Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - A potential mechanism

European Journal of Immunology

Volumn 31, Issue 2, 2001, Pages 480-489

  Grimshaw, Matthew J ^a   Balkwill, Frances R ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Chemotaxis; Hypoxia; MAPK; MKP 1; Monocyte

Indexed keywords

ALPHA INTERFERON; CHEMOATTRACTANT; COBALT; DEFEROXAMINE; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATASE; RNA;

ARTICLE; CELL MIGRATION; CELL PH; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE ACTIVATION; GENETIC SCREENING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; INFLAMMATION; MACROPHAGE; MITOCHONDRIAL RESPIRATION; MONOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CATALASE; CELL CYCLE PROTEINS; CELL HYPOXIA; CHEMOTAXIS; DACTINOMYCIN; DEFEROXAMINE; HUMANS; IMMEDIATE-EARLY PROTEINS; INFLAMMATION; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE-PHOSPHATASE; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035101398     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200102)31:2<480::AID-IMMU480>3.0.CO;2-L     Document Type: Article

References (40)

1. Current status of knowledge and critical issues in tumor oxygenation. Results from 25 years research in tumor pathophysiology
2. Hypoxia down-regulates MCP-1 expression: Implications for macrophage distribution in tumors
3. Hypoxia inhibits macrophage migration
4. Cytokines and proteases in invasive processes: Molecular similarities between inflammation and cancer
5. Tumor stroma
6. Biological implications of macrophage infiltration in human tumor angiogenesis
7. Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes
8. Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein
9. Transactivation and inhibitory domains of hypoxia-inducible factor 1α. Modulation of transcriptional activity by oxygen tension
10. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
11. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
12. Structural and functional analysis of hypoxia-inducible factor 1
13. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
14. Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α
15. Response of tumor cells to hypoxia: Role of p53 and NFκB
16. Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-κ B and NF-IL6 in cardiac myocytes
17. Nuclear factor interleukin 6 motifs mediate tissue-specific gene transcription in hypoxia
18. Normal fibroblasts induce the C/EBP beta and ATF-4 bZIP transcription factors in response to anoxia
19. The deleterious effect of reduced pH and hypoxia on neutrophil migration in vitro
20. 2 homeostasis
21. Mammalian oxygen sensing, signaling and gene regulation
22. The influence of oxygen and carbon dioxide tension on the production of TNF-α by activated macrophages
23. Influence of hypoxia and glucose deprivation on tumor necrosis factor- alpha and granulocyte-macrophage colony-stimulating factor expression in human cultured monocytes
24. Hypoxia induces a human macrophage cell line to release tumor necrosis factor-α and its soluble receptors in vitro
25. Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
26. Hypoxia-associated induction of early growth response-1 gene expression
27. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells
28. Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. Effect of actinomycin D and antisense oligonucleotides
29. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
30. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia- inducible kinase/c-Jun N-terminal protein kinase activity
31. MCP-1-mediated chemotaxis requires activation of non-overlapping signal transduction pathways
32. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration
33. Activation of mitogen-activated protein kinase regulates eotaxin- induced eosinophil migration
34. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
35. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
36. Regulation of cell motility by mitogen-activated protein kinase
37. Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1
38. Identification of a novel mechanism for endotoxin-mediated down- modulation of CC chemokine receptor expression
39. Arbitrarily primed PCR fingerprinting of RNA