Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats

Magnetic Resonance in Medicine

Volumn 56, Issue 6, 2006, Pages 1242-1250

  Quintana, Harry Karmouty ^a,b   Cannet, Catherine ^a   Zurbruegg, Stefan ^a   Blé, François Xavier ^a,c   Fozard, John R ^a   Page, Clive P ^b   Beckmann, Nicolau ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Air trapping; Chronic obstructive pulmonary disease (COPD); Elastase; Emphysema; Lung MRI

Indexed keywords

ANTHROPOMETRY; AUTOMOBILE BODIES; PULMONARY DISEASES; RATS; SIGNAL SYSTEMS;

AIR TRAPPING; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; ELASTASE; EMPHYSEMA; LUNG MRIS;

BIOLOGICAL ORGANS;

DRUG VEHICLE; PANCREATIC ELASTASE; RETINOIC ACID; SODIUM CHLORIDE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING; CELL INFILTRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; EDEMA; ENZYME ANALYSIS; ENZYME INDUCTION; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE QUALITY; LUNG EMPHYSEMA; LUNG FUNCTION TEST; LUNG INJURY; LUNG PARENCHYMA; LUNG VOLUME; MALE; NON INVASIVE MEASUREMENT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RAT STRAIN; SIGNAL DETECTION;

EID: 33845244617     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21051     Document Type: Article

References (40)

1. Barnes PJ. Mechanisms in COPD: differences from asthma. Chest 2000;117:10S-14S.
2. Barnes PJ. New treatments for COPD. Nat Rev Drug Disc 2002;1:437-446.
3. Sharp JT, Hammond MD. Pressure volume relationships. In: Crystal RG, West JB, Barnes PJ, Cherniack NS, Weibel ER, editors. The lung: scientific foundations. New York: Raven Press Ltd.: 1991, p 839-854.
4. Chooi WK, Morcos SK. High resolution volume imaging of airways and lung parenchyma with multislice CT. Br J Radiol 2004;77(spec no 1):S98-S105.
5. Kauczor HU. Hyperpolarized helium-3 gas magnetic resonance imaging of the lung. Top Magn Reson Imaging 2003;14:223-230.
6. Busch RH, Lauhala KE, Loscutoff SM, McDonald KE. Experimental pulmonary emphysema induced in the rat by intratracheally administered elastase: morphogenesis. Environ Res 1984;33:497-513.
7. Eidelman DH, Bellofiore S, Chiche D, Cosio MG, Martin JG. Behavior of morphometric indices in pancreatic elastase-induced emphysema in rats. Lung 1990;168:159-169.
8. Chen XJ, Hedlund LW, Moeller HE, Chawla MS, Maronpot RR, Johnson GA. Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. Proc Natl Acad Sci USA 2000;97:11478-11481.
9. Edelman RR, Hatabu H, Tadamura E, Li W, Prasad PV. Noninvasive assessment of regional ventilation in the human lung using oxygen-enhanced magnetic resonance imaging. Nat Med 1996;2:1236-1239.
10. Beckmann N, Cannet C, Zurbruegg S, Rudin M, Tigani B. Proton MRI of lung parenchyma reflects allergen-induced airway remodelling and endotoxin-aroused hyperresponsiveness: a step toward ventilation studies in spontaneously breathing rats. Magn Reson Med 2004;52:258-268.
11. Massaro GD, Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med 1997;3:675-677.
12. Massaro D, Massaro GD. Retinoids, alveolus formation, and alveolar deficiency: clinical implications. Am J Respir Cell Mol Biol 2003;28:271-274.
13. Beckmann N, Tigani B, Ekatodiamis D, Borer R, Mazzoni L, Fozard JR. Pulmonary edema induced by allergen challenge in the rat: noninvasive assessment by magnetic resonance imaging. Magn Reson Med 2001;45:88-95.
14. Beckmann N, Tigani B, Mazzoni L, Fozard JR. MRI of lung parenchyma in rats and mice using a gradient-echo sequence. NMR Biomed 2001;14:297-306.
15. Beckmann N, Tigani B, Sugar R, Jackson AD, Jones G, Mazzoni L, Fozard JR. Noninvasive detection of endotoxin-induced mucus hypersecretion in rat lung by MRI. Am J Physiol Lung Cell Mol Physiol 2002;283:L22-L30.
16. Walder B, Fontao E, Totsch M, Morel DR. Time and tidal volume-dependent ventilator-induced lung injury in healthy rats. Eur J Anaesthesiol 2005;10:785-794.
17. Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004;114:1248-1259.
18. Elias H, Hyde DM. An elementary introduction to stereology (quantitative microscopy). Am J Anat 1980;159:411-446.
19. O'Byrne PM, Postma DS. The many faces of airway inflammation. Am J Respir Crit Care Med 1999;159:S41-S63.
20. Kawabata K, Hagio T, Matsuoka S. The role of neutrophil elastase in acute lung injury. Eur J Pharmacol 2002;451:1-10.
21. Negrini D, Passi A, De Luca G, Miserocchi G. Proteoglycan involvement during development of lesional pulmonary edema. Am J Physiol Lung Cell Mol Physiol 1998;274:L203-L211.
22. Houtz PK, Jones PD, Aronson NE, Richardson LM, Lai-Fook SJ. Effect of pancreatic and leukocyte elastase on hydraulic conductivity in lung interstitial segments. J Appl Physiol 2004;97:2139-2147.
23. Yuan H, Kononov S, Cavalcante FS, Lutchen KR, Ingenito EP, Suki B. Effects of collagenase and elastase on the mechanical properties of lung tissue strips. J Appl Physiol 2000;89:3-14.
24. Lucey EC, Stone PJ, Snider GL. Consequences of proteolytic injury. In: Crystal RG, West JB, Barnes PJ, Cherniack NS, Weibel ER, editors. The lung: scientific foundations. New York: Raven Press Ltd.; 1991. p 1789-1801.
25. Shapiro SD. Animal models for COPD. Chest 2000;117:223S-227S.
26. Belloni PN, Garvin L, Mao CP, Bailey-Healy I, Leaffer D. Effects of all-trans-retinoic acid in promoting alveolar repair. Chest 2000;117:235S-241S.
27. Nishi Y, Boswell V, Ansari T, Piprawala F, Satchi S, Page CP. Elastase-induced changes in lung function: relationship to morphometry and effect of drugs. Pulm Pharmacol Ther 2003;16:221-229.
28. Morris AH, Blatter DD, Case TA, Cutillo AG, Ailion DC, Durney CH, Johnson SA. A new nuclear magnetic resonance property of lung. J Appl Physiol 1985;58:759-762.
29. Case TA, Durney CH, Ailion DC, Cutillo AG, Morris AH. A mathematical model of diamagnetic line broadening in lung tissue and similar heterogeneous systems: calculations and measurements. J Magn Reson 1997;73:304-314.
30. March TH, Cossey PY, Esparza DC, Dix KJ, McDonald JD, Bowen LE. Inhalation administration of all-trans-retinoic acid for treatment of elastase-induced pulmonary emphysema in Fischer 344 rats. Exp Lung Res 2004;30:383-404.
31. Fujita M, Ye Q, Ouchi H, Nakashima N, Hamada N, Hagimoto N, Kuwano K, Mason RJ, Nakanishi Y. Retinoic acid fails to reverse emphysema in adult mouse models. Thorax 2004;59:224-230.
32. Mao JT, Goldin JG, Dermand J, Ibrahim G, Brown MS, Emerick A, McNitt-Gray MF, Gjertson DW, Estrada F, Tashkin DP, Roth MD. A pilot study of all-trans-retinoic acid for the treatment of human emphysema. Am J Respir Crit Care Med 2002;165:718-723.
33. Massaro GD, Massaro D. Related Retinoic acid treatment partially rescues failed septation in rats and in mice. Am J Physiol Lung Cell Mol Physiol 2000;278:L955-L960.
34. Peces-Barba G, Ruiz-Cabello J, Cremillieux Y, Rodriguez I, Dupuich D, Callot V, Ortega M, Rubio Arbo ML, Cortijo M, Gonzalez-Mangado N. Helium-3 MRI diffusion coefficient: correlation to morphometry in a model of mild emphysema. Eur Respir J 2003;22:14-19.
35. Dugas JP, Garbow JR, Kobayashi DK, Conradi MS. Hyperpolarized (3)He MRI of mouse lung. Magn Reson Med 2004;52:1307-1310.
36. Chen XJ, Chawla MS, Hedlund LW, Moller HE, MacFall JR, Johnson GA. MR microscopy of lung airways with hyperpolarized 3He. Magn Reson Med 1998;39:79-84.
37. Heverhagen JT, Hahn HK, Wegmann M, Herz U, Shaffer Whitaker CD, Matschl V, Alfke H. Volumetric analysis of mice lungs in a clinical magnetic resonance imaging scanner. MAGMA 2004;17:80-85.
38. Perez-Sanchez JM, Perez de Alejo R, Rodriguez I, Cortijo M, Peces-Barba G, Ruiz-Cabello J. In vivo diffusion weighted 19F MRI using SF6. Magn Reson Med 2005;54:460-463.
39. Petrache I, Natarajan V, Zhen L, Medler TR, Richter AT, Cho C, Hubbard WC, Berdyshev EV, Tuder RM. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med 2005;5:491-498.
40. Beckmann N, Tigani B, Mazzoni L, Fozard JR. Magnetic resonance imaging of the lung provides potential for noninvasive preclinical evaluation of drugs. Trends Pharmacol Sci 2003;24:550-554.