Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, IκB kinase activation and NF-κB-regulated gene expression

Oncogene

Volumn 25, Issue 10, 2006, Pages 1463-1473

  Shishodia, S ^a   Aggarwal, B B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Akt; Diosgenin; IKK; Invasion; NF B; Osteoclastogenesis

Indexed keywords

ANTINEOPLASTIC AGENT; BFL 1 A1 PROTEIN; CYCLIN D1; CYCLOOXYGENASE 2; CYTOKINE; DIOSGENIN; FLICE INHIBITORY PROTEIN; GELATINASE B; I KAPPA B ALPHA; I KAPPA B ALPHA KINASE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; MYC PROTEIN; PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; SAPONIN; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL INVASION; CELL MATURATION; CELL PROLIFERATION; DNA BINDING; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FENUGREEK; GENE EXPRESSION REGULATION; HERBAL MEDICINE; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REPORTER GENE;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL LINE; CELL MIGRATION INHIBITION; DIOSGENIN; DOWN-REGULATION; ENZYME INHIBITORS; GROWTH INHIBITORS; HUMANS; I-KAPPA B KINASE; MEMBRANE GLYCOPROTEINS; MICE; NF-KAPPA B; OSTEOCLASTS; PROTO-ONCOGENE PROTEINS C-AKT; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA; TUMOR NECROSIS FACTORS;

ANIMALIA; TRIGONELLA FOENUM-GRAECUM;

EID: 33644840279     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209194     Document Type: Article

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