Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking

Genomics

Volumn 90, Issue 6, 2007, Pages 690-702

  Vadasz, Csaba ^a,b   Saito, Mariko ^a,b   Gyetvai, Beatrix M ^b   Oros, Melinda ^b,c   Szakall, Istvan ^b,d   Kovacs, Krisztina M ^b   Prasad, Vidudala V T S ^b,e   Toth, Reka ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d Bayer Hungaria Kft ^*  (Hungary)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcohol drinking; Alcoholism; Gene identification; Genetics; Psychiatric disorders; QTG; QTL; Recombinant QTL introgression; RQI

Indexed keywords

ALCOHOL; DOPAMINE; GLUTAMATE RECEPTOR 7; METABOTROPIC RECEPTOR 7;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGENIC STRAIN; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DRUG DEPENDENCE; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE INTERACTION; GENE MAPPING; GENE SEGREGATION; MALE; MICROARRAY ANALYSIS; MOUSE; NEAR ISOGENIC LINE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RECEPTOR INTRINSIC ACTIVITY; REWARD; RISK FACTOR;

ALCOHOL DRINKING; ANIMALS; BASE SEQUENCE; BRAIN; CHROMOSOME MAPPING; CROSSES, GENETIC; DNA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LINKAGE (GENETICS); MALE; MICE; MICE, CONGENIC; MICE, INBRED STRAINS; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RECEPTORS, METABOTROPIC GLUTAMATE; RNA, MESSENGER;

ANIMALIA; MUS;

EID: 36448952285     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2007.08.006     Document Type: Article

References (87)

1. Belknap J.K., and Atkins A.L. The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mamm. Genome 12 (2001) 893-899
2. Treadwell J.A., Pagniello K.B., and Singh S.M. Genetic segregation of brain gene expression identifies retinaldehyde binding protein 1 and syntaxin 12 as potential contributors to ethanol preference in mice. Behav. Genet. 34 (2004) 425-439
3. Fehr C., et al. The syntaxin binding protein 1 gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2. Alcohol. Clin. Exp. Res. 29 (2005) 708-720
4. Liang T., et al. alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. Proc. Natl. Acad. Sci. USA 100 (2003) 4690-4695
5. Shirley R.L., et al. Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat. Neurosci. 7 (2004) 699-700
6. Vadasz C., et al. Scanning of five chromosomes for alcohol consumption loci. Alcohol 22 (2000) 25-34
7. Vadasz C., et al. Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. Neurochem. Res. 32 (2007) 1099-1112
8. Beck J.A., et al. Genealogies of mouse inbred strains. Nat. Genet. 24 (2000) 23-25
9. Wade C.M., et al. The mosaic structure of variation in the laboratory mouse genome. Nature 420 (2002) 574-578
10. Mehrabian M., et al. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat. Genet. 37 (2005) 1224-1233
11. Brem R.B., et al. Genetic dissection of transcriptional regulation in budding yeast. Science 296 (2002) 752-755
12. Klose J., et al. Genetic analysis of the mouse brain proteome. Nat. Genet. 30 (2002) 385-393
13. Monks S.A., et al. Genetic inheritance of gene expression in human cell lines. Am. J. Hum. Genet. 75 (2004) 1094-1105
14. Morley M., et al. Genetic analysis of genome-wide variation in human gene expression. Nature 430 (2004) 743-747
15. Schadt E.E., et al. Genetics of gene expression surveyed in maize, mouse and man. Nature 422 (2003) 297-302
16. Bystrykh L., et al. Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat. Genet. 37 (2005) 225-232
17. Chesler E.J., et al. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat. Genet. 37 (2005) 233-242
18. Churchill G.A., and Doerge R.W. Empirical threshold values for quantitative trait mapping. Genetics 138 (1994) 963-971
19. Eaves I.A., et al. Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes. Genome Res. 12 (2002) 232-243
20. Mulligan M.K., et al. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc. Natl. Acad. Sci. USA 103 (2006) 6368-6373
21. Belknap J.K., Crabbe J.C., and Young E.R. Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology 112 (1993) 503-510
22. Rodriguez L.A., et al. Alcohol acceptance, preference, and sensitivity in mice. I. Quantitative genetic analysis using BXD recombinant inbred strains. Alcohol. Clin. Exp. Res. 18 (1994) 1416-1422
23. Gill K., et al. Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci. Mamm. Genome 9 (1998) 929-935
24. Vorel S.R., et al. Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science 292 (2001) 1175-1178
25. Vadasz C., et al. Analysis of the mesotelencephalic dopamine system by quantitative-trait locus introgression. Neurochem. Res. 23 (1998) 1337-1354
26. Vadasz C., et al. Transfer of brain dopamine system-specific quantitative trait loci onto a C57BL/6ByJ background. Mamm. Genome 5 (1994) 735-737
27. Vadasz C. Development of congenic recombinant inbred neurological animal model lines. Mouse Genome 88 (1990) 16-18
28. Abiola O., et al. The nature and identification of quantitative trait loci: a community's view. Nat. Rev., Genet. 4 (2003) 911-916
29. Wahlsten D., et al. Different data from different labs: lessons from studies of gene-environment interaction. J. Neurobiol. 54 (2003) 283-311
30. Crabbe J.C., Wahlsten D., and Dudek B.C. Genetics of mouse behavior: interactions with laboratory environment. Science 284 (1999) 1670-1672
31. Korstanje R., and Paigen B. From QTL to gene: the harvest begins. Nat. Genet. 31 (2002) 235-236
32. Kroymann J., and Mitchell-Olds T. Epistasis and balanced polymorphism influencing complex trait variation. Nature 435 (2005) 95-98
33. Stylianou I.M., et al. Complex genetic architecture revealed by analysis of high-density lipoprotein cholesterol in chromosome substitution strains and F2 crosses. Genetics 174 (2006) 999-1007
34. Flor P.J., et al. A novel splice variant of a metabotropic glutamate receptor, human mGluR7b. Neuropharmacology 36 (1997) 153-159
35. Schulz H.L., Stohr H., and Weber B.H. Characterization of three novel isoforms of the metabotropic glutamate receptor 7 (GRM7). Neurosci. Lett. 326 (2002) 37-40
36. Dev K.K., Nakanishi S., and Henley J.M. Regulation of mglu(7) receptors by proteins that interact with the intracellular C-terminus. Trends Pharmacol. Sci. 22 (2001) 355-361
37. Saugstad J.A., et al. Cloning and expression of a new member of the l-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. Mol. Pharmacol. 45 (1994) 367-372
38. Nakajima Y., et al. A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7. J. Biol. Chem. 274 (1999) 27573-27577
39. Corti C., et al. Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8. Eur. J. Neurosci. 10 (1998) 3629-3641
40. Kinoshita A., et al. Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: a light and electron microscopic study. J. Comp. Neurol. 393 (1998) 332-352
41. Lu J., et al. Transcript-based redefinition of grouped oligonucleotide probe sets using AceView: high-resolution annotation for microarrays. BMC Bioinformatics 8 (2007) 108
42. Wunderle V.M., et al. Cloning and characterization of SOX5, a new member of the human SOX gene family. Genomics 36 (1996) 354-358
43. Brent A.E., Braun T., and Tabin C.J. Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 132 (2005) 515-528
44. Schoepp D.D. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J. Pharmacol. Exp. Ther. 299 (2001) 12-20
45. Masugi M., et al. Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. J. Neurosci. 19 (1999) 955-963
46. Kinzie J.M., et al. Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain. Neuroscience 69 (1995) 167-176
47. Simonyi A., Miller L.A., and Sun G.Y. Region-specific decline in the expression of metabotropic glutamate receptor 7 mRNA in rat brain during aging. Brain Res. Mol. Brain Res. 82 1-2 (2000) 101-106
48. Nadler J.J., et al. Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype. Genetics 174 (2006) 1229-1236
49. Cryan J.F., et al. Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur. J. Neurosci. 17 (2003) 2409-2417
50. Mitsukawa K., et al. Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders. Neuropsychopharmacology 31 (2006) 1112-1122
51. Mitsukawa K., et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc. Natl. Acad. Sci. USA 102 (2005) 18712-18717
52. Johnson M.P., Kelly G., and Chamberlain M. Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists. J. Neuroendocrinol. 13 (2001) 670-677
53. Tasker J.G., Boudaba C., and Schrader L.A. Local glutamatergic and GABAergic synaptic circuits and metabotropic glutamate receptors in the hypothalamic paraventricular and supraoptic nuclei. Adv. Exp. Med. Biol. 449 (1998) 117-121
54. Sarnyai Z., Shaham Y., and Heinrichs S.C. The role of corticotropin-releasing factor in drug addiction. Pharmacol. Rev. 53 (2001) 209-243
55. Sillaber I., et al. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science 296 (2002) 931-933
56. Nie Z., et al. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science 303 (2004) 1512-1514
57. Plappert C.F., and Pilz P.K. Difference in anxiety and sensitization of the acoustic startle response between the two inbred mouse strains BALB/cAN and DBA/2N. Genes Brain Behav. 1 (2002) 178-186
58. Depino A.M., and Gross C. Simultaneous assessment of autonomic function and anxiety-related behavior in BALB/c and C57BL/6 mice. Behav. Brain Res. 177 (2007) 254-260
59. DeFries J.C., Gervais M.C., and Thomas E.A. Response to 30 generations of selection for open-field activity in laboratory mice. Behav. Genet. 8 (1978) 3-13
60. Vadasz C., Kobor G., and Lajtha A. Motor activity and the mesotelencephalic dopamine function: II. Multivariate analysis of genetically segregating generations. Behav. Brain Res. 48 (1992) 41-47
61. Vadasz C., Kobor G., and Lajtha A. Motor activity and the mesotelencephalic dopamine function: I. High-resolution temporal and genetic analysis of open-field behavior. Behav. Brain Res. 48 (1992) 29-39
62. Priebe K., et al. Maternal influences on adult stress and anxiety-like behavior in C57BL/6J and BALB/cJ mice: a cross-fostering study. Dev. Psychobiol. 47 (2005) 398-407
63. Wise R.A. Addictive drugs and brain stimulation reward. Annu. Rev. Neurosci. 19 (1996) 319-340
64. Wise R.A., and Bozarth M.A. A psychomotor stimulant theory of addiction. Psychol. Rev. 94 (1987) 469-492
65. Nestler E.J. Is there a common molecular pathway for addiction?. Nat. Neurosci. 8 (2005) 1445-1449
66. Kalivas P.W. Glutamate systems in cocaine addiction. Curr. Opin. Pharmacol. 4 (2004) 23-29
67. Swanson C.J., and Kalivas P.W. Regulation of locomotor activity by metabotropic glutamate receptors in the nucleus accumbens and ventral tegmental area. J. Pharmacol. Exp. Ther. 292 (2000) 406-414
68. Mao L., Lau Y.S., and Wang J.Q. Activation of group III metabotropic glutamate receptors inhibits basal and amphetamine-stimulated dopamine release in rat dorsal striatum: an in vivo microdialysis study. Eur. J. Pharmacol. 404 (2000) 289-297
69. Mao L., and Wang J.Q. Distinct inhibition of acute cocaine-stimulated motor activity following microinjection of a group III metabotropic glutamate receptor agonist into the dorsal striatum of rats. Pharmacol. Biochem. Behav. 67 (2000) 93-101
70. Hodge C.W., et al. The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Psychopharmacology (Berlin) 183 (2006) 429-438
71. Simonyi A., et al. Chronic ethanol on mRNA levels of IP3R1, IP3 3-kinase and mGluR1 in mouse Purkinje neurons. NeuroReport 7 (1996) 2115-2118
72. Simonyi A., et al. Chronic ethanol-induced subtype- and subregion-specific decrease in the mRNA expression of metabotropic glutamate receptors in rat hippocampus. Alcohol. Clin. Exp. Res. 28 (2004) 1419-1423
73. Backstrom P., et al. mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29 (2004) 921-928
74. Schroeder J.P., Overstreet D.H., and Hodge C.W. The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology (Berlin) 179 (2005) 262-270
75. Besheer J., and Hodge C.W. Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol. Neuropsychopharmacology 30 (2005) 747-757
76. Bills C., et al. Effects of metabotropic glutamate receptor 5 on latent inhibition in conditioned taste aversion. Behav. Brain Res. 157 (2005) 71-78
77. Spooren W.P., et al. Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders. Trends Pharmacol. Sci. 22 (2001) 331-337
78. Li X., et al. Activation of metabotropic glutamate receptor 7 (mGluR7) by AMN082 attenuates the rewarding effects of cocaine by a DA-independent mechanism in rats. Society for Neuroscience Meeting, Atlanta (2006) [Abstract 21.7]
79. Xi Z.X., et al. Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens. J. Neurochem. 87 (2003) 1204-1212
80. Ponomarev I., et al. Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors. J. Neurosci. 26 (2006) 5673-5683
81. Dick D.M., et al. Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample. Alcohol. Clin. Exp. Res. 30 (2006) 1101-1110
82. Everitt B.J., and Robbins T.W. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8 (2005) 1481-1489
83. Fuchs R.A., et al. The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats. Neuropsychopharmacology 30 (2005) 296-309
84. Yalcin B., et al. Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice. Proc. Natl. Acad. Sci. USA 101 (2004) 9734-9739
85. Vadasz C., et al. Ventral tegmental transcriptome response to intermittent nicotine treatment and withdrawal in BALB/cJ, C57BL/6ByJ, and quasi-congenic RQI mice. Neurochem. Res. 32 (2007) 457-480
86. Irizarry R.A., et al. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 31 (2003) e15
87. Cartharius K., et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21 (2005) 2933-2942