Lung MRI for experimental drug research

European Journal of Radiology

Volumn 64, Issue 3, 2007, Pages 381-396

  Beckmann, Nicolau ^a   Cannet, Catherine ^a   Karmouty Quintana, Harry ^a,b   Tigani, Bruno ^a   Zurbruegg, Stefan ^a   Blé, François Xavier ^a,c   Crémillieux, Yannick ^d   Trifilieff, Alexandre ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d UNIVERSITÉ LYON 1   (France)

Author keywords

Asthma; Chronic obstructive pulmonary disease; COPD; Drug development; Fibrosis; Lung; Magnetic resonance imaging; MRI

Indexed keywords

BIOLOGICAL ORGANS; MAGNETIC RESONANCE IMAGING; MAMMALS; PATIENT TREATMENT; PULMONARY DISEASES;

ASTHMA; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; DRUG DEVELOPMENT; FIBROSIS;

DRUG PRODUCTS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE COURSE; DRUG RESEARCH; HUMAN; LUNG EMPHYSEMA; LUNG FIBROSIS; LUNG VENTILATION; MOUSE; NERVE STIMULATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; RESPIRATORY TRACT INFLAMMATION; RODENT; SENSORY NERVE; WELLBEING;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; IMAGE ENHANCEMENT; LUNG DISEASES; MAGNETIC RESONANCE IMAGING; PNEUMONIA; PULMONARY EMPHYSEMA; PULMONARY FIBROSIS; RESPIRATORY PHYSIOLOGY;

EID: 36148983768     PISSN: 0720048X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejrad.2007.08.012     Document Type: Article

References (140)

1. In: Beckmann N (Ed). In vivo MR techniques in drug discovery and development (2006), Taylor & Francis, New York
2. Rudin M., Beckmann N., Porszasz T.D., Bochelen, and Sauter A. In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives. NMR Biomed 12 (1999) 69-97
3. Beckmann N., Mueggler T., Allegrini P.R., Laurent D., and Rudin M. From anatomy to the target: contributions of magnetic resonance imaging to preclinical pharmaceutical research. Anat Rec 265 (2001) 85-100
4. Beckmann N., Laurent D., Tigani B., Panizzutti R., and Rudin M. Magnetic resonance imaging in drug discovery: lessons from disease areas. Drug Discov Today 9 (2004) 35-42
5. Beckmann N., Tigani B., Mazzoni L., and Fozard J.R. Magnetic resonance imaging of the lung provides potential for non-invasive preclinical evaluation of drugs. Trends Pharmacol Sci 24 (2003) 550-554
6. Kroegel C., Virchow Jr. J.C., Luttmann W., Walker C., and Warner J.A. Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part I). Eur Respir J 7 4 (1994) 519-543
7. Barnes P.J. Pathophysiology of asthma. Br J Clin Pharmacol 42 (1996) 3-10
8. Moqbel R. Eosinophil-derived cytokines in allergic inflammation and asthma. Ann N Y Acad Sci 796 (1996) 209-217
9. Barnes P.J. New Treatments for COPD. Nat Rev Drug Discov 1 6 (2002) 437-446
10. Sethi S. Pathogenesis and treatment of acute exacerbations of chronic obstructive pulmonary disease. Semin Respir Crit Care Med 26 2 (2005) 192-203
11. Dawkins P.A., and Stockley R.A. Animal models of chronic obstructive pulmonary disease. Thorax 56 12 (2001) 972-977
12. Canning B.J. Modeling asthma and COPD in animals: a pointless exercise?. Curr Op Pharmacol 3 3 (2003) 244-250
13. Isenberg-Feig H., Justice J.P., and Keane-Myers A. Animal models of allergic asthma. Curr Allergy Asthma Rep 3 1 (2003) 70-78
14. Renzi P.M., Olivenstein R., and Martin J.G. Inflammatory cell populations in the airways and parenchyma after antigen challenge in the rat. Am Rev Resp Dis 147 (1993) 967-974
15. Haczku A., Macary P., Huang T.J., et al. Adoptive transfer of allergen-specific CD4+ T cells induces airway inflammation and hyperresponsiveness in brown-Norway rats. Immunology 91 2 (1997) 176-185
16. Hannon J.P., Tigani B., Williams I., Mazzoni L., and Fozard J.R. Mechanism of airway hyperresponsiveness to adenoside induced by allergen challenge in actively sensitized Brown Norway rats. Br J Pharmacol 132 7 (2001) 1509-1523
17. Watson R.W., Redmond H.P., and Bouchier-Hayes D. Role of endotoxin in mononuclear phagocyte-mediated inflammatory responses. J Leukoc Biol 56 1 (1994) 95-103
18. Yang R.B., Mark M.R., Gray A., et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395 6699 (1998) 284-288
19. Albelda S.M., Smith C.W., and Ward P.A. Adhesion molecules and inflammatory injury. FASEB J 8 (1994) 504-512
20. Tesfaigzi Y., Fischer M.J., Martin A.J., and Seagrave J. Bcl-2 in LPS- and allergen-induced hyperplastic mucous cells in airway epithelia of Brown Norway rats. Am J Physiol Lung Cell Mol Physiol 279 (2000) L1210-L1217
21. Tigani B., Schaeublin E., Sugar R., Jackson A.D., Fozard J.R., and Beckmann N. Pulmonary inflammation monitored non-invasively by MRI in freely breathing rats. Biochem Biophys Res Commun. 292 (2002) 216-221
22. Harkema J.R., and Hotchkiss J.A. In vivo effects of endotoxin on intraepithelial mucosubstances in rat pulmonary airways. Quantitative histochemistry. Am J Pathol 141 (1992) 307-317
23. Beckmann N., Tigani B., Mazzoni L., and Fozard J.R. MRI of lung parenchyma in rats and mice using a gradient-echo sequence. NMR Biomed 14 (2001) 297-306
24. Bergin C.J., Pauly J.M., and Macovski A. Lung parenchyma: projection reconstruction MR imaging. Radiology 179 (1991) 777-781
25. Gewalt S.L., Glover G.H., Hedlund L.W., Cofer G.P., MacFall J.R., and Johnson G.A. MR microscopy of the rat lung using projection reconstruction. Magn Reson Med 29 (1993) 99-106
26. Liao J.R., Pauly J.M., Brosnan T.J., and Pelc N.J. Reduction of motion artifacts in cine MRI using variable-density spiral trajectories. Magn Reson Med 37 (1997) 569-575
27. Hedlund L.W., Cofer G.P., Owen S.J., and Johnson G.A. MR-compatible ventilator for small animals: computer-controlled ventilation for proton and noble gas imaging. Magn Reson Imaging 18 (2000) 753-759
28. Karzai W., Cui X., Heinicke N., et al. Neutrophil stimulation with granulocyte colony-stimulating factor worsens ventilator-induced lung injury and mortality in rats. Anesthesiology 103 (2005) 996-1005
29. Peng X., Abdulnour R.E., Sammani S., et al. Inducible nitric oxide synthase contributes to ventilator-induced lung injury. Am J Respir Crit Care Med 172 (2005) 470-479
30. Walder B., Fontao E., Totsch M., and Morel D.R. Time and tidal volume-dependent ventilator-induced lung injury in healthy rat. Eur J Anaesthesiol 10 (2005) 785-794
31. Beckmann N., Tigani B., Ekatodramis D., Borer R., Mazzoni L., and Fozard J.R. Pulmonary edema induced by allergen challenge in the rat: noninvasive assessment by magnetic resonance imaging. Magn Reson Med 45 (2001) 88-95
32. Edelman R.R., Hatabu H., Tadamura E., Li W., and Prasad P.V. Noninvasive assessment of regional ventilation in the human lung using oxygen-enhanced magnetic resonance imaging. Nature Med 2 (1991) 1236-1239
33. Beckmann N., Cannet C., Zurbruegg S., Rudin M., and Tigani B. Proton MRI of lung parenchyma reflects allergen-induced airway remodeling and endotoxin-aroused hyporesponsiveness: a step towards ventilation studies in spontaneously breathing rats. Magn Reson Med 52 (2004) 258-268
34. Kuethe D.O., Caprihan A., Fukushima E., and Waggoner R.A. Imaging lungs using inert fluorinated gases. Magn Reson Med 39 (1998) 85-88
35. Kuethe D.O., Caprihan A., Gach H.M., Lowe I.J., and Fukushima E. Imaging obstructed ventilation with NMR using inert fluorinated gases. J Appl Physiol 88 (2000) 2279-2286
36. Kuethe D.O., Behr V.C., and Begay S. Volume of rat lungs measured throughout the respiratory cycle using 19F NMR of the inert gas SF6. Magn Reson Med 48 (2002) 547-549
37. Goodson B.M. Nuclear magnetic resonance of laser-polarized noble gases in molecules, materials, and organisms. J Magn Reson 155 (2002) 157-216
38. Möller H.E., Chen X.J., Saam B., et al. MRI of the Lungs Using Hyperpolarized Noble Gases. Magn Reson Med 47 (2002) 1029-1051
39. Albert M.S., Cates G.D., Driehuys B., et al. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature 370 (1994) 199-201
40. Middleton H., Black R.D., Saam B., et al. MR imaging with hyperpolarized 3He gas. Magn Reson Med 33 (1995) 271-275
41. 3He diffusion. Proc Natl Acad Sci USA 97 (2000) 11478-11481
42. Chen B.T., Brau A.C., and Johnson G.A. Measurement of regional lung function in rats using hyperpolarized 3helium dynamic MRI. Magn Reson Med 49 (2003) 78-88
43. Dupuich D., Berthezene Y., Clouet P.L., Stupar V., Canet E., and Cremillieux Y. Dynamic 3He imaging for quantification of regional lung ventilation parameters. Magn Reson Med 50 (2003) 777-783
44. Chen B.T., and Johnson G.A. Dynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction. Magn Reson Med 52 (2004) 1080-1086
45. Imai H., Narazaki M., Inoshita H., Kimura A., and Fujiwara H. MR imaging of mouse lung using hyperpolarized 3He: image acquisition and T1 estimation under spontaneous respiration. Magn Reson Med Sci 5 (2006) 57-64
46. Mosbah K., Cremillieux Y., Adeleine P., et al. Quantitative measurements of regional lung ventilation using helium-3 MRI in a methacholine-induced bronchoconstriction model. J Magn Reson Imaging 24 (2006) 611-616
47. Stupar V., Berthezene Y., Canet E., Tournier H., Dupuich D., and Cremillieux Y. Helium3 polarization using spin exchange technique: application to simultaneous pulmonary ventilation/perfusion imaging in small animals. Invest Radiol 38 (2003) 334-340
48. Stupar V., Canet-Soulas E., Gaillard S., Alsaid H., Beckmann N., and Cremillieux Y. Retrospective cine (3)He ventilation imaging under spontaneous breathing conditions: a non-invasive protocol for small-animal lung function imaging. NMR Biomed 20 (2007) 104-112
49. Oros A.M., and Shah N.J. Hyperpolarized xenon in NMR and MRI. Phys Med Biol 49 (2004) R105-R153
50. Narazaki M., Wakayama T., Imai H., Kimura A., and Fujiwara H. Analysis of hyperpolarized 129Xe dynamics in mouse lungs under spontaneous respiration for separate determination of lung functional parameters and relaxation time. Magn Reson Med Sci 5 (2006) 119-128
51. Driehuys D., Cofer G.P., Pollaro J., Mackel J.B., Hedlund L.W., and Johnson G.A. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci USA 103 (2006) 18278-18283
52. Hedlund L.W., Moller H.E., Chen X.J., Chawla M.S., Cofer G.P., and Johnson G.A. Mixing oxygen with hyperpolarized (3)He for small-animal lung studies. NMR Biomed 13 (2000) 202-206
53. Ramirez M.P., Sigaloff K.C., Kubatina L.V., Donahue M.A., Venkatesh A.K., and Albert M.S. Physiological response of rats to delivery of helium and xenon: implications for hyperpolarized noble gas imaging. NMR Biomed 13 (2000) 253-264
54. Chen B.T., Yordanov A.T., and Johnson G.A. Ventilation-synchronous magnetic resonance microscopy of pulmonary structure and ventilation in mice. Magn Reson Med 53 (2005) 69-75
55. Hatabu H., Gaa J., Kim D., Li W., Prasad P.V., and Edelman R.R. Pulmonary perfusion: qualitative assessment with dynamic contrast-enhanced MRI using ultra-short TE and inversion recovery Turbo FLASH. Magn Reson Med 36 (1996) 503-508
56. Mai V.M., Liu B., Polzin J.A., et al. Ventilation-perfusion ratio of signal intensity in human lung using oxygen-enhanced and arterial spin labeling techniques. Magn Reson Med 48 (2002) 341-350
57. Lipson D.A., Roberts D.A., Hansen-Flaschen J., et al. Pulmonary ventilation and perfusion scanning using hyperpolarized helium-3 MRI and arterial spin tagging in healthy normal subjects and in pulmonary embolism and orthotopic lung transplant patients. Magn Reson Med 47 (2002) 1073-1076
58. Berthezène Y., Vexler V., Clement O., Muhler A., Moseley M.E., and Brasch R.C. Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion. Radiology 183 (1992) 667-672
59. 3He ventilation NMR study in rat lungs. Magn Reson Med 47 (1999) 645-648
60. Viallon M., Berthezene Y., Decorps M., et al. Laser-polarized 3He as a probe for dynamic regional measurements of lung perfusion and ventilation using magnetic resonance imaging. Magn Reson Med 44 (2000) 1-4
61. Callot V., Canet E., Brochot J., et al. MR perfusion imaging using encapsulated laser-polarized 3He. Magn Reson Med 46 (2001) 535-540
62. Callot V., Canet E., Brochot J., et al. Hyperpolarized helium3 encapsulated in microbubbles: a new class of blood pool MRI contrast agent. Acad Radiol 9 (2002) S501-S503
63. Wilkinson M.H., Berger P.J., Blanch N., and Brodecky V. Effect of venous oxygenation on arterial desaturation rate during repetitive apneas in lambs. Respir Physiol 101 (1995) 321-331
64. West J.B. Respiratory physiology: the essentials. 6th ed. (1999), Lippincott Williams & Wilkins, Baltimore
65. 2. Phys Rev A 52 (1995) 862-865
66. Deninger A.J., Eberle B., Ebert M., et al. Quantification of regional intrapulmonary oxygen partial pressure evolution during apnea by 3He MRI. J Magn Reson 141 (1999) 207-216
67. Wild J.M., Fischele S., Woodhouse N., Paley M.N.J., Kasuboski L., and van Beek E.J.R. 3D volume-localized pO2 measurement in the human lung with 3He MRI. Magn Reson Med 53 (2005) 1055-1064
68. Deninger A.J., Eberle B., Bermuth J., et al. Assessment of a single-acquisition imaging sequence for oxygen-sensitive 3He. Magn Reson Med 47 (2002) 105-114
69. Fischer M.C., Spector Z.Z., Ishii M., et al. Single-acquisition sequence for the measurement of oxygen partial pressure by hyperpolarized gas MRI. Magn Reson Med 52 (2004) 766-773
70. Jalali A., Ishii M., Edvinsson J.M., et al. Detection of simulated pulmonary embolism in a porcine model using hyperpolarized 3He MRI. Magn Reson Med 51 (2004) 291-298
71. Yu J., Fischer M.C., Ishii M., et al. Measurements of regional alveolar oxygen pressure and oxygen depletion rate by hyperpolarized 3He MRI in small animals. Proceedings of the 13th Annual Meeting of ISMRM. Miami Beach, FL, USA (2005) (Abstract 1830)
72. Möller H.E., Hedlund L.W., Chen X.J., et al. Measurements of hyperpolarized gas properties in the lung. Part III: 3He T1. Magn Reson Med 45 (2001) 421-430
73. Cieślar K., Stupar V., Canet-Soulas E., Gaillard S., and Crémillieux Y. Alveolar oxygen partial pressure and oxygen depletion rate mapping in rats using 3He ventilation imaging. Magn Reson Med 57 (2007) 423-430
74. Cieślar K., Alsaid H., Stupar V., et al. Measurement of nonlinear pO2 decay in mouse lungs using 3He-MRI. NMR Biomed 20 (2007) 383-391
75. Tigani B., Cannet C., and Zurbruegg S. Resolution of the oedema associated with allergic pulmonary inflammation in rats. Br J Pharmacol 140 (2003) 239-246
76. Tigani B., Cannet C., Quintana H.K., et al. Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI. Am J Physiol Lung Cell Mol Physiol 292 (2007) L644-L653
77. Beckmann N., Tigani B., Sugar R., et al. Non-invasive detection of endotoxin induced mucus hypersecretion in rat lung by magnetic resonance imaging. Am J Physiol Lung Cell Mol Physiol 283 (2002) L22-L30
78. Saam B.T., Yablonskiy D.A., Kodibagkar V.D., et al. MR imaging of diffusion of (3)He gas in healthy and diseased lungs. Magn Reson Med 44 (2000) 174-179
79. Salerno M., de Lange E.E., Altes T.A., Truwit J.D., Brookeman J.R., and Mugler III J.P. Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes-initial experience. Radiology 222 (2002) 252-260
80. Salerno M., Altes T.A., Brookeman J.R., de Lange E.E., and Mugler III J.P. Rapid hyperpolarized 3He diffusion MRI of healthy and emphysematous human lungs using an optimized interleaved-spiral pulse sequence. J Magn Reson Imaging 7 (2003) 1-588
81. Busch R.H., Lauhala K.E., Loscutoff S.M., and McDonald K.E. Experimental pulmonary emphysema induced in the rat by intratracheally administered elastase: morphogenesis. Environ Res 3 (1984) 97-513
82. Peces-Barba G., Ruiz-Cabello J., Cremillieux Y., et al. Helium-3 MRI diffusion coefficient: correlation to morphometry in a model of mild emphysema. Eur Respir J 2 (2003) 4-19
83. Dugas J.P., Garbow J.R., Kobayashi D.K., and Conradi M.S. Hyperpolarized (3)He MRI of mouse lung. Magn Reson Med 2 (2004) 310-1317
84. Quintana HK, Cannet C, Zurbruegg S, et al. Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats. Magn Reson Med 2006;56:1242-50.
85. Shapiro S.D. Animal models for COPD. Chest 117 (2000) 223S-227S
86. Belloni P.N., Garvin L., Mao C.P., Bailey-Healy I., and Leaffer D. Effects of all-trans-retinoic acid in promoting alveolar repair. Chest 117 (2000) 235S-241S
87. Heverhagen J.T., Hahn H.K., Wegmann M., et al. Volumetric analysis of mice lungs in a clinical magnetic resonance imaging scanner. MAGMA 17 (2004) 80-85
88. Lundblad K.A.L., Irvin C.G., Adler A., and Bates J.H.T. A reevaluation of the validity of unrestrained plethysmography in mice. J Appl Physiol 93 (2002) 1198-1207
89. Bates J.H., and Irvin C.G. Measuring lung function in mice: the phenotyping uncertainty principle. J Appl Physiol 94 (2003) 1297-1306
90. Beckmann N., Crémillieux Y., Tigani B., Quintana H.K., Blé F.X., and Fozard J.R. Lung MRI in small rodents as a tool for the evaluation of drugs in models of airways diseases. In: Beckmann N. (Ed). In vivo MR techniques in drug discovery and development (2006), Taylor & Francis, New York 351-372
91. Ebina M., Takahashi T., Chiba T., and Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study. Am Rev Respir Dis 148 (1993) 720-726
92. Martin J.G., Duguet A., and Eidelman D.H. The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease. Eur Respir J 16 (2000) 349-354
93. Halayko A.J., and Amrani Y. Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma. Respir Physiol Neurobiol 137 (2003) 209-222
94. Pauwels R.A., Kips J.C., Peleman R.A., and van der Straeten M.E. The effect of endotoxin inhalation on airway responsiveness and cellular influx in rats. Am Rev Respir Dis 141 (1990) 540-545
95. Kips J.C., Lefebvre R.A., Peleman R.A., Joos G.F., and Pauwels R.A. The effect of a nitric oxide synthase inhibitor on the modulation of airway responsiveness in rats. Am J Respir Crit Care Med 151 (1995) 1165-1169
96. Kobzik L., Bredt D.S., Lowenstein C.J., et al. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 9 (1993) 371-377
97. Ca channel in airway smooth muscle by nitric oxide: Involvement of a nitrothiosylation mechanism?. Am J Respir Cell Mol Biol 19 (1998) 485-497
98. Lazenby A.J., Crouch E.C., McDonald J.A., and Kuhn III C. Remodeling of the lung in bleomycin-induced pulmonary fibrosis in the rat. An immunohistochemical study of laminin, type IV collagen, and fibronectin. Am Rev Respir Dis 142 (1990) 206-214
99. Katzenstein A.L., and Myers J.L. Idiopathic pulmonary fibrosis. Clinical relevance of pathological classification. Am J Respir Crit Care Med 157 (1998) 1301-1315
100. Gross T.J., and Hunninghake G.W. Idiopathic pulmonary fibrosis. N Engl J Med 345 (2001) 517-525
101. Brewster C.E., Howarth P.H., Djukanovic R., Wilson J., Holgate S.T., and Roche W.R. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 3 (1990) 507-511
102. Roche W.R., Beasley R., Williams J.H., and Holgate S.T. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1 (1989) 520-524
103. Holgate S.T., Davies D.E., Lackie P.M., Wilson S.J., Puddicombe S.M., and Lordan J.L. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol 105 (2000) 193-204
104. Jeffery P.K. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 164 (2001) S28-S38
105. International consensus statement 2000. Idiopathic pulmonary fibrosis: diagnosis and treatment, Am J Respir Crit Care Med 161;2000:646-64.
106. Ueda Y., Saito A., Fukuoka Y., et al. Interactions of beta-lactam antibiotics and antineoplastic agents. Antimicrob Agents Chemother 23 (1983) 374-378
107. Snider G.L., Hayes J.A., and Korthy A.L. Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin: pathology and stereology. Am Rev Respir Dis 117 (1978) 1099-1108
108. Hay J., Shahzeidi S., and Laurent G. Mechanisms of bleomycin-induced lung damage. Arch Toxicol 65 (1991) 81-94
109. Aso Y., Yoneda K., and Kikkawa Y. Morphologic and biochemical study of pulmonary changes induced by bleomycin in mice. Labor Invest 35 (1976) 558-568
110. Izbicki G., Segel M.J., Christensen T.G., Conner M.W., and Breuer R. Time course of bleomycin-induced lung fibrosis. Int J Exp Pathol 83 (2002) 111-211
111. Karmouty-Quintana H, Cannet C, Zurbruegg S, et al. Bleomycin-induced lung injury assessed non-invasively in spontaneously breathing rats by proton MRI, J Magn Reson Imaging, in press.
112. Chaudhary N.I., Schnapp A., and Park J.E. Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model. Am J Respir Crit Care Med 173 (2006) 769-776
113. Tani K., Yasuoka S., Ogushi F., et al. Thrombin enhances lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 5 (1991) 34-40
114. Walsh J., Absher M., and Kelley J. Variable expression of platelet-derived growth factor family proteins in acute lung injury. Am J Respir Cell Mol Biol 9 (1993) 637-644
115. Rogers D.F. Airway mucus hypersecretion in asthma: an undervalued pathology?. Curr Opin Pharmacol 4 (2004) 241-250
116. Rogers D.F. Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options. Pulm Pharmacol Ther 18 (2005) 1-8
117. Vestbo J., Prescott E., Lange P., and Copenhagen City Heart Study Group. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Am J Respir Crit Care Med 153 (1996) 1530-1535
118. Melton L. Does mucus hypersecretion matter in airway disease?. Lancet 359 (2002) 1924
119. Rogers D.F. Neurogenic inflammation in lung disease: burn out?. Inflammopharmacol 5 (1997) 319-329
120. Joos G.F., De Swert K.O., Schelfhout V., and Pauwels R.A. The role of neural inflammation in asthma and chronic obstructive pulmonary disease. Ann N Y Acad Sci 992 (2003) 218-230
121. Patacchini R., and Maggi C.A. Tachykinin receptors and receptor subtypes. Arch Int Pharmacodyn Ther 329 (1995) 161-184
122. Mapp C.E., Miotto D., Braccioni F., et al. The distribution of neurokinin-1 and neurokinin-2 receptors in human central airways. Am J Respir Crit Care Med 161 (2000) 207-215
123. Germonpre P.R., Joos G.F., Everaert E., Kips J.C., and Pauwels R.A. Characterization of neurogenic inflammation in the airways of two highly inbred rat strains. Am J Respir Crit Care Med 152 (1995) 1796-1804
124. Rogers D.F. Motor control of airway goblet cells and glands. Resp Physiol 125 (2001) 129-144
125. Reynolds P.N., Holmes M.D., and Scicchitano R. Role of tachykinins in bronchial hyper-responsiveness. Clin Exp Pharmacol Physiol 24 (1997) 273-280
126. Karmouty-Quintana H.K., Cannet C., Sugar R., Fozard J.R., Page C.P., and Beckmann N. Capsaicin-induced mucus secretion in the airways evidenced in vivo and non-invasively by magnetic resonance imaging (MRI). Br J Pharmacol 150 (2007) 1022-1030
127. Barnes B.J. New drugs for asthma. Nat Rev Drug Discov 3 (2004) 831-844
128. Trifilieff A., Wyss D., Walker C., Mazzoni L., and Hersperger R. Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative, with anti-inflammatory activities. J Pharmacol Exp Ther 301 (2002) 241-248
129. Tigani B., Di Padova F., Zurbruegg S., et al. Effects of a mitogen-activated protein kinase inhibitor on allergic airways inflammation in the rat studied by magnetic resonance imaging. Eur J Pharmacol 482 (2003) 319-324
130. Massaro G.D., and Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med 3 (1997) 675-677
131. Massaro D., and Massaro G.D. Retinoids, alveolus formation, and alveolar deficiency: clinical implications. Am J Respir Cell Mol Biol 28 (2003) 271-274
132. Fujita M., Ye Q., Ouchi H., et al. Retinoic acid fails to reverse emphysema in adult mouse models. Thorax 59 (2004) 224-230
133. March T.H., Cossey P.Y., Esparza D.C., Dix K.J., McDonald J.D., and Bowen L.E. Inhalation administration of all-trans-retinoic acid for treatment of elastase-induced pulmonary emphysema in Fischer 344 rats. Exp Lung Res 30 (2004) 383-404
134. Nishi Y., Boswell V., Ansari T., Piprawala F., Satchi S., and Page C.P. Elastase-induced changes in lung function: relationship to morphometry and effect of drugs. Pulm Pharmacol Ther 16 (2003) 221-229
135. Mao J.T., Goldin J.G., Dermand J., et al. A pilot study of all-trans-retinoic acid for the treatment of human emphysema. Am J Respir Crit Care Med 165 (2002) 718-723
136. Olsson L.E., Lindahl M., Onnervik P.O., et al. Measurement of MR signal and T2* in lung to characterize a tight skin mouse model of emphysema using single-point imaging. J Magn Reson Imaging 25 (2007) 488-494
137. Schuster D.P., Kovacs A., Garbow J., and Piwnica-Worms D. Recent advances in imaging the lungs of intact small animals. Am J Respir Cell Mol Biol 30 (2004) 129-138
138. Driehuys B., and Hedlund L.W. Imaging techniques for small animal models of pulmonary disease: MR microscopy. Toxicol Pathol 35 (2007) 49-58
139. Beckmann N., Kneuer R., Gremlich H.U., Karmouty-Quintana H., Ble F.X., and Muller M. In vivo mouse imaging and spectroscopy in drug discovery. NMR Biomed 20 (2007) 154-185
140. Griese M., Essl R., Schmidt R., et al., BEAT Study Group. Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Am J Respir Crit Care Med 170 (2004) 1000-1005