Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS

Journal of Neuroscience

Volumn 20, Issue 19, 2000, Pages 7384-7393

  Lomaga, M A ^a   Henderson, J T ^a   Elia, A J ^a   Robertson, J ^a   Noyce, R S ^a   Yeh, W C ^a   Mak, T W ^a  

^a AMGEN INSTITUTE   (Canada)

Author keywords

CNS; Diencephalon; Gene targeting; Neural tube closure; Programmed cell death; Thalamus; TUNEL

Indexed keywords

ADAPTOR PROTEIN; BROXURIDINE; DNA NUCLEOTIDYLEXOTRANSFERASE; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DIENCEPHALON; EMBRYO; EMBRYO DEVELOPMENT; EXENCEPHALY; FEMALE; GENE DELETION; IMMUNOHISTOCHEMISTRY; MESENCEPHALON; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL TUBE DEFECT; NICK END LABELING; NONHUMAN; PATHOGENESIS; PENETRANCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034307624     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-19-07384.2000     Document Type: Article

References (41)

1. Tumor necrosis factor receptor-associated factors (TRAFs): A family of adapter proteins that regulates life and death
2. Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development
3. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappa B
4. TRAF6 is a signal transducer for interleukin-1
5. The embryonic development of mammalian neural tube defects
6. Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
7. Whole mount in situ hybridization of mouse embryos
8. RANK is essential for osteoclast and lymph node development
9. Phenotypic and functional characterization of mice that lack the type 1 receptor for IL-1
10. Differential requirement for caspase 9 in apoptotic pathways in vivo
11. Mini-review: Toward understanding mechanisms of genetic neural tube defects in mice
12. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
13. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the lps gene product
14. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal centre formation
15. Association of the p75 neurotrophin receptor with TRAF6
16. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
17. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
18. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
19. A Drosophila TNF-receptor-associated factor (TRAF) binds the Ste20 kinase Misshapen and activates Jun kinase
20. Traf6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
21. RIP2 is a novel NF-kappa B-activating and cell-death-inducing kinase
22. Identification of a TRAF (TNF receptor-associated factor) gene in Caenorhabditis elegans
23. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
24. Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
25. Multifactorial inheritance of neural tube defects: Localization of the major gene and recognition modifiers in ct mutant mice
26. The kinase TAK1 can activate the NIK-I kappa B as well as the MAP kinase cascade in the IL-1 signalling pathway
27. The Drosophila jun-n-terminal kinase is required for cell morphogenesis but not for djun-dependent cell fate specification in the eye
28. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75kDa tumor necrosis factor receptor
29. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
30. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
31. A subset of p53-deficient embryos exhibit exencephaly
32. A jnk signal transduction pathway mediates morphogenesis and immune response in Drosophila
33. Neurulation: Coming to closure
34. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
35. Anatomy of TRAF2. Distinct domains for nuclear factor-kappa B activation and association with tumor necrosis signaling proteins
36. Regulation of JNK by Src during Drosophila development
37. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-src
38. Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses
39. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
40. Early lethality, functional NF-kB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
41. Apaf1 is required for mitochondrial pathways of apoptosis and brain development