A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes

Journal of Immunology

Volumn 177, Issue 11, 2006, Pages 7559-7566

  Su, Leon ^a   Lineberry, Neil ^a   Huh, Yul ^a   Soares, Luis ^a   Fathman, C Garrison ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE RELATED TO ANERGY IN LYMPHOCYTE PROTEIN; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 2; NUCLEIC ACID BINDING PROTEIN; PROTEIN CDC42; RAC1 PROTEIN; RAS PROTEIN; RHO FACTOR; RHO GUANINE DISSOCIATION INHIBITOR; RHO GUANOSINE TRIPHOSPHATASE; RHOA GUANINE TRIPHOSPHATASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CLONAL ANERGY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROKARYOTE; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; T LYMPHOBLAST; UBIQUITINATION;

EID: 33751583077     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.11.7559     Document Type: Article

References (28)

1. Pickart, C. M. 2001. Ubiquitin enters the new millennium. Mol. Cell 8: 499-504.
2. Hicke, L., and R. Dunn. 2003. Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu. Rev. Cell. Dev. Biol. 19: 141-172.
3. Sun, L., and Z. J. Chen. 2004. The novel functions of ubiquitination in signaling. Curr. Opin. Cell Biol. 16: 119-126.
4. Pickart, C. M. 2001. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70: 503-533.
5. + T cells. Immunity 18: 535-547.
6. Seroogy, C. M., L. Soares, E. A. Ranheim, L. Su, C. Holness, D. Bloom, and C. G. Fathman. 2004. The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells. J. Immunol. 173: 79-85.
7. Olofsson, B. 1999. Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell. Signal. 11: 545-554.
8. Pickart, C. M., and D. Fushman. 2004. Polyubiquitin chains: polymeric protein signals. Curr. Opin. Chem. Biol. 8: 610-616.
9. Bonifacino, J. S., and A. M. Weissman. 1998. Ubiquitin and the control of protein fate in the secretory and endocytic pathways. Annu. Rev. Cell. Dev. Biol. 14: 19-57.
10. Deng, L., C. Wang, E. Spencer, L. Yang, A. Braun, J. You, C. Slaughter, C. Pickart, and Z. J. Chen. 2000. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103: 351-361.
11. Hall, A. 1998. Rho GTPases and the actin cytoskeleton. Science 279: 509-514.
12. Etienne-Manneville, S., and A. Hall. 2002. Rho GTPases in cell biology. Nature 420: 629-635.
13. Nobes, C., and A. Hall. 1994. Regulation and function of the Rho subfamily of small GTPases. Curr. Opin. Genet. Dev. 4: 77-81.
14. + T cells. Science 271: 1276-1278.
15. DeSilva, D. R., W. S. Feeser, E. J. Tancula, and P. A. Scherle. 1996. Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways. J. Exp. Med. 183: 2017-2023.
16. + T cells. Science 271: 1272-1276.
17. + T cells have defective expression and function of the activating protein-1 transcription factor. J. Immunol. 161: 5930-5936.
18. Marinissen, M. J., M. Chiariello, T. Tanos, O. Bernard, S. Narumiya, and J. S. Gutkind. 2004. The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol. Cell 14: 29-41.
19. Mayer, T., M. Meyer, A. Janning, A. C. Schiedel, and A. Barnekow. 1999. A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts. Oncogene 18: 2117-2128.
20. Ghosh, P. M., N. Ghosh-Choudhury, M. L. Moyer, G. E. Mott, C. A. Thomas, B. A. Foster, N. M. Greenberg, and J. I. Kreisberg. 1999. Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. Oncogene 18: 4120-4130.
21. Tharaux, P. L., R. C. Bukoski, P. N. Rocha, S. D. Crowley, P. Ruiz, C. Nataraj, D. N. Howell, K. Kaibuchi, R. F. Spurney, and T. M. Coffman. 2003. Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. J. Immunol. 171: 96-105.
22. Angkachatchai, V., and T. H. Finkel. 1999. ADP-ribosylation of rho by C3 ribosyltransferase inhibits IL-2 production and sustained calcium influx in activated T cells. J. Immunol. 163: 3819-3825.
23. Fang, D., and Y. C. Liu. 2001. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat. Immunol. 2: 870-875.
24. Burridge, K., and K. Wennerberg. 2004. Rho and Rac take center stage. Cell 116: 167-179.
25. Wennerberg, K., and C. J. Der. 2004. Rho-family GTPases: it's not only Rac and Rho (and I like it). J. Cell Sci. 117: 1301-1312.
26. Sechi, A. S., J. Buer, J. Wehland, and M. Probst-Kepper. 2002. Changes in actin dynamics at the T-cell/APC interface: implications for T-cell anergy? Immunol. Rev. 189: 98-110.
27. Hill, C. S., J. Wynne, and R. Treisman. 1995. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81: 1159-1170.
28. Chang, J. H., J. C. Pratt, S. Sawasdikosol, R. Kapeller, and S. J. Burakoff. 1998. The small GTP-binding protein Rho potentiates AP-1 transcription in T cells. Mol. Cell. Biol. 18: 4986-4993.