Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines

Molecular Cancer

Volumn 6, Issue , 2007, Pages

  Cosse, Jean Philippe ^a   Sermeus, Audrey ^a   Vannuvel, Kayleen ^a   Ninane, Noelle ^a   Raes, Martine ^a   Michiels, Carine ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; PROTEIN P53; DNA; HYPOXIA INDUCIBLE FACTOR 1;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER RESISTANCE; CARCINOMA CELL; CELL STRAIN HEPG2; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG MECHANISM; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; HYPOXIA; LIVER CELL CARCINOMA; LUNG CARCINOMA; MICROARRAY ANALYSIS; PROTEIN STABILITY; CELL HYPOXIA; DNA DAMAGE; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL HYPOXIA; CELL LINE, TUMOR; DNA; DNA DAMAGE; ETOPOSIDE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 36849046868     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-6-61     Document Type: Article

References (41)

1. Harris AL Hypoxia - a key regulatory factor in tumour growth Nat Rev Cancer 2002, 2(1):38-47 10.1038/nrc704 11902584
2. Brown JM The hypoxic cell: A target for selective cancer therapy - eighteenth Bruce F. Cain Memorial Award lecture Cancer Res 1999, 59(23):5863-5870 10606224
3. Zhong H De Marzo AM Laughner E Lim M Hilton DA Zagzag D Buechler P Isaacs WB Semenza GL Simons JW Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases Cancer Res 1999, 59(22):5830-5835 10582706
4. Vaupel P Harrison L Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response Oncologist 2004, 9(Suppl 5):4-9 10.1634/theoncologist.9-90005-4 15591417
5. Hockel M Schlenger K Aral B Mitze M Schaffer U Vaupel P Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix Cancer Res 1996, 56(19):4509-4515 8813149
6. Evans SM Koch CJ Prognostic significance of tumor oxygenation in humans Cancer Lett 2003, 195(1): 1-16 10.1016/S0304-3835(03)00012-0 12767506
7. Harrison L Blackwell K Hypoxia and anemia: Factors in decreased sensitivity to radiation therapy and chemotherapy? Oncologist 2004, 9(Suppl 5):31-40 10.1634/theoncologist.9-90005-31 15591420
8. Semenza GL Targeting HIF-1 for cancer therapy Nat Rev Cancer 2003, 3(10):721-732 10.1038/nrc1187 13130303
9. Ivan M Kondo K Yang H Kim W Valiando J Ohh M Salic A Asara JM Lane WS Kaelin WG Jr. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing Science 2001, 292(5516):464-468 11292862
10. Jaakkola P Mole DR Tian YM Wilson MI Gielbert J Gaskell SJ Kriegsheim A Hebestreit HF Mukherji M Schofield CJ Maxwell PH Pugh CW Ratcliffe PJ Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation Science 2001, 292(5516):468-472 11292861
11. Lando D Peet DJ Gorman JJ Whelan DA Whitelaw ML Bruick RK FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor Genes Dev 2002, 16(12):1466-1471 186346 12080085 10.1101/gad.991402
12. Piret JP Mottet D Raes M Michiels C Is HIF-1alpha a pro- or an anti-apoptotic protein? Biochem Pharmacol 2002, 64(5-6):889-892 10.1016/ S0006-2952(02)01155-3 12213583
13. Greijer AE van der Wall E The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis J Clin Pathol 2004, 57(10):1009-1014 10.1136/jcp.2003.015032 15452150 1770458
14. An WG Kanekal M Simon MC Maltepe E Blagosklonny MV Neckers LM Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha Nature 1998, 392(6674):405-408 10.1038/32925 9537326
15. Zhou J Schmid T Schnitzer S Brune B Tumor hypoxia and cancer progression Cancer Lett 200,6 237(1):10-21 10.1016/j.canlet.2005.05.028 16002209
16. Bruick RK Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia Proc Natl Acad Sci U S A 2000, 97(16):9082-9087 16825 10922063 10.1073/pnas.97.16.9082
17. Lee MJ Kim JY Suk K Park JH Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway Mol Cell Biol 2004, 24(9):3918-3927 387743 15082785 10.1128/MCB.24.9.3918-3927.2004
18. Tanaka T Miyata T Inagi R Kurokawa K Adler S Fujita T Nangaku M Hypoxia-induced apoptosis in cultured glomerular endothelial cells: involvement of mitochondrial pathways Kidney Int 2003, 64(6):2020-2032 10.1046/j.1523-1755.2003.00301.x 14633124
19. Karpinich NO Tafani M Rothman RJ Russo MA Farber JL The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c J Biol Chem 2002, 277(19):16547-16552 10.1074/jbc.M110629200 11864976
20. Piret JP Cosse JP Ninane N Raes M Michiels C Hypoxia protects HepG2 cells against etoposide-induced apoptosis VIA a HIF-1-independent pathway Exp Cell Res 2006, 16844113
21. Rogakou EP Pilch DR Orr AH Ivanova VS Bonner WM DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 J Biol Chem 1998, 273(10):5858-5868 10.1074/jbc.273.10.5858 9488723
22. Fels DR Koumenis C HIF-1alpha and p53: The ODD couple? Trends Biochem Sci 2005, 30(8):426-429 10.1016/j.tibs.2005.06.009 15996866
23. Hubert A Paris S Piret JP Ninane N Raes M Michiels C Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level J Cell Sci 2006, 119(Pt 16):3351-3362 10.1242/jcs.03069 16882692
24. Koumenis C Alarcon R Hammond E Sutphin P Hoffman W Murphy M Derr J Taya Y Lowe SW Kastan M Giaccia A Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation Mol Cell Biol 2001, 21(4):1297-1310 99582 11158315 10.1128/MCB.21.4.1297-1310.2001
25. Pan Y Oprysko PR Asham AM Koch CJ Simon MC p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment Oncogene 2004, 23(29):4975-4983 10.1038/sj.onc.1207657 15107830
26. Suzuki H Tomida A Tsuruo T Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia Oncogene 2001, 20(41):5779-5788 10.1038/sj.onc.1204742 11593383
27. Chi JT Wang Z Nuyten DS Rodriguez EH Schaner ME Salim A Wang Y Kristensen GB Helland A Borresen-Dale AL Giaccia A Longaker MT Hastie T Yang GP Vijver MJ Brown PO Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers PLoS Med 2006, 3(3):e47 1334226 16417408 10.1371/ journal.pmed.0030047
28. Moll UM Wolff S Speidel D Deppert W Transcription-independent pro-apoptotic functions of p53 Curr Opin Cell Biol 2005, 17(6):631-636 10.1016/j.ceb.2005.09.007 16226451
29. Kim M Park SY Pai HS Kim TH Billiar TR Seol DW Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation Cancer Res 2004, 64(12):4078-4081 10.1158/ 0008-5472.CAN-04-0284 15205314
30. Erler JT Cawthorne CJ Williams KJ Koritzinsky M Wouters BG Wilson C Miller C Demonacos C Stratford IJ Dive C Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance Mol Cell Biol 2004, 24(7):2875-2889 371100 15024076 10.1128/ MCB.24.7.2875-2889.2004
31. Krieg AJ Hammond EM Giaccia AJ Functional analysis of p53 binding under differential stresses Mol Cell Biol 2006, 26(19):7030-7045 1592883 16980608 10.1128/MCB.00322-06
32. Koshiji M Kageyama Y Pete EA Horikawa I Barrett JC Huang LE HIF-1alpha induces cell cycle arrest by functionally counteracting Myc Embo J 2004, 23(9):1949-1956 404317 15071503 10.1038/sj.emboj.7600196
33. Wang J Biju MP Wang MH Haase VH Dong Z Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: Involvement of mitochondrial inhibition and p53 suppression J Am Soc Nephrol 2006, 17(7):1875-1885 10.1681/ASN.2005121371 16762987
34. Bjorling-Poulsen M Issinger OG cDNA array analysis of alterations in gene expression in the promyelocytic leukemia cell line, HL-60, after apoptosis induction with etoposide Apoptosis 2003, 8(4):377-388 10.1023/ A:1024177119658 12815281
35. Lozano J Menendez S Morales A Ehleiter D Liao WC Wagman R Haimovitz-Friedman A Fuks Z Kolesnick R Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts J Biol Chem 2001 276, 1:442-448 10.1074/jbc.M006353200 11031259
36. Wellington CL Ellerby LM Hackam AS Margolis RL Trifiro MA Singaraja R McCutcheon K Salvesen GS Propp SS Bromm M Rowland KJ Zhang T Rasper D Roy S Thornberry N Pinsky L Kakizuka A Ross CA Nicholson DW Bredesen DE Hayden MR Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract J Biol Chem 1998, 273(15):9158-9167 10.1074/ jbc.273.15.9158 9535906
37. Chen Y Takeshita A Ozaki K Kitano S Hanazawa S Transcriptional regulation by transforming growth factor beta of the expression of retinoic acid and retinoid X receptor genes in osteoblastic cells is mediated through AP-1 J Biol Chem 1996, 271(49):31602-31606 10.1074/ jbc.271.49.31602 8940178
38. Kern SE Pietenpol JA Thiagalingam S Seymour A Kinzler KW Vogelstein B Oncogenic forms of p53 inhibit p53-regulated gene expression Science 1992, 256(5058):827-830 10.1126/science.1589764 1589764
39. de Longueville F Surry D Meneses-Lorente G Bertholet V Talbot V Evrard S Chandelier N Pike A Worboys P Rasson JP Le Bourdelles B Remacle J Gene expression profiling of drug metabolism and toxicology markers using a low-density DNA microarray Biochem Pharmacol 2002, 64(1):137-149 10.1016/ S0006-2952(02)01055-9 12106614
40. de Longueville F Atienzar FA Marcq L Dufrane S Evrard S Wouters L Leroux F Bertholet V Gerin B Whomsley R Arnould T Remacle J Canning M Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes Toxicol Sci 2003, 75(2):378-392 10.1093/toxsci/kfg196 12883083
41. Debacq-Chainiaux F Borlon C Pascal T Royer V Eliaers F Ninane N Carrard G Friguet B de Longueville F Boffe S Remacle J Toussaint O Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway J Cell Sci 2005, 118(Pt 4):743-758 10.1242/jcs.01651 15671065