Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice

Endocrinology

Volumn 145, Issue 1, 2004, Pages 243-252

  Albarado, Diana C ^a   McClaine, Jennifer ^a   Stephens, Jacqueline M ^b   Mynatt, Randall L ^a   Ye, Jianping ^a   Bannon, Anthony W ^c   Richards, William G ^c   Butler, Andrew A ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c AMGEN INC   (United States)

Author keywords

Fatty acid metabolism; Insulin resistance; Liver; Melanocortin; Steatosis

Indexed keywords

FATTY ACID; FATTY ACID SYNTHASE; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; ENERGY EXPENDITURE; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY LIVER; FEMALE; GENE EXPRESSION; GENE MUTATION; HAPLOIDY; HYPERINSULINEMIA; HYPERPHAGIA; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIPID STORAGE; LIPOGENESIS; MOUSE; NONHUMAN; NUTRIENT UPTAKE; OBESITY; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BODY WEIGHT; DIETARY FATS; EATING; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FATTY LIVER; FEMALE; GENE EXPRESSION; HYPERINSULINISM; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; LIPIDS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; OXIDATION-REDUCTION; PHOSPHOPROTEINS; RECEPTOR, MELANOCORTIN, TYPE 4; TRIGLYCERIDES;

EID: 1042275338     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0452     Document Type: Article

References (56)

1. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP 2001 The continuing epidemics of obesity and diabetes in the United States. Jama 286:1195-200
2. Bray GA 1998 Obesity: a time bomb to be defused. Lancet 352:160-1
3. Ukkola O, Bouchard C 2001 Clustering of metabolic abnormalities in obese individuals: the role of genetic factors. Ann Med 33:79-90.
4. Reifsnyder PC, Leiter EH 2002 Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes 51:825-32
5. Snitker S, Macdonald I, Ravussin E, Astrup A 2000 The sympathetic nervous system and obesity: role in aetiology and treatment. Obes Rev 1:5-15
6. Branson R, Potoczna N, Kral JG, Lentes K-L, Hoehe MR, Horber FF 2003 Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 348:1096-1103
7. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S 2003 Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348:1085-1095
8. Farooqi IS, Yeo GS, Keogh JM, et al. 2000 Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106:271-9.
9. Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P 2000 Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 106:253-62.
10. Jacobson P, Ukkola O, Rankinen T, et al. 2002 Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort. J Clin Endocrinol Metab 87:4442-6
11. Weide K, Christ N, Moar KM, et al. 2003 Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice. Physiol Genomics 13:47-56
12. Ste Marie L, Miura GI, Marsh DJ, Yagaloff K, Palmiter RD 2000 A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci U S A 97:12339-44.
13. Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, Elmquist JK 2003 Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 457:213-35
14. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD 1994 Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8:1298-308.
15. Liu H, Kishi T, Roseberry AG, et al. 2003 Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 23:7143-54
16. Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, Cone RD 2001 Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 4:605-11.
17. Xu B, Goulding EH, Zang K, et al. 2003 Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6:736-42
18. Rahmouni K, Haynes WG, Morgan DA, Mark AL 2003 Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci 23:5998-6004
19. Chen AS, Metzger JM, Trumbauer ME, et al. 2000 Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res 9:145-54.
20. Marsh DJ, Hollopeter G, Huszar D, et al. 1999 Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21:119-22.
21. Lu XY, Barsh GS, Akil H, Watson SJ 2003 Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci 23:7863-72
22. Fekete C, Sarkar S, Rand WM, et al. 2002 Agouti-Related Protein (AGRP) Has a Central Inhibitory Action on the Hypothalamic-Pituitary-Thyroid (HPT) Axis; Comparisons between the Effect of AGRP and Neuropeptide Y on Energy Homeostasis and the HPT Axis. Endocrinology 143:3846-53
23. Fekete C, Legradi G, Mihaly E, Tatro JB, Rand WM, Lechan RM 2000 alpha-Melanocyte stimulating hormone prevents fasting-induced suppression of corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus. Neurosci Lett 289:152-6.
24. Huszar D, Lynch CA, Fairchild-Huntress V, et al. 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-41.
25. Fan W, Dinulescu DM, Butler AA, Zhou J, Marks DL, Cone RD 2000 The central melanocortin system can directly regulate serum insulin levels. Endocrinology 141:3072-9.
26. Namae M, Mori Y, Yasuda K, Kadowaki T, Kanazawa Y, Komeda K 1998 New method for genotyping the mouse Lep(ob) mutation, using a polymerase chain reaction assay. Lab Anim Sci 48:103-4.
27. Butler AA, Kesterson RA, Khong K, et al. 2000 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141:3518-21.
28. Elia M, Livesey G 1988 Theory and validity of indirect calorimetry during net lipid synthesis. Am J Clin Nutr 47:591-607
29. Liu X, Rossmeisl M, McClaine J, Kozak LP 2003 Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest 111:399-407
30. Bligh EG, Dyer WJ 1959 A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917
31. Atkinson LL, Fischer MA, Lopaschuk GD 2002 Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J Biol Chem 277:29424-30
32. Coulter AA, Bearden CM, Liu X, Koza RA, Kozak LP 2003 Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat. Physiol Genomics 14:139-47
33. Hofmann WE, Liu X, Bearden CM, Harper ME, Kozak LP 2001 Effects of genetic background on thermoregulation and fatty acid- induced uncoupling of mitochondria in UCP1-deficient mice. J Biol Chem 276:12460-5.
34. Levert KL, Waldrop GL, Stephens JM 2002 A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis. J Biol Chem 277:16347-50
35. Bush EN, Shapiro RL, Nuss ME, et al. Adiposity, leptin resistance, hyperphagia, hyperglycemia, glucose intolerance and insulin resistance in C57BL/6J mice fed high fat diets. Endocrine Society, Denver, 2001
36. Elia M 1992 Organ and tissue contribution to metabolic rate. In: Kinney JM (ed) Enegy metabolism: tissue determinants and cellular corollaries. Raven Press, New York, pp 61-77
37. Breslow MJ, Min-Lee K, Brown DR, Chacko VP, Palmer D, Berkowitz DE 1999 Effect of leptin deficiency on metabolic rate in ob/ob mice. Am J Physiol 276:E443-9.
38. Weyer C, Pratley RE, Salbe AD, Bogardus C, Ravussin E, Tataranni PA 2000 Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change. J Clin Endocrinol Metab 85:1087-94.
39. Flatt JP 1995 Carbohydrate balance and food intake regulation. Am J Clin Nutr 62:155-7
40. Flatt JP 1995 Use and storage of carbohydrate and fat. Am J Clin Nutr 61:952S-959S
41. Haluzik M, Dietz KR, Kim JK, et al. 2002 Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity. Diabetes 51:2113-8
42. Coleman DL, Hummel KP 1973 The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia 9:287-93
43. Hummel KP, Coleman DL, Lane PW 1972 The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains. Biochem Genet 7:1-13
44. Meegalla RL, Billheimer JT, Cheng D 2002 Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochem Biophys Res Commun 298:317-23
45. Memon RA, Tecott LH, Nonogaki K, et al. 2000 Up-regulation of peroxisome proliferator-activated receptors (PPAR- alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma- responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 141:4021-31.
46. Uyeda K, Yamashita H, Kawaguchi T 2002 Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage. Biochem Pharmacol 63:2075-80
47. Horton JD, Goldstein JL, Brown MS 2002 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125-31
48. Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS 2003 Liver-specific mRNA for Insig-2 downregulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci U S A 100:3155-60
49. Matsusue K, Haluzik M, Lambert G, et al. 2003 Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 111:737-47
50. Gavrilova O, Haluzik M, Matsusue K, et al. 2003 Liver PPARgamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem
51. Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL 2000 Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6:77-86.
52. Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS, Goldstein JL 2001 Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proc Natl Acad Sci U S A 98:3756-61.
53. Colombo C, Haluzik M, Cutson JJ, et al. 2002 Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice: Role of triglyceride clearance. J Biol Chem
54. Lan H, Rabaglia ME, Stoehr JP, et al. 2003 Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes 52:688-700
55. Shimomura I, Bashmakov Y, Horton JD 1999 Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274:30028-32.
56. Yahagi N, Shimano H, Hasty AH, et al. 2002 Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem 277:19353-7