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Journal of the American Chemical Society

Volumn 123, Issue 38, 2001, Pages 9313-9323

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues

(12) Nicolaou, K C a,b Namoto, K a,b Ritzen A a,b Ulven, T a,b Shoji, M a,b Li, J a,b D'Amico, G c Liotta, D c French, C T d Wartmann, M e Altmann, K H e Giannakakou, P d

a SCRIPPS RESEARCH INSTITUTE (United States)

b UNIVERSITY OF CALIFORNIA (United States)

c EMORY UNIVERSITY (United States)

d EMORY UNIVERSITY SCHOOL OF MEDICINE (United States)

e NOVARTIS PHARMA AG (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL EVALUATION;

POLYMERIZATION; STEREOCHEMISTRY; TOXIC MATERIALS;

CHEMICAL ANALYSIS;

12,13 CYCLOBUTYL EPOTHILONE DERIVATIVE; 12,13 CYCLOPROPYL EPOTHILONE DERIVATIVE; CYTOTOXIC AGENT; EPOTHILONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; POLYMERIZATION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; FEMALE; HUMANS; OVARIAN NEOPLASMS; PYRIDINES; THIAZOLES; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0035955176 PISSN: 00027863 EISSN: None Source Type: Journal
DOI: 10.1021/ja011338b Document Type: Article

Times cited : (89)

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