Apoptosis in developing retinal tissue

Progress in Retinal and Eye Research

Volumn 18, Issue 2, 1999, Pages 133-165

  Linden, R ^a   Rehen, S K ^a   Chiarini, L B ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; CYCLIC AMP; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; EXCITOTOXIN; OXIDOREDUCTASE; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ANTIBODY LABELING; APOPTOSIS; ARTICLE; CALCIUM MOBILIZATION; CELL CYCLE; CELL DEATH; CELL DEGENERATION; CELL DIFFERENTIATION; CELL DIVISION; CELL INTERACTION; CELL MATURATION; CELL NUCLEUS; CELL PROLIFERATION; CELL TYPE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; MITOSIS; NONHUMAN; ONCOGENE C FOS; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; RETINA CELL; TISSUE;

EID: 0032895722     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1350-9462(98)00020-2     Document Type: Article

References (260)

1. Abate, C., Patel, L., Rauscher, F. J. and Curran, T. (1990) Redox regulation of the Fos and Jun DNA-binding activity in vitro. Science 249, 1157-1161.
2. Afshari, C. A., Bivins, H. M. and Barrett, J. C. (1994) Utilization of a Fos-lacZ plasmid to investigate the activation of c-fos during cellular senescence and okadaic acid-induced apoptosis. J. Gerontol. 49, B263-B269.
3. Aguayo, A. J., Clarke, D. B., Jelsma, T. N., Kittlerova, P., Friedman, H. C. and Bray, G. (1996) Effects of neurotrophins on the survival and regrowth of injured retinal neurons. Ciba Found. Symp. 196, 135-144.
4. Albers, K. M., Perrone, T. N., Goodness, T. P., Jones, M. E., Green, M. A. and Davis, B. M. (1996) Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation. J. Cell Biol. 134, 487-497.
5. Alexiades, M. R. and Cepko, C. (1996) Quantitative analysis of proliferation and cell cycle length during development of the rat retina. Dev. Dyn. 205, 293-307.
6. Alexiades, M. R. and Cepko, C. L. (1997) Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny. Development 124, 1119-1131.
7. Amati, B., Brooks, M. W., Levy, N., Littlewood, T. D., Evan, G. I. and Land, H. (1993a) Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 72, 233-245.
8. Amati, B., Littlewood, T. D., Evan, G. I. and Land, H. (1993b) The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 12, 5083-5087.
9. Araujo, E. G. and Linden, R. (1993) Trophic factors produced by retinal cells increase the survival of retinal ganglion cells in vitro. Eur. J. Neurosci. 5, 1181-1188.
10. Ary-Pires, R., Nakatani, M., Rehen, S. K. and Linden, R. (1997) Developmentally regulated release of intraretinal neurotrophic factors in vitro. Int. J. Dev. Neurosci. 15, 239-255.
11. Ary-Pires, R., Rehen, S. K. and Linden, R. (1992) Evidence for a developmentally regulated neurotrophic activity from chick retina affecting the survival of retinal ganglion cells from newborn rats. Braz. J. Med. Biol. Res. 25, 845-848.
12. Bahr, M., Przyrembel, C. and Bastmeyer, M. (1995) Astrocytes from adult rat optic nerves are nonpermissive for regenerating retinal ganglion cell axons. Exp. Neurol. 131, 211-220.
13. Bakhshi, A., Jensen, J. P., Goldman, P., Wright, J. J., McBride, O. W., Epstein, A. L. and Korsmeyer, S. J. (1985) Cloning the chromosomal breakpoint of t(14:18) human lymphomas: clustering around JH on chromosome 14 and near a transcription unit on 18. Cell 41, 899-906.
14. Baldin, V., Lukas, J., Marcote, M. J., Pagano, M. and Draetta, G. (1993) Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 7, 812-821.
15. Barbacid, M. (1995) Neurotrophic factors and their receptors. Curr. Opin. Cell Biol. 7, 148-155.
16. Barres, B. A. and Raff, M. C. (1994) Control of oligodendrocyte number in the developing rat optic nerve. Neuron 12, 935-942.
17. Bates, R. C., Lincz, L. F. and Burns, G. F. (1995) Involvement of integrins in cell survival. Cancer Metastasis Rev. 14, 191-203.
18. Beauvais, F., Michel, L. and Dubertret, L. (1995) The nitric oxide donors, azide and hydroxylamine, inhibit the programmed cell death of cytokine-deprived human eosinophils. FEBS Lett. 361, 229-232.
19. Beazley, L. D., Perry, V. H., Baker, B. and Darby, J. E. (1987) An investigation into the role of ganglion cells in the regulation of division and death of other retinal cells. Dev. Brain Res. 33, 169-184.
20. Berkelaar, M., Clarke, D. B., Wang, Y. C., Bray, G. M. and Aguayo, A. J. (1994) Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J. Neurosci. 14, 4368-4374.
21. Berninger, T. A., Bird, A. C. and Arden, G. B. (1989) Leber's hereditary optic atrophy. Ophthalmic Paediatr Genet 10, 211-227.
22. Bissonette, R. P., Shi, Y., Mahboubi, A., Glynn, J. M. and Green, D. R. (1994) c-myc and apoptosis. In Apoptosis II: the molecular basis of cell death (ed. L. D. Tomei and F. O. Cope), pp. 327-356. Cold Spring Harbor Laboratory Press.
23. Blaschke, A. J., Staley, K. and Chun, J. (1996) Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development 122, 1165-1174.
24. Bossy Wetzel, E., Bakiri, L. and Yaniv, M. (1997) Induction of apoptosis by the transcription factor c-Jun. EMBO J. 16, 1695-1709.
25. Bowen, I. D. (1993) Apoptosis or programmed cell death? Cell Biol. Intern. 17, 365-380.
26. Bradshaw, A. D., Mcnagny, K. M., Gervin, D. B., Cann, G. M., Graf, T. and Clegg, D. O. (1995) Integrin alpha(2)-beta(1) mediates interactions between developing embryonic retinal cells and collagen. Development 121, 3593-3602.
27. Buchi, E. R. (1992) Cell death in the rat retina after a pressure-induced ischaemia-reperfusion insult: an electron microscopic study. Exp. Eye Res. 55, 605-613.
28. Buys, Y. M., Trope, G. E. and Tatton, W. G. (1995) (-)-Deprenyl increases the survival of rat retinal ganglion cells after optic nerve crush. Curr. Eye Res. 14, 119-126.
29. Canman, C. E., Gilmer, T. M., Coutts, S. B. and Kastan, M. B. (1995) Growth factor modulation of p53-mediated growth arrest versus apoptosis. Gene Develop. 9, 600-611.
30. Carmignoto, G., Maffei, L., Candeo, P., Canella, R. and Comelli, M. C. (1989) Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section. J. Neurosci. 9, 1263-1272.
31. Carri, N. G., Perris, R., Johansson, S. and Ebendal, T. (1988) Differential outgrowth of retinal neurites on purified extracellular matrix molecules. J. Neurosci. Res. 19, 428-439.
32. Carri, N. G., Rubin, K., Gullberg, D. and Ebendal, T. (1992) Neuritogenesis on collagen substrates. Involvement of integrin-like matrix receptors in retinal fibre outgrowth on collagen. Int. J. Dev. Neurosci. 10, 393-405.
33. Carri, N. G. and Ebendal, T. (1983) Organotypic cultures of neural retina: neurite outgrowth stimulated by brain extracts. Dev. Brain Res. 6, 219-229.
34. Carri, N. G. and Ebendal, T. (1987) Target-field specificity in the induction of retinal neurite outgrowth. Dev. Brain Res. 31, 83-90.
35. Chalazonitis, A. (1996) Neurotrophin-3 as an essential signal for the developing nervous system. Mol. Neurobiol. 12, 39-53.
36. Chang, G. Q., Hao, Y. and Wong, F. (1993) Apoptosis - final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 11, 595-605.
37. Chao, D. T., Linette, G. P., Boise, L. H., White, L. S., Thompson, C. B. and Korsmeyer, S. J. (1995) Bcl-X(L) and Bcl-2 repress a common pathway of cell death. J. Exp. Med. 182, 821-828.
38. Chen, D. F., Jhaveri, S. and Schneider, G. E. (1995) Intrinsic changes in developing retinal neurons result in regenerative failure of their axons. Proc. Natl. Acad. Sci. U.S.A. 92, 7287-7291.
39. Chen, J., Flannery, J. G., LaVail, M. M., Steinberg, R. H., Xu, J. and Simon, M. I. (1996) bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proc. Natl. Acad. Sci. U.S.A. 93, 7042-7047.
40. Chen, S. T., Garey, L. J. and Jen, L. S. (1994) Bcl-2 protooncogene protein immunoreactivity in normally developing and axotomised rat retinas. Neurosci. Lett. 172, 11-14.
41. Clarke, P. G. H. (1985) Neuronal death in the development of the vertebrate nervous system. Trends Neurosci. 8, 345-349.
42. Cohen, G. M., Sun, X. M., Snowden, R. T., Dinsdale, D. and Skilleter, D. N. (1992) Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem. J. 286, 331-334.
43. Cohen, G. M., Sun, X. M., Fearnhead, H., Macfarlane, M., Brown, D. G., Snowden, R. T. and Dinsdale, D. (1994) Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J. Immunol. 153, 507-516.
44. Collins, M. K. L., Perkins, G. R., Rodrigueztarduchy, G., Nieto, M. A. and Lopezrivas, A. (1994) Growth factors as survival factors - regulation of apoptosis. BioEssays 16, 133-138.
45. Colotta, F., Polentarutti, N., Sironi, M. and Mantovani, A. (1992) Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J. Biol. Chem. 267, 18278-18283.
46. Craft, J. L., Fulton, A. B., Silver, J. and Albert, D. M. (1982) Development of the outer plexiform layer in albino rats. Cur. Eye Res. 2, 295-299.
47. Cui, Q. and Harvey, A. R. (1994) NT-4/5 reduces naturally occurring retinal ganglion cell death in neonatal rats. NeuroReport 5, 1882-1884.
48. Curran, T., Abate, C., Cohen, D. R., MacGregor, P. F., Rauscher, F. J. I., Sonnenberg, J. L., Connor, J. A. and Morgan, J. I. (1990) Inducible proto-oncogene transcription factors: third messengers in the brain? Cold Spring Harbor Symp. Quant. Biol. 55, 225-234.
49. Curran, T. and Morgan, J. I. (1995) Fos: an immediate-early transcription factor in neurons. J. Neurobiol. 26, 403-412.
50. De Mello, F. G., De Mello, M. C. F., Hudson, R. and Klein, W. L. (1990) Selective expression of factors preventing cholinergic dedifferentiation. J. Neurochem. 54, 886-892.
51. Deckwerth, T. L. and Johnson, E. M. (1993) Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol. 123, 1207-1222.
52. Denham, S. (1967) A cell proliferation study of the neural retina in the two-day rat. J. Embryol. Exp. Morphol. 18, 53-66.
53. Desbarats, L., Schneider, A., Muller, D., Burgin, A. and Eilers, M. (1996) Myc: a single gene controls both proliferation and apoptosis in mammalian cells. Experientia 52, 1123-1129.
54. Ellis, R. E. and Horvitz, H. R. (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44, 817-829.
55. Estus, S., Zaks, W. J., Freeman, R. S., Gruda, M., Bravo, R. and Johnson, E. M. (1994) Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127, 1717-1727.
56. Evan, G., Harrington, E., Fanidi, A., Land, H., Amati, B. and Bennett, M. (1994) Integrated control of cell proliferation and cell death by the c-myc oncogene. Philos. Trans. R. Soc. Lond. [Biol]. 345, 269-275.
57. Faktorovich, E. G., Steinberg, R. H., Yasumura, D., Matthes, M. T. and LaVail, M. M. (1990) Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature 347, 83-86.
58. Ferrer, I., Olive, M., Blanco, R., Cinos, C. and Planas, A. M. (1996a) Selective c-Jun overexpression is associated with ionizing radiation-induced apoptosis in the developing cerebellum of the rat. Brain Res. Mol. Brain Res. 38, 91-100.
59. Ferrer, I., Olive, M., Ribera, J. and Planas, A. M. (1996b) Naturally occurring (programmed) and radiation-induced apoptosis are associated with selective c-Jun expression in the developing rat brain. Eur. J. Neurosci. 8, 1286-1298.
60. Fesus, L. (1993) Biochemical events in naturally occurring forms of cell death. FEBS Lett. 328, 1-5.
61. 2+ influx but not Trk activation. J. Neurosci. 15, 643-664.
62. Freemerman, A. J., Turner, A. J., Birrer, M. J., Szabo, E., Valerie, K. and Grant, S. (1996) Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C. Mol. Pharmacol. 49, 788-795.
63. Frisch, S. M. and Francis, H. (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626.
64. Fujita, S. (1962) Kinetics of cellular proliferation. Exp. Cell Res. 28, 52-60.
65. Fukuda, K., Kojiro, M. and Chiu, J. F. (1993) Induction of apoptosis by transforming growth factor-beta-1 in the rat hepatoma cell line McA-RH7777 - a possible association with tissue transglutaminase expression. Hepatology 18, 945-953.
66. Gajate, C., Alonso, M. T., Schimmang, T. and Mollinedo, F. (1996) C-Fos is not essential for apoptosis. Biochem. Biophys. Res. Commun. 218, 267-272.
67. Galli-Resta, L. and Ensini, M. (1996) An intrinsic time limit between the genesis and death of individual neurons in the developing retinal ganglion cell layer. J. Neurosci. 16, 2318-2324.
68. Garciavalenzuela, E., Gorczyca, W., Darzynkiewicz, Z. and Sharma, S. C. (1994) Apoptosis in adult retinal ganglion cells after axotomy. J. Neurobiol. 25, 431-438.
69. Garrah, J. M., Bisby, M. A. and Rossiter, J. P. (1998) Immunolabeling of the cytoplasm and processes of apoptotic facial motoneurons following axotomy in the neonatal rat. Acta Neuropathol. 95, 223-228.
70. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
71. Goldstone, S. D. and Lavin, M. F. (1994) Prolonged expression of c-Jun and associated activity of the transcription factor AP-1 during apoptosis in a human leukaemic cell line. Oncogene 9, 2305-2311.
72. Goodness, T. P., Albers, K. M., Davis, F. E. and Davis, B. M. (1997) Overexpression of nerve growth factor in skin increases sensory neuron size and modulates Trk receptor expression. Eur. J. Neurosci. 9, 1574-1585.
73. Goureau, O., Jeanny, J. C., Becquet, F., Hartmann, M. P. and Courtois, Y. (1993) Protection against light-induced retinal degeneration by an inhibitor of no synthase. NeuroReport 5, 233-236.
74. Grand, R. J. A., Milner, A. E., Mustoe, T., Johnson, G. D., Owen, D., Grant, M. L. and Gregory, C. D. (1995) A novel protein expressed in mammalian cells undergoing apoptosis. Exp. Cell Res. 218, 439-451.
75. Granerus, M. and Engstrom, W. (1996) Growth factors and apoptosis. Cell Proliferation 29, 309-314.
76. Gregory, C. Y. and Bird, A. C. (1995) Cell loss in retinal dystrophies by apoptosis - death by informed consent!. Br. J. Ophthalmol. 79, 186-190.
77. Haas Kogan, D. A., Yount, G., Haas, M., Levi, D., Kogan, S. S., Hu, L., Vidair, C., Deen, D. F., Dewey, W. C. and Israel, M. A. (1996a) p53-Dependent G1 arrest and p53-independent apoptosis influence the radiobiologic response of glioblastoma. Int. J. Radiat. Oncol. Biol. Phys 36, 95-103.
78. Haas Kogan, D. A., Yount, G., Haas, M., Levi, D., Kogan, S. S., Hu, L., Vidair, C., Deen, D. F., Dewey, W. C. and Israel, M. A. (1996b) p53-Dependent G(1) arrest and p53-independent apoptosis influence the radiobiologic response of glioblastoma. Int. J. Radiat. Oncol. Biol. Phys. 36, 95-103.
79. Hafezi, F., Steinbach, J. P., Marti, A., Munz, K., Wang, Z. Q., Wagner, E. F., Aguzzi, A. and Reme, C. E. (1997) The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo [see comments]. Nat. Med. 3, 346-349.
80. Haimovitzfriedman, A., Balaban, N., Mcloughlin, M., Ehleiter, D., Michaeli, J., Vlodavsky, I. and Fuks, Z. (1994) Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis. Cancer Res. 54, 2591-2597.
81. Hallbook, F., Backstrom, A., Kullander, K., Ebendal, T. and Carri, N. G. (1996) Expression of neurotrophins and trk receptors in the avian retina. J. comp. Neurol. 364, 664-676.
82. Ham, J., Babij, C., Whitfield, J., Pfarr, C. M., Lallemand, D., Yaniv, M. and Rubin, L. L. (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14, 927-939.
83. Hammes, H. P., Federoff, H. J. and Brownlee, M. (1995) Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Mol. Med. 1, 527-534.
84. Han, J. H., Gileadi, C., Rajapaksa, R., Kosek, J. and Greenberg, P. L. (1995) Modulation of apoptosis in human myeloid leukemic cells by GM-CSF. Exp. Hematol. 23, 265-272.
85. Hansen, R. and Oren, M. (1997) p53; From inductive signal to cellular effect. Curr. Opin. Genet. Dev. 7, 46-51.
86. Harman, A. M., Snell, L. L. and Beazley, L. D. (1989) Cell death in tthe inner and outer nuclear layers of the developing retina in the wallaby setonix brachyurus (quokka). J. Comp. Neurol. 289, 1-10.
87. Henderson, C. E., Phillips, H. S., Pollock, R. A., Davies, A. M., Lemeulle, C., Armanini, M., Simpson, L. C., Moffet, B., Vandlen, R. A., Koliatsos, V. E., Rosenthal, A. (1994) GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266, 1062-1064.
88. Hicks, D. and Barnstable, C. J. (1987) Different rhodopsin monoclonal antibodies reveal different binding patterns on developing and adult rat retina. J. Histochem. Cytrochem. 35, 1317-1328.
89. Hopewell, R. and Ziff, E. B. (1995) The nerve growth factor-responsive PC12 cell line does not express the Myc dimerization partner Max. Mol. Cell Biol. 15, 3470-3478.
90. Horie, H., Ito, S. and Takano, M. (1994) Regional differences in neurite regeneration of postnatal mouse retinal explants. Brain Res. Bull. 34, 381-384.
91. Hu, L., Hatano, M., Ruther, U. and Tokuhisa, T. (1996) Overexpression of c-Fos induces apoptosis of CD43+ pro-B cells. J. Immunol. 157, 3804-3811.
92. Hull, M. and Bahr, M. (1994a) Regulation of immediate-early gene expression in rat retinal ganglion cells after axotomy and during regeneration through a peripheral nerve graft. J. Neurobiol. 25, 92-105.
93. Hull, M. and Bahr, M. (1994b) Differential regulation of c-JUN expression in rat retinal ganglion cell after proximal and distal optic nerve transection. Neurosci. Lett. 178, 39-42.
94. Hume, D. A., Perry, V. H. and Gordon, S. (1983) Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. J. Cell Biol. 97, 253-257.
95. Isenmann, S. and Bahr, M. (1997) Expression of c-Jun protein in degenerating retinal ganglion cells after optic nerve lesion in the rat. Exp. Neurol. 147, 28-36.
96. Jans, D. A. (1995) The regulation of protein transport to the nucleus by phosphorylation. Biochem. J. 311, 705-716.
97. Jeffery, G. and Perry, V. H. (1982) Evidence for ganglion cell death during development of the ipsilateral retinal projection in the rat. Dev. Brain Res. 2, 176-180.
98. Jewell, A. P., Worman, C. P., Lydyard, P. M., Yong, K. L., Giles, F. J. and Goldstone, A. H. (1994) Interferon-alpha up-regulates bcl-2 expression and protects B-CLL cells from apoptosis in vitro and in vivo. Br. J. Haematol. 88, 268-274.
99. 2+-ATPase inhibitor thapsigargin. Exp. Cell Res. 212, 84-92.
100. Johnson, J. and Oppenheim, R. W. (1994) Neurotrophins: keeping track of changing neurotrophic theory. Curr. Biol. 4, 662-665.
101. Joseph, R. M. and Li, T. (1996) Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration. Invest Ophthalmol. Vis. Sci. 37, 2434-2446.
102. Kaiser, P. K. and Lipton, S. A. (1990) VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro. Neuron 5, 373-381.
103. Karin, M., Zg, Liu and Zandi, E. (1997) AP-1 function and regulation. Curr. Opin. Cell Biol. 9, 240-246.
104. Kasten, M. M. and Giordano, A. (1998) pRb and the Cdks in apoptosis and the cell cycle. Cell death and differentiation 5, 132-140.
105. Kerr, J. F. R., Wyllie, A. H. and Currie, A. H. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
106. Kerr, J. F. R. and Harmon, B. V. (1991) Definition and incidence of apoptosis: an historical perspective. In Apoptosis: the molecular basis of cell death (ed. L. D. Tomei and F. D. Cope), pp. 5-29. Cold Spring Harbor Laboratory Press, Plainview, NY.
107. Kerrigan, L. A., Zack, D. J., Quigley, H. A., Smith, S. D. and Pease, M. E. (1997) TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch. Ophthalmol. 115, 1031-1035.
108. King, K. L. and Cidlowski, J. A. (1995) Cell cycle and apoptosis: common pathways to life and death. J. Cell Biochem. 58, 175-180.
109. Korsmeyer, S. J. (1995) Regulators of cell death. Trends Genet. 11, 101-105.
110. Kubo, T., Nonomura, T., Enokido, Y. and Hatanaka, H. (1995) Brain-derived neurotrophic factor (BDNF) can prevent apoptosis of rat cerebellar granule neurons in culture. Brain Res. Dev. Brain Res. 85, 249-258.
111. Lam, T. T., Fu, J., Hrynewycz, M. and Tso, M. O. M. (1995) The effect of aurintricarboxylic acid, an endonuclease inhibitor, on ischemia/reperfusion damage in rat retina. J. Ocul. Pharmacol. Therapeut. 11, 253-259.
112. Lam, T. T. (1997) The effect of 3-aminobenzamide, an inhibitor of poly-ADP-ribose polymerase, on ischemia/reperfusion damage in rat retina. Res. Commun. Mol. Pathol. Pharmacol. 95, 241-252.
113. Lam, T. T., Siew, E., Chu, R. and Tso, M. O. (1997) Ameliorative effect of MK-801 on retinal ischemia. J. Ocul. Pharmacol. Ther. 13, 129-137.
114. Lambiase, A. and Aloe, L. (1996) Nerve growth factor delays retinal degeneration in C3H mice. Graefes. Arch Clin. Exp. Ophthalmol. 234(Suppl 1), S96-100.
115. Lanni, J. S., Lowe, S. W., Licitra, E. J., Liu, J. O. and Jacks, T. (1997) p53-Independent apoptosis induced by paclitaxel through an indirect mechanism. Proc. Natl. Acad. Sci. U.S.A. 94, 9679-9683.
116. Lassus, P., Ferlin, M., Piette, J. and Hibner, U. (1996) Antiapoptotic activity of low levels of wild-type p53. EMBO J. 15, 4566-4573.
117. LaVail, M. M., Unoki, K., Yasumura, D., Matthes, M. T., Yancopoulos, G. D. and Steinberg, R. H. (1992) Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc. Natl. Acad. Sci. U.S.A. 89, 11249-11253.
118. Lehwalder, D., Jeffrey, P. L. and Unsicker, K. (1989) Survival of purified embryonic chick retinal ganglion cells in the presence of neurotrophic factors. J. Neurosci. Res. 24, 329-337.
119. Levin, L. A., Schlamp, C. L., Spiedloch, R. L., Geszvain, K. M. and Nickells, R. W. (1997) Identification of the bcl-2 family of genes in the rat retina. Invest. Ophthalmol. Vis. Sci. 38, 2545-2553.
120. Levin, L. A. and Louhab, A. (1996) Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. Arch. Ophthalmol. 114, 488-491.
121. Liebermann, D. A., Hoffman, B. and Steinman, R. A. (1995) Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways. Oncogene 11, 199-210.
122. Linden, R., Cavalcante, L. A. and Barradas, P. C. (1986) Mononuclear phagocytes in the retina of developing rats. Histochemistry 85, 335-340.
123. Linden, R. (1994) The survival of developing neurons - a review of afferent control. Neurosci. 58, 671-682.
124. Linden, R. and Perry, V. H. (1982) Ganglion cell death within the developing retina: a regulatory role for retinal dendrites. Neurosci. 7, 2813-2827.
125. Linden, R. and Pinto, L. H. (1985) Developmental genetics of the retina: evidence that the pearl mutation in the mouse affects the time course of natural neuronal death in the ganglion cell layer. Exp. Brain Res. 60, 79-86.
126. Lindsey, J. D. and Weinreb, R. N. (1994) Survival and differentiation of purified retinal ganglion cells in a chemically defined microenvironment. Invest. Ophthalmol. Vis. Sci. 35, 3640-3648.
127. Lockshin, R. A., and Z. F. Zakeri (1991) Programmed cell death and apoptosis. In Apoptosis: the molecular basis of cell death (ed. L. D. Tomei and F. D. Cope), pp. 47-60. Cold Spring Harbor Laboratory Press, Plainview, NY.
128. Lomo, J., Blomhoff, H. K., Beiske, K., Stokke, T. and Smeland, E. B. (1995) TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes. J. Immunol. 154, 1634-1643.
129. Longthorne, V. L. and Williams, G. T. (1997) Caspase activity is required for commitment to Fas-mediated apoptosis. EMBO J. 16, 3805-3812.
130. Macfarlane, D. E. and O'Donnell, P. S. (1993) Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant. Leukemia 7, 1846-1851.
131. Mahadevan, L. C., Wills, A. J., Hirst, E. A., Rathjen, P. D. and Heath, J. K. (1990) 2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Oncogene 5, 327-335.
132. Malcomson, R. D. G., Oren, M., Wyllie, A. H. and Harrison, D. J. (1995) P53-Independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs. Br. J. Cancer 72, 952-957.
133. Mansour-Robaey, S., Clarke, D. B., Wang, Y. C., Bray, G. M. and Aguayo, A. J. (1994) Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc. Natl. Acad. Sci. U.S.A. 91, 1632-1636.
134. Martinou, J. C., Duboisdauphin, M., Staple, J. K., Rodriguez, I., Frankowski, H., Missotten, M., Albertini, P., Talabot, D., Catsicas, S., Pietra, C. and Huarte, J. (1994) Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13, 1017-1030.
135. Masuda, K., Watanabe, I., Unoki, K., Ohba, N. and Muramatsu, T. (1995) Functional rescue of photoreceptors from the damaging effects of constant light by survival-promoting factors in the rat. Invest. Ophthalmol. Vis. Sci. 36, 2142-2146.
136. Matter, J. M., Mattersadzinski, L. and Ballivet, M. (1995) Activity of the beta 3 nicotinic receptor promoter is a marker of neuron fate determination during retina development. J. Neurosci. 15, 5919-5928.
137. Mayo, M. W., Wang, C. Y., Cogswell, P. C., Rogers-Graham, K. S., Lowe, S. W., Der, C. J. and Baldwin, A. S., Jr (1997) Requirement of NF-kappaB activation to supress p53-independent apoptosis induced by oncogene Ras. Science 278, 1812-1815.
138. McCaffery, C. A., Raju, T. R. and Bennett, M. R. (1985) Retinal ganglion cell survival is mediated by cell contact with immature rat astroglia. Neurosci. Lett. 57, 319-324.
139. Mekori, Y. A., Oh, C. K. and Metcalfe, D. D. (1995) The role of c-Kit and its ligand, stem cell factor, in mast cell apoptosis. Int. Arch. Allergy Immunol. 107, 136-138.
140. Meredith, J. E., Fazeli, B. and Schwartz, M. A. (1993) The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961.
141. Messmer, U. K., Lapetina, E. G. and Brune, B. (1995) Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A activating compounds. Mol. Pharmacol. 47, 757-765.
142. Messmer, U. K. and Brune, B. (1996) Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways. Biochem. J. 319, 299-305.
143. Mey, J. and Thanos, S. (1993) Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res. 602, 304-317.
144. Meyerfranke, A., Kaplan, M. R., Pfrieger, F. W. and Barres, B. A. (1995) Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron 15, 805-819.
145. Mikulski, S. M. (1994) Pathogenesis of cancer in view of mutually opposing apoptotic and anti-apoptotic growth signals. Int. J. Oncol. 4, 1257-1263.
146. Miller, D. K. (1997) The role of the Caspase family of cysteine proteases in apoptosis. Semin. Immunol. 9, 35-49.
147. Miller, N. M. and Oberdorfer, M. (1981) Neuronal and neuroglial responses following retinal lesions in the neonatal rats. J. Comp. Neurol. 202, 493-504.
148. Miyashita, T. and Reed, J. C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299.
149. Morgan, J. I. and Curran, T. (1991) Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun. Ann. Rev. Neurosci. 14, 421-451.
150. Moscona, A. (1961) Rotation-mediated histogenetic aggregation of dissocciated cells: a quantitative approach to cell interactions in vitro. Exp. Cell Res. 22, 455-475.
151. Nickells, R. W. (1996) Retinal ganglion cell death in glaucoma: the how, the why, and the maybe. J. Glaucoma 5, 345-356.
152. Okada, M., Sakaguchi, T. and Kawasaki, K. (1997) Proliferating cell nuclear antigen in neurons: induction by UV-irradiation. NeuroReport 7, 1770-1772.
153. Okazaki, T., Chung, U. I., Nishishita, T., Ebisu, S., Usuda, S., Mishiro, S., Xanthoudakis, S., Igarashi, T. and Ogata, E. (1994) A redox factor protein, Ref-1 is involved in negative gene regulation by extracellular calcium. J. Biol. Chem. 269, 27855-27862.
154. Oltvai, Z. N., Milliman, C. L. and Korsmeyer, S. J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74, 609-619.
155. Oltvai, Z. N. and Korsmeyer, S. J. (1994) Checkpoints of dueling dimers foil death wishes. Cell 79, 189-192.
156. Ono, Y., Watanabe, M., Inoue, Y., Ohmoto, T., Akiyama, K., Tsutsu, K. and Seki, S. (1995) Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains. Dev. Brain Res. 86, 1-5.
157. Oostra, R. J., Bolhuis, P. A. and Bleeker Wagemakers, E. M. (1993) Mitochondrial DNA analysis as a diagnostic tool in singleton cases of Leber's hereditary optic neuropathy [see comments]. Ophthalmic Paediatr. Genet. 14, 109-115.
158. Oppenheim, R. W. (1991) Cell death during development of the nervous system. Ann. Rev. Neurosci. 14, 453-501.
159. Orrenius, S. (1995) Apoptosis: molecular mechanisms and implications for human disease. J. Intern. Med. 237, 529-536.
160. Pandey, P., Raingeaud, J., Kaneki, M., Weichselbaum, R., Davis, R. J., Kufe, D. and Kharbanda, S. (1996) Activation of p38 mitogen-activated protein kinase by c- Abl-dependent and -independent mechanisms. J. Biol. Chem. 271, 23775-23779.
161. Pandey, S. and Wang, E. (1995) Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2 and RB phosphorylation, resembling events of early cell-cycle traverse. J. Cell Biochem. 58, 135-150.
162. Papassotiropoulos, A., Ludwing, M., Naib-Majani, W. and Rao, G. S. (1996) Induction of apoptosis and secondary necrosis in rat dorsal root ganglion cell cultures by oxidized low density lipoprotein. Neurosci. Lett. 209, 33-36.
163. 2+ binding proteins and synaptic markers in the retina but not in the cerebral cortex neurons of the rat. Neurosci. Lett. 186, 65-68.
164. Parker, P. J. and Pawson, T. (1996) Cell Signalling. Cold Spring Harbor Laboratory Press, Plainview, p. 386.
165. Pearson, H. E., Payne, B. R. and Cunningham, T. J. (1993) Microglial invasion and activation in response to naturally occurring neuronal degeneration in the ganglion cell layer of the postnatal cat retina. Dev. Brain Res. 76, 249-255.
166. Peichl, L. and Gonzales-Soriano, J. (1994) Morphological types of horizontal cells in rodent retinae: a comparison of rat, mouse, gerbil and guinea pig. Vis. Neurosci. 11, 501-517.
167. Perez, M. T., Arner, K. and Hakansson, A. (1997) DNA fragmentation characteristic of apoptosis and cell loss induced by kainic acid in rabbit retinas. Neurochem. Int. 31, 251-260.
168. Perez, M. T. R. and Caminos, E. (1995) Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina. Neurosci. Lett. 183, 96-99.
169. Perry, J., Du, J., Kjeldbye, H. and Gouras, P. (1995) The effects of bFGF on RCS rat eyes. Curr. Eye Res. 14, 585-592.
170. Perry, V. H., Henderson, Z. and Linden, R. (1983) Postnatal changes in retinal ganglion cell and optic axon populations in the pigmented rat. J. Comp. Neurol. 219, 356-368.
171. Portera Cailliau, C., Sung, C. H., Nathans, J. and Adler, R. (1994) Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc. Natl. Acad. Sci. U.S.A. 91, 974-978.
172. Potts, R. A., Dreher, B. and Bennett, M. R. (1982) The loss of ganglion cells in the developing retina of the rat. Dev. Brain Res. 3, 481-486.
173. Rabacchi, S. A., Bonfanti, L., Liu, X. H. and Maffei, L. (1994a) Apoptotic cell death induced by optic nerve lesion in the neonatal rat. J. Neurosci. 14, 5292-5301.
174. Rabacchi, S. A., Ensini, M., Bonfanti, L., Gravina, A. and Maffei, L. (1994b) Nerve growth factor reduces apoptosis of axotomized retinal ganglion cells in the neonatal rat. Neurosci. 63, 969-973.
175. Raff, M. C. (1992) Social controls on cell survival and cell death. Nature 356, 397-400.
176. Raju, T. R., Rao, M. S., Nagaraja, T. N., Meti, B. L. and Schulz, M. (1994) Retinal ganglion cell survival and neurite regeneration in vitro after cell death period are dependent upon target derived trophic factor and retinal glial factor(s). Brain Res. 664, 247-251.
177. Raju, T. R. and Bennett, M. R. (1986) Retinal ganglion cell survival requirements: a major but transient dependence on Muller glia during development. Brain Res. 383, 165-176.
178. Rakic, P. and Riley, K. P. (1983) Overproduction and elimination of retinal axons in the fetal rhesus monkey. Science 219, 1441-1444.
179. Rapaport, D. H., Robinson, S. R. and Stone, J. (1984) Cell movement and birth in the developing cat retina. In Stone, J. et al. (eds.) Development of Visual Pathways in Mammals, pp. 23-38. New York Alan R. Liss.
180. Reed, J. C. (1994) Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6.
181. Reed, S. I., Bailly, E., Dulic, V., Hengst, L., Resnitzky, D. and Slingerland, J. M. (1994) G1 control in mammalian cells. J. Cell Sci. 18, 69-73.
182. Reed, S. I. (1998) Control of the G1/S transition. In Kowtan, M. B. (ed.) Checkpoint controls and cancer. Cold Spring Harbor Laboratory Press, Plain view. pp. 7-23.
183. Rehen, S. K., Ary-Pires, R. and Linden, R. (1993) Intraretinal neurotrophic activity prevents the degeneration of ganglion cells in retinal explants. Braz. J. Med. Biol. Res. 26, 955-959.
184. Rehen, S. K., Varella, M. H., Freitas, F. G., Moraes, M. O. and Linden, R. (1996) Contrasting effects of protein synthesis inhibition and of cyclic AMP on apoptosis in the developing retina. Development 122, 1439-4448.
185. Rehen, S. K. and Linden, R. (1994) Apoptosis in the developing retina: paradoxical effects of protein synthesis inhibition. Braz. J. Med. Biol. Res. 27, 1647-1651.
186. Rich, K. A., Zhan, Y. and Blanks, J. C. (1997) Aberrant expression of c-Fos accompanies photoreceptor cell death in the rd mouse. J. Neurobiol. 32, 593-612.
187. Ringstedt, T., Kucera, J., Lendahl, U., Ernfors, P. and Ibanez, C. F. (1997) Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system. Development 124, 2603-2613.
188. Robinson, G. A. (1994) Immediate early gene expression in axotomized and regenerating retinal ganglion cells of the adult rat. Mol. Brain Res. 24, 43-54.
189. Robinson, G. A. (1995) Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells. Mol. Brain Res. 30, 61-69.
190. Robinson, S. R. (1988) Cell death in the inner and outer nuclear layers of the developing cat retina. J. Comp. Neurol. 267, 507-515.
191. Robson, C. N. and Hickson, I. D. (1991) Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (endonuclease III) mutants. Nucleic Acids Res. 19, 5519-5523.
192. Rocha, M., Martins, R. A. P. and Linden, R. (1998) NMDA protects against glutamate neurotroxicity in the developing retina: involvement of neurotrophins. Submitted.
193. Roffler Tarlov, S., Brown, J. J., Tarlov, E., Stolarov, J., Chapman, D. L., Alexiou, M. and Papaioannou, V. E. (1996) Programmed cell death in the absence of c-Fos and c-Jun. Development 122, 1-9.
194. Ross, M. E. (1996) Cell division and the nervous system: regulating the cycle from neural differentiation to death. Trends Neurosci 19, 62-68.
195. Rydel, R. E. and Greene, L. A. (1988) cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor. Proc. Natl. Acad. Sci. U.S.A. 85, 1257.
196. Sadoul, R., Quiquerez, A. L., Martinou, I., Fernandez, P. A. and Martinou, J. C. (1996) p53 protein in sympathetic neurons: cytoplasmic localization and no apparent function in apoptosis. J. Neurosci. Res. 43, 594-601.
197. Samuel, C. E. (1992) Role of the RNA-dependent protein kinase in the regulated expression of genes in transfected cells. Pharmacology and Therapeutics 54, 307-317.
198. Samuel, C. E. (1993) The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans. J. Biol. Chem. 268, 7603-7606.
199. Sauer, F. C. (1935) Mitosis in the neural tube. J. Comp. Neurol. 62, 377-405.
200. Saunders, Jr (1966) Death in embryonic systems: death of cells in the usual accompaniment of embryonic growth and differentiation. Science 154, 604-612.
201. Savill, J., Fadok, V., Henson, P. and Haslett, C. (1993) Phagocyte recognition of cells undergoing apoptosis. Immunol. Today 14, 131-136.
202. Schlingensiepen, K. H., Wollnik, F., Kunst, M., Schlingensiepen, R., Herdegen, T. and Brysch, W. (1994) The role of jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptations in vivo. Cell Mol. Neurobiol. 14, 487-505.
203. Schulzeosthoff, K., Krammer, P. H. and Droge, W. (1994) Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J. 13, 4587-4596.
204. Schwartz, L. M. and Osborne, B. A. (1993) Programmed cell death, apoptosis and killer genes. Immunol. Today 14, 582-590.
205. Sherr, C. J. (1993) Mammalian G1 Cyclins. Cell 73, 1059-1065.
206. Sherr, C. J. (1996) Cancer cell cycles. Science 274, 1672-1676.
207. Shibata, M. A., Maroulakou, I. G., Jorcyk, C. L., Gold, L. G., Ward, J. M. and Green, J. E. (1996) p53-Independent apoptosis during mammary tumor progression in C3(1)/SV40 large T antigen transgenic mice: suppression of apoptosis during the transition from preneoplasia to carcinoma. Cancer Res 56, 2998-3003.
208. Sicinski, P., Donaher, J. L., Parkwe, S. B. and Weinberg, R. A. (1995) Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82, 621-630.
209. Sidman, R. L. (1961) Histogenesis of mouse retina studied with thymidine-H. In The structure of the eye (ed. G. K. Smelser), pp. 487-506. Academic Press, New York.
210. Siliprandi, R., Canella, R. and Carmignoto, G. (1993) Nerve growth factor promotes functional recovery of retinal ganglion cells after ischemia. Invest. Ophthalmol. Vis. Sci. 34, 3232-3245.
211. Silver, J. and Hughes, A. F. W. (1974) The relationship between morphogenetic cell death and the development of congenital anophthalmia. J. Comp. Neurol. 157, 281-301.
212. Smeyne, R. J., Vendrell, M., Hayward, M., Baker, S. J., Miao, G. G., Schilling, K., Robertson, L. M., Curran, T. and Morgan, J. I. (1993) Continuous c-fos expression precedes programmed cell death in vivo. Nature 363, 166-169.
213. Steller, H. (1995) Mechanisms and genes of cellular suicide. Science 267, 1445-1449.
214. Stier, H. and Schlosshauer, B. (1995) Axonal guidance in the chicken retina. Development 121, 1443-1454.
215. Sullivan, L. S. and Daiger, S. P. (1996) Inherited retinal degeneration: exceptional genetic and clinical heterogeneity. Mol. Med. Today 2, 380-386.
216. Tagawa, T., Kuroki, T., Vogt, P. K. and Chida, K. (1995) The cell cycle-dependent nuclear import of v-Jun is regulated by phosphorylation of a serine adjacent to the nuclear localization signal. J. Cell Biol. 130, 255-263.
217. Tata, J. R. (1966) Requirement for RNA and protein synthesis for induced regression of the tadpole tail in organ cultures. Dev. Biol. 13, 77-94.
218. Thomaidou, D., Mione, M. C., Cavanagh, J. F. and Parnavelas, J. G. (1997) Apoptosis and its relation to the cell cycle in the developing cerebral cortex. J. Neurosci. 17, 1075-1085.
219. Thorburn, J., Frost, J. and Thorburn, A. (1994) Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle hypertrophy. J. Cell Biol. 126, 1565-1572.
220. Tso, M. O. (1989) Experiments on visual cells by nature and man: in search of treatment for photoreceptor degeneration. Invest. Ophthalmol. Vis. Sci. 30, 2430-2454.
221. Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E. and Croce, C. M. (1985) The t(14:18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229, 1390-1393.
222. Unoki, K. and LaVail, M. M. (1994) Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Invest. Ophthalmol. Vis. Sci. 35, 907-915.
223. Vardimon, L., Fox, L. E. and Moscona, A. A. (1986) Developmental regulation of glutamine synthetase and carbonic anhydrase II in neural retina. Proc. Natl. Acad. Sci. U.S.A. 83, 9060-9064.
224. Varella, M. H., Correa, D. F., Campos, C. B., Chiarini, L. B. and Linden, R. (1997) Protein kinases selectively modulate apoptosis in the developing retina in vitro. Neurochem. Int. 31, 217-227.
225. Vastrik, I., Kaipainen, A., Penttila, T. L., Lymboussakis, A., Alitalo, R., Parvinen, M. and Alitalo, K. (1995) Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro. J. Cell Biol. 128, 1197-1208.
226. Vermes, I., Haanen, C., Schaafsma, M. R., Kalsbeck-Batenburg, E. and Reutenlingsperger, C. P. (1997) Apoptosis and secondary necrosis of lymphocytes in culture. Acta Haematol. 98, 8-13.
227. Volonté, C., Rukenstein, A., Loeb, D. M. and Greene, L. A. (1989) Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase. J. Cell Biol. 109, 2395-2403.
228. Volonté, C., Angelastro, J. M. and Greene, L. A. (1993) Association of protein kinases ERK1 and ERK2 with p75 Nerve Growth Factor receptors. J. Biol. Chem. 268, 21410-21415.
229. Von Bartheld, C. S. (1998) Neurotrophins in the developing and regenerating visual system. Histology and Histopathology 13, 437-459.
230. Walker, L. J., Craig, R. B., Harris, A. L. and Hickson, I. D. (1994) A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nuclei Acids Research 22, 4884-4889.
231. Walker, P. R. and Sikorska, M. (1994) Endonuclease activities, chromatin structure, and DNA degradation in apoptosis - review. Biochem. Cell Biol. 72, 615-623.
232. Walton, M., Lawlor, P., Sirimanne, E., Williams, C., Gluckman, P., Dragunow, M. and Takahashi, R. (1997) Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons [p53]. Brain Res. Mol. Brain Res. 24, 1381-1385.
233. Watson, A., Eilers, A., Lallemand, D., Kyriakis, J., Rubin, L. L. and Ham, J. (1998) Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J. Neurosci. 18, 751-762.
234. Weber, M., Mohand Said, S., Hicks, D., Dreyfus, H. and Sahel, J. A. (1996) Monosialoganglioside GM1 reduces ischemia-reperfusion-induced injury in the rat retina. Invest. Ophthalmol. Vis. Sci. 37, 267-273.
235. Williams, G. T. and Smith, C. A. (1993) Molecular regulation of apoptosis - genetic controls on cell death. Cell 74, 777-779.
236. Williams, M. A., Pinon, L. G. P., Linden, R. and Pinto, L. H. (1990) The pearl mutation accelerates the schedule of natural cell death in the early postnatal retina. Exp. Brain. Res. 82, 393-400.
237. Williams, R. W., Bastiani, M. J., Lia, B. and Chalupa, L. M. (1986) Growth cones, dying axons, and developmental fluctuations in the fiber population of the cat's optic nerve. J. Comp. Neurol. 246, 32-69.
238. Wong, P. (1994) Apoptosis, retinitis pigmentosa, and degeneration - review. Biochem. Cell Biol. 72, 489-498.
239. Wyllie, A. H. (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555-556.
240. Wyllie, A. H., Morris, R. G., Smith, A. L. and Dunlop, D. (1984) Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol. 142, 66.
241. Wyllie, A. H. (1994) Death from inside out: an overview. Philos. Trans. R. Soc. Lond. [Biol]. 345, 237-241.
242. Xanthoudakis, S., Miao, G., Wang, F., Pan, Y. C. E. and Curran, T. (1992) Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 11, 3323-3335.
243. Xanthoudakis, S., Miao, G. and Curran, T. (1994) The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc. Natl. Acad. Sci. U.S.A. 91, 23-27.
244. Xia, Z. G., Dickens, M., Raingeaud, J., Davis, R. J. and Greenberg, M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
245. Xiang, J. L., Lahti, J. M. and Kidd, V. J. (1994) 2-aminopurine overrides a late telophase delay created by ectopic expression of the PITSLREbeta1 protein kinase. Biochem. Biophys. Res. Commun. 199, 1167-1173.
246. Xie, K. P., Huang, S. Y., Dong, Z. Y. and Fidler, I. J. (1993) Cytokine-induced apoptosis in transformed murine fibroblasts involves synthesis of endogenous nitric oxide. Int. J. Oncol. 3, 1043-1048.
247. Xu, G. Z., Li, W. W. and Tso, M. O. (1996) Apoptosis in human retinal degenerations. Trans. Am. Ophthalmol. Soc. 94, 411-430.
248. Yamasaki, E. N., Krupnik, V. E., Chang, Y. and Chun, L. L. Y. (1993) A new monoclonal antibody (RT10F7) recognizes Muller cells in the adult and developing rat retina. Soc. Neurosci. Abstr. 19(Abstract), 44.
249. Yan, G. Z. and Ziff, E. B. (1995) NGF regulates the PC12 cell cycle machinery through specific inhibition of the cdk kinases and induction of cyclin D1. J. Neurosci. 15, 6200-6212.
250. Yang, E., Zha, J. P., Jockel, J., Boise, L. H., Thompson, C. B. and Korsmeyer, S. J. (1995) Bad, a heterodimeric partner for Bcl-x(L) and Bcl-2, displaces Bax and promotes cell death. Cell 80, 285-291.
251. Yao, K. S., Clayton, M. and O'Dwyer, P. J. (1995) Apoptosis in human adenocarcinoma HT29 eels induced by exposure to hypoxia. J. Natl. Cancer Inst. 87, 117-122.
252. Yin, X. M., Oltvai, Z. N., Veisnovack, D. J., Linette, G. P. and Korsmeyer, S. J. (1994) Bcl-2 gene family and the regulation of programmed cell death. Cold Spring Harb. Symp. Quant. Biol. 59, 387-393.
253. Yoshida, K. and Gage, F. H. (1992) Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Brain Res. 569, 14-25.
254. Young, R. W. (1984) Cell death during differentiation of the retina in the mouse. J. Comp. Neurol. 229, 362-373.
255. Young, R. W. (1985) Cell differentiation in the retina of the mouse. Anat. Rec. 212, 199-205.
256. Yuge, K., Nakajima, M., Uemura, Y., Miki, H., Uyama, M. and Tsubura, A. (1995) Immunohistochemical features of the human retina and retinoblastoma. Virchows Archiv. 426, 571-575.
257. Yuge, K., Nambu, H., Senzaki, H., Nakao, I., Miki, H., Uyama, M. and Tsubura, A. (1996) N-methyl-N-nitrosourea-induced photoreceptor apoptosis in the mouse retina. In Vivo 10, 483-488.
258. Zhang, D. R. and Yeh, H. H. (1991) Protein kinase C-like immunoreactivity in rod bipolar cells of the rat retina: a developmental study. Vis. Neurosci. 6, 429-437.
259. Zhou, F. and Thompson, E. B. (1996) Role of c-jun induction in the glucocorticoid-evoked apoptotic pathway in human leukemic lymphoblasts. Mol. Endocrinol. 10, 306-316.
260. Ziv, I., Melamed, E., Nardi, N., Luria, D., Achiron, A., Offen, D. and Barzilai, A. (1994) Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons - a possible novel pathogenetic mechanism in Parkinsons disease. Neurosci. Lett. 170, 136-140.