Influence of the interleukin-6 - 174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexes

Journal of Applied Physiology

Volumn 97, Issue 4, 2004, Pages 1338-1342

  McKenzie, Jennifer A ^a   Weiss, Edward P ^a   Ghiu, Ioana A ^a   Kulaputana, Onanong ^a   Phares, Dana A ^a   Ferrell, Robert E ^b   Hagberg, James M ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Genetics; Oral glucose tolerance test

Indexed keywords

DNA; GLUCOSE; INTERLEUKIN 6;

ADULT; AGE; AGED; AREA UNDER THE CURVE; ARTICLE; BODY FAT; BODY WEIGHT; CARDIOVASCULAR DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; COVARIANCE; DNA POLYMORPHISM; DUAL ENERGY X RAY ABSORPTIOMETRY; ETHNOLOGY; EXERCISE; FITNESS; GENDER; GENE FREQUENCY; GENOTYPE; GLUCOSE TOLERANCE; HUMAN; HUMAN EXPERIMENT; INSULIN SENSITIVITY; MALE; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; OXYGEN CONSUMPTION; POSTMENOPAUSE; PRIORITY JOURNAL; SITTING; TRAINING; TRANSLATION INITIATION;

AGE FACTORS; AGED; BLOOD GLUCOSE; DIABETES MELLITUS; EXERCISE; EXERCISE THERAPY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INTERLEUKIN-6; MALE; MIDDLE AGED; PHYSICAL EDUCATION AND TRAINING; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS; SEX FACTORS;

EID: 4644289990     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00199.2004     Document Type: Article

References (32)

1. American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. Philadelphia, PA: Lea and Febiger, 2000.
2. American Heart Association. 2002 Heart and Stroke Statistical Update. Dallas, TX: American Heart Association, 2001.
3. Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, and Hainque B. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85: 3338-3342, 2000.
4. Berthier MT, Paradis AM, Tchernof A, Bergeron J, Prud'homme D, Despres JP, and Vohl MC. The interleukin 6 - 174G/C polymorphism is associated with indices of obesity in men. J Hum Genet 48: 14-19, 2003.
5. Chen X, Levine L, and Kwok PY. Fluorescence polarization in homogeneous nucleic acid analysis. Genome Res 9: 492-498, 1999.
6. Dengel DR, Hagberg JM, Coon PJ, Drinkwater DT, and Goldberg AP. Effects of weight loss by diet alone or combined with aerobic exercise on body composition in older obese men. Metabolism 43: 867-871, 1994.
7. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection. Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285: 2486-2497, 2001.
8. Fernandez-Real JM, Broch M, Vendrell J, Gutierrez C, Casamitjana R, Pugeat M, Richart C, and Ricart W. Interleukin-6 gene polymorphism and insulin sensitivity. Diabetes 49: 517-520, 2000.
9. Fernandez-Real JM, Broch M, Vendrell J, Richart C, and Ricart W. Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. J Clin Endocrinol Metab 85: 1334-1339, 2000.
10. Fernandez-Real JM, Vayreda M, Richart C, Gutierrez C, Broch M, Vendrell J, and Ricart W. Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J Clin Endocrinol Metab 86: 1154-1159, 2001.
11. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, and Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102: 1369-1376, 1998.
12. Fried SK, Bunkin DA, and Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83: 847-850, 1998.
13. Jenny NS, Tracy RP, Ogg MS, Luong IA, Kuller LH, Arnold AM, Sharrett AR, and Humphries SE. In the elderly, interleukin-6 plasma levels and the - 174G/C polymorphism are associated with the development of cardiovascular disease. Arterioscler Thromb Vasc Biol 22: 2066-2071, 2002.
14. Kern PA, Ranganathan S, Li C, Wood L, and Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280: E745-E751, 2001.
15. King DS, Dalsky GP, Clutter WE, Young DA, Staten MA, Cryer PE, and Holloszy JO. Effects of exercise and lack of exercise on insulin sensitivity and responsiveness. J Appl Physiol 64: 1942-1946, 1988.
16. Kirwan JP, Kohrt WM, Wojta DM, Bourey RE, and Holloszy JO. Endurance exercise training reduces glucose-stimulated insulin levels in 60- to 70-year-old men and women. J Gerontol 48: M84-M90, 1993.
17. Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels SR, Deckelbaum RJ, Erdman JW Jr, Kris-Etherton P, Goldberg IJ, Kotchen TA, Lichtenstein AH, Mitch WE, Mullis R, Robinson K, Wylie-Rosett J, St Jeor S, Suttie J, Tribble DL and Bazzarre TL. AHA dietary guidelines: revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation 102: 2284-2299, 2000.
18. Kubaszek A, Pihlajamaki J, Komarovski V, Lindi V, Lindstrom J, Eriksson J, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, and Laakso M. Promoter polymorphisms of the TNF-α (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to Type 2 diabetes: the Finnish diabetes prevention study. Diabetes 52: 1872-1876, 2003.
19. Kubaszek A, Pihlajamaki J, Punnonen K, Karhapaa P, Vauhkonen I, and Laakso M. The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity. Diabetes 52: 558-561, 2003.
20. Matsuda M and DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470, 1999.
21. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, and Coppack SW. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab 82: 4196-4200, 1997.
22. Nicklas BJ, Rogus EM, Colman EG, and Goldberg AP. Visceral adiposity, increased adipocyte lipolysis, and metabolic dysfunction in obese postmenopausal women. Am J Physiol Endocrinol Metab 270; E72-E78, 1996.
23. Pickup JC, Mattock MB, Chusney GD, and Burt D. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40: 1286-1292, 1997.
24. Ridker PM, Rifai N, Stampfer MJ, and Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101: 1767-1772, 2000.
25. Seals DR, Hagberg JM, Allen WK, Hurley BF, Dalsky GP, Ehsani AA, and Holloszy JO. Glucose tolerance in young and older athletes and sedentary men. J Appl Physiol 56: 1521-1525, 1984.
26. Straub RH, Hense HW, Andus T, Scholmerich J, Riegger GA, and Schunkert H. Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study. J Clin Endocrinol Metab 85: 1340-1344, 2000.
27. Terry CF, Loukaci V, and Green FR. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 275: 18138-18144, 2000.
28. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, and Chrousos GP. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab 82: 1313-1316, 1997.
29. Volpato S, Guralnik JM, Ferrucci L, Balfour J, Chaves P, Fried LP, and Harris TB. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation 103: 947-953, 2001.
30. Vozarova B, Fernandez-Real JM, Knowler WC, Gallart L, Hanson RL, Gruber JD, Ricart W, Vendrell J, Richart C, Tataranni PA, and Wolford JK. The interleukin-6 (-174) G/C promoter polymorphism is associated with Type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet 112: 409-413, 2003.
31. Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, Ohlsson C, and Jansson JO. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8: 75-79, 2002.
32. Wilund KR, Ferrell RE, Phares DA, Goldberg AP, and Hagberg JM. Changes in high-density lipoprotein-cholesterol subfractions with exercise training may be dependent on cholesteryl ester transfer protein (CETP) genotype. Metabolism 51: 774-778, 2002.