parfenova H., Eidson T.H., and Leffler C.W. Upregulation of COX-2 in cerebral microvascular endothelial cells by smooth muscle cell signals. Am. J. Physiol. 273 (1997) C277-C288
137. Pasinetti G., and Aisen P. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. J. Neurosci. 87 (1998) 319-324
138. Post A., Holsboer F., and Behl C. Induction of NF-kappaB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: suppression of NF-kappaB and neuroprotection by antioxidants. J. Neurosci. 18 (1998) 8236-8246
139. Prasad M., Dhillon H., Carbary T., Dempsey R., and Scheff S. Enhanced phosphodiestric breakdown of phophotidylinositol bisphosphate after experimental brain injury. J. Neurochem. 63 (1994) 773-776
140. Quadros A., Patel N., Crescentini R., Crawford F., Paris D., and Mullan M. Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice. Neurosci. Lett. 353 (2003) 66-68
141. Resnick D., Graham S., Dixon C., and Marion D. Role of cyclooxygenase 2 in acute spinal cord injury. J. Neurotrauma 15 (1998) 1005-1013
142. Richter M., Weiss M., Weinberger I., Furstenberger G., and Marian B. Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors. Carcinogenesis 22 (2001) 17-25
143. Rimpilainen J., Pokela M., Kiviluoma K., Anttila V., Vainionpaa V., Hirvonen J., Ohtonen P., Mennander A., Remes E., and Juvonen T. Leukocyte filtration improves brain protection after a prolonged period of hypothermic circulatory arrest: A study in a chronic porcine model. J. Thoracic Cardiovasc. Surgery 120 (2000) 1131-1141
144. Rouzer C.A., Jacobs A.T., Nirodi C.S., Kingsley P.J., Morrow J.D., and Marnett L.J. RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-alpha secretion. J. Lipid Res. 46 (2005) 1027-1037
145. Sacco S., Agnello D., Sottocorno M., Lozza G., Monopoli A., Villa P., and Ghezzi P. Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats. J. Neurochem. 71 (1998) 2063-2070
146. Sanfeliu C.H.A.P.A.J. Exposure to N-methyl-d-aspartate increases release of arachidonic acid in primary cultures of rat hippocampal neurons and not in astrocytes. Brain Res. 526 (1990) 241-248
147. Sanz O., Estrada A., Ferrer I., and Planas A.M. Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid. Neuroscience 80 (1997) 221-232
148. Sanzgiri R.P., Araque A., and Haydon P.G. Prostaglandin E(2) stimulates glutamate receptor-dependent astrocyte neuromodulation in cultured hippocampal cells. J. Neurobiol. 41 (1999) 221-229
149. Saper C.B., and Breder C.D. Endogenous pyrogens in the CNS: role in the febrile response. Prog. Brain Res. 93 (1992) 419-428 (discussion 428-419)
150. Sapirstein A., Saito H., Texel S.J., Samad T.A., O'Leary E., and Bonventre J.V. Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 (2005) R1774-R1782
151. Sasaki T., Kitagawa K., Sugiura S., Omura-Matsuoka E., Tanaka S., Yagita Y., Okano H., Matsumoto M., and Hori M. Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia. J. Neurosci. Res. 72 (2003) 461-471
152. Scali C., Giovannini M.G., Prosperi C., Bellucci A., Pepeu G., and Casamenti F. The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo. Neuroscience 117 (2003) 909-919
153. Scali C., Prosperi C., Vannucchi M.G., Pepeu G., and Casamenti F. Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. Eur. J. Neurosci. 12 (2000) 1900-1912
154. Schilter B., Andersen M.R., Acharya C., and Omiecinski C.J. Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers. J. Pharmacol. Exp. Therapeut. 294 (2000) 916-922
155. Schilter B., and Omiecinski C.J. Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain. Mol. Pharmacol. 44 (1993) 990-996
156. Schramm M., and Eimerl S.E.C. Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: Role of the glutamate receptor responsive to N-methyl-d-aspartate. Proc. Natl. Acad. Sci. USA 87 (1990) 1193-1197
157. Seibert K., Zhang Y., Leahy K., Hauser S., Masferrer J., Perkins W., Lee L., and Isakson P. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA 91 (1994) 12013-12017
158. Sevanian A., and Kim E. Phospholipase A2 dependent release of fatty acids from peroxidized membranes. J. Free Radical Biol. Med. 1 (1985) 263-271
159. Shapira Y., Shohami E., Sidi A., Soffer D., Freeman S., and Cotev S. Experimental closed head injury in rats: mechanical, pathophysiologic, and neurologic properties. Crit. Care Med. 16 (1988) 258-265
160. Shaw K.N., Commins S., and O'Mara S.M. Deficits in spatial learning and synaptic plasticity induced by the rapid and competitive broad-spectrum cyclooxygenase inhibitor ibuprofen are reversed by increasing endogenous brain-derived neurotrophic factor. Eur. J. Neurosci. 17 (2003) 2438-2446
161. Shohami E., Cotev S., and Shapira Y. The role of eicosanoids in the development of delayed brain damage. J. Basic Clin. Physiol. Pharmacol. 1 (1990) 203-206
162. Shohami E., Shapira Y., Sidi A., and Cotev S. Head injury induces increased prostaglandin synthesis in rat brain. J. Cereb. Blood Flow Metab. 7 (1987) 58-63
163. Slanina K.A., and Schweitzer P. Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus. Neuropharmacology 49 (2005) 653-659
164. Smith W., and Dewitt D. Prostaglandin endoperoxide H synthases-1 and -2. Adv. Immunol. 62 (1996) 167-215
165. Spielman L., Winger D., Ho L., Aisen P.S., Shohami E., and Pasinetti G.M. Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Acta Neuropathol. 103 (2002) 157-162
166. Stephenson D.T., Lemere C.A., Selkoe D.J., and Clemens J.A. Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol. Dis. 3 (1996) 51-63
167. Strauss K.I., Barbe M.F., Marshall R.M., Raghupathi R., Mehta S., and Narayan R.K. Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat. J. Neurotrauma 17 (2000) 695-711
168. Strauss K.I., and Marini A.M. Cyclooxygenase-2 inhibition protects cultured cerebellar granule neurons from glutamate-mediated excitotoxic cell death. J. Neurotrauma 19 (2002) 627-638
169. Strauss K.I., Meagher R.J., and Narayan R.K. Hippocampal prostaglandin changes following TBI- treatment with COX2 inhibitors. Restor. Neurol. Neurosci. 16 (2000) 263 (P298)
170. 2+ independent phospholipase A2 and n-3 polyunsaturated fatty acid docosahexaenoic acid in prostanoid production in brain: perspectives for protection in neuroinflammation. Int. J. Dev. Neurosci. 22 (2004) 551-557
171. Stuhlmeier K.M., Kao J.J., and Bach F.H. Arachidonic acid influences proinflammatory gene induction by stabilizing the inhibitor-kappaBalpha/nuclear factor-kappaB (NF-kappaB) complex, thus suppressing the nuclear translocation of NF-kappaB. J. Biol. Chem. 272 (1997) 24679-24683
172. Sugimoto Y., Shigemoto R., Namba T., Negishi M., Mizuno N., Narumiya S., and Ichikawa A. Distribution of the messenger RNA for the prostaglandin E receptor subtype EP3 in the mouse nervous system. Neuroscience 62 (1994) 919-928
173. Tamatani M., Mitsuda N., Matsuzaki H., Okado H., Miyake S., Vitek M.P., Yamaguchi A., Tohyama M., Grilli M., and Memo M. A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2. J. Neurochem. 75 (2000) 683-693
174. Tanaka E., Niiyama S., Sato S., Yamada A., and Higashi H. Arachidonic acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia. J. Neurophysiol. 90 (2003) 3213-3223
175. Tetsuka T., Baier L.D., and Morrison A.R. Antioxidants inhibit interleukin-1-induced cyclooxygenase and nitric-oxide synthase expression in rat mesangial cells Evidence for post-transcriptional regulation. J. Biol. Chem. 271 (1996) 11689-11693
176. Tocco G., Freire-Moar J., Schreiber S.S., Sakhi S.H., Aisen P.S., and Pasinetti G.M. Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease. Exp. Neurol. 144 (1997) 339-349
177. Tsubokura S., Watanabe Y., Ehara H., Imamura K., Sugimoto O., Kagamiyama H., Yamamoto S., and Hayaishi O. Localization of prostaglandin endoperoxide synthase in neurons and glia in monkey brain. Brain Res. 543 (1991) 15-24
178. Tzeng S.F., Hsiao H.Y., and Mak O.T. Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr. Drug Targets Inflamm. Allergy 4 (2005) 335-340
179. Uz T., and Manev H. Circadian expression of pineal 5-lipoxygenase mRNA. Neuroreport 9 (1998) 783-786
180. Vassiliou E., Jing H., and Ganea D. Prostaglandin E2 inhibits TNF production in murine bone marrow-derived dendritic cells. Cell. Immunol. 223 (2003) 120-132
181. Vaughan C.W., Ingram S.L., Connor M.A., and Christie M.J. How opioids inhibit GABA-mediated neurotransmission [see comments]. Nature 390 (1997) 611-614
182. Vollgraf U., Wegner M., and Richter-Landsberg C. Activation of AP-1 and nuclear factor-kappaB transcription factors is involved in hydrogen peroxide-induced apoptotic cell death of oligodendrocytes. J. Neurochem. 73 (1999) 2501-2509
183. Wallace C., Lyford G., Worley P., and Steward O. Differential intracellular sorting of immediate early gene mRNAs depends on signals in the mRNA sequence. J. Neurosci. Res. 18 (1998) 26-35
184. Walton M., Sirimanne E., Williams C., Gluckman P.D., Keelan J., Mitchell M.D., and Dragunow M. Prostaglandin H synthase-2 and cytosolic phospholipase A2 in the hypoxic-ischemic brain: role in neuronal death or survival?. Mol. Brain Res. 50 (1997) 165-170
185. Weaver K.D., Branch C.A., Hernandez L., Miller C.H., and Quattrocchi K.B. Effect of leukocyte-endothelial adhesion antagonism on neutrophil migration and neurologic outcome after cortical trauma. J. Trauma 48 (2000) 1081-1090
186. Wei E.P., Kontos H.A., Dietrich W.D., Povlishock J.T., and Ellis E.F. Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats. Circul. Res. 48 (1981) 95-103
187. Westcott J.Y., Murphy R.C., and Stenmark K. Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. Prostaglandins 34 (1987) 877-887
188. Whalen M.J., Carlos T.M., Kochanek P.M., Clark R.S., Heineman S., Schiding J.K., Franicola D., Memarzadeh F., Lo W., Marion D.W., and Dekosky S.T. Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats. J. Neurotrauma 16 (1999) 583-594
189. Yakovlev A.G., Knoblach S.M., Fan L., Fox G.B., Goodnight R., and Faden A.I. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J. Neurosci. 17 (1997) 7415-7424
190. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., and Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11 (1993) 371-386
191. Yermakova A.V., Rollins J., Callahan L.M., Rogers J., and O'Banion M.K. Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. J. Neuropathol. Exp. Neurol. 58 (1999) 1135-1146
192. Yoshida H., Kubota T., and Krueger J.M. A cyclooxygenase-2 inhibitor attenuates spontaneous and TNF-alpha-induced non-rapid eye movement sleep in rabbits. Am. J. Physiol. Regul. Integ. Comp. Physiol. 285 (2003) R99-R109
193. Yu Z., Huse L.M., Adler P., Graham L., Ma J., Zeldin D.C., and Kroetz D.L. Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. Mol. Pharmacol. 57 (2000) 1011-1020
194. Yu Z., Xu F., Huse L.M., Morisseau C., Draper A.J., Newman J.W., Parker C., Graham L., Engler M.M., Hammock B.D., Zeldin D.C., and Kroetz D.L. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circul. Res. 87 (2000) 992-998
195. Zeldin D.C., and Liao J.K. Reply: new role for epoxyeicosatrienoic acids as anti-inflammatory mediators. Trends Pharmacol. Sci. 21 (2000) 127-128
196. Zeldin D.C., Wei S., Falck J.R., Hammock B.D., Snapper J.R., and Capdevila J.H. Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. Arch. Biochem. Biophys. 316 (1995) 443-451
197. Zhang J., and Rivest S. Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide. J. Neurochem. 76 (2001) 855-864
198. Zou J., and Crews F. CREB and NF-kappaB transcription factors regulate sensitivity to excitotoxic and oxidative stress induced neuronal cell death. Cell Mol. Neurobiol. 26 (2006) 385-405