A light- and electron-microscopic histopathological study of human bladder mucosa after intravesical resiniferatoxin application

BJU International

Volumn 88, Issue 4, 2001, Pages 355-360

  Silva, C ^a   Avelino, A ^b   Souto Moura, C ^a   Cruz, F ^a,b,c  

^a HOSPITAL DE SÃO JOÃO   (Portugal)

^b University of Porto   (Portugal)

^c Faculty of Medicine of Oporto   (Portugal)

Author keywords

Bladder; Histopathology; Human; Resiniferatoxin; Ultrastructure

Indexed keywords

ALCOHOL; GLUTARALDEHYDE; HEMATOXYLIN; PARAFFIN; PARAFORMALDEHYDE; RESIN; RESINIFERATOXIN; SCHIFF BASE;

ADULT; ARTICLE; BASEMENT MEMBRANE; BLADDER BIOPSY; BLADDER CAPACITY; BLADDER MUCOSA; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTOMETRY; CYSTOSCOPY; DISEASE COURSE; DRUG INSTILLATION; ELECTRON MICROSCOPY; FEMALE; HEART RATE; HISTOPATHOLOGY; HUMAN; HYPERREFLEXIA; INCONTINENCE; INFLAMMATORY CELL; LAMINA PROPRIA; MALE; MEMBRANE VESICLE; MICTURITION; MORPHOLOGY; PRIORITY JOURNAL; UROTHELIUM; VARICOSIS;

ADMINISTRATION, INTRAVESICAL; ADULT; BIOPSY; DITERPENES; FEMALE; HUMANS; MALE; MICROSCOPY; MICROSCOPY, ELECTRON; MIDDLE AGED; MUCOUS MEMBRANE; MULTIPLE SCLEROSIS; NEUROTOXINS; REFLEX, ABNORMAL; URINARY BLADDER; URINARY BLADDER DISEASES;

EID: 0035693147     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.2001.02339.x     Document Type: Article

References (30)

1. Suppression of bladder hyperreflexia by intravesical resiniferatoxin
2. Urodynamic effects of intravesical resiniferatoxin in humans: Preliminary results in stable and unstable detrusor
3. Desensitization of bladder sensory fibres by intravesical resiniferatoxin, a capsaicin analogue: Long-term results for the treatment of detrusor hyper-reflexia
4. Can desensitization of bladder sensory fibers relieve urinary symptoms in patients with detrusor instability?. Preliminary report with intravesical resinifera-toxin
5. Intravesical resiniferatoxin for the treatment of hypersensitive disorder: A randomized placebo controlled study
6. Desensitization of bladder sensory fibers by intravesical capsaicin or capsaicin analogues. A new strategy for treatment of urge incontinence in patients with spinal detrusor hyperreflexia or bladder hypersensitive disorders
7. Intravesical treatment of overactive bladder
8. Minireview. Euphorbium: Modern research on its active principle, resiniferatoxin, revives an ancient medicine
9. Vanilloid (capsaicin) receptors and mechanisms
10. Different biological targets for resiniferatoxin and phorbol 12-myristate 13 acetate
11. Similarities and differences in the action of resiniferatoxin and capsaicin on central and peripheral endings of primary sensory neurons
12. Long-lasting desensitization of bladder afferents following intravesical resiniferatoxin and capsaicin in the rat
13. Intravesical resiniferatoxin desensitizes rat bladder sensory fibres without causing intense noxious excitation. A c-fos study
14. Peptide immunoreactivity and ultra-structure of the rat urinary bladder nerve fibers after topical desensitization by capsaicin or resiniferatoxin
15. Tumor initiators and promotors in the induction of Epstein-Barr virus
16. Neurogenic component of phorbol ester-induced mouse skin inflammation
17. Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae
18. Incidence of squamous cell carcinoma in patients with long term catheter drainage
19. Comparative pathology of dome and trigone of urinary bladder mucosa of paraplegic and tetraplegic patients
20. Effect of intravesical capsaicin and vehicle on bladder integrity in control and spinal cord injured rats
21. Bladder surface glycosaminoglycans: An epithelial permeability barrier
22. Intravesical resiniferatoxin does not induce structural changes of the human bladder mucosa. A light and electron microscope study
23. The effects of capsaicin on the neurogenic hyperreflexic detrusor. A double blind placebo controlled study in patients with spinal cord disease. Preliminary study
24. Treating the human bladder with capsaicin: Is it safe?
25. Protein kinase C as the receptor for the phorbol ester tumor promotors. Sixth Rhoads Memorial Award Lecture
26. Structure activity relationships in diterpene esters irritants and cocarcinogenic to mouse skin
27. Cellular mechanisms of the action of capsaicin
28. The effect of intravesical capsaicin on the suburothelial innervation in patients with detrusor hyper-reflexia
29. Increased levels of GMAP, VIP and nitric oxide synthase, and their mRNAs, in lumbar dorsal root ganglia of the rat following systemic resiniferatoxin treatment