메뉴 건너뛰기




Volumn 93, Issue 1, 2008, Pages 95-103

Association between KCNJ11 E23K genotype and cardiovascular and glucose metabolism phenotypes in older men and women

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2;

EID: 37349056377     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2007.038893     Document Type: Article
Times cited : (10)

References (43)
  • 1
    • 23844479300 scopus 로고    scopus 로고
    • 12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes
    • 12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes. Diabetologia 48, 1503 1509.
    • (2005) Diabetologia , vol.48 , pp. 1503-1509
    • Adamo, K.B.1    Sigal, R.J.2    Williams, K.3    Kenny, G.4    Prud'Homme, D.5    Tesson, F.6
  • 4
    • 4243062602 scopus 로고    scopus 로고
    • Candidate gene association study in type 2 diabetes indicates a role for genes involved in β-cell function as well as insulin action
    • Barroso I, Luan J, Middelberg RP, Harding AH, Franks PW, Jakes RW et al 2003). Candidate gene association study in type 2 diabetes indicates a role for genes involved in β-cell function as well as insulin action. PLoS Biol 1, E20.
    • (2003) PLoS Biol , vol.1
    • Barroso, I.1    Luan, J.2    Middelberg, R.P.3    Harding, A.H.4    Franks, P.W.5    Jakes, R.W.6    Al, E.7
  • 5
    • 0028922064 scopus 로고
    • Changes in physical fitness and all-cause mortality. a prospective study of healthy and unhealthy men
    • Blair SN, Kohl HW III., Barlow CE, Paffenbarger RS Jr., Gibbons LW & Macera CA (1995). Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. JAMA 273, 1093 1098.
    • (1995) JAMA , vol.273 , pp. 1093-1098
    • Blair, S.N.1    Kohl Iii., H.W.2    Barlow, C.E.3    Paffenbarger Jr., R.S.4    Gibbons, L.W.5    MacEra, C.A.6
  • 7
    • 0032588152 scopus 로고    scopus 로고
    • Familial aggregation of response to exercise training: Results from the HERITAGE Family Study
    • Bouchard C, An P, Rice T, Skinner JS, Wilmore JH, Gagnon J et al 1999). Familial aggregation of response to exercise training: results from the HERITAGE Family Study. J Appl Physiol 87, 1003 1008.
    • (1999) J Appl Physiol , vol.87 , pp. 1003-1008
    • Bouchard, C.1    An, P.2    Rice, T.3    Skinner, J.S.4    Wilmore, J.H.5    Gagnon, J.6    Al, E.7
  • 10
    • 33750584981 scopus 로고    scopus 로고
    • Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance
    • Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD et al 2006). Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55, 2654 2659.
    • (2006) Diabetes , vol.55 , pp. 2654-2659
    • Damcott, C.M.1    Pollin, T.I.2    Reinhart, L.J.3    Ott, S.H.4    Shen, H.5    Silver, K.D.6    Al, E.7
  • 11
    • 9444289880 scopus 로고    scopus 로고
    • Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes
    • Florez JC, Sjogren M, Burtt N, Orho-Melander M, Schayer S, Sun M et al 2004). Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes. Diabetes 53, 3313 3318.
    • (2004) Diabetes , vol.53 , pp. 3313-3318
    • Florez, J.C.1    Sjogren, M.2    Burtt, N.3    Orho-Melander, M.4    Schayer, S.5    Sun, M.6    Al, E.7
  • 12
    • 0035043009 scopus 로고    scopus 로고
    • Association studies of variants in promoter and coding regions of β-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus
    • Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S & Turner RC (2001). Association studies of variants in promoter and coding regions of β-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus. Diabet Med 18, 206 212.
    • (2001) Diabet Med , vol.18 , pp. 206-212
    • Gloyn, A.L.1    Hashim, Y.2    Ashcroft, S.J.3    Ashfield, R.4    Wiltshire, S.5    Turner, R.C.6
  • 13
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    • Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G et al 2003). Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52, 568 572.
    • (2003) Diabetes , vol.52 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3    Turner, M.J.4    Knight, B.A.5    Hitman, G.6    Al, E.7
  • 14
    • 0031978984 scopus 로고    scopus 로고
    • Exercise, glucose transport, and insulin sensitivity
    • Goodyear LJ & Kahn BB (1998). Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 49, 235 261.
    • (1998) Annu Rev Med , vol.49 , pp. 235-261
    • Goodyear, L.J.1    Kahn, B.B.2
  • 15
    • 0031773333 scopus 로고    scopus 로고
    • + channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians
    • + channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians. Diabetologia 41, 1511 1515.
    • (1998) Diabetologia , vol.41 , pp. 1511-1515
    • Hani, E.H.1    Boutin, P.2    Durand, E.3    Inoue, H.4    Permutt, M.A.5    Al, E.6
  • 16
    • 0031051534 scopus 로고    scopus 로고
    • Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM
    • Hansen L, Echwald SM, Hansen T, Urhammer SA, Clausen JO & Pedersen O (1997). Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM. Diabetes 46, 508 512.
    • (1997) Diabetes , vol.46 , pp. 508-512
    • Hansen, L.1    Echwald, S.M.2    Hansen, T.3    Urhammer, S.A.4    Clausen, J.O.5    Pedersen, O.6
  • 17
    • 21244439539 scopus 로고    scopus 로고
    • Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes
    • Hansen SK, Nielsen EM, Ek J, Andersen G, Glumer C, Carstensen B et al 2005). Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes. J Clin Endocrinol Metab 90, 3629 3637.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3629-3637
    • Hansen, S.K.1    Nielsen, E.M.2    Ek, J.3    Andersen, G.4    Glumer, C.5    Carstensen, B.6    Al, E.7
  • 19
    • 0036021855 scopus 로고    scopus 로고
    • Invited review: Effects of acute exercise and exercise training on insulin resistance
    • Henriksen EJ (2002). Invited review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 93, 788 796.
    • (2002) J Appl Physiol , vol.93 , pp. 788-796
    • Henriksen, E.J.1
  • 20
    • 0022523667 scopus 로고
    • Effects of exercise on glucose tolerance and insulin resistance - Brief review and some preliminary results
    • Holloszy J, Schultz J, Kusnierkiewicz J, Hagberg JM & Ehsani A (1986). Effects of exercise on glucose tolerance and insulin resistance - brief review and some preliminary results. Acta Med Scand 711, 55 65.
    • (1986) Acta Med Scand , vol.711 , pp. 55-65
    • Holloszy, J.1    Schultz, J.2    Kusnierkiewicz, J.3    Hagberg, J.M.4    Ehsani, A.5
  • 22
    • 29144529013 scopus 로고    scopus 로고
    • The KCNQ1 potassium channel: From gene to physiological function
    • Jespersen T, Grunnet M & Olesen SP (2005). The KCNQ1 potassium channel: from gene to physiological function. Physiology (Bethesda) 20, 408 416.
    • (2005) Physiology (Bethesda) , vol.20 , pp. 408-416
    • Jespersen, T.1    Grunnet, M.2    Olesen, S.P.3
  • 24
    • 33846608291 scopus 로고    scopus 로고
    • Polymorphisms of KCNJ11 (Kir6.2 gene) are associated with Type 2 diabetes and hypertension in the Korean population
    • Koo BK, Cho YM, Park BL, Cheong HS, Shin HD, Jang HC et al 2007). Polymorphisms of KCNJ11 (Kir6.2 gene) are associated with Type 2 diabetes and hypertension in the Korean population. Diabet Med 24, 178 186.
    • (2007) Diabet Med , vol.24 , pp. 178-186
    • Koo, B.K.1    Cho, Y.M.2    Park, B.L.3    Cheong, H.S.4    Shin, H.D.5    Jang, H.C.6    Al, E.7
  • 25
    • 0029742917 scopus 로고    scopus 로고
    • Dietary guidelines for healthy American adults. a statement for health professionals from the Nutrition Committee, American Heart Association
    • Krauss RM, Deckelbaum RJ & Ernst N (1996). Dietary guidelines for healthy American adults. A statement for health professionals from the Nutrition Committee, American Heart Association. Circulation 94, 1795 1800.
    • (1996) Circulation , vol.94 , pp. 1795-1800
    • Krauss, R.M.1    Deckelbaum, R.J.2    Ernst, N.3
  • 26
    • 10344246071 scopus 로고    scopus 로고
    • Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. the Finnish Diabetes Prevention Study
    • Laukkanen O, Pihlajamaki J, Lindstrom J, Eriksson J, Valle TT, Hamalainen H et al 2004). Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study. J Clin Endocrinol Metab 89, 6286 6290.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 6286-6290
    • Laukkanen, O.1    Pihlajamaki, J.2    Lindstrom, J.3    Eriksson, J.4    Valle, T.T.5    Hamalainen, H.6    Al, E.7
  • 27
    • 1842526874 scopus 로고    scopus 로고
    • Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification
    • Spec 1
    • McCarthy MI (2004). Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification. Hum Mol Genet 13, Spec 1, R33 R41.
    • (2004) Hum Mol Genet , vol.13
    • McCarthy, M.I.1
  • 29
    • 4644289990 scopus 로고    scopus 로고
    • Influence of the interleukin-6-174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexes
    • McKenzie JA, Weiss EP, Ghiu IA, Kulaputana O, Phares DA et al 2004). Influence of the interleukin-6-174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexes. J Appl Physiol 97, 1338 1342.
    • (2004) J Appl Physiol , vol.97 , pp. 1338-1342
    • McKenzie, J.A.1    Weiss, E.P.2    Ghiu, I.A.3    Kulaputana, O.4    Phares, D.A.5    Al, E.6
  • 30
    • 0037312864 scopus 로고    scopus 로고
    • The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes
    • Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glumer C et al 2003). The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. Diabetes 52, 573 577.
    • (2003) Diabetes , vol.52 , pp. 573-577
    • Nielsen, E.M.1    Hansen, L.2    Carstensen, B.3    Echwald, S.M.4    Drivsholm, T.5    Glumer, C.6    Al, E.7
  • 32
    • 12344279952 scopus 로고    scopus 로고
    • Genetic factors in type 2 diabetes: The end of the beginning?
    • O'Rahilly S, Barroso I & Wareham NJ (2005). Genetic factors in type 2 diabetes: the end of the beginning? Science 307, 370 373.
    • (2005) Science , vol.307 , pp. 370-373
    • O'Rahilly, S.1    Barroso, I.2    Wareham, N.J.3
  • 33
    • 33750682655 scopus 로고    scopus 로고
    • The human gene map for performance and health related fitness phenotypes: The 2005 update
    • Rankinen T, Bray MS, Hagberg JM, Perusse L, Roth SM et al 2006). The human gene map for performance and health related fitness phenotypes: the 2005 update. Med Sci Sports Exerc 38, 1863 1888.
    • (2006) Med Sci Sports Exerc , vol.38 , pp. 1863-1888
    • Rankinen, T.1    Bray, M.S.2    Hagberg, J.M.3    Perusse, L.4    Roth, S.M.5    Al, E.6
  • 34
    • 0141643279 scopus 로고    scopus 로고
    • Kir6.2 polymorphisms sensitize β-cell ATP-sensitive potassium channels to activation by acyl CoAs: A possible cellular mechanism for increased susceptibility to type 2 diabetes?
    • Riedel MJ, Boora P, Steckley D, de Vries G & Light PE (2003). Kir6.2 polymorphisms sensitize β-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes? Diabetes 52, 2630 2635.
    • (2003) Diabetes , vol.52 , pp. 2630-2635
    • Riedel, M.J.1    Boora, P.2    Steckley, D.3    De Vries, G.4    Light, P.E.5
  • 35
    • 10744222367 scopus 로고    scopus 로고
    • A genome-wide search for type 2 diabetes susceptibility genes in West Africans: The Africa America Diabetes Mellitus (AADM) Study
    • Rotimi CN, Chen G, Adeyemo AA, Furbert-Harris P, Parish-Gause D, Zhou J et al 2004). A genome-wide search for type 2 diabetes susceptibility genes in West Africans: the Africa America Diabetes Mellitus (AADM) Study. Diabetes 53, 838 841.
    • (2004) Diabetes , vol.53 , pp. 838-841
    • Rotimi, C.N.1    Chen, G.2    Adeyemo, A.A.3    Furbert-Harris, P.4    Parish-Gause, D.5    Zhou, J.6    Al, E.7
  • 36
    • 0029740428 scopus 로고    scopus 로고
    • Sequence variations in the human Kir6.2 gene, a subunit of the β-cell ATP-sensitive K-channel: No association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro
    • Sakura H, Wat N, Horton V, Millns H, Turner RC & Ashcroft FM (1996). Sequence variations in the human Kir6.2 gene, a subunit of the β-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro. Diabetologia 39, 1233 1236.
    • (1996) Diabetologia , vol.39 , pp. 1233-1236
    • Sakura, H.1    Wat, N.2    Horton, V.3    Millns, H.4    Turner, R.C.5    Ashcroft, F.M.6
  • 39
    • 0033635776 scopus 로고    scopus 로고
    • Potassium channels: Molecular defects, diseases, and therapeutic opportunities
    • Shieh CC, Coghlan M, Sullivan JP & Gopalakrishnan M (2000). Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev 52, 557 594.
    • (2000) Pharmacol Rev , vol.52 , pp. 557-594
    • Shieh, C.C.1    Coghlan, M.2    Sullivan, J.P.3    Gopalakrishnan, M.4
  • 41
    • 9644255938 scopus 로고    scopus 로고
    • Endurance training-induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator-activated receptor-γ2 Pro12Ala genotype in men but not in women
    • Weiss EP, Kulaputana O, Ghiu IA, Brandauer J, Wohn CR, Phares DA et al 2005). Endurance training-induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator-activated receptor-γ2 Pro12Ala genotype in men but not in women. Metabolism 54, 97 102.
    • (2005) Metabolism , vol.54 , pp. 97-102
    • Weiss, E.P.1    Kulaputana, O.2    Ghiu, I.A.3    Brandauer, J.4    Wohn, C.R.5    Phares, D.A.6    Al, E.7
  • 42
    • 0036281792 scopus 로고    scopus 로고
    • Changes in high-density lipoprotein-cholesterol subfractions with exercise training may be dependent on cholesteryl ester transfer protein genotype
    • Wilund KR, Ferrell RE, Phares DA, Goldberg AP & Hagberg JM (2002). Changes in high-density lipoprotein-cholesterol subfractions with exercise training may be dependent on cholesteryl ester transfer protein genotype. Metabolism 51, 774 778.
    • (2002) Metabolism , vol.51 , pp. 774-778
    • Wilund, K.R.1    Ferrell, R.E.2    Phares, D.A.3    Goldberg, A.P.4    Hagberg, J.M.5
  • 43
    • 20144389794 scopus 로고    scopus 로고
    • An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese
    • Zhao JY, Xiong MM, Huang W, Wang H, Zuo J, Wu GD et al 2005). An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese. J Mol Med 83, 209 215.
    • (2005) J Mol Med , vol.83 , pp. 209-215
    • Zhao, J.Y.1    Xiong, M.M.2    Huang, W.3    Wang, H.4    Zuo, J.5    Wu, G.D.6    Al, E.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.