Inhibition of antagonist and agonist binding to the human brain muscarinic receptor by arachidonic acid

Journal of Molecular Neuroscience

Volumn 10, Issue 3, 1998, Pages 209-217

  Kjome, Jacob R ^a   Swenson, Kathryn A ^a   Johnson, Melissa N ^a   Bordayo, Elizabeth Z ^a   Anderson, Lisa E ^a   Klevan, Lars C ^a   Fraticelli, Ada I ^a   Aldrich, Steven L ^a   Fawcett, John R ^a   Venters Jr , Homer D ^a   Ala, Thomas A ^a   Frey II, William H ^a  

^a REGIONS HOSPITAL   (United States)

Author keywords

Agonist; Antagonist; Arachidonic acid; Binding; Feedback inhibition; Inhibitor; Muscarinic; Receptor

Indexed keywords

ARACHIDONIC ACID; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT;

ARTICLE; BINDING COMPETITION; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; FEEDBACK SYSTEM; HUMAN; HUMAN TISSUE; RECEPTOR BINDING; RECEPTOR BLOCKING;

EID: 15644364109     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02761775     Document Type: Article

References (28)

1. Aronstam R. S., Abood L. G., and Baumgold J. (1977) Role of phospholipids in muscarinic binding by neural membranes. Biochem. Pharmacol. 26, 1689-1695.
2. Axelrod J., Burch R. M., and Jelsema C. L. (1988) Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers. Trends Neurosci. 11, 117-123.
3. Conklin B. R., Brann M. R., Buckley N. J., Ma A. L., Bonner T. I., and Axelrod J. (1988) Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells. Proc. Natl. Acad. Sci. USA 85, 8698-8702.
4. Davies P. (1985) A critical review of the role of the cholinergic systems in human memory and cognition. Ann. NY Acad. Sci. 444, 212-216.
5. Davies P. and Maloney A. J. F. (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2, 1403.
6. De Souza E. B. (1993) Preclinical strategies for symptomatic treatment of cognitive deficits seen in Alzheimer's disease: focus on cholinergic mechanisms, in Alzheimer's Disease: Advances in Clinical and Basic Research (Corain B., Iqbal K., Nicolini M., Winblad B., Wisniewski H., and Zatta P., eds.), Wiley, Chichester, UK, pp. 539-548.
7. Drachman D. A. and Leavitt J. (1974) Human memory and the cholinergic system: a relationship to aging? Arch. Neurol. 30, 113-121.
8. Felder C. C., Dieter P., Kinsella J., Tamura K., Kanterman R. Y., and Axelrod J. (1990) A transfected m5 muscarinic acetylcholine receptor stimulates phospholipase A2 by inducing both calcium influx and activation of protein kinase C. J. Pharmacol. Exp. Ther. 256, 1140-1147.
9. Fields J. Z., Roeske W. R., Morkin E., and Yamamura M. I. (1978) Cardiac muscarinic cholinergic receptors. J. Biol. Chem. 253, 3251-3258.
10. Frey W. H. II, Emory C. R., Wiebenga M. E., Saxena S., Cardelli D., Ala T.-A., and Tollfeson G. D. (1994) Inhibitor of antagonist binding to the muscarinic receptor is elevated in Alzheimer's brain. Brain Res. 655, 153-160.
11. Frey W. H. II, Najarian M. M., Kumar K. S., Emory C. R., Menning J. C., Johnson M. N., and Ala T. A. (1996) Endogenous Alzheimer's brain factor and oxidized glutathione inhibit antagonist binding to the muscarinic receptor. Brain Res. 714, 87-94.
12. Frey W. H. II, Kjome J., Swenson K., Fraticelli A. I., Johnson M. N., Venters H. D. Jr., and Ala T. A. (1997) Inhibition of antagonist binding to the muscarinic receptor by arachidonic acid (abstract). FASEB J. 11(9), A919.
13. Glass D. B., Frey W. H. II, Carr D. W., and Goldberg N. D. (1977) Stimulation of human platelet guanylate cyclase by fatty acids. J. Biol. Chem. 252, 1279-1285.
14. Kanfer J. N., Singh I. N., Pettegrew J. W., McCartney D. G., and Sorrentino G. (1996) Phospholipid metabolism in Alzheimer's disease and in a human cholinergic cell. J. Lipid Mediators Cell Signall. 14, 361-363.
15. Katzman R. and Thal L. J. (1989) The neurochemistry of Alzheimer's disease, in Basic Neurochemistry (Siegel G., Arganoff B., Alberts R. W., and Molinoff P., eds.), Raven, New York, pp. 827-838.
16. Kinouchi H., Imaizumi S., Yoshimoto T., and Motomiya M. (1990) Phenytoin affects metabolism of free fatty acids and nucleotides in rat cerebral ischemia. Stroke 21, 1326-1332.
17. Marks M. J. and Collins A. C. (1982) Characterization of nicotine binding in mouse brain and comparison with the binding of α-bungarotoxin and quinuclidinly benzilate. Mol. Pharmacol. 22, 554-564.
18. Maruyama Y. (1990) Inhibitory effects of arachidonic acid on muscarinic current response in single pancreatic acinar cells of rats. J. Physiol. 430, 471-482.
19. 3H]-quinuclidinyl benzylate binding to cardiac muscarinic receptor by long chain fatty acids can be attenuated by ligand occupation of the receptor. J. Mol. Cell Cardiol. 21, 495-506.
20. Staub F., Winkler A., Peters J., Kempski O., Kachel V., and Baetmann A. (1994) Swelling, acidosis, and irreversible damage of glial cells from exposure to arachidonic acid in vitro. J. Cerebral Blood Flow Metab. 14, 1030-1039.
21. Stephenson D. T., Lemere C. A., Selkoe D. J., and Clemens J. A. (1996) Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol. Dis. 3(1), 51-63.
22. Strosznajder J., Samochocki M., and Duran M. (1994) Aging diminishes serotonin-stimulated arachidonic acid uptake and cholinergic receptor-activated arachidonic acid release in rat brain cortex membrane. J. Neurochem. 62, 1048-1054.
23. Tence M., Jocelyne C., Premont J., and Glowinski J. (1994) Muscarinic cholinergic agonists stimulate arachidonic acid release from mouse striatal neurons in primary culture. J. Pharmacol. Exp. Ther. 269, 646-653.
24. Tomlinson G. (1988) Inhibition of radioligand binding to receptors: a competitive business. TIPS 9, 159-162.
25. Venters H. D. Jr., Bonilla L. E., Jensen T., Garner H., Bordayo E., Najarian M. M., Ala T. A., Mason R. P., and Frey W. H. II. (1997) Heme from Alzheimer's brain inhibits muscarinic receptor binding via thiyl radical generation. Brain Res. 764, 93-100.
26. Vijayaraghavan S., Huang B., Blumenthal E. M., and Berg D. K. (1995) Arachidonic acid as a possible negative feedback inhibitor of nicotinic acetyl-choline receptors on neurons. J. Neurosci. 15, 3679-3687.
27. Whitehouse P. J., Price D. L., Struble R. G., Clark A. W., Coyle J. T., and DeLong M. R. (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215, 1237-1239.
28. Wolfe L. S. (1989) Eicosanoids, in Basic Neurochemistry (Siegel G., Arganoff B., Alberts R. W., and Molinoff P., eds.), Raven, New York, pp. 399-414.