Region-specific decline in the expression of metabotropic glutamate receptor 7 mRNA in rat brain during aging

Molecular Brain Research

Volumn 82, Issue 1-2, 2000, Pages 101-106

  Simonyi, Agnes ^a   Miller, Laura A ^a   Sun, Grace Y ^a  

^a University of Missouri   (United States)

Author keywords

Aging; In situ hybridization; Metabotropic glutamate receptor 4; Metabotropic glutamate receptor 7; Rat brain

Indexed keywords

EXCITATORY AMINO ACID RECEPTOR; MESSENGER RNA; METABOTROPIC GLUTAMATE RECEPTOR 7; METABOTROPIC RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

AGING; ANIMAL TISSUE; ARTICLE; BRAIN REGION; COGNITION; CONTROLLED STUDY; DENTATE GYRUS; FRONTAL CORTEX; GRANULE CELL; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PARIETAL LOBE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; SENSORIMOTOR FUNCTION; TEMPORAL CORTEX; THALAMUS NUCLEUS;

AGING; ANIMAL; BRAIN; CEREBRAL CORTEX; DENTATE GYRUS; MALE; NUCLEUS ACCUMBENS; ORGAN SPECIFICITY; RATS; RATS, INBRED F344; RECEPTORS, METABOTROPIC GLUTAMATE; SUPPORT, NON-U.S. GOV'T;

ANIMALIA; MARTES PENNANTI;

EID: 0034693157     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00189-3     Document Type: Article

References (33)

1. Metabotropic glutamate receptors: Electrophysiological properties and role in plasticity
2. Different age-related changes in NMDA and glycine receptors in the rat brain
3. Effect of N(G)-nitro-L-arginine on age-related changes of glutamate receptor systems and immunophilin in rats
4. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies
5. The need of multiple time points in aging studies
6. Pharmacology and functions of metabotropic glutamate receptors
7. Involvement of hippocampal synaptic plasticity in age-related memory decline
8. Altered spatial learning and memory in mice lacking the mGluR4 subtype of metabotropic glutamate receptor
9. Metabotropic glutamate receptor activation and blockade: Their role in long-term potentiation, learning and neurotoxicity
10. Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult brain
11. Possible roles of L-phosphoserine in the pathogenesis of Alzheimer's disease
12. Long-term depression in hippocampal interneurons: Joint requirement for pre- and postsynaptic events
13. Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion
14. 3H]MK-801 binding in the Fisher 344 rat brain
15. Life and death of neurons in aging brain
16. AMPA-selective glutamate receptor subunits in the rat hippocampus during aging
17. Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?
18. Distributions of the mRNAs for l-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain
19. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction
20. Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor
21. Immunohistochemical localisation of mGluR7 protein in the rodent and human cerebellar cortex using subtype specific antibodies
22. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
23. The neurobiology of cerebellar senescence
24. Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone
25. Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus
26. 3 3-kinase and mGluR1 in mouse Purkinje neurons
27. Age differences in the expression of metabotropic glutamate receptor 1 and inositol 1,4,5-trisphosphate receptor in mouse cerebellum
28. Region- and subtype-specific changes in the expression of metabotropic glutamate receptors in rat brain during aging
29. Molecular indices of neuronal and glial plasticity in the hippocampal formation in a rodent model of age-induced spatial learning impairment
30. A family of metabotropic glutamate receptors
31. Signal transduction, pharmacological properties, and expression patterns of two metabotropic glutamate receptors, mGluR3 and mGluR4
32. Group III metabotropic glutamate receptors control corticothalamic synaptic transmission in the rat thalamus in vitro