Association between GABRA1 and drinking behaviors in the Collaborative Study on the Genetics of Alcoholism sample

Alcoholism: Clinical and Experimental Research

Volumn 30, Issue 7, 2006, Pages 1101-1110

  Dick, Danielle M ^a,f   Plunkett, Jevon ^a   Wetherill, Leah Flury ^b   Xuei, Xiaoling ^b   Goate, Alison ^a   Hesselbrock, Victor ^c   Schuckit, Marc ^d   Crowe, Raymond ^e   Edenberg, Howard J ^b   Foroud, Tatiana ^b  

^a WASHINGTON UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol Dependence; Association Analyses; Chromosome 5; Drinking Behavior; GABA Receptor Genes

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR;

ALCOHOLISM; ARTICLE; CHROMOSOME 5Q; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUNKENNESS; FAMILY; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE OF ONSET; ALCOHOL DRINKING; ALCOHOLIC INTOXICATION; ALCOHOLISM; CHROMOSOMES, HUMAN, PAIR 5; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GABA-A;

ANIMALIA; RODENTIA;

EID: 33745155398     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2006.00136.x     Document Type: Article

References (45)

1. Abecasis GR Cookson WO ( 2000) GOLD - graphical overview of linkage disequilibrium. Bioinformatics 16 : 182 183.
2. American Psychiatric Association ( 1987) Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. revised., American Psychiatric Association, Washington, DC.
3. Bergeson SE Kyle Warren R Crabbe JC Metten P Gene Erwin V Belknap JK ( 2003) Chromosomal loci influencing chronic alcohol withdrawal severity. Mamm Genome 14 : 454 463.
4. Boehnke M ( 1991) Allele frequency estimation from pedigree data. Am J Hum Genet 48 : 22 25.
5. Boehm SL II. Ponomarev I Jennings AW Whiting PJ Rosahl TW Garrett EM Blednov YA Harris RA ( 2004) Gamma-aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions. Biochem Pharmacol 68 : 1581 1602.
6. Bucholz KK Cadoret R Cloninger CR Dinwiddie SH Hesselbrock VM Nurnberger JI Jr. Reich T Schmidt I Schuckit MA ( 1994) A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol 55 : 149 158.
7. Buck KJ Hood HM ( 1998) Genetic association of a GABAA receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol. Mamm Genome 9 : 975 978.
8. Buck KJ Metten P Belknap JK Crabbe JC ( 1997) Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci 17 : 3946 3955.
9. Dick DM Edenberg HJ Xuei X Goate A Hesselbrock V Schuckit M Crowe R Foroud T ( 2005) No association of the GABAA receptor genes on chromosome 5 with alcoholism in the Collaborative Study on the Genetics of Alcoholism sample. Am J Med Genet B Neuropsychiatr Genet 132 : 24 28.
10. Dudbridge F ( 2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25 : 115 121.
11. Ghosh S Begleiter H Porjesz B Chorlian DB Edenberg HJ Foroud T Goate A Reich T ( 2003) Linkage mapping of beta 2 EEG waves via non-parametric regression. Am J Med Genet B Neuropsychiatr Genet 118 : 66 71.
12. Grant BF Stinson FS Harford TC ( 2001) Age of onset of alcohol use and DSM-IV alcohol abuse and dependence: a 12-year follow-up. J Subst Abuse 13 : 493 504.
13. Grobin AC Matthews DB Devaud LL Morrow AL ( 1998) The role of GABAA receptors in the acute and chronic effects of ethanol. Psychopharmacology 139 : 2 19.
14. Hanchar HJ Dodson PD Olsen RW Otis TS Wallner M ( 2005) Alcohol-induced motor impairment caused by increased extrasynaptic GABAA receptor activity. Nat Neurosci 8 : 339 345.
15. Hesselbrock M Easton C Bucholz KK Schuckit M Hesselbrock V ( 1999) A validity study of the SSAGA - a comparison with the SCAN. Addiction 94 : 1361 1370.
16. Hingson R Heeren T Winter MR Wechsler H ( 2003) Early age of first drunkenness as a factor in college students' unplanned and unprotected sex attributable to drinking. Pediatrics 111 : 34 41.
17. Hsu YP Seow SV Loh EW Wang YC Chen CC Yu JM Cheng AT ( 1998) Search for mutations near the alternately spliced 8-amino-acid exon in the GABA-A receptor gamma 2 subunit gene and lack of allelic association with alcoholism among four aboriginal groups and Han Chinese in Taiwan. Mol Brain Res 56 : 284 286.
18. Hu X Oroszi G Chun J Smith TL Goldman D Schuckit MA ( 2005) An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism Risk. Alcohol Clin Exp Res 29 : 8 16.
19. Iwata N Cowley DS Radel M Roy-Byrne PP Goldman D ( 1999) Relationship between a GABAA alpha 6 Pro385Ser substitution and benzodiazepine sensitivity. Am J Psychiatr 156 : 1447 1449.
20. Kralic JE Criswell HE Osterman JL O'Buckley TK Wilkie ME Matthews DB Hamre K Breese GR Homanics GE Morrow AL ( 2005) Genetic essential tremor in gamma-aminobutyric acidA receptor α1 subunit knockout mice. J Clin Invest 115 : 774 779.
21. Li J Ji L ( 2005) Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 95 : 221 227.
22. Liu Y Dietrich RA ( 1998) Role of GABA in the actions of ethanol in rats selectively bred for ethanol sensitivity. Pharmacol Biochem Behav 60 : 793 801.
23. Loh EW Ball D ( 2000) Role of the GABAAbeta2, GABAAalpha6, GABAAalpha1, GABAAgamma2 receptor subunit gene cluster in drug response and the development of alcohol dependence. Neurochem Int 37 : 413 423.
24. Loh EW Smith I Murray R McLaughlin M McNulty S Ball D ( 1999) Association between variants at the GABA-A B2, GABA-A A6, GABA-A G2 gene cluster and alcohol dependence in a Scottish population. Mol Psychiatry 4 : 539 544.
25. Martin ER Monks SA Warren LL Kaplan NL ( 2000) A test for linkage and association in general pedigrees: the Pedigree Disequilibrium Test. Am J Hum Genet 67 : 146 154.
26. McBride WJ Li TK ( 1998) Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobio 12 : 339 369.
27. Mc Gue M Iacono WG Legrand LN Elkins I ( 2001) Origins and consequences of age of first drink. II. Familial risk and heritability. Alcohol Clin Exp Res 25 : 1166 1173.
28. Nelson EC Heath AC Bucholz KK Madden PA Fu Q Knopik V Lynskey MT Whitfield JB Statham DJ Martin NG ( 2004) Genetic epidemiology of alcohol-induced blackouts. Arch Gen Psychiatry 61 : 257 263.
29. Nyholt DR ( 2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74 : 765 769.
30. Parsian A Cloninger CR ( 1997) Human GABAA receptor alpha1 and alpha3 subunits genes and alcoholism. Alcohol Clin Exp. Res 21 : 430 433.
31. Prescott C Kendler K ( 1999) Age at first drink and risk for alcoholism: a noncausal association. Alcohl Clin Exp Res 23 : 101 107.
32. Radel M Vallejo RL Long LC Goldman D ( 1999) Sib-pair linkage analysis of GABRG2 to alcohol dependence. Alcohol Clin Exp Res 23 : 59A.
33. Radel M Vallejo RL Iwata N Aragon R Long JC Virkkunen M Goldman D ( 2005) Haplotype-based localization of an alcohol dependence gene to the 5q34 gamma-aminobutyric acid type A gene cluster. Arch Gen Psychiatry 62 : 47 55.
34. Reich T ( 1996) A genomic survey of alcohol dependence and related phenotypes: results from the collaborative study on the genetics of alcoholism (COGA). Alcohol Clin Exp Res 20 (Suppl) : 133A 137A.
35. Reich T Edenberg HJ Goate A Williams JT Rice JP Van Eerdewegh P Foroud T Hesselbrock V Schuckit MA Bucholz K Porjesz B Li TK Conneally PM Nurnberger JI Jr. Tischfield JA Crowe RR Cloninger CR Wu W Shears S Carr K Crose C Willig C Begleiter H ( 1998) Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81 : 207 215.
36. Reily MT Buck KJ ( 2000) GABAA receptor beta2 subunit mRNA content is differentially regulated in ethanol-dependent DBA/2J and C57BL/6J mice. Neurochem Int 37 : 443 452.
37. Sander T Ball D Murray R Patel J Samochowiec J Winterer G Rommelspacher H Schmidt LG ( 1999) Association analysis of sequence variants of the GABAA alpha6, beta2, and gamma2 gene cluster and alcohol dependence. Alcohol Clin Exp Res 23 : 427 431.
38. Sanna A Congeddu E Saba L Porcella A Marchese G Ruiu S Casti P Saba P Pani L ( 2003) The cerebellar GABAA alpha6 subunit is differentially modulated by chronic ethanol exposure in normal (R100R) and mutated (Q100R) sNP rats. Brain Res 998 : 148 154.
39. Schuckit MA Tipp JE Smith TL Wiesbeck GA Kalmijn J ( 1997) The self-rating of the effects of alcohol (SRE) form as a retrospective measure of the risk for alcoholism. Addiction 92 : 979 988.
40. Schuckit MA Mazzanti C Smith TL Ahmed U Radel M Iwata N Goldman D ( 1999) Selective genotyping role of 5-HT2A, 5-HT2C, and GABA α receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Alcohol Clin Exp Res 23 : 427 431.
41. Schuckit MA Smith TL Kalmijn J ( 2004) The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. Alcohol Clin Exp Res 28 : 1449 1458.
42. Sobel E Lange K ( 1996) Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker sharing statistics. Am J Hum Genet 58 : 1323 1337.
43. Song J Koller DL Foroud T Carr K Zhao J Rice J Nurnberger JI Jr. Begleiter H Porjesz B Smith TL Schuckit MA Edenberg HJ ( 2003) Association of GABAA receptors and alcohol dependence and the effects of genetic imprinting. Am J Med Genet Neuropsychiatr Genet 117B : 39 45.
44. Wilhelmsen KC Schuckit M Smith TL Lee JV Segall SK Feiler HS Kalmijn J ( 2003) The search for genes related to a low-level response to alcohol determined by alcohol challenges. Alcohol Clin Exp Res 27 : 1041 1047.
45. Zhang S Zhang K Li J Sun F Zhao H ( 2001) Test of association for quantitative traits in general pedigrees: the quantitative pedigree disequilibrium test. Genetic Epidemiol 21 (Suppl 1) : S370 S375.