Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease

Journal of Gastroenterology and Hepatology (Australia)

Volumn 20, Issue 9, 2005, Pages 1448-1455

  Gulsen, Mustafa ^a   Yesilova, Zeki ^a   Bagci, Sait ^a   Uygun, Ahmet ^a   Ozcan, Ayhan ^a   Ercin, C Nuri ^a   Erdil, Ahmet ^a   Sanisoglu, S Yavuz ^a   Cakir, Erdinç ^a   Ates, Yuksel ^a   Erbil, M Kemal ^a   Karaeren, Necmettin ^a   Dagalp, Kemal ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Fatty liver; Folate; Homocysteine; Insulin resistance

Indexed keywords

CYANOCOBALAMIN; CYSTATHIONINE BETA SYNTHASE; FOLIC ACID; HOMOCYSTEINE; INSULIN; LIPOPROTEIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; BLOOD LEVEL; CHRONIC HEPATITIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE SEVERITY; FEMALE; FOLIC ACID BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOCYSTINURIA; HUMAN; HUMAN TISSUE; HYPERHOMOCYSTEINEMIA; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPOPROTEIN BLOOD LEVEL; LIVER BIOPSY; LIVER NECROSIS; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PATIENT SELECTION; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL; BLOOD; FATTY LIVER; HEPATITIS; MIDDLE AGED; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING;

ADULT; FATTY LIVER; FEMALE; HEPATITIS; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS;

EID: 33644649625     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2005.03891.x     Document Type: Article

References (27)

1. Finkelstein JD, Martin JJ. Methionine metabolism in mammals: adaptation to methionine excess. J. Biol. Chem. 1986 261 : 1582 7.
2. Mato JM, Alvarez L, Ortiz P, Pajares MA. S-adenosylmethionine synthesis: molecular mechanisms and clinical implications. Pharmacol. Ther. 1997 73 : 265 80.
3. Avila MA, Berasain C, Torres L et al. Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J. Hepatol. 2000 33 : 907 14.
4. Brunt EM. Non-alcoholic steatohepatitis. Semin. Liver Dis. 2004 24 : 3 20.
5. Marchesini G, Bugianesi E, Forlani G et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003 37 : 917 23.
6. Gaull G, Starman JA, Schaffner N. Homocystinuria due to cystathionine synthase deficiency: enzymatic and ultrastructural studies. J. Pediatr. 1974 84 : 381 90.
7. Watanabe M, Osada J, Aratani Y et al. Mice deficient in cystathionine β-synthase: animal models for mild and severe homocyst(e)inemia. Proc. Natl Acad. Sci. USA 1995 92 : 1585 9.
8. Bosy-Westphal A, Ruschmeyer M, Czech N et al. Determinants of hyperhomocysteinemia in patients with chronic liver disease and after orthotopic liver transplantation. Am. J. Clin. Nutr. 2003 77 : 1269 77.
9. Look MP, Riezler R, Reichel C et al. Is the increase in serum cystathionine levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of gamma-cystathionase? Scand. J. Gastroenterol. 2000 35 : 866 72.
10. Ferre N, Gomez F, Camps J et al. Plasma homocysteine concentrations in patients with liver cirrhosis. Clin. Chem. 2002 48 : 183 5.
11. Gigliozzi A, Romeo R, Fraioli F et al. Effect of S-adenosyl-L-methionine and dilinoleoylphosphatidylcholine on liver lipid composition and ethanol hepatotoxicity in isolated perfused rat liver. Dig. Dis. Sci. 1998 43 : 2211 22.
12. Cravo ML, Gloria LM, Selhub J et al. Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B12, and vitamin B16 status. Am. J. Clin. Nutr. 1996 63 : 220 4.
13. Hultberg B, Berglund M, Andersson A, Frank A. Elevated plasma homocysteine in alcoholics. Alcohol. Clin. Exp. Res. 1993 17 : 687 9.
14. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am. J. Gastroenterol. 1999 94 : 2467 74.
15. Araki A, Sako Y. Determination of free and homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 1987 422 : 43 52.
16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from plasma fasting blood sugar and insulin concentrations in man. Diabetologia 1985 28 : 412 19.
17. Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 2003 124 : 1488 99.
18. Yahagi N, Shimano H, Hasty AH et al. Absence of sterol regulatory elment-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J. Biol. Chem. 2002 277 : 19 53 7.
19. Werstuck GH, Lentz SR, Dayal S et al. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin. Invest. 2001; 107 : 1263 73.
20. Sanyal AJ, Campbell-Sargent C, Mirshahi F et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001 120 : 1183 92.
21. Giltay EJ, Hoogeveen EK, Elbers JM, Gooren LJ, Asscheman H, Stehouwer CD. Insulin resistance is associated with elevated plasma homocysteine levels in healthy, non-obese subjects. Atherosclerosis 1998 139 : 197 8.
22. Fonseca VA, Mudaliar S, Schmidt B, Fink LM, Kern PA, Henry RR. Plasma homocysteine concentrations are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects. Metabolism 1998 47 : 686 9.
23. Jacobs RL, House JD, Brosnan ME, Brosnan JT. Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in rat. Diabetes 1998 47 : 1967 70.
24. Oshaug A, Bugge KH, Refsum H. Diet, an independent determinant for plasma homocysteine. A cross sectional study of Norwegian workers on platforms in the North Sea. Eur. J. Clin. Nutr. 1998 52 : 7 11.
25. Huang RF, Hsu YC, Lin HL, Yang FL. Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. J. Nutr. 2001 131 : 33 8.
26. Torres L, Garcia-Trevijano ER, Rodriguez JA et al. Induction of TIMP-1 expression in rat hepatic stellate cells and hepatocytes: a new role for homocysteine in liver fibrosis. Biochim. Biophys. Acta 1999 1455 : 12 22.
27. Varela-Moreiras G, Alonso-Aperte E, Rubio M et al. Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment. Hepatology. 1995 22 : 1310 15.