Imaging obstructed ventilation with NMR using inert fluorinated gases

Journal of Applied Physiology

Volumn 88, Issue 6, 2000, Pages 2279-2286

  Kuethe, Dean O ^a,e   Caprihan, Arvind ^b   Gach, H Michael ^c,d   Lowe, Irving J ^c   Fukushima, Eiichi ^b  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b New Mexico Resonance   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e NMR   (United States)

Author keywords

Lung; Magnetic resonance imaging; Nuclear magnetic resonance; Perfusion; Probability density function; Quotient; Sulfur hexafluoride

Indexed keywords

FLUORINE; INERT GAS; SULFUR HEXAFLUORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS OBSTRUCTION; IMAGE ANALYSIS; LUNG PERFUSION; LUNG VENTILATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SIGNAL NOISE RATIO;

EID: 0033923180     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.6.2279     Document Type: Article

References (52)

1. Ailion DC. Introduction to magnetic resonance imaging techniques used in lung. In: Application of Magnetic Resonance to the Study of Lung. edited by Cutillo AG. Armonk, NY: Futura, 1996, p. 33-48.
2. Ailion DC. Lung and mediastinum: a discussion of the relevant physics. In: Encyclopedia of Nuclear Magnetic Resonance, edited by Grant DM and Williams RK. New York: Wiley, 1996, vol. 5, p. 2867-2873.
3. 129Xe. Nature 370: 199-201, 1994.
4. 3He. Magn Reson Med 36: 192-196, 1996.
5. Barbara JA, Riverola A, Roca J, Ramirez J, Wagner PD, Ros D, Wiggs BR, and Rodriguez-Roisin R. Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive pulmonary disease. Am J Respir Crit Care Med 149: 423-429, 1994.
6. Bergin CJ, Hauschildt J, Rios G, Belezzuoli EV, Huynh T, and Channick RN. Accuracy of MR angiography compared with radionuclide scanning in identifying the cause of pulmonary arterial hypertension. Am J Roentgenol Radium Ther 168: 1549-1555, 1997.
7. Bergin CJ, Pauly JM, and Macovski A. Lung parenchyma: projection reconstruction MR imaging. Radiology 179: 777-781, 1991.
8. 2 gas pressure differences due to ventilation-perfusion variations. J Appl Physiol 10: 165-172, 1957.
9. 3He NMR lineshape measurements in the live guinea pig lung. Magn Reson Med 40: 61-65, 1998.
10. Durney CH, Ailion DC, and Cutillo AG. Susceptibility effects (tissue-induced inhomogeneous broadening) in lung magnetic resonance imaging. In: Application of Magnetic Resonance to the Study of Lung, edited by Cutillo AG. Armonk, NY: Futura, 1996, p. 141-176.
11. Edelstein WA, Glover GH, Hardy CJ, and Redington RW. The intrinsic signal-to-noise ratio in NMR imaging. Magn Reson Med 3: 604-618, 1986.
12. Farhi LE. Elimination of inert gas by the lung. Respir Physiol 3: 1-11, 1967.
13. Farhi LE and Olszowka AJ. Analysis of alveolar gas exchange in the presence of soluble inert gases. Respir Physiol 5: 53-67, 1968.
14. Fenn WO, Rahn H, and Otis AB. A theoretical study of the composition of alveolar air at altitude. Am J Physiol 146: 637-653, 1946.
15. Ferrer A, Roca J, Wagner PD, Lopez FA, and RodriguezRoisin R. Airway obstruction and ventilation-perfusion relationships in acute severe asthma. Am Rev Respir Dis 147: 579-584, 1993.
16. 4. J Chem Phys 67: 4004-4011, 1977.
17. Ganesan K, Ailion DC, Hackmann A, Laicher G, Chan PH, and Cutillo AG. NMR relaxation and water self-diffusion mechanisms in lung. In: Application of Magnetic Resonance to the Study of Lung, edited by Cutillo AG. Armonk, NY: Futura, 1996, p. 115-140.
18. Gao J-H, Lernen L, Xiong J, Patyal B, and Fox PT. Magnetization and diffusion effects in NMR imaging of hyperpolarized substances. Magn Reson Med 37: 153-158, 1997.
19. Gefter WB, Hatabu H, Holland GA, Gupta KB, Henschke CI, and Palevsky HI. Pulmonary thromboembolism: recent diagnosis with CT and MR imaging. Radiology 197: 561-574, 1995.
20. Gluck EH, Onorato DJ, and Castriotta R. Helium-oxygen mixtures in intubated patients with status asthmaticus and respiratory acidosis. Chest 98: 693-698, 1990.
21. Gradshteyn IS and Ryzhik IM. Table of Integrals, Series, and Products, edited by Jeffrey A. New York: Academic, 1965, p. 338, formula 3.462.5.
22. Hatabu H and Gefter WB. MR imaging of the pulmonary vasculature: basic concepts and clinical applications. In: Application of Magnetic Resonance to the Study of Lung, edited by Cutillo AG. Armonk, NY: Futura, 1996, p. 287-322.
23. Hlastala MP. Multiple inert gas elimination technique. J Appl Physiol 56: 1-7, 1984.
24. Hlastala MP and Domino KB. Roles of hypoxia and blood flow in modulating V̇A/Q̇ heterogeneity in the lungs. Adv Exp Med Biol 345: 67-73, 1994.
25. Hlastala MP and Robertson HT. Inert gas elimination characteristics of the normal and abnormal lung. J Appl Physiol 44: 258-266, 1978.
26. Johnson GA, Cates G, Chen XJ, Cofer GP, Driehuys B, Happer W, Hedlund LW, Saam B, Shattuck MD, and Swartz J. Dynamics of magnetization in hyperpolarized gas MRI of the lung. Magn Reson Med 38: 66-71, 1997.
27. Kamerud DB. The random variable X/Y, X, Y, normal. Am Math Monthly 85: 206-207, 1978.
28. Kass JE and Castriotta RJ. Helium therapy in acute severe asthma. Chest 107: 757-760, 1995.
29. Kauczor HU. Contrast-enhanced magnetic resonance angiography of the pulmonary vasculature: a review. Invest Radial 33: 606-617, 1998.
30. 3He MRI: preliminary clinical experience in 18 patients with and without lung disease. J Magn Reson Imaging 7: 538-543, 1997.
31. Kuethe DO, Caprihan A, Fukushima E, and Waggoner RA. Imaging lungs using inert fluorinated gases. Magn Reson Med 39: 85-88, 1998.
32. Kuethe DO, Caprihan A, Lowe IJ, Madio DP, and Gach HM. Transforming NMR data despite missing points. J Magn Reson 139: 18-25, 1999.
33. Lizak MJ, Conradi MS, and Fry CG. NMR imaging of gas imbibed into porous ceramic. J Magn Reson 95: 548-557, 1991.
34. 3He gas. Magn Reson Med 33: 271-275, 1995.
35. 6. J Chem Phys 53: 461-462, 1970.
36. Moller HE, Chen XJ, Chawla MS, Driehuys B, Hedlund LW, and Johnson GA. Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases. J Magn Reson 135: 133-143, 1998.
37. 6 in the critical temperature region. JETPLett 15: 103-105, 1972.
38. Rinck PA, Petersen SB, and Lauterbur PC. NMR imaging of fluorine-containing substances. 19-Fluorine ventilation and perfusion studies. ROFO Fortschr Geb Rontgenstr Nuklearmed 140: 239-243, 1984.
39. 2. Physiol Rev 52: 862-865, 1995.
40. Schmidt-Nielsen K. Scaling: Why Is Animal Size So Important? Cambridge, UK: Cambridge Univ. Press, 1984, p. 241.
41. Severinghaus JW. Blood gas calculator. J Appl Physiol 21: 1108-1116, 1966.
42. 2 of normal lung. Magn Reson Med 16: 49-56, 1990.
43. Shiue S-T and Gluck EH. The use of helium-oxygen mixtures in the support of patients with status asthmaticus and respiratory acidosis. JAsthma 26: 177-180, 1989.
44. Swensen ER, Robertson HT, and Hlastala MP. Effects of inspired carbon dioxide on ventilation-perfusion matching in normoxia, hypoxia, and hyperoxia. Am J Respir Crit Care Med 149: 1563-1569, 1994.
45. Swidwa DM, Montenegro HD, Goldman MD, Lutchen KR, and Saidel GM. Helium-oxygen breathing in severe chronic obstructive pulmonary disease. Chest 87: 790-795, 1985.
46. Voelkel NF. Mechanisms of hypoxic pulmonary vasoconstriction. Am Rev Respir Dis 133: 1186-1195, 1986.
47. 2. J Clin Invest 54: 54-68, 1974.
48. Wagner PD, Salzman HA, and West JF. Measurement of continuous distribution of ventilation-perfusion ratios. J Appl Physiol 36: 588-599, 1974.
49. West JB. Ventilation-perfusion relationships. Am Rev Respir Dis 116: 919-943, 1977.
50. Wielopolski PA, Haacke EM, and Adler LP. Three-dimensional MR imaging of the pulmonary vasculature: preliminary experience. Radiology 183: 465-472, 1992.
51. Wielopolski PA, Haacke EM, and Adler LP. Three-dimensional MR imaging of the pulmonary vascular system. In: Application of Magnetic Resonance to the Study of Lung, edited by CutilloAG. Armonk, NY: Futura, 1996, p. 323-386.
52. 4 with inert gases. J Chem Phys 67: 4012-4018, 1977.