Comparison of (+)-11C-McN5652 and 11C-DASB as serotonin transporter radioligands under various experimental conditions

Journal of Nuclear Medicine

Volumn 43, Issue 5, 2002, Pages 678-692

  Szabo, Zsolt ^a   McCann, Una D ^a   Wilson, Alan A ^a   Scheffel, Ursula ^a   Owonikoko, Taofeek ^a   Mathews, William B ^a   Ravert, Hayden T ^a   Hilton, John ^a   Dannals, Robert F ^a   Ricaurte, George A ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

( ) 3,4 methylenedioxymethamphetamine; Paroxetine; PET; Serotonin; Transporters

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; 3 AMINO 4 (2 DIMETHYLAMINOMETHYLPHENYLSULFANYL)BENZONITRILE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; CARBON 11; PAROXETINE; RADIOLIGAND; SEROTONIN; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BABOON; BRAIN INJURY; BRAIN LEVEL; COMPARTMENT MODEL; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG UPTAKE; LIGAND BINDING; MALE; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOISOTOPE DISTRIBUTION;

ANILINE COMPOUNDS; ANIMALS; CARBON RADIOISOTOPES; CARRIER PROTEINS; ISOQUINOLINES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NERVE TISSUE PROTEINS; PAPIO; PAROXETINE; PROTEIN BINDING; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SULFIDES; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0036255441     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Radioligand development for studying serotonin uptake sites with positron emission tomography
2. 123I]5-iodo-6-nitroquipazine
3. 123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography
4. 2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): An improved serotonin transporter ligand
5. Serotonin in aging, late-life depression, and Alzheimer's disease: The emerging role of functional imaging
6. 11C]WAY-100635 in humans: Comparison of arterial and reference tissue input functions
7. Radioligands for the study of the 5-HT transporter in vivo
8. 11C](+)McN5652
9. 11C]McN5652
10. 11C]McN5652
11. In vivo detection of short- and long-term MDMA neurotoxicity: A positron emission tomography study in the living baboon brain
12. Positron emission tomographic evidence of toxic effect of MDMA ("ecstasy") on brain serotonin neurons in human beings
13. Toxicodynamics and long-term toxicity of the recreational drug, 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")
14. 11C]McN5652: A serotonin transporter radioligand
15. 11C](+)McN-5652: Assessment of methods
16. Radiosynthesis of carbon-11 labeled N-methyl-2-(arylthio) benzylamines: Potential radiotracers for the serotonin reuptake receptor
17. Novel radiotracers for imaging the serotonin transporter by positron emission tomography: Synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines
18. 11C]DASB
19. 11C]DASB PET imaging study
20. Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+)3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy")
21. Altered serotonin innervation patterns in the forebrain of monkeys treated with MDMA seven years previously: Factors influencing abnormal recovery
22. 11C]McN-5652-Z
23. Column switching HPLC for the analysis of plasma in PET imaging studies
24. NetCDF: An interface for scientific data access
25. Rapid automated algorithm for aligning and reslicing PET images
26. MRI-PET registration with automated algorithm
27. 11C]Tropanyl benzylate-binding to muscarinic cholinergic receptors: Methodology and kinetic modeling alternatives
28. An algorithm for least-squares estimation of nonlinear parameters
29. Lasting effects of (+)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: Neurochemical observations
30. Tables of the Bonferroni t statistics
31. Analysis of C-11 alpha-methyltryptophan kinetics for the estimation of serotonin synthesis rate in vivo
32. 3H]paroxetine
33. 3H]paroxetine binding, a marker of serotonin uptake sites
34. 3H]paroxetine binding to serotonin uptake sites in human brain tissue
35. Novel aspects on central 5-hydroxytryptamine neurotransmission: Focus on the cerebellum
36. The serotoninergic system in the cerebellum: Origin, ultrastructural relationships, and physiological effects
37. Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations
38. 11C-methyl]-(-)-cocaine PET studies in human species
39. 3-Dimensional, 4-methylenedioxymethamphetamine (MDMA, "ecstasy"): Pharmacology and toxicology in animals and humans
40. (+)3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") selectively destroys brain serotonin terminals in rhesus monkey