Overexpression of the Neuropilin 1 (NRP1) Gene Correlated with Poor Prognosis in Human Glioma

Anticancer Research

Volumn 24, Issue 2 B, 2004, Pages 547-552

  Osada, Hideo ^a,b   Tokunaga, Tetsuji ^a,b   Nishi, Masatake ^a   Hatanaka, Hiroyuki ^a   Abe, Yoshiyuki ^a   Tsugu, Atsushi ^a   Kijima, Hiroshi ^a   Yamazaki, Hitoshi ^a   Ueyama, Yoshito ^a   Nakamura, Masato ^a,c  

^a TOKAI UNIVERSITY   (Japan)

^b Japan Self Defense Forces Hospital Yokosuka   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Flt 1; Glioma; KDR; Neuropilin 1; Prognosis; VEGF

Indexed keywords

CD34 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD34; NEUROPILIN 1; NEUROPILIN 2; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CANCER GRADING; CONTROLLED STUDY; GENE; GENE OVEREXPRESSION; GLIOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NRP1 GENE; PRIORITY JOURNAL; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; BRAIN NEOPLASMS; GENE EXPRESSION; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION, PATHOLOGIC; NEUROPILIN-1; NEUROPILIN-2; PROGNOSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 2442466969     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Shweiki D, Itin A, Soffer D and Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843-845, 1992.
2. Plate KH, Breier G, Weich HA and Risau W: Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359: 845-848, 1992.
3. Takano S, Yoshii Y, Kondo S, Suzuki H, Maruno T, Shirai S and Nose T: Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res 56: 2185-2190, 1996.
4. Goldman CK, Kim J, Wong WL, King V, Brock T and Gillespie GY: Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 4: 121-133, 1993.
5. Feldkamp MM, Lau N, Rak J, Kerbel RS and Guha A: Normomic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras. Int J Cancer 81: 118-124, 1999.
6. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML and Schuh AC: Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66, 1995.
7. Carmeliet P, Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W and Nagy A: Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435-439, 1996.
8. Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM and Feder J: Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84: 1470-1478, 1989.
9. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS and Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluids. Science 219: 983-985, 1983.
10. He Z and Tessier-Lavigne M: Neuropilin is a receptor for the axonal chemorepellent sematophorin III. Cell 90: 739-751, 1997.
11. Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ and Ginty DD: Neuropilin is a semapholin III receptor. Cell 90: 753-762, 1997.
12. Takagi S, Tsuji T, Amagai T, Takamatsu T and Fujisawa H: Specific cell surface labels in the visual centers of Xenopus laevis tadpole identified using monoclonal antibodies. Dev Biol 122: 90-100, 1987.
13. Soker S, Takashima S, Miao HQ, Neufeld G and Klagsbrun M: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform specific receptor for vascular endothelial growth factor. Cell 92: 735-745, 1998.
14. Kitsukawa T, Shimano A, Kawakami A, Kondoh H and Fujisawa H: Overexpression of a membrane protein, neuropilin, in chimeric mice causes anormalies in the cardiovascular system, nervous system and limbs. Development 121: 4309-4318, 1995.
15. Kawasaki T, Kitsukawa T, Bekku Y, Matsuda Y, Sanbo M, Yagi T and Fujisawa H: A requirement for neuropilin-1 in embryonic vessel formation. Development 126: 4895-4902, 1999.
16. Tokunaga T, Oshika Y, Abe Y, Ozeki Y, Sadahiro S, Kijima H, Tsuchida T, Yamazaki H, Ueyama Y, Tamaoki N and Nakamura M: Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer. Br J Cancer 77: 998-1002, 1998.
17. Oshika Y, Nakamura M, Tokunaga T, Ozeki Y, Fukushima Y, Abe Y, Yamazaki H, Kijima H, Tamaoki N and Ueyama Y: Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer. Int J Oncol 12: 541-544, 1998.
18. Lee Y, Tokunaga T, Oshika Y Suto R, Yanagisawa K, Fukuda H, Nakano H, Abe S, Tateishi A, Kijima H, Yamazaki H, Tamaoki N, Ueyama Y and Nakamura M: Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. Eur J Cancer 35: 1089-1093, 1999.
19. Tokunaga T, Nakamura M, Oshika Y, Abe Y, Ozeki Y, Fukushima Y, Hatanaka H, Sadahiro S, Kijima H, Tsuchida T, Yamazaki H, Tamaoki N and Ueyama Y: Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer. Br J Cancer 79: 354-359, 1999.
20. Kawakami T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Abe Y, Osamura Y, Inoue H, Ueyama Y and Nakamura M: Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma. Cancer 95: 2196-2201, 2002.
21. Oshika Y, Masuda K, Tokunaga T, Hatanaka H, Kamiya T, Abe Y, Ozeki Y, Kijima H, Yamazaki H, Tamaoki N, Ueyama Y and Nakamura M: Thrombospondin 2 gene expression is correlated with decreased vascularity in non-small cell lung cancer. Clin Cancer Res 4: 1785-1788, 1998.
22. Handa A, Tokunaga T, Tsuchida T, Lee YH, Kijima H, Yamazaki H, Ueyama Y, Fukuda H and Nakamura M: Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. Eur J Cancer 17: 291-295, 2000.
23. Stephenson JM, Banerjee S, Saxena NK, Cherian R and Banerjee SK: Neuropilin-1 is differentially expressed in myoepithelial cells and vascular smooth muscle cells in preneoplastic and neoplastic human breast: a possible marker for the progression of breast cancer. Int J Cancer 101: 409-414, 2002.
24. Fakhari M, Pullirsch D, Paya K, Hofbauer R, Holzfeind P, Hofmann M and Aharinejad S:.Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma. Cancer 94: 258-263, 2002.
25. Latil A, Bieche I, Pesche S, Valeri A, Fournier G, Cussenot O and Lidereau R: VEGF overexpression in clinically localized prostate tumors and neuropilin-1 overexpression in metastatic forms. Int J Cancer 89: 167-171, 2000.
26. Ding H, Wu X, Roncari L, Lau N, Shannon P, Nagy A and Guha A: Expression and regulation of neuropilin-1 in human astrocytomas. Int J Cancer 88: 584-592, 2000.