Pyrogenic cytokines injected into the rat cerebral ventricle induce cyclooxygenase-2 in brain endothelial cells and also upregulate their receptors

European Journal of Neuroscience

Volumn 13, Issue 9, 2001, Pages 1781-1790

  Cao, Chunyu ^a   Matsumura, Kiyoshi ^a,b   Shirakawa, Noriyuki ^a   Maeda, Mitsuyo ^c   Jikihara, Ikuyo ^c   Kobayashi, Shigeo ^b   Watanabe, Yasuyoshi ^a,c  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cyclooxygenase; Cytokine interaction; Endothelial cells; Fever; Prostaglandin

Indexed keywords

BRAIN ENZYME; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; CYTOKINE RECEPTOR; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN; PYROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN VENTRICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INDUCTION; FEVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION;

ANIMALS; BRAIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; CYTOKINES; ENDOTHELIUM, VASCULAR; FEVER; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN-1; INTERLEUKIN-6; ISOENZYMES; MALE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; RECEPTORS, CYTOKINE; RECEPTORS, INTERLEUKIN-1; RECEPTORS, INTERLEUKIN-6; RNA, MESSENGER; UP-REGULATION;

EID: 0035021417     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816x.2001.01551.x     Document Type: Article

References (28)

1. Bankers-Fulbright, J.L., Kalli, K.R. & McKean, D.J. (1996) Interleukin-1 signal transduction. Life Sci., 59, 61-83.
2. Cao, C., Matsumura, K., Ozaki, M. & Watanabe, Y. (1999) Lipopolysaccharide injected into the cerebral ventricle evokes fever through induction of cyclooxygenase-2 in brain endothelial cells. J. Neurosci., 19, 716-725.
3. Cao, C., Matsumura, K., Yamagata, K. & Watanabe, Y. (1995) Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response. Brain Res., 697, 187-196.
4. Cao, C., Matsumura, K., Yamagata, K. & Watanabe, Y. (1996) Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1b: a possible site of prostaglandin synthesis responsible for fever. Brain Res., 733, 263-272.
5. Cao, C., Matsumura, K., Yamagata, K. & Watanabe, Y. (1997) Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA in the rat brain by LPS. Am. J. Physiol., 272, R1712-R1725.
6. Cao, C., Matsumura, K., Yamagata, K. & Watanabe, Y. (1998) Cyclooxygenase-2 is induced in brain blood vessels during fever evoked by peripheral or central administration of tumor necrosis factor. Mol. Brain Res., 56, 45-56.
7. Chai, Z., Gatti, S., Toniatti, C., Poli, V. & Bartfai, T. (1996) Interleukin (IL) -6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficiem mice. J. Exp. Med., 183, 311-316.
8. Dinarello, C.A. (1992) Role of interleukin-1 in infectious diseases. Immunol. Rev., 127, 119-146.
9. Dinarello, C.A. (1999) Cytokines as endogenous pyrogen. J. Infect. Dis., 179 (Suppl. 2), S294-S304.
10. Futaki, N., Arai, I., Hamasaka, Y., Takahashi, S., Higuchi, S. & Otomo, S. (1993a) Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation. J. Pharm. Pharmacol., 45, 753-755.
11. Futaki, N., Takahashi, S., Yokoyama, M., Arai, I., Higuchi, S. & Otomo, S. (1994) NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins, 47, 55-59.
12. Futaki, N., Yoshikawa, K., Hamasaka, Y., Arai, I., Higuchi, S., Iizuka, H. & Otomo, S. (1993b) NS-389, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen. Pharmacol., 24, 105-110.
13. Gierse, J.K., Hauser, S.D., Creely, D.P., Koboldt, C., Rangwala, S.H., Isakson, P.C. & Seibert, K. (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem. J., 305, 479-484.
14. Herschman, H.R. (1996) Prostaglandin synthase 2. Biochim. Biophys. Acta, 1299, 125-140.
15. Kluger, M.J. (1991) Fever: role of pyrogens and cryogens. Physiol. Rev., 71, 93-127.
16. Laflamme, N., Lacroix, S. & Rivest, S. (1999) An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia. J. Neurosci., 19, 10923-10930.
17. LeMay, L.G., Vander, A.J. & Kluger, M.J. (1990) Role of interleukin 6 in fever in rats. Am. J. Physiol., 258, R798-R803.
18. Li, S., Wand, Y., Matsumura, K.R.B.L., Morham, S.G. & Blatteis, C.M. (1999) The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2 (-/-), but not in cyclooxygenase-1 (-/-) mice. Brain Res., 825, 86-94.
19. Masferrer, J.L., Zweifel, B.S., Manning, P.T., Hauser, S.D., Leahy, K.M., Simth, W.G., Isakson, P.C. & Seibert, K. (1994) Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci., USA, 91, 3228-3232.
20. Matsumura, K., Cao, C., Ozaki, M., Morii, H., Nakadate, K. & Watanabe, Y. (1998) Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: Light and electron microscopic immunocytochemical studies. J. Neurosci., 18, 6279-6289.
21. Nakamori, T., Morimoto, A., Yamaguchi, K., Watanabe, T. & Murakami, N. (1994) Interleukin-1 beta production in the rabbit brain during endotoxin-induced fever. J. Physiol. (Lond.), 476, 177-186.
22. Paxinos, G. & Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, London.
23. Quan, N., Whiteside, M. & Herkenham, M. (1998) Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide. Brain Res., 802, 189-197.
24. Stitt, J.T. (1986) Prostaglandin E as the neural mediator of the febrile response. Yale J. Biol. Med., 59, 137-149.
25. Sundgren-Andersson, A.K., Ostlund, P. & Bartfai, T. (1998) IL-6 is essential in TNF-alpha-induced fever. Am. J. Physiol., 275, R2028-R2034.
26. Vallieres, L. & Rivest, S. (1997) Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta. J. Neurochem., 69, 1668-1683.
27. Van Dam, A.-M., Brouns, M., Louisse, S. & Berkenbosch, F. (1992) Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness? Brain Res., 588, 291-296.
28. Wagner, D.D. & Marder, V.J. (1983) Biosynthesis of von Willebrand protein by human endothelial cells. J. Biol. Chem., 258, 2065-2067.