Time course of bleomycin-induced lung fibrosis

International Journal of Experimental Pathology

Volumn 83, Issue 3, 2002, Pages 111-119

  Izbicki, G ^a   Segel, M J ^b   Christensen, T G ^b   Conner, M W ^b   Breuer, Raphael ^b  

^a HEBREW UNIVERSITY   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Bleomycin; Computer assisted morphometry; Fibrosis; Interstitial lung disease; Lung; Mice

Indexed keywords

BLEOMYCIN; HYDROXYPROLINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; COMPUTER PROGRAM; CONTROLLED STUDY; IMAGE ANALYSIS; LUNG ALVEOLUS WALL; LUNG FIBROSIS; LUNG LAVAGE; LUNG PARENCHYMA; LYMPHOCYTE; MALE; MEASUREMENT; MICROSCOPY; MORPHOMETRICS; MORTALITY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; HYDROXYPROLINE; IMAGE PROCESSING, COMPUTER-ASSISTED; INSTILLATION, DRUG; LUNG; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; PULMONARY FIBROSIS; TIME FACTORS;

EID: 0036408364     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.2002.00220.x     Document Type: Article

References (45)

1. Berkman N., Kremer S., Or R. et al. (2001) Human recombinant interferon-α2a and interferon-αA/D have different effects on bleomycin-induced lung injury. Respiration 68, 169-177
2. Brentjens J.R., O'Connell D.W., Pawlowski I.B., Hsu K.C. & Andres G.A. (1974) Experimental immune complex disease of the lung. The pathogenesis of a laboratory model resembling certain human interstitial lung diseases. J. Exp. Ned. 140, 105-125.
3. Chandler D.B., Hyde D.M. & Giri S.N. (1983) Morphometric estimates of infiltrative cellular changes during the development of bleomycin-induced pulmonary fibrosis in hamsters. Am. J. Pathol. 112, 170-177.
4. Coalson J.J. (1982) The ultrastructure of human fibrosing alveolitis. Virchows Arch. A. Pathol. Anat. Histol. 395, 181-199.
5. Dall'Aglio P.P., Pesci A., Bertorelli G., Brianti E. & Scarpa S. (1988) Study of immune complexes in bronchoalveolar lavage fluids. Respiration 54 (Suppl.), 136-141.
6. Dobashi N., Fujita J., Murota M. et al. (2000a) Elevation of anti-cytokeratin 18 antibody and circulating cytokeratin 18: Anti-cytokeratin 18 antibody immune complexes in sera of patients with idiopathic pulmonary fibrosis. Lung 178, 171-179.
7. Dobashi N., Fujita J., Ohtsuki Y. et al. (2000b) Circulating cytokeratin 8: Anti-cytokeratin 8 antibody immune complexes in sera of patients with pulmonary fibrosis. Respiration 67, 397-401.
8. Eisenberg H., Simmons D.H. & Barnett E.V. (1979) Diffuse pulmonary interstitial disease: An immunohistologic study. Chest 75 (Suppl.), 262-264.
9. Ekimoto H., Aikawa M., Ohnuki T. et al. (1985) Immunological involvement in pulmonary fibrosis induced by peplomycin. J. Antibiot. 38, 94-98.
10. Endo Y., Matsushita H., Matsuya S. & Hara M. (1990) A study of human interstitial lung diseases with special reference to immune complexes and hyaline membrane. Acta Pathol. Jpn. 40, 239-248.
11. Fleischman R.W., Baber J.R., Thompson G.R. Et al. (1971) Bleomycin induced interstitial pneumonia in dogs. Thorax 26, 675-682.
12. Gelb A.F., Dreisen R.B., Epstein J.D. et al. (1983) Immune complexes, gallium lung scans, and bronchoalveolar lavage in idiopathic interstitial pneumonitis fibrosis. Chest 84, 148-153.
13. Gross T.J. & Hunninghake G.W. (2001) Idiopathic pulmonary fibrosis. N. Engl. J. Med. 345, 517-525.
14. Harrison J.H. & Lazo J.S. (1987) High dose continuous infusion of bleomycin in mice: A new model for drug-induced pulmonary fibrosis. J. Pharmacol. Exp. Ther. 243, 1185-1194.
15. Haslam P.L., Thompson B., Mohammed I. et al. (1979) Circulating immune complexes in patients with cryptogenic fibrosing alveolitis. Clin. Exp. Immunol. 37, 381-390.
16. Hibbs M.S., Postlethwaite A.E., Mainardi C.L., Seyer J.M. & Kang A.H. (1983) Alterations in collagen production in mixed mononuclear leukocyte-fibroblast cultures. J. Exp. Med. 157, 47-59.
17. Janick-Buckner D., Ranges G.E. & Hacker M.P. (1986) T-cell modulation of bleomycin-induced pulmonary fibrosis. Pharmacologist 28, 152.
18. Janick-Buckner D., Ranges G.E. & Hacker M.P. (1989) Effect of cytotoxic monoclonal antibody depletion of T-lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice. Toxicol. Appl. Pharmacol. 100, 474-484.
19. Johnson R.L. & Ziff U. (1976) Lymphokine stimulation of collagen accumulation. J. Clin. Invest. 58, 240-252.
20. Karpel J.P., Aldrich T.K., Mitsudo S. & Norin A.J. (1989) Lung lymphocytes in bleomycin-induced pulmonary disease. Lung 167, 163-172.
21. Katzenstein A.A. & Myers J.L. (1998) Idiopathic pulmonary fibrosis. Clinical relevance of pathological classification. Am. J. Respir. Crit. Care Med. 157, 1301-1315.
22. Kremer S., Breuer R., Lossos I.S. et al. (1999) Effect of immunomodulators on bleomycin-induced lung injury. Respiration 66, 455-462.
23. Kumar R.K. (1984) Separation and characterization of lymphocytes from rat lung parenchyma. Exp. Lung Res. 7, 113-122.
24. Laxer U., Lossos I.S., Gillis S. et al. (1999) The effect of enoxaparin on bleomycin-induced lung injury in mice. Exp. Lung Res. 25, 531-541.
25. Lindenschnidt E.G., Tryka A.F., Godfrey G.A., Frome A.L. & Witschi H. (1986) Intratracheal versus intravenous administration of bleomycin in mice: Acute effects. Toxicol. Appl. Pharmacol. 85, 69-77.
26. Lossos I.S., Izbicki G., Or R., Goldstein R.H. & Breuer R. (2000) The effect of suramin on bleomycin-induced lung injury. Life Sci. 67, 2873-2881.
27. Phan S.H., Thrall R.S. & Williams C. (1981) Bleomycin-induced pulmonary fibrosis: Effects of steroid on lung collagen metabolism. Am. Rev. Respir. Dis. 14, 428-434.
28. Postlethwaite A.E. (1983) Cell-cell interaction in collagen biosynthesis and fibroblast migration. In: Advances in Inflammation Research, Vol. 5 (Ed. G. Weissmann). New York: Raven Press, pp. 27-55.
29. Postlethwaite A.E., Smith G.H. & Mainardi C.L. (1984) Lymphocyte modulation of fibroblast function in vitro: Stimulation and inhibition of collagen production by different effector molecules. J. Immunol. 132, 2470-2477.
30. Reynolds H.Y., Fulmer J.D., Kazmierowski J.A., Roberts W.C., Frank M.M. & Crystal R.G. (1977) Analysis of cellular and protein content of broncho-alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis. J. Clin. Invest. 59, 165-175.
31. Schrier D.J., Phan S.H. & McGarry B.M. (1983) The effects of the nude (nu/nu) mutation on bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 127, 614-617.
32. Schwarz M.I., Dreisin R.B., Pratt D.S. & Stanford R.E. (1978) Immunofluorescent patterns in the idiopathic interstitial pneumonias. J. Lab. Clin. Med. 91, 929-938.
33. Sharma S.K., MacLean J.A., Pinto C. & Kradin R.L. (1996) The effect of an anti-CD3 monoclonal antibody on bleomycin-induced lymphokine production and lung injury. Am. J. Respir. Crit. Care Ned. 154, 193-200.
34. Snedecor G.W. & Cochran W.G. (1967) Statistical Methods, 6th Edn. Ames, IA: Iowa State University Press; pp. 258-298.
35. Snider G.L., Celli R.R., Goldstein R.H., O'Brien J.J. & Lucey E.C. (1978) Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin. Am. Rev. Respir. Dis. 117, 289-297.
36. Struhar D., Harbeck R.J., Horiuchi T., Edelson J. & Mason R.J. (1986) Class II antigens of the major histocompatibility complex are expressed in lung tissue of bleomycin treated rats and patients with idiopathic pulmonary fibrosis (IPF). Am. Rev. Respir. Dis. 133, A144.
37. Struhar D., Greif J. & Harbeck R.J. (1990) Class II antigens of the major histocompatibility complex are increased in lungs of bleomycin-treated rats. Immunol. Lett. 26, 197-202.
38. Swiderski R.E., Dencoff J.E., Floerchinger C.S., Shapiro S.D. & Hunninghake G.W. (1998) Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 152, 821-828.
39. Szapiel S.V., Elson N.A., Fulmer J.D., Hunninghake G.W. & Crystal R.G. (1979) Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. Am. Rev. Respir. Dis. 120, 893-899.
40. Tarnell E.B., Oliver B.L., Johnson G.M., Watts F.L. & Thrall R.S. (1992) Superoxide production by rat neutrophils in the bleomycin model of lung injury Lung 170, 41-50
41. Thrall R.S., McCormick J.R., Jack R.M., Phan S.H. & Ward P.A. (1979) The effect of antilymphocyte globulin on the development of bleomycin induced pulmonary fibrosis in the rat. Am. Rev. Respir. Dis. 119 (S), 83.
42. Thrall R.S., Lovely E.J. III, Baron R.W., McCormick J.R., Phan S.H. & Ward P.A. (1980) The effect of T-cell depletion on the development of bleomycin induced pulmonary fibrosis in the rat. Am. Rev. Respir. Dis. 121 (S), 99.
43. Thrall R.S. & Barton R.W. (1984) A comparison of lymphocyte populations in lung tissue and in bronchoalveolar lavage fluid of rats at various times during the development of bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 129, 279-283.
44. Wahl S.M. & Gately C.L. (1983) Modulation of fibroblast growth by a lymphokine of human T cell continuous T cell line origin. J. Immunol. 130, 1226-1230.
45. Wallace W.A., Howie S.E., Krajewski A.S. & Lamb D. (1996) The immunological architecture of B-lymphocyte aggregates in cryptogenic fibrosing alveolitis. J. Pathol. 178, 323-329.