Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing

Genes and Development

Volumn 21, Issue 23, 2007, Pages 3110-3122

  Linhart, Heinz G ^a   Lin, Haijiang ^a,f   Yamada, Yasuhiro ^b   Moran, Eva ^a   Steine, Eveline J ^a   Gokhale, Sumita ^a   Lo, Grace ^c   Cantu, Erika ^c   Ehrich, Mathias ^d   He, Timothy ^e   Meissner, Alex ^a   Jaenisch, Rudolf ^a,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d SEQUENOM INC   (United States)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^f UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

APC; Cancer; DNA methylation; Dnmt3b; Epigenetics

Indexed keywords

APC PROTEIN; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; SOMATOMEDIN BINDING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; COLON ADENOMA; COLON TUMOR; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE SILENCING; GENE TARGETING; GENOME IMPRINTING; METHYLATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR PROMOTION; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

ADENOMA; ANIMALS; CARCINOGENS; COLONIC NEOPLASMS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DOWN-REGULATION; GENE SILENCING; GENES, APC; GENOMIC IMPRINTING; HUMANS; INSULIN-LIKE GROWTH FACTOR II; LOSS OF HETEROZYGOSITY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

MUS;

EID: 36849004469     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1594007     Document Type: Article

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