The nature and identification of quantitative trait loci: A community's view

Nature Reviews Genetics

Volumn 4, Issue 11, 2003, Pages 911-916

  Abiola, Oduola ^a   Angel, Joe M ^b   Avner, Philip ^c   Bachmanov, Alexander A ^d   Belknap, John K ^e   Bennett, Beth ^f   Blankenhorn, Elizabeth P ^g   Blizard, David A ^h   Bolivar, Valerie ⁱ   Brockmann, Gudrun A ^j   Buck, Kari J ^k   Bureau, Jean Francois ^c   Casley, William L ^l   Chesler, Elissa J ^m   Cheverud, James M ⁿ   Churchill, Gary A ^o   Cook, Melloni ^p   Crabbe, John C ^k   Crusio, Wim E ^q   Darvasi, Ariel ^r   de Haan, Gerald ^s   Demant, Peter ^t   Doerge, R W ^u   Elliott, Rosemary W ^t   Farber, Charles R ^v   Flaherty, Lorraine ⁱ   Flint, Jonathan ^w   Gershenfeld, Howard ^x   Gibson, John P ^y   Gu, Jing ^m   Gu, Weikuan ^m   Himmelbauer, Heinz ^z   Hitzemann, Robert ^e   Hsu, Hui Chen ^aa   Hunter, Kent ^ab   Iraqi, Fuad A ^y   Jansen, Ritsert C ^s   Johnson, Thomas E ^f   Jones, Byron C ^h   Kempermann, Gerd ^ac   Lammert, Frank ^ad   Lu, Lu ^m   Manly, Kenneth F ^t   Matthews, Douglas B ^p   Medrano, Juan F ^v   Mehrabian, Margarete ^ae   Mittleman, Guy ^p   Mock, Beverly A ^ab   Mogil, Jeffrey S ^af   Montagutelli, Xavier ^c   Morahan, Grant ^ag   Mountz, John D ^aa   Nagase, Hiroki ^t   Nowakowski, Richard S ^ah   O'Hara, Bruce F ^ai   Osadchuk, Alexander V ^aj   Paigen, Beverly ^o   Palmer, Abraham A ^ak   Peirce, Jeremy L ^al   Pomp, Daniel ^am   Rosemann, Michael ^an   Rosen, Glenn D ^ao   Schalkwyk, Leonard C ^a   Seltzer, Ze'ev ^ap   Settle, Stephen ^aq   Shimomura, Kazuhiro ^ar   Shou, Siming ^as   Sikela, James M ^at   Siracusa, Linda D ^au   Spearow, Jimmy L ^v   Teuscher, Cory ^av   Threadgill, David W ^aw   Toth, Linda A ^ax   Toye, Ayo A ^ay   Vadasz, Csaba ^az   Van Zant, Gary ^ba   Wakeland, Edward ^x   Williams, Robert W ^m   Zhang, Huang Ge ^aa   Zou, Fei ^bb   more..

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF TEXAS   (United States)

^c INSTITUT PASTEUR   (France)

^d MONELL CHEMICAL SENSES CENTER   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f UNIVERSITY OF COLORADO   (United States)

^g DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^h PENNSYLVANIA STATE UNIVERSITY   (United States)

ⁱ WADSWORTH CENTER   (United States)

^j LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^k OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^l HEALTH CANADA   (Canada)

^m UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

ⁿ WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o JACKSON LABORATORY   (United States)

^p University of Memphis   (United States)

^q UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^r HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^s UNIVERSITY OF GRONINGEN   (Netherlands)

^t ROSWELL PARK CANCER INSTITUTE   (United States)

^u PURDUE UNIVERSITY   (United States)

^v UNIVERSITY OF CALIFORNIA   (United States)

^w UNIVERSITY OF OXFORD   (United Kingdom)

^x UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^y INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE   (Kenya)

^z MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^aa UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^ab NATIONAL CANCER INSTITUTE   (United States)

^ac CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^ad UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^ae UNIVERSITY OF CALIFORNIA   (United States)

^af MCGILL UNIVERSITY   (Canada)

^ag ROYAL MELBOURNE HOSPITAL   (Australia)

^ah RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^ai STANFORD UNIVERSITY   (United States)

^aj INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

^ak New York Presbyterian Columbia University Medical Center   (United States)

^al PRINCETON UNIVERSITY   (United States)

^am UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^an INSTITUTE OF EPIDEMIOLOGY   (Germany)

^ao HARVARD MEDICAL SCHOOL   (United States)

^ap UNIVERSITY OF TORONTO   (Canada)

^aq VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ar NORTHWESTERN UNIVERSITY   (United States)

^as Shriners Hospital   (United States)

^at UNIVERSITY OF COLORADO   (United States)

^au THOMAS JEFFERSON UNIVERSITY   (United States)

^av UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^aw UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^ax SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ay MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^az NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ba UNIVERSITY OF KENTUCKY   (United States)

^bb University of North Carolina at Chapel Hill   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GENE CONTROL; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; TRANSGENICS;

NON-PROGRAMMATIC;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHROMOSOME MAPPING; HUMANS; QUANTITATIVE TRAIT LOCI;

EID: 0242291131     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrg1206     Document Type: Review

References (35)

1. Gibson, G. & Mackay, T. F. Enabling population and quantitative genomics. Genet. Res. 80, 1-6 (2002).
2. Nadeau, J. H. & Frankel, W. N. The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs. Nature Genet. 25, 381-384 (2000).
3. Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241-247 (1995).
4. Wehner, J. M., Radcliffe, R. A. & Bowers, B. J. Quantitative genetics and mouse behavior. Annu. Rev. Neurosci. 24, 845-867 (2001).
5. Mackay, T. F. The genetic architecture of quantitative traits. Annu. Rev. Genet. 30, 303-339 (2001).
6. Korstanje, R. & Paigen, B. From QTL to gene: the harvest begins. Nature Genet. 31, 235-236 (2002).
7. Threadgill, D. W., Hunter, K. W. & Williams, R. W. Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mamm. Genome 13, 175-178 (2002).
8. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860-921 (2001).
9. Venter, J. C. et al. The sequence of the human genome. Science 291, 1304-1351 (2001).
10. Ikeda, A. et al. Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). Nature Genet. 30, 401-405 (2002).
11. Glazier, A. M., Nadeau, J. H. & Altman, T. J. Finding genes that underlie complex traits, Science 298, 2345-2349 (2002).
12. Darvasi, A. & Soller, M. Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 141, 1199-1207 (1995).
13. Silver, L. M. Mouse Genetics (Oxford Univ. Press, New York, 1995).
14. Bailey, D. W. Recombinant-inbred strains: an aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation 11, 325-327 (1971).
15. Talbot, C. J. et al. High-resolution mapping of quantitative trait loci in outbred mice. Nature Genet. 21, 305-308 (1999).
16. Bennett, B., Beeson, M., Gordon, L., Carosone, L. & Johnson, T. E. Genetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines. Alcohol Clin. Exp. Res. 26, 1615-1624 (2002).
17. Stassen, A. P., Groot, P. C., Eppig, J. T. & Demant, P. Genetic composition of the recombinant congenic strains. Mamm. Genome 7, 55-58 (1996).
18. Nadeau, J. H., Singer, J. B., Matin, A. & Lander, E. S. Analysing complex genetic traits with chromosome substitution strains. Nature Genet. 24, 221-225 (2000).
19. Martin, G. B., Williams, J. G. & Tanksley, S. D. Rapid identification of markers linked to a Pseudomonas resistance gene in tomato by using random primers and near-isogenic lines. Proc. Natl. Acad. Sci. USA 88, 2336-2340 (1991).
20. Vadasz, C., Saito, M., Gyetvai, B., Mikics, E. & Vadasz, C. Scanning of five chromosomes for alcohol consumption loci. Alcohol 22, 25-34 (2000).
21. Bolivar, V. J., Cook, M. N. & Flaherty, L. Mapping of quantitative trait loci with knockout/congenic strains. Genome Res. 11, 1549-1552 (2001).
22. Shalom, A. & Darvasi, A. Experimental designs for QTL fine mapping in rodents. Methods Mol. Biol. 195, 199-223 (2002).
23. Lander, E. S. & Botstein, D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121, 185-199 (1989).
24. Doerge, R. W. & Churchill, G. A. Permutation tests for multiple loci affecting a quantitative character. Genetics 142, 285-294 (1996).
25. Belknap, J. K. & Atkins, A. L. The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mamm. Genome 12, 893-899 (2001).
26. Haston, C. K. et al. Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice. Mamm. Genome 13, 605-613 (2002).
27. Fehr, C., Shirley, R. L., Belknap, J. K., Crabbe, J. C. & Buck, K. J. Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. J. Neurosci. 22, 3730-3738 (2002).
28. Buck, K. J., Metten, P., Belknap, J. K. & Crabbe, J. C. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J. Neurosci. 17, 3946-3955 (1997).
29. Belknap, J. K., Richards, S. P., O'Toole, L. A., Helms, M. L. & Phillips, T. J. Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice. Behav. Genet. 27, 55-66 (1997).
30. Heintz, N. BAC to the future: the use of bac transgenic mice for neuroscience research. Nature Rev. Neurosci. 2, 861-870 (2001).
31. Liu, P., Jenkins, N. A. & Copeland, N. G. A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res. 13, 476-484 (2003).
32. Pasyukova, E. G., Vieira, C. & Mackay, T. F. Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster. Genetics 156, 1129-1146 (2000).
33. Ma, R. Z. et al. Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Science 297, 620-623 (2002).
34. Vivian, J. L., Chen, Y., Yee, D., Schneider, E. & Megnuson, T. An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N-nitrosourea-mutagenized mouse embryonic stem cells. Proc. Natl. Acad. Sci. USA 99,15542-15547 (2002).
35. Vogel, G. Scientists dream of 1001 complex mice. Science 301, 456-457 (2003).