Gliomagenesis and neural stem cells: Key role of hypoxia and concept of tumor "neo-niche"

Medical Hypotheses

Volumn 70, Issue 1, 2008, Pages 96-104

  Diabira, Sylma ^a   Morandi, Xavier ^a  

^a PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR5; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; LEUKEMIA INHIBITORY FACTOR; PLATELET DERIVED GROWTH FACTOR; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; BRAIN TUMOR; CELL DIFFERENTIATION; CELL HYPOXIA; CELL RENEWAL; CENTRAL NERVOUS SYSTEM; CONCEPT FORMATION; GLIOMA; HOMEOSTASIS; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MICROENVIRONMENT; MOLECULAR BIOLOGY; MOLECULAR MECHANICS; NEO NICHE CONCEPT; NEURAL STEM CELL; PRIORITY JOURNAL; TUMOR GROWTH;

ANOXIA; BRAIN NEOPLASMS; GLIOMA; GLUCONEOGENESIS; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; NEURONS; STEM CELLS;

EID: 36348971065     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.04.024     Document Type: Article

References (94)

1. Weingart J., and Brem H. Biology and therapy of glial tumors. Curr Opin Neurol Neurosurg 6 (1992) 808-812
2. Maher E.A., Furnari F.B., Bachoo R.M., Rowitch D.H., Louis D.N., Cavenee W.K., et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev 11 (2001) 1311-1333
3. Kleihues P., Louis D.N., Scheithauer B.W., Rorke L.B., Reifenberger G., Burger P.C., et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 3 (2002) 215-225 [discussion 226-9]
4. Stupp R., Mason W.P., van den Bent M.J., Weller M., Fisher B., Taphoorn M.J., et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 10 (2005) 987-996
5. Hall P.A., and Watt F.M. Stem cells: the generation and maintenance of cellular diversity. Development 4 (1989) 619-633
6. Potten C.S., and Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 4 (1990) 1001-1020
7. Gage F.H. Stem cells of the central nervous system. Curr Opin Neurobiol 5 (1998) 671-676
8. Morrison S.J., Shah N.M., and Anderson D.J. Regulatory mechanisms in stem cell biology. Cell 3 (1997) 287-298
9. Zipori D. The stem state: plasticity is essential, whereas self-renewal and hierarchy are optional. Stem Cells 6 (2005) 719-726
10. Weiss S., and van der Kooy D. CNS stem cells: where's the biology (a.k.a. beef)?. J Neurobiol 2 (1998) 307-314
11. Doetsch F., Caille I., Lim D.A., Garcia-Verdugo J.M., and Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 6 (1999) 703-716
12. Johansson C.B., Momma S., Clarke D.L., Risling M., Lendahl U., and Frisen J. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 1 (1999) 25-34
13. Morshead C.M., and van der Kooy D. A new 'spin' on neural stem cells?. Curr Opin Neurobiol 1 (2001) 59-65
14. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 1-2 (1978) 7-25
15. Adams G.B., and Scadden D.T. The hematopoietic stem cell in its place. Nat Immunol 4 (2006) 333-337
16. Sanai N., Tramontin A.D., Quinones-Hinojosa A., Barbaro N.M., Gupta N., Kunwar S., et al. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature 6976 (2004) 740-744
17. Eriksson P.S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A., et al. Neurogenesis in the adult human hippocampus. Nat Med 11 (1998) 1313-1317
18. Nunes M.C., Roy N.S., Keyoung H.M., Goodman R.R., McKhann II G., et al. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 4 (2003) 439-447
19. Spradling A., Drummond-Barbosa D., and Kai T. Stem cells find their niche. Nature 6859 (2001) 98-104
20. He X.C., Zhang J., and Li L. Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior. Ann N Y Acad Sci (2005) 28-38
21. Li L., and Neaves W.B. Normal stem cells and cancer stem cells: the niche matters. Cancer Res 9 (2006) 4553-4557
22. Kindler V. Postnatal stem cell survival: does the niche, a rare harbor where to resist the ebb tide of differentiation, also provide lineage-specific instructions?. J Leukoc Biol 4 (2005) 836-844
23. Dello Sbarba P., Cipolleschi M.G., and Olivotto M. Hemopoietic progenitor cells are sensitive to the cytostatic effect of pyruvate. Exp Hematol 2 (1987) 137-142
24. Cipolleschi M.G., Dello Sbarba P., and Olivotto M. The role of hypoxia in the maintenance of hematopoietic stem cells. Blood 7 (1993) 2031-2037
25. D'Ippolito G., Diabira S., Howard G.A., Roos B.A., and Schiller P.C. Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells. Bone 3 (2006) 513-522
26. Morrison S.J., Csete M., Groves A.K., Melega W., Wold B., and Anderson D.J. Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells. J Neurosci 19 (2000) 7370-7376
27. Morrison S.J., White P.M., Zock C., and Anderson D.J. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells. Cell 5 (1999) 737-749
28. Studer L., Csete M., Lee S.H., Kabbani N., Walikonis J., Wold B., et al. Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J Neurosci 19 (2000) 7377-7383
29. Semenza G.L. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 1 (2001) 1-3
30. Kourembanas S., Hannan R.L., and Faller D.V. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J Clin Invest 2 (1990) 670-674
31. Namiki A., Brogi E., Kearney M., Kim E.A., Wu T., Couffinhal T., et al. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem 52 (1995) 31189-31195
32. Hatten M.E. Central nervous system neuronal migration. Annu Rev Neurosci (1999) 511-539
33. Morshead C.M., Craig C.G., and van der Kooy D. In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain. Development 12 (1998) 2251-2261
34. Lois C., and Alvarez-Buylla A. Long-distance neuronal migration in the adult mammalian brain. Science 5162 (1994) 1145-1148
35. Dirks P.B. Glioma migration: clues from the biology of neural progenitor cells and embryonic CNS cell migration. J Neurooncol 2 (2001) 203-212
36. Edmondson J.C., Liem R.K., Kuster J.E., and Hatten M.E. Astrotactin: a novel neuronal cell surface antigen that mediates neuron-astroglial interactions in cerebellar microcultures. J Cell Biol 2 (1988) 505-517
37. Zheng C., Heintz N., and Hatten M.E. CNS gene encoding astrotactin, which supports neuronal migration along glial fibers. Science 5260 (1996) 417-419
38. Cremer H., Lange R., Christoph A., Plomann M., Vopper G., Roes J., et al. Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature 6462 (1994) 455-459
39. Powell E.M., Mars W.M., and Levitt P. Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon. Neuron 1 (2001) 79-89
40. Aboody K.S., Brown A., Rainov N.G., Bower K.A., Liu S., Yang W., et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 23 (2000) 12846-12851
41. Yip S., Aboody K.S., Burns M., Imitola J., Boockvar J.A., Allport J., et al. Neural stem cell biology may be well suited for improving brain tumor therapies. Cancer J 3 (2003) 189-204
42. Ehtesham M., Yuan X., Kabos P., Chung N.H., Liu G., Akasaki Y., et al. Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4. Neoplasia 3 (2004) 287-293
43. Zhou Y., Larsen P.H., Hao C., and Yong V.W. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem 51 (2002) 49481-49487
44. Ma Q., Jones D., and Springer T.A. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 4 (1999) 463-471
45. Muller A., Homey B., Soto H., Ge N., Catron D., Buchanan M.E., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 6824 (2001) 50-56
46. Phillips R.J., Burdick M.D., Lutz M., Belperio J.A., Keane M.P., and Strieter R.M. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med 12 (2003) 1676-1686
47. Pan J., Mestas J., Burdick M.D., Phillips R.J., Thomas G.V., Reckamp K., et al. Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis. Mol Cancer (2006) 56
48. Balkwill F. The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 3 (2004) 171-179
49. Kucia M., Jankowski K., Reca R., Wysoczynski M., Bandura L., Allendorf D.J., et al. CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol 3 (2004) 233-245
50. Zlotnik A. Chemokines in neoplastic progression. Semin Cancer Biol 3 (2004) 181-185
51. Bachelder R.E., Wendt M.A., and Mercurio A.M. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res 24 (2002) 7203-7206
52. Salcedo R., and Oppenheim J.J. Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses. Microcirculation 3-4 (2003) 359-370
53. Grimshaw M.J., and Balkwill F.R. Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation-a potential mechanism. Eur J Immunol 2 (2001) 480-489
54. Schioppa T., Uranchimeg B., Saccani A., Biswas S.K., Doni A., Rapisarda A., et al. Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med 9 (2003) 1391-1402
55. Kucia M., Ratajczak J., and Ratajczak M.Z. Bone marrow as a source of circulating CXCR4 + tissue-committed stem cells. Biol Cell 2 (2005) 133-146
56. Schneider S.W., Ludwig T., Tatenhorst L., Braune S., Oberleithner H., Senner V., et al. Glioblastoma cells release factors that disrupt blood-brain barrier features. Acta Neuropathol (Berl) 3 (2004) 272-276
57. Sawyers C.L., Denny C.T., and Witte O.N. Leukemia and the disruption of normal hematopoiesis. Cell 2 (1991) 337-350
58. Lapidot T., Sirard C., Vormoor J., Murdoch B., Hoang T., Caceres-Cortes J., et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 6464 (1994) 645-648
59. Bonnet D., and Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 7 (1997) 730-737
60. Wechsler-Reya R., and Scott M.P. The developmental biology of brain tumors. Annu Rev Neurosci (2001) 385-428
61. Goodrich L.V., Milenkovic L., Higgins K.M., and Scott M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 5329 (1997) 1109-1113
62. Marino S., Vooijs M., van Der Gulden H., Jonkers J., and Berns A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 8 (2000) 994-1004
63. Wechsler-Reya R.J., and Scott M.P. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 1 (1999) 103-114
64. Kenney A.M., and Rowitch D.H. Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol Cell Biol 23 (2000) 9055-9067
65. Pomeroy S.L., Tamayo P., Gaasenbeek M., Sturla L.M., Angelo M., McLaughlin M.E., et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 6870 (2002) 436-442
66. Palma E., Torchia G., Limatola C., Trettel F., Arcella A., Cantore G., et al. BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes. Proc Natl Acad Sci USA 5 (2005) 1667-1672
67. Machold R., Hayashi S., Rutlin M., Muzumdar M.D., Nery S., Corbin J.G., et al. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 6 (2003) 937-950
68. Alvarez-Buylla A., and Lim D.A. For the long run: maintaining germinal niches in the adult brain. Neuron 5 (2004) 683-686
69. Dahmane N., Sanchez P., Gitton Y., Palma V., Sun T., Beyna M., et al. The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 24 (2001) 5201-5212
70. Ruizi Altaba A., Stecca B., and Sanchez P. Hedgehog-Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer. Cancer Lett 2 (2004) 145-157
71. Read T.A., Hegedus B., Wechsler-Reya R., and Gutmann D.H. The neurobiology of neurooncology. Ann Neurol 1 (2006) 3-11
72. Richardson W.D., Pringle N., Mosley M.J., Westermark B., and Dubois-Dalcq M. A role for platelet-derived growth factor in normal gliogenesis in the central nervous system. Cell 2 (1988) 309-319
73. Raff M.C., Lillien L.E., Richardson W.D., Burne J.F., and Noble M.D. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture. Nature 6173 (1988) 562-565
74. Jori F.P., Galderisi U., Piegari E., Cipollaro M., Cascino A., Peluso G., et al. EGF-responsive rat neural stem cells: molecular follow-up of neuron and astrocyte differentiation in vitro. J Cell Physiol 2 (2003) 220-233
75. Doetsch F., Petreanu L., Caille I., Garcia-Verdugo J.M., and Alvarez-Buylla A. EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 6 (2002) 1021-1034
76. Kornblum H.I., Hussain R., Wiesen J., Miettinen P., Zurcher S.D., Chow K., et al. Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor. J Neurosci Res 6 (1998) 697-717
77. Bachoo R.M., Maher E.A., Ligon K.L., Sharpless N.E., Chan S.S., You M.J., et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 3 (2002) 269-277
78. Dai C., Celestino J.C., Okada Y., Louis D.N., Fuller G.N., and Holland E.C. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 15 (2001) 1913-1925
79. Brat D.J., and Mapstone T.B. Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression. Ann Int Med 8 (2003) 659-668
80. Evans S.M., Judy K.D., Dunphy I., Jenkins W.T., Hwang W.T., Nelson P.T., et al. Hypoxia is important in the biology and aggression of human glial brain tumors. Clin Cancer Res 24 (2004) 8177-8184
81. Kaur B., Khwaja F.W., Severson E.A., Matheny S.L., Brat D.J., and Van Meir E.G. Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro-oncol 2 (2005) 134-153
82. Hockel M., Schlenger K., Aral B., Mitze M., Schaffer U., and Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 19 (1996) 4509-4515
83. Brizel D.M., Scully S.P., Harrelson J.M., Layfield L.J., Bean J.M., Prosnitz L.R., et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 5 (1996) 941-943
84. Takano S., Yoshii Y., Kondo S., Suzuki H., Maruno T., Shirai S., et al. Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res 9 (1996) 2185-2190
85. Broholm H., and Laursen H. Vascular endothelial growth factor (VEGF) receptor neuropilin-1's distribution in astrocytic tumors. Apmis 4-5 (2004) 257-263
86. Millauer B., Shawver L.K., Plate K.H., Risau W., and Ullrich A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 6463 (1994) 576-579
87. Osada H., Tokunaga T., Nishi M., Hatanaka H., Abe Y., Tsugu A., et al. Overexpression of the neuropilin 1 (NRP1) gene correlated with poor prognosis in human glioma. Anticancer Res 2B (2004) 547-552
88. Wick W., Platten M., and Weller M. Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. J Neurooncol 2 (2001) 177-185
89. Schlegel U., Moots P.L., Rosenblum M.K., Thaler H.T., and Furneaux H.M. Expression of transforming growth factor alpha in human gliomas. Oncogene 12 (1990) 1839-1842
90. Zadeh G., Qian B., Okhowat A., Sabha N., Kontos C.D., and Guha A. Targeting the Tie2/Tek receptor in astrocytomas. Am J Pathol 2 (2004) 467-476
91. Sanai N., Alvarez-Buylla A., and Berger M.S. Neural stem cells and the origin of gliomas. N Engl J Med 8 (2005) 811-822
92. Vick N.A., Lin M.J., and Bigner D.D. The role of the subependymal plate in glial tumorigenesis. Acta Neuropathol (Berl) 1 (1977) 63-71
93. Zipori D. The nature of stem cells: state rather than entity. Nat Rev Genet 11 (2004) 873-878
94. Hochedlinger K., and Jaenisch R. Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. N Engl J Med 3 (2003) 275-286