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Volumn 37, Issue 11, 2005, Pages 1224-1233

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE;

EID: 27644549928     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1619     Document Type: Article
Times cited : (188)

References (41)
  • 1
    • 2942667688 scopus 로고    scopus 로고
    • Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase
    • McClung, J.P. et al. Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc. Natl. Acad. Sci. USA 101, 8852-8857 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 8852-8857
    • McClung, J.P.1
  • 2
    • 0037177625 scopus 로고    scopus 로고
    • Genetic dissection of transcriptional regulation in budding yeast
    • Brem, R.B., Yvert, G., Clinton, R. & Kruglyak, L. Genetic dissection of transcriptional regulation in budding yeast. Science 296, 752-755 (2002).
    • (2002) Science , vol.296 , pp. 752-755
    • Brem, R.B.1    Yvert, G.2    Clinton, R.3    Kruglyak, L.4
  • 3
    • 0035827344 scopus 로고    scopus 로고
    • In silico mapping of complex disease-related traits in mice
    • Grupe, A. et al. In silico mapping of complex disease-related traits in mice. Science 292, 1915-1918 (2001).
    • (2001) Science , vol.292 , pp. 1915-1918
    • Grupe, A.1
  • 4
    • 5944254200 scopus 로고    scopus 로고
    • Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma
    • Karp, C.L. et al. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat. Immunol. 1, 221-226 (2000).
    • (2000) Nat. Immunol. , vol.1 , pp. 221-226
    • Karp, C.L.1
  • 5
    • 18544382234 scopus 로고    scopus 로고
    • Genetic analysis of the mouse brain proteome
    • Klose, J. et al. Genetic analysis of the mouse brain proteome. Nat. Genet. 30, 385-393 (2002).
    • (2002) Nat. Genet. , vol.30 , pp. 385-393
    • Klose, J.1
  • 6
    • 7444225272 scopus 로고    scopus 로고
    • In silico genetics: Identification of a functional element regulating H2-Ealpha gene expression
    • Liao, G. et al. In silico genetics: identification of a functional element regulating H2-Ealpha gene expression. Science 306, 690-695 (2004).
    • (2004) Science , vol.306 , pp. 690-695
    • Liao, G.1
  • 7
    • 8844244726 scopus 로고    scopus 로고
    • Genetic inheritance of gene expression in human cell lines
    • Monks, S.A. et al. Genetic inheritance of gene expression in human cell lines. Am. J. Hum. Genet. 75, 1094-1105 (2004).
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 1094-1105
    • Monks, S.A.1
  • 8
    • 4043128071 scopus 로고    scopus 로고
    • Genetic analysis of genome-wide variation in human gene expression
    • Morley, M. et al. Genetic analysis of genome-wide variation in human gene expression. Nature 430, 743-747 (2004).
    • (2004) Nature , vol.430 , pp. 743-747
    • Morley, M.1
  • 9
    • 0037456823 scopus 로고    scopus 로고
    • Genetics of gene expression surveyed in maize, mouse and man
    • Schadt, E.E. et al. Genetics of gene expression surveyed in maize, mouse and man. Nature 422, 297-302 (2003).
    • (2003) Nature , vol.422 , pp. 297-302
    • Schadt, E.E.1
  • 10
    • 20144383240 scopus 로고    scopus 로고
    • Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
    • Bystrykh, L. et al. Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat. Genet. 37, 225-232 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 225-232
    • Bystrykh, L.1
  • 11
    • 20144386111 scopus 로고    scopus 로고
    • Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    • Chesler, E.J. et al. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat. Genet. 37, 233-242 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 233-242
    • Chesler, E.J.1
  • 12
    • 20144377218 scopus 로고    scopus 로고
    • Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
    • Hubner, N. et al. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat. Genet. 37, 243-253 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 243-253
    • Hubner, N.1
  • 13
    • 0032561246 scopus 로고    scopus 로고
    • The transcriptional program of sporulation in budding yeast
    • Chu, S. et al. The transcriptional program of sporulation in budding yeast. Science 282, 699-705 (1998).
    • (1998) Science , vol.282 , pp. 699-705
    • Chu, S.1
  • 15
    • 0034616930 scopus 로고    scopus 로고
    • Functional discovery via a compendium of expression profiles
    • Hughes, T.R. et al. Functional discovery via a compendium of expression profiles. Cell 102, 109-126 (2000).
    • (2000) Cell , vol.102 , pp. 109-126
    • Hughes, T.R.1
  • 16
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha, V.K. et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34, 267-273 (2003).
    • (2003) Nat. Genet. , vol.34 , pp. 267-273
    • Mootha, V.K.1
  • 17
    • 0034704219 scopus 로고    scopus 로고
    • Functional genomics identifies monopolin: A kinetochore protein required for segregation of homologs during meiosis i
    • Toth, A. et al. Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i. Cell 103, 1155-1168 (2000).
    • (2000) Cell , vol.103 , pp. 1155-1168
    • Toth, A.1
  • 18
    • 0345876776 scopus 로고    scopus 로고
    • Genetic loci determining bone density in mice with diet-induced atherosclerosis
    • Drake, T.A. et al. Genetic loci determining bone density in mice with diet-induced atherosclerosis. Physiol. Genomics 5, 205-215 (2001).
    • (2001) Physiol. Genomics , vol.5 , pp. 205-215
    • Drake, T.A.1
  • 19
    • 0034277623 scopus 로고    scopus 로고
    • Genetics of atherosclerosis: The search for genes acting at the level of the vessel wall
    • Villa-Colinayo, V., Shi, W., Araujo, J. & Lusis, A.J. Genetics of atherosclerosis: the search for genes acting at the level of the vessel wall. Curr. Atheroscler. Rep. 2, 380-389 (2000).
    • (2000) Curr. Atheroscler. Rep. , vol.2 , pp. 380-389
    • Villa-Colinayo, V.1    Shi, W.2    Araujo, J.3    Lusis, A.J.4
  • 20
    • 0031975307 scopus 로고    scopus 로고
    • Experimental strategies for the genetic dissection of complex traits in animal models
    • Darvasi, A. Experimental strategies for the genetic dissection of complex traits in animal models. Nat. Genet. 18, 19-24 (1998).
    • (1998) Nat. Genet. , vol.18 , pp. 19-24
    • Darvasi, A.1
  • 21
    • 18444402182 scopus 로고    scopus 로고
    • The Ensembl genome database project
    • Hubbard, T. et al. The Ensembl genome database project. Nucleic Acids Res. 30, 38-41 (2002).
    • (2002) Nucleic Acids Res. , vol.30 , pp. 38-41
    • Hubbard, T.1
  • 22
    • 0037204994 scopus 로고    scopus 로고
    • A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome
    • Mural, R.J. et al. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science 296, 1661-1671 (2002).
    • (2002) Science , vol.296 , pp. 1661-1671
    • Mural, R.J.1
  • 23
    • 1542563409 scopus 로고    scopus 로고
    • Initial sequencing and comparative analysis of the mouse genome
    • Waterston, R.H. et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520-562 (2002).
    • (2002) Nature , vol.420 , pp. 520-562
    • Waterston, R.H.1
  • 24
    • 19844366096 scopus 로고    scopus 로고
    • Cis-acting expression quantitative trait loci in mice
    • Doss, S., Schadt, E.E., Drake, T.A. & Lusis, A.J. Cis-acting expression quantitative trait loci in mice. Genome Res. 15, 681-691 (2005).
    • (2005) Genome Res. , vol.15 , pp. 681-691
    • Doss, S.1    Schadt, E.E.2    Drake, T.A.3    Lusis, A.J.4
  • 25
    • 9144272249 scopus 로고    scopus 로고
    • Regulation of bone mass in mice by the lipoxygenase gene Alox15
    • Klein, R.F. et al. Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 303, 229-232 (2004).
    • (2004) Science , vol.303 , pp. 229-232
    • Klein, R.F.1
  • 26
    • 22844446947 scopus 로고    scopus 로고
    • An integrative genomics approach to infer causal associations between gene expression and disease
    • Schadt, E.E. et al. An integrative genomics approach to infer causal associations between gene expression and disease. Nat. Genet. 37, 710-717 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 710-717
    • Schadt, E.E.1
  • 27
    • 0037178728 scopus 로고    scopus 로고
    • Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    • Mehrabian, M. et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ. Res. 91, 120-126 (2002).
    • (2002) Circ. Res. , vol.91 , pp. 120-126
    • Mehrabian, M.1
  • 28
    • 0037495055 scopus 로고    scopus 로고
    • Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog
    • Kuhn, H., Anton, M., Gerth, C. & Habenicht, A. Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog. Arterioscler. Thromb. Vasc. Biol. 23, 1072-1076 (2003).
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 1072-1076
    • Kuhn, H.1    Anton, M.2    Gerth, C.3    Habenicht, A.4
  • 29
    • 0142093151 scopus 로고    scopus 로고
    • 5-lipoxygenase and atherosclerosis
    • Mehrabian, M. & Allayee, H. 5-lipoxygenase and atherosclerosis. Curr. Opin. Lipidol. 14, 447-457 (2003).
    • (2003) Curr. Opin. Lipidol. , vol.14 , pp. 447-457
    • Mehrabian, M.1    Allayee, H.2
  • 30
    • 0346003777 scopus 로고    scopus 로고
    • Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression
    • Yu, S. et al. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J. Biol. Chem. 278, 498-505 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 498-505
    • Yu, S.1
  • 31
    • 3242806720 scopus 로고    scopus 로고
    • An integrative genomics approach to the reconstruction of gene networks in segregating populations
    • Zhu, J. et al. An integrative genomics approach to the reconstruction of gene networks in segregating populations. Cytogenet. Genome Res. 105, 363-374 (2004).
    • (2004) Cytogenet. Genome Res. , vol.105 , pp. 363-374
    • Zhu, J.1
  • 32
    • 0033529194 scopus 로고    scopus 로고
    • Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption
    • Yoshitake, H., Rittling, S.R., Denhardt, D.T. & Noda, M. Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc. Natl. Acad. Sci. USA 96, 8156-8160 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8156-8160
    • Yoshitake, H.1    Rittling, S.R.2    Denhardt, D.T.3    Noda, M.4
  • 33
    • 0031892092 scopus 로고    scopus 로고
    • Obesity and hyperleptinemia in metallothionein (-I and -II) null mice
    • Beattie, J.H. et al. Obesity and hyperleptinemia in metallothionein (-I and -II) null mice. Proc. Natl. Acad. Sci. USA 95, 358-363 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 358-363
    • Beattie, J.H.1
  • 34
    • 2142808834 scopus 로고    scopus 로고
    • Fat's loss is bone's gain
    • Pei, L. & Tontonoz, P. Fat's loss is bone's gain. J. Clin. Invest. 113, 805-806 (2004).
    • (2004) J. Clin. Invest. , vol.113 , pp. 805-806
    • Pei, L.1    Tontonoz, P.2
  • 35
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub, T.R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531-537 (1999).
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1
  • 36
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy, S., Ross, K.N., Lander, E.S. & Golub, T.R. A molecular signature of metastasis in primary solid tumors. Nat. Genet. 33, 49-54 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 37
    • 33947219859 scopus 로고    scopus 로고
    • The functional landscape of mouse gene expression
    • Zhang, W. et al. The functional landscape of mouse gene expression. J. Biol. 3, 21 (2004).
    • (2004) J. Biol. , vol.3 , pp. 21
    • Zhang, W.1
  • 38
    • 0035072249 scopus 로고    scopus 로고
    • Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer
    • Hughes, T.R. et al. Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat. Biotechnol. 19, 342-347 (2001).
    • (2001) Nat. Biotechnol. , vol.19 , pp. 342-347
    • Hughes, T.R.1
  • 39
    • 0037944217 scopus 로고    scopus 로고
    • Microarray standard data set and figures of merit for comparing data processing methods and experiment designs
    • He, Y.D. et al. Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics 19, 956-965 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 956-965
    • He, Y.D.1
  • 40
    • 0035920262 scopus 로고    scopus 로고
    • Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia
    • Mehrabian, M. et al. Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ. Res. 89, 125-130 (2001).
    • (2001) Circ. Res. , vol.89 , pp. 125-130
    • Mehrabian, M.1
  • 41
    • 0035158822 scopus 로고    scopus 로고
    • Atherogenic high-fat diet reduces bone mineralization in mice
    • Parhami, F. et al. Atherogenic high-fat diet reduces bone mineralization in mice. J. Bone Miner. Res. 16, 182-188 (2001).
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 182-188
    • Parhami, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.