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Volumn 18, Issue 1, 2008, Pages 17-26

DNA damage-induced cell death: Lessons from the central nervous system

Author keywords

Apoptosis; ATM; Ionizing radiation; Neonatal retina; Neuroblasts; P53; Phosphorylation

Indexed keywords


EID: 38049136456     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2007.110     Document Type: Article
Times cited : (117)

References (79)
  • 1
    • 0034641963 scopus 로고    scopus 로고
    • Defying death after DNA damage
    • Rich T, Allen RL, Wyllie AH. Defying death after DNA damage. Nature 2000; 407:777-783.
    • (2000) Nature , vol.407 , pp. 777-783
    • Rich, T.1    Allen, R.L.2    Wyllie, A.H.3
  • 2
    • 34047218911 scopus 로고    scopus 로고
    • Programs for cell death: Apoptosis is only one way to go
    • Blank M, Shiloh Y. Programs for cell death: apoptosis is only one way to go. Cell Cycle 2007; 6:686-695.
    • (2007) Cell Cycle , vol.6 , pp. 686-695
    • Blank, M.1    Shiloh, Y.2
  • 3
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • Roos WP, Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol Med 2006; 12:440-450.
    • (2006) Trends Mol Med , vol.12 , pp. 440-450
    • Roos, W.P.1    Kaina, B.2
  • 4
    • 33751291259 scopus 로고    scopus 로고
    • New tricks for old drugs: The anticarcinogenic potential of DNA repair inhibitors
    • Bentle MS, Bey EA, Dong Y, Reinicke KE, Boothman DA. New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors. J Mol Histol 2006; 37:203-218.
    • (2006) J Mol Histol , vol.37 , pp. 203-218
    • Bentle, M.S.1    Bey, E.A.2    Dong, Y.3    Reinicke, K.E.4    Boothman, D.A.5
  • 5
    • 34250850978 scopus 로고    scopus 로고
    • DNA-damage sensitizers: Potential new therapeutical tools to improve chemotherapy
    • Michod D, Widmann C. DNA-damage sensitizers: potential new therapeutical tools to improve chemotherapy. Crit Rev Oncol Hematol 2007; 63:160-171.
    • (2007) Crit Rev Oncol Hematol , vol.63 , pp. 160-171
    • Michod, D.1    Widmann, C.2
  • 6
    • 10044259944 scopus 로고    scopus 로고
    • Coordination of repair, checkpoint, and cell death responses to DNA damage
    • Wang JY, Cho SK. Coordination of repair, checkpoint, and cell death responses to DNA damage. Adv Protein Chem 2004; 69:101-135.
    • (2004) Adv Protein Chem , vol.69 , pp. 101-135
    • Wang, J.Y.1    Cho, S.K.2
  • 7
    • 14644410453 scopus 로고    scopus 로고
    • The signals and pathways activating cellular senescence
    • Ben-Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 2005; 37:961-976.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 961-976
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 8
    • 34347393519 scopus 로고    scopus 로고
    • Radiation-induced DNA damage responses
    • Jeggo P, Lobrich M. Radiation-induced DNA damage responses. Radiat Prot Dosimetry 2006; 122:124-127.
    • (2006) Radiat Prot Dosimetry , vol.122 , pp. 124-127
    • Jeggo, P.1    Lobrich, M.2
  • 9
    • 34247483506 scopus 로고    scopus 로고
    • ATM activation and DNA damage response
    • Lavin MF, Kozlov S. ATM activation and DNA damage response. Cell Cycle 2007; 6:931-942.
    • (2007) Cell Cycle , vol.6 , pp. 931-942
    • Lavin, M.F.1    Kozlov, S.2
  • 10
    • 33847737716 scopus 로고    scopus 로고
    • DNA damage checkpoints: From initiation to recovery or adaptation
    • Bartek J, Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol 2007; 19:238-245.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 238-245
    • Bartek, J.1    Lukas, J.2
  • 11
    • 33847308224 scopus 로고    scopus 로고
    • Inhibiting transient protein-protein interactions: Lessons from the Cdc25 protein tyrosine phosphatases
    • Rudolph J. Inhibiting transient protein-protein interactions: lessons from the Cdc25 protein tyrosine phosphatases. Nat Rev Cancer 2001; 7:202-211.
    • (2001) Nat Rev Cancer , vol.7 , pp. 202-211
    • Rudolph, J.1
  • 12
    • 34250865564 scopus 로고    scopus 로고
    • CDC25 phosphatases in cancer cells: Key players? Good targets?
    • Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer 2001; 7:495-507.
    • (2001) Nat Rev Cancer , vol.7 , pp. 495-507
    • Boutros, R.1    Lobjois, V.2    Ducommun, B.3
  • 13
    • 33751419716 scopus 로고    scopus 로고
    • Surviving the breakup: The DNA damage checkpoint
    • Harrison JC, Haber JE. Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet 2006; 40:209-235.
    • (2006) Annu Rev Genet , vol.40 , pp. 209-235
    • Harrison, J.C.1    Haber, J.E.2
  • 16
    • 33746691847 scopus 로고    scopus 로고
    • Cellular senescence and DNA repair
    • Lou Z, Chen J. Cellular senescence and DNA repair. Exp Cell Res 2006; 312:2641-2646.
    • (2006) Exp Cell Res , vol.312 , pp. 2641-2646
    • Lou, Z.1    Chen, J.2
  • 17
    • 33847779345 scopus 로고    scopus 로고
    • ATM and ATR: Components of an integrated circuit
    • Hurley PJ, Bunz F. ATM and ATR: components of an integrated circuit. Cell Cycle 2007; 6:414-417.
    • (2007) Cell Cycle , vol.6 , pp. 414-417
    • Hurley, P.J.1    Bunz, F.2
  • 18
    • 0032534752 scopus 로고    scopus 로고
    • Shaping limbs by apoptosis
    • Chen Y, Zhao X. Shaping limbs by apoptosis. J Exp Zool 1998; 282:691-702.
    • (1998) J Exp Zool , vol.282 , pp. 691-702
    • Chen, Y.1    Zhao, X.2
  • 19
    • 33845480548 scopus 로고    scopus 로고
    • Caspase function in programmed cell death
    • Kumar S. Caspase function in programmed cell death. Cell Death Differ 2007; 14:32-43.
    • (2007) Cell Death Differ , vol.14 , pp. 32-43
    • Kumar, S.1
  • 20
    • 34547801766 scopus 로고    scopus 로고
    • Pathways regulating apoptosis during patterning and development
    • Domingos PM, Steller H. Pathways regulating apoptosis during patterning and development. Curr Opin Genet Dev 2007; 17:294-299.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 294-299
    • Domingos, P.M.1    Steller, H.2
  • 21
    • 0035975986 scopus 로고    scopus 로고
    • The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis
    • Schumacher B, Hofmann K, Boulton S, Gartner A. The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis. Curr Biol 2001; 11:1722-1727.
    • (2001) Curr Biol , vol.11 , pp. 1722-1727
    • Schumacher, B.1    Hofmann, K.2    Boulton, S.3    Gartner, A.4
  • 22
    • 13544264756 scopus 로고    scopus 로고
    • Schumacher B, Schertet C, Wittenburg N, et al. C. elegans ced13 can promote apoptosis and is induced in response to DNA damage. Cell Death Differ 2005; 12:153-161.
    • Schumacher B, Schertet C, Wittenburg N, et al. C. elegans ced13 can promote apoptosis and is induced in response to DNA damage. Cell Death Differ 2005; 12:153-161.
  • 23
    • 33751005017 scopus 로고    scopus 로고
    • Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans
    • Salinas LS, Maldonado E, Navarro RE. Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans. Cell Death Differ 2006; 13:2129-2139.
    • (2006) Cell Death Differ , vol.13 , pp. 2129-2139
    • Salinas, L.S.1    Maldonado, E.2    Navarro, R.E.3
  • 24
    • 0142227023 scopus 로고    scopus 로고
    • No PUMA, no death: Implications for p53-dependent apoptosis
    • Yu J, Zhang L. No PUMA, no death: implications for p53-dependent apoptosis. Cancer Cell 2003; 4:248-249.
    • (2003) Cancer Cell , vol.4 , pp. 248-249
    • Yu, J.1    Zhang, L.2
  • 25
    • 0034927279 scopus 로고    scopus 로고
    • Biomarkers of apoptosis: Release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2′- deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene
    • Abu-Qare AW, Abou-Donia MB. Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2′- deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene. J Toxicol Environ Health B Crit Rev 2001; 4:313-332.
    • (2001) J Toxicol Environ Health B Crit Rev , vol.4 , pp. 313-332
    • Abu-Qare, A.W.1    Abou-Donia, M.B.2
  • 26
    • 17444383660 scopus 로고    scopus 로고
    • Apoptosome dysfunction in human cancer
    • Hajra KM, Liu JR. Apoptosome dysfunction in human cancer. Apoptosis 2004; 9:691-704.
    • (2004) Apoptosis , vol.9 , pp. 691-704
    • Hajra, K.M.1    Liu, J.R.2
  • 27
    • 0037041392 scopus 로고    scopus 로고
    • p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
    • Flores ER, Tsai KY, Crowley D, et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 2002; 416:560-564.
    • (2002) Nature , vol.416 , pp. 560-564
    • Flores, E.R.1    Tsai, K.Y.2    Crowley, D.3
  • 28
    • 34547753615 scopus 로고    scopus 로고
    • p63 and p73 in human cancer: Defining the network
    • Deyoung MP, Ellisen LW. p63 and p73 in human cancer: defining the network. Oncogene 2007; 26:5169-5183.
    • (2007) Oncogene , vol.26 , pp. 5169-5183
    • Deyoung, M.P.1    Ellisen, L.W.2
  • 29
    • 35148893194 scopus 로고    scopus 로고
    • The Wipl phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
    • Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA. The Wipl phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell 2001; 12:342-354.
    • (2001) Cancer Cell , vol.12 , pp. 342-354
    • Lu, X.1    Ma, O.2    Nguyen, T.A.3    Jones, S.N.4    Oren, M.5    Donehower, L.A.6
  • 30
    • 34547935761 scopus 로고    scopus 로고
    • Living with p53, dying of p53
    • Aylon Y, Oren M. Living with p53, dying of p53. Cell 2007; 130:597-600.
    • (2007) Cell , vol.130 , pp. 597-600
    • Aylon, Y.1    Oren, M.2
  • 31
    • 0842332406 scopus 로고    scopus 로고
    • Dynamics of the p53-Mdm2 feedback loop in individual cells
    • Lahav G, Rosenfeld N, Sigal A, et al. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet 2004; 36:147-150.
    • (2004) Nat Genet , vol.36 , pp. 147-150
    • Lahav, G.1    Rosenfeld, N.2    Sigal, A.3
  • 32
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • He L, He X, Lim LP, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007; 447:1130-1134.
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1    He, X.2    Lim, L.P.3
  • 33
    • 34249822779 scopus 로고    scopus 로고
    • Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    • Raver-Shapira N, Marciano E, Meiri E, et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 2007; 26:731-743.
    • (2007) Mol Cell , vol.26 , pp. 731-743
    • Raver-Shapira, N.1    Marciano, E.2    Meiri, E.3
  • 34
    • 12244268624 scopus 로고    scopus 로고
    • Apoptosis-inducing factor (AIF): Key to the conserved caspase-independent pathways of cell death?
    • Cande C, Cecconi F, Dessen P, Kroemer G. Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci 2002; 115:4727-4734.
    • (2002) J Cell Sci , vol.115 , pp. 4727-4734
    • Cande, C.1    Cecconi, F.2    Dessen, P.3    Kroemer, G.4
  • 35
    • 0033010612 scopus 로고    scopus 로고
    • Apoptosis inducing factor (AIF): Aphylogenetically old, caspase-independent effector of cell death
    • Lorenzo HK, Susin SA, Penninger J, Kroemer G. Apoptosis inducing factor (AIF): aphylogenetically old, caspase-independent effector of cell death. Cell Death Differ 1999; 6:516-524.
    • (1999) Cell Death Differ , vol.6 , pp. 516-524
    • Lorenzo, H.K.1    Susin, S.A.2    Penninger, J.3    Kroemer, G.4
  • 36
    • 0037184817 scopus 로고    scopus 로고
    • History of the events leading to the formulation of the apoptosis concept
    • Kerr JF. History of the events leading to the formulation of the apoptosis concept. Toxicology 2002; 181-182:471-474.
    • (2002) Toxicology , vol.181-182 , pp. 471-474
    • Kerr, J.F.1
  • 37
    • 24644507240 scopus 로고    scopus 로고
    • Caspase-dependent and -independent cell death pathways after DNA damage (Review)
    • Kim R, Emi M, Tanabe K. Caspase-dependent and -independent cell death pathways after DNA damage (Review). Oncol Rep 2005; 14:595-599.
    • (2005) Oncol Rep , vol.14 , pp. 595-599
    • Kim, R.1    Emi, M.2    Tanabe, K.3
  • 38
    • 2342481172 scopus 로고    scopus 로고
    • Programmed cell deaths. Apoptosis and alternative deathstyles
    • Assuncao Guimaraes C, Linden R. Programmed cell deaths. Apoptosis and alternative deathstyles. Eur J Biochem 2004; 271:1638-1650.
    • (2004) Eur J Biochem , vol.271 , pp. 1638-1650
    • Assuncao Guimaraes, C.1    Linden, R.2
  • 39
    • 0037306785 scopus 로고    scopus 로고
    • Molecular response of human glioblastoma multiforme cells to ionizing radiation: Cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy
    • Yao KC, Komata T, Kondo Y, Kanzawa T, Kondo S, Germano IM. Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg 2003; 98:378-384.
    • (2003) J Neurosurg , vol.98 , pp. 378-384
    • Yao, K.C.1    Komata, T.2    Kondo, Y.3    Kanzawa, T.4    Kondo, S.5    Germano, I.M.6
  • 40
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • Yu L, Alva A, Su H, et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304:1500- 1502.
    • (2004) Science , vol.304 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3
  • 41
    • 33846604677 scopus 로고    scopus 로고
    • Key note lecture: Toward a mechanistic taxonomy for cell death programs
    • Bredesen DE. Key note lecture: toward a mechanistic taxonomy for cell death programs. Stroke 2007; 38:652-660.
    • (2007) Stroke , vol.38 , pp. 652-660
    • Bredesen, D.E.1
  • 43
    • 33749178260 scopus 로고    scopus 로고
    • Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response
    • Festjens N, Vanden Berghe T, Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta 2006; 1757:1371-1387.
    • (2006) Biochim Biophys Acta , vol.1757 , pp. 1371-1387
    • Festjens, N.1    Vanden Berghe, T.2    Vandenabeele, P.3
  • 44
    • 2642536197 scopus 로고    scopus 로고
    • Alkylating DNA damage stimulates a regulated form of necrotic cell death
    • Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 2004; 18:1272-1282.
    • (2004) Genes Dev , vol.18 , pp. 1272-1282
    • Zong, W.X.1    Ditsworth, D.2    Bauer, D.E.3    Wang, Z.Q.4    Thompson, C.B.5
  • 45
    • 0028841484 scopus 로고
    • Different basal NAD levels determine opposite effects of poly(ADP-ribosylpolymerase inhibitors on H2O2-induced apoptosis
    • Coppola S, Nosseri C, Maresca V, Ghibelli L. Different basal NAD levels determine opposite effects of poly(ADP-ribosylpolymerase inhibitors on H2O2-induced apoptosis. Exp Cell Res 1995; 221:462-469.
    • (1995) Exp Cell Res , vol.221 , pp. 462-469
    • Coppola, S.1    Nosseri, C.2    Maresca, V.3    Ghibelli, L.4
  • 46
    • 0029100890 scopus 로고
    • Poly(adenosine diphosphate ribose) polymerase inhibition prevents necrosis induced by H2O2 but not apoptosis
    • Watson AJ, Askew JN, Benson RS. Poly(adenosine diphosphate ribose) polymerase inhibition prevents necrosis induced by H2O2 but not apoptosis. Gastroenterology 1995; 109:472-482.
    • (1995) Gastroenterology , vol.109 , pp. 472-482
    • Watson, A.J.1    Askew, J.N.2    Benson, R.S.3
  • 47
    • 34249941528 scopus 로고    scopus 로고
    • Reduction of apoptosis in Rbdeficient embryos via Abl knockout
    • Borges HL, Hunton IC, Wang JY. Reduction of apoptosis in Rbdeficient embryos via Abl knockout. Oncogene 2007; 26:3868-3877.
    • (2007) Oncogene , vol.26 , pp. 3868-3877
    • Borges, H.L.1    Hunton, I.C.2    Wang, J.Y.3
  • 48
    • 2442660386 scopus 로고    scopus 로고
    • Radiation-induced apoptosis in developing mouse retina exhibits dose-dependent requirement for ATM phosphorylation of p53
    • Borges HL, Chao C, Xu Y, Linden R, Wang JY. Radiation-induced apoptosis in developing mouse retina exhibits dose-dependent requirement for ATM phosphorylation of p53. Cell Death Differ 2004; 11:494-502.
    • (2004) Cell Death Differ , vol.11 , pp. 494-502
    • Borges, H.L.1    Chao, C.2    Xu, Y.3    Linden, R.4    Wang, J.Y.5
  • 49
    • 33745752959 scopus 로고    scopus 로고
    • Serl 8 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression
    • Chao C, Herr D, Chun J, Xu Y. Serl 8 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. Embo J 2006; 25:2615-2622.
    • (2006) Embo J , vol.25 , pp. 2615-2622
    • Chao, C.1    Herr, D.2    Chun, J.3    Xu, Y.4
  • 50
    • 0032524070 scopus 로고    scopus 로고
    • Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
    • Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 1998; 280:1089-1091.
    • (1998) Science , vol.280 , pp. 1089-1091
    • Herzog, K.H.1    Chong, M.J.2    Kapsetaki, M.3    Morgan, J.I.4    McKinnon, P.J.5
  • 51
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • Raff MC. Social controls on cell survival and cell death. Nature 1992; 356:397-400.
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 52
    • 0032895722 scopus 로고    scopus 로고
    • Linden R, Rehen SK, Chiarini LB. Apoptosis in developing retinal tissue. Prog Retin Eye Res 1999; 18:133-165.
    • Linden R, Rehen SK, Chiarini LB. Apoptosis in developing retinal tissue. Prog Retin Eye Res 1999; 18:133-165.
  • 53
    • 0026648848 scopus 로고
    • The effect of cycloheximide on natural and X-ray-induced cell death in the developing cerebral cortex
    • Ferrer I. The effect of cycloheximide on natural and X-ray-induced cell death in the developing cerebral cortex. Brain Res 1992; 588:351-357.
    • (1992) Brain Res , vol.588 , pp. 351-357
    • Ferrer, I.1
  • 54
    • 0027439248 scopus 로고
    • Radiosensitive populations and recovery in X-ray-induced apoptosis in the developing cerebellum
    • Ferrer I, Serrano T, Rivera R, Olive M, Zujar MJ, Graus F. Radiosensitive populations and recovery in X-ray-induced apoptosis in the developing cerebellum. Acta Neuropathol 1993; 86:491-500.
    • (1993) Acta Neuropathol , vol.86 , pp. 491-500
    • Ferrer, I.1    Serrano, T.2    Rivera, R.3    Olive, M.4    Zujar, M.J.5    Graus, F.6
  • 55
    • 0033490280 scopus 로고    scopus 로고
    • Gamma irradiation leads to two waves of apoptosis in distinct cell populations of the retina of newborn rats
    • Borges HL, Linden R. Gamma irradiation leads to two waves of apoptosis in distinct cell populations of the retina of newborn rats. J Cell Sci 1999; 112(Pt 23):4315-4324.
    • (1999) J Cell Sci , vol.112 , Issue.PART 23 , pp. 4315-4324
    • Borges, H.L.1    Linden, R.2
  • 56
    • 34247159940 scopus 로고    scopus 로고
    • Responding to DNA double strand breaks in the nervous system
    • Lee Y, McKinnon PJ. Responding to DNA double strand breaks in the nervous system. Neuroscience 2007; 145:1365-1374.
    • (2007) Neuroscience , vol.145 , pp. 1365-1374
    • Lee, Y.1    McKinnon, P.J.2
  • 58
    • 33846518931 scopus 로고    scopus 로고
    • Radiation response of neural precursor cells
    • x
    • Fike JR, Rola R, Limoli CL. Radiation response of neural precursor cells. Neurosurg Clin NAm 2007; 18:115-127, x.
    • (2007) Neurosurg Clin NAm , vol.18 , pp. 115-127
    • Fike, J.R.1    Rola, R.2    Limoli, C.L.3
  • 59
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003; 4:321-328.
    • (2003) Cancer Cell , vol.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3
  • 60
    • 0034681136 scopus 로고    scopus 로고
    • Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system
    • Chong MJ, Murray MR, Gosink EC, et al. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci USA 2000; 97:889-894.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 889-894
    • Chong, M.J.1    Murray, M.R.2    Gosink, E.C.3
  • 61
    • 0034508217 scopus 로고    scopus 로고
    • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
    • Lindsten T, Ross AJ, King A, et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 2000; 6:1389-1399.
    • (2000) Mol Cell , vol.6 , pp. 1389-1399
    • Lindsten, T.1    Ross, A.J.2    King, A.3
  • 62
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX, BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei MC, Zong WX, Cheng EH, et al. Proapoptotic BAX, BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001; 292:727-730.
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1    Zong, W.X.2    Cheng, E.H.3
  • 63
    • 0242267127 scopus 로고    scopus 로고
    • Caspase regulation of genotoxin-induced neural precursor cell death
    • D'Sa C, Klocke BJ, Cecconi F, et al. Caspase regulation of genotoxin-induced neural precursor cell death. J Neurosci Res 2003; 74:435-445.
    • (2003) J Neurosci Res , vol.74 , pp. 435-445
    • D'Sa, C.1    Klocke, B.J.2    Cecconi, F.3
  • 64
    • 8844219687 scopus 로고    scopus 로고
    • Deficiency of Bax and Bak protects photoreceptors from light damage in vivo
    • Hahn P, Lindsten T, Lyubarsky A, et al. Deficiency of Bax and Bak protects photoreceptors from light damage in vivo. Cell Death Differ 2004; 11:1192-1197.
    • (2004) Cell Death Differ , vol.11 , pp. 1192-1197
    • Hahn, P.1    Lindsten, T.2    Lyubarsky, A.3
  • 65
    • 18644375649 scopus 로고    scopus 로고
    • Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
    • Takai H, Naka K, Okada Y, et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. Embo J 2002; 21:5195-5205.
    • (2002) Embo J , vol.21 , pp. 5195-5205
    • Takai, H.1    Naka, K.2    Okada, Y.3
  • 67
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chkl and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chkl and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000; 14:289-300.
    • (2000) Genes Dev , vol.14 , pp. 289-300
    • Shieh, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 68
    • 0042854721 scopus 로고    scopus 로고
    • Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain
    • Craig A, Scott M, Burch L, Smith G, Ball K, Hupp T. Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. EMBO Rep 2003; 4:787-792.
    • (2003) EMBO Rep , vol.4 , pp. 787-792
    • Craig, A.1    Scott, M.2    Burch, L.3    Smith, G.4    Ball, K.5    Hupp, T.6
  • 69
    • 0032906633 scopus 로고    scopus 로고
    • p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
    • Liu L, Scolnick DM, Trievel RC, et al. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol 1999; 19:1202-1209.
    • (1999) Mol Cell Biol , vol.19 , pp. 1202-1209
    • Liu, L.1    Scolnick, D.M.2    Trievel, R.C.3
  • 70
    • 0034710870 scopus 로고    scopus 로고
    • Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
    • Chao C, Saito S, Anderson CW, Appella E, Xu Y. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci USA 2000; 97:11936-11941.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11936-11941
    • Chao, C.1    Saito, S.2    Anderson, C.W.3    Appella, E.4    Xu, Y.5
  • 71
    • 33748667324 scopus 로고    scopus 로고
    • Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage
    • Chao C, Wu Z, Mazur SJ, et al. Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol 2006; 26:6859-6869.
    • (2006) Mol Cell Biol , vol.26 , pp. 6859-6869
    • Chao, C.1    Wu, Z.2    Mazur, S.J.3
  • 72
    • 0035448927 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status
    • Lee Y, Chong MJ, McKinnon PJ. Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status. J Neurosci 2001; 21:6687-6693.
    • (2001) J Neurosci , vol.21 , pp. 6687-6693
    • Lee, Y.1    Chong, M.J.2    McKinnon, P.J.3
  • 73
    • 0030309291 scopus 로고    scopus 로고
    • Death in a dish: controls of apoptosis within the developing retinal tissue, Su 1 Pt 1:89-103
    • Linden R, Rehen SK, Chiarini LB, et al. Death in a dish: controls of apoptosis within the developing retinal tissue. Rev Bras Biol 1996; 56(Su 1 Pt 1):89-103.
    • (1996) Rev Bras Biol , vol.56
    • Linden, R.1    Rehen, S.K.2    Chiarini, L.B.3
  • 74
    • 0033428811 scopus 로고    scopus 로고
    • Selective sensitivity of early postmitotic retinal cells to apoptosis induced by inhibition of protein synthesis
    • Rehen SK, Neves DD, Fragel-Madeira L, Britto LR, Linden R. Selective sensitivity of early postmitotic retinal cells to apoptosis induced by inhibition of protein synthesis. Eur J Neurosci 1999; 11:4349-4356.
    • (1999) Eur J Neurosci , vol.11 , pp. 4349-4356
    • Rehen, S.K.1    Neves, D.D.2    Fragel-Madeira, L.3    Britto, L.R.4    Linden, R.5
  • 75
    • 0001807820 scopus 로고
    • Kinetics of cellular proliferation
    • Fujita S. Kinetics of cellular proliferation. Exp Cell Res 1962; 28:52-60.
    • (1962) Exp Cell Res , vol.28 , pp. 52-60
    • Fujita, S.1
  • 76
    • 33745254719 scopus 로고    scopus 로고
    • Fas/CD95 death receptor and lipid rafts: New targets for apoptosis-directed cancer therapy
    • Mollinedo F, Gajate C. Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy. Drug Resist Updat 2006; 9:51-73.
    • (2006) Drug Resist Updat , vol.9 , pp. 51-73
    • Mollinedo, F.1    Gajate, C.2
  • 77
    • 33748747194 scopus 로고    scopus 로고
    • A vision of cell death: Fas ligand and immune privilege 10 years later
    • Ferguson TA, Griffith TS. A vision of cell death: Fas ligand and immune privilege 10 years later. Immunol Rev 2006; 213:228-238.
    • (2006) Immunol Rev , vol.213 , pp. 228-238
    • Ferguson, T.A.1    Griffith, T.S.2
  • 78
    • 0042337427 scopus 로고    scopus 로고
    • Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl
    • Truong T, Sun G, Doorly M, Wang JY, Schwartz MA. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proc Natl Acad Sci USA 2003; 100:10281-10286.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10281-10286
    • Truong, T.1    Sun, G.2    Doorly, M.3    Wang, J.Y.4    Schwartz, M.A.5
  • 79
    • 33746891461 scopus 로고    scopus 로고
    • Adhesion dependent signalling in the tumour microenvironment: The future of drug targetting
    • Bewick MA, Lafrenie RM. Adhesion dependent signalling in the tumour microenvironment: the future of drug targetting. Curr Pharm Des 2006; 12:2833-2848.
    • (2006) Curr Pharm Des , vol.12 , pp. 2833-2848
    • Bewick, M.A.1    Lafrenie, R.M.2


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