-
1
-
-
0034989311
-
Biological consequences of tumor hypoxia
-
M. Hockel, and P. Vaupel Biological consequences of tumor hypoxia Semin. Oncol. 28 Suppl. 8 2001 36 41
-
(2001)
Semin. Oncol.
, vol.28
, Issue.8 SUPPL.
, pp. 36-41
-
-
Hockel, M.1
Vaupel, P.2
-
2
-
-
0035925098
-
Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
-
M. Hockel, and P. Vaupel Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects J. Natl. Cancer Inst. 93 2001 266 276
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
4
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation Science 292 2001 468 472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
5
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-(α) chains activated by prolyl hydroxylation
-
N. Masson Independent function of two destruction domains in hypoxia-inducible factor-(α) chains activated by prolyl hydroxylation EMBO J. 20 2001 5197 5206
-
(2001)
EMBO J.
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
-
6
-
-
0035917313
-
2 sensing
-
2 sensing Science 292 2001 464 468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
-
7
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
-
D. Lando Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch Science 295 2002 858 861
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
-
8
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
K.S. Hewitson Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family J. Biol. Chem. 277 2002 26351 26355
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
-
9
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
G.L. Semenza Targeting HIF-1 for cancer therapy Nat. Rev. Cancer 3 2003 721 732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
10
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
R. Honda Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 FEBS Lett. 420 1997 25 27
-
(1997)
FEBS Lett.
, vol.420
, pp. 25-27
-
-
Honda, R.1
-
11
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Y. Haupt Mdm2 promotes the rapid degradation of p53 Nature 387 1997 296 299
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
-
12
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
M.H. Kubbutat Regulation of p53 stability by Mdm2 Nature 387 1997 299 303
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.1
-
13
-
-
0032192140
-
The complexity of p53 modulation: Emerging patterns from divergent signals
-
A.J. Giaccia, and M.B. Kastan The complexity of p53 modulation: emerging patterns from divergent signals Genes Dev. 12 1998 2973 2983
-
(1998)
Genes Dev.
, vol.12
, pp. 2973-2983
-
-
Giaccia, A.J.1
Kastan, M.B.2
-
14
-
-
0036674617
-
Live or let die: The cell's response to p53
-
K.H. Vousden, and X. Lu Live or let die: the cell's response to p53 Nat. Rev. Cancer 2 2002 594 604
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
15
-
-
0028110809
-
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
-
T.G. Graeber Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status Mol. Cell. Biol. 14 1994 6264 6277
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6264-6277
-
-
Graeber, T.G.1
-
16
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
-
T.G. Graeber Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors Nature 379 1996 88 91
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
-
17
-
-
0035140981
-
Regulation of p53 by hypoxia: Dissociation of protein accumulation transciptional repression and apoptosis from p53-dependent transactivation
-
C. Koumenis Regulation of p53 by hypoxia: dissociation of protein accumulation transciptional repression and apoptosis from p53-dependent transactivation Mol. Cell. Biol. 21 2001 1297 1310
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1297-1310
-
-
Koumenis, C.1
-
18
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1α
-
W.G. An Stabilization of wild-type p53 by hypoxia-inducible factor 1α Nature 392 1998 405 408
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
-
19
-
-
0038529602
-
Direct interactions between HIF-1α and Mdm2 modulate p53 function
-
D. Chen Direct interactions between HIF-1α and Mdm2 modulate p53 function J. Biol. Chem. 278 2003 13595 13598
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13595-13598
-
-
Chen, D.1
-
20
-
-
0032524285
-
P53 inhibits hypoxia-inducible factor-stimulated transcription
-
M.V. Blagosklonny p53 inhibits hypoxia-inducible factor-stimulated transcription J. Biol. Chem. 273 1998 11995 11998
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11995-11998
-
-
Blagosklonny, M.V.1
-
21
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
-
R. Ravi Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α Genes Dev. 14 2000 34 44
-
(2000)
Genes Dev.
, vol.14
, pp. 34-44
-
-
Ravi, R.1
-
22
-
-
2642574174
-
P300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1)
-
T. Schmid p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1) Biochem. J. 380 2004 289 295
-
(2004)
Biochem. J.
, vol.380
, pp. 289-295
-
-
Schmid, T.1
-
23
-
-
0036678830
-
Two sequence motifs from HIF-1α bind to the DNA-binding site of p53
-
L.O. Hansson Two sequence motifs from HIF-1α bind to the DNA-binding site of p53 Proc. Natl. Acad. Sci. U. S. A. 99 2002 10305 10309
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 10305-10309
-
-
Hansson, L.O.1
-
24
-
-
11344292626
-
Binding of natively unfolded HIF-1(α) ODD domain to p53
-
N. Sanchez-Puig Binding of natively unfolded HIF-1(α) ODD domain to p53 Mol. Cell 17 2005 11 21
-
(2005)
Mol. Cell
, vol.17
, pp. 11-21
-
-
Sanchez-Puig, N.1
-
25
-
-
0036153571
-
What does it mean to be natively unfolded?
-
V.N. Uversky What does it mean to be natively unfolded? Eur. J. Biochem. 269 2002 2 12
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 2-12
-
-
Uversky, V.N.1
-
26
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1α
-
2 homeostasis by hypoxia-inducible factor 1α Genes Dev. 12 1998 149 162
-
(1998)
Genes Dev.
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
-
27
-
-
0036179376
-
Hypoxia links ATR and p53 through replication arrest
-
E.M. Hammond Hypoxia links ATR and p53 through replication arrest Mol. Cell. Biol. 22 2002 1834 1843
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1834-1843
-
-
Hammond, E.M.1
-
28
-
-
3042779529
-
P53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment
-
Y. Pan p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment Oncogene 23 2004 4975 4983
-
(2004)
Oncogene
, vol.23
, pp. 4975-4983
-
-
Pan, Y.1
-
29
-
-
0032535077
-
Up-regulation of hypoxia-inducible factor-1α is not sufficient for hypoxic/anoxic p53 induction
-
R.H. Wenger Up-regulation of hypoxia-inducible factor-1α is not sufficient for hypoxic/anoxic p53 induction Cancer Res. 58 1998 5678 5680
-
(1998)
Cancer Res.
, vol.58
, pp. 5678-5680
-
-
Wenger, R.H.1
-
30
-
-
0034980863
-
Inhibition of HIF-1- and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions
-
M.V. Blagosklonny Inhibition of HIF-1- and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions Carcinogenesis 22 2001 861 867
-
(2001)
Carcinogenesis
, vol.22
, pp. 861-867
-
-
Blagosklonny, M.V.1
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