Increase in tumor necrosis factor-α production linked to the toxicity of indomethacin for the rat small intestine

British Journal of Pharmacology

Volumn 124, Issue 7, 1998, Pages 1385-1394

  Bertrand, Viviane ^a   Guimbaud, Rosine ^a   Tulliez, Micheline ^a   Mauprivez, Cédric ^a   Sogni, Philippe ^a   Couturier, Daniel ^a   Giroud, Jean Paul ^a   Chaussade, Stanislas ^a   Chauvelot Moachon, Laurence ^a  

^a Ctr Hosp Univ Cochin Port Royal ^*  (France)

Author keywords

Inducible NO synthase; Intestinal inflammation; Myeloperoxidase; Nitric oxide; Nonsteroidal anti inflammatory drugs; Prostaglandins; RO 20 1724; Small intestine; TNF ; Type IV phosphodiesterase inhibitors

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; INDOMETACIN; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE; NITRITE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENTERITIS; ENZYME ACTIVITY; GASTROINTESTINAL TOXICITY; ILEUM; INTESTINE ULCER; JEJUNUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DIGESTIVE SYSTEM; INDOMETHACIN; JEJUNUM; MALE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA; ULCER;

EID: 0031876482     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701968     Document Type: Article

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