DNA-Damage Control: Claspin Destruction Turns off the Checkpoint

Current Biology

Volumn 16, Issue 21, 2006, Pages

  Gewurz, Benjamin E ^a   Harper, J Wade ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CHECKPOINT KINASE 1; PROTEASOME; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBIQUITIN;

ANIMAL; CELL CYCLE; CELL LINE; DNA DAMAGE; DNA REPAIR; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SHORT SURVEY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; DNA DAMAGE; DNA REPAIR; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 33750617461     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2006.09.046     Document Type: Short Survey

References (20)

1. Kastan M.B., and Bartek J. Cell-cycle checkpoints and cancer. Nature 432 (2004) 316-323
2. Mamely I., van Vugt M., Smits V.A.J., Semple J.I., Lemmens B., Perrakis A., Medema R.H., and Freire R. Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr Biol. 16 (2006) 1950-1955
3. Zhang D., Zaugg K., Mak T.W., and Elledge S.J. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 126 (2006) 529-542
4. Peschiaroli A., Dorrello N.V., Guardavaccaro D., Venere M., Halazonetis T., Sherman N.E., and Pagano M. SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol. Cell 23 (2006) 319-329
5. Mailand N., Bekker-Jensen S., Bartek J., and Lukas J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell 23 (2006) 307-318
6. Wang X., Zou L., Lu T., Bao S., Hurov K.E., Hittelman W.N., Elledge S.J., and Li L. Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol. Cell 23 (2006) 331-341
7. Cortez D., Guntuku S., Qin J., and Elledge S.J. ATR and ATRIP: partners in checkpoint signaling. Science 294 (2001) 1713-1716
8. Zou L., and Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300 (2003) 1542-1548
9. Zou L., Cortez D., and Elledge S.J. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16 (2002) 198-208
10. Bao S., Tibbetts R.S., Brumbaugh K.M., Fang Y., Richardson D.A., Ali A., Chen S.M., Abraham R.T., and Wang X.F. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 411 (2001) 969-974
11. Ang X.L., and Harper J.W. SCF-mediated protein degradation and cell cycle control. Oncogene 24 (2004) 2860-2870
12. Jin J., Shirogane T., Xu L., Nalepa G., Qin J., Elledge S.J., and Harper J.W. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev. 17 (2003) 3062-3074
13. Busino L., Donzelli M., Chiesa M., Guardavaccaro D., Ganoth D., Dorrello N.V., Hershko A., Pagano M., and Draetta G.F. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 426 (2003) 87-91
14. Hansen D.V., Loktev A.V., Ban K.H., and Jackson P.K. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Mol. Biol. Cell 15 (2004) 5623-5634
15. Moshe Y., Boulaire J., Pagano M., and Hershko A. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. Proc. Natl. Acad. Sci. USA 101 (2004) 7937-7942
16. Watanabe N., Arai H., Nishihara Y., Taniguchi M., Watanabe N., Hunter T., and Osada H. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc. Natl. Acad. Sci. USA 101 (2004) 4419-4424
17. van Vugt M.A., Bras A., and Medema R.H. Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol. Cell 15 (2004) 799-811
18. Smits V.A., Klompmaker R., Arnaud L., Rijksen G., Nigg E.A., and Medema R.H. Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat. Cell Biol. 2 (2000) 672-676
19. Yoo H.Y., Kumagai A., Shevchenko A., Shevchenko A., and Dunphy W.G. Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell 117 (2004) 575-588
20. Alcasabas A.A., Osborn A.J., Bachant J., Hu F., Werler P.J., Bousset K., Furuya K., Diffley J.F., Carr A.M., and Elledge S.J. Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat. Cell Biol. 3 (2001) 958-965