-
1
-
-
22244459880
-
Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage
-
Tao W et al. Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage. Cancer Cell 2005; 8: 49-59.
-
(2005)
Cancer Cell
, vol.8
, pp. 49-59
-
-
Tao, W.1
-
2
-
-
15744404844
-
Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells
-
Marcus Al et al. Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells. J Biol Chem 2005; 280: 11569-11577.
-
(2005)
J Biol Chem
, vol.280
, pp. 11569-11577
-
-
Marcus, A.1
-
3
-
-
0035172929
-
CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells
-
McEwen BF et al. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol Biol Cell 2001; 12: 2776-2789.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 2776-2789
-
-
McEwen, B.F.1
-
4
-
-
4644266184
-
Roles of polo-like kinase 1 in the assembly of functional mitotic spindles
-
Sumara I et al. Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr Biol 2004; 14: 1712-1722.
-
(2004)
Curr Biol
, vol.14
, pp. 1712-1722
-
-
Sumara, I.1
-
5
-
-
0038624074
-
Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells
-
Liu X, Erikson RL. Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc Natl Acad Sci U S A 2003; 100: 5789-5794.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 5789-5794
-
-
Liu, X.1
Erikson, R.L.2
-
6
-
-
0033135640
-
Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast
-
Tanaka T, Kimura M, Matsunaga K et al. Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res 1999; 59: 2041-2044.
-
(1999)
Cancer Res
, vol.59
, pp. 2041-2044
-
-
Tanaka, T.1
Kimura, M.2
Matsunaga, K.3
-
7
-
-
17744384260
-
Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation
-
Sakakura C, Hagiwara A, Yasuoka R et al. Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. Br J Cancer 2001; 84: 824-831.
-
(2001)
Br J Cancer
, vol.84
, pp. 824-831
-
-
Sakakura, C.1
Hagiwara, A.2
Yasuoka, R.3
-
8
-
-
0032100685
-
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
-
Bischoff JR, Anderson L, Zhu Y et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 1998; 17: 3052-3065.
-
(1998)
EMBO J
, vol.17
, pp. 3052-3065
-
-
Bischoff, J.R.1
Anderson, L.2
Zhu, Y.3
-
9
-
-
0037019736
-
Amplification/overexpression of a mitotic kinase gene in human bladder
-
Sen S, Zhou H, Zhang RD et al. Amplification/overexpression of a mitotic kinase gene in human bladder. J Natl Cancer Inst 2002; 94: 1320-1329.
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 1320-1329
-
-
Sen, S.1
Zhou, H.2
Zhang, R.D.3
-
10
-
-
18144425117
-
AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells
-
Zhu J, Abbruzzese JL, Izzo J et al. AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. Cancer Genet Cytogenet 2005; 159: 10-17.
-
(2005)
Cancer Genet Cytogenet
, vol.159
, pp. 10-17
-
-
Zhu, J.1
Abbruzzese, J.L.2
Izzo, J.3
-
11
-
-
0037386929
-
Activation and overexpression of centrosome kinase BTAK/Aurora A, in human ovarian cancer
-
Gritsko TM, Coppola D, Paciga JE et al. Activation and overexpression of centrosome kinase BTAK/Aurora A, in human ovarian cancer. Clin Cancer Res 2003; 9: 1420-1426.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1420-1426
-
-
Gritsko, T.M.1
Coppola, D.2
Paciga, J.E.3
-
12
-
-
0035266301
-
Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression
-
Pihan GA, Purohit A, Wallace J et al. Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. Cancer Res 2001; 61: 2212-2219.
-
(2001)
Cancer Res
, vol.61
, pp. 2212-2219
-
-
Pihan, G.A.1
Purohit, A.2
Wallace, J.3
-
13
-
-
16344361846
-
The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma
-
Tanaka E, Hashimoto Y, Ito T et al. The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clin Cancer Res 2005; 11(5): 1827-1834.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.5
, pp. 1827-1834
-
-
Tanaka, E.1
Hashimoto, Y.2
Ito, T.3
-
14
-
-
0038341158
-
The Aurora kinases: Role in cell transformation and tumorigenesis
-
Katayama H, Brinkley WR, Sen S. The Aurora kinases: Role in cell transformation and tumorigenesis. Cancer Metastasis Rev 2003; 22(4): 451-464.
-
(2003)
Cancer Metastasis Rev
, vol.22
, Issue.4
, pp. 451-464
-
-
Katayama, H.1
Brinkley, W.R.2
Sen, S.3
-
15
-
-
0035984896
-
APC/Fizzy-related targets aurora-A kinase for proteolysis
-
Castro A, Arlot-Bonnemains Y, Vigneron S et al. APC/Fizzy-related targets aurora-A kinase for proteolysis. EMBO Rep 2002; 3: 457-462.
-
(2002)
EMBO Rep
, vol.3
, pp. 457-462
-
-
Castro, A.1
Arlot-Bonnemains, Y.2
Vigneron, S.3
-
16
-
-
0036714512
-
Identfication of a new APC/C recogniton domain, the A box, which is required for the Cdh 1-dependent destruction of the kinase aurora-A during mitotic exit
-
Littepage, LE, Ruderman JV. Identfication of a new APC/C recogniton domain, the A box, which is required for the Cdh 1-dependent destruction of the kinase aurora-A during mitotic exit. Genes Dev 2002; 16: 2274-2285.
-
(2002)
Genes Dev
, vol.16
, pp. 2274-2285
-
-
Littepage, L.E.1
Ruderman, J.V.2
-
17
-
-
0037180488
-
Identification of phosphorylated residues that affect the activity of the mitotic kinase aurora-A
-
Littlepage LE, Wu H, Andresson T et al. Identification of phosphorylated residues that affect the activity of the mitotic kinase aurora-A. Proc Natl Acad Sci U S A 2002; 99: 15440-15445.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15440-15445
-
-
Littlepage, L.E.1
Wu, H.2
Andresson, T.3
-
18
-
-
0037160088
-
Aurora-A kinase interacting protein (AJP), a novel negative regulator of human aurora-A kinase
-
Kiat LS, Hui KM, Gopalan G. Aurora-A kinase interacting protein (AJP), a novel negative regulator of human aurora-A kinase. J Biol Chem 2002; 277: 45558-45565.
-
(2002)
J Biol Chem
, vol.277
, pp. 45558-45565
-
-
Kiat, L.S.1
Hui, K.M.2
Gopalan, G.3
-
19
-
-
0035824660
-
Interaction and feedback regulation between STK15/BTAK/aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle
-
Katayama H, Zhou H, Li Q et al. Interaction and feedback regulation between STK15/BTAK/aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem 2001; 276: 46219-46224.
-
(2001)
J Biol Chem
, vol.276
, pp. 46219-46224
-
-
Katayama, H.1
Zhou, H.2
Li, Q.3
-
21
-
-
0141429171
-
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
-
Hirota T et al. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 2003; 114: 585-598.
-
(2003)
Cell
, vol.114
, pp. 585-598
-
-
Hirota, T.1
-
22
-
-
0347324949
-
Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells
-
Marumoto T et al. Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol Chem 2003; 278: 51786-51795.
-
(2003)
J Biol Chem
, vol.278
, pp. 51786-51795
-
-
Marumoto, T.1
-
23
-
-
3042734502
-
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition
-
Dutertre S et al. Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci 2004; 117: 2523-2531.
-
(2004)
J Cell Sci
, vol.117
, pp. 2523-2531
-
-
Dutertre, S.1
-
24
-
-
18844464851
-
hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division
-
Garrett S, Auer K, Compton DA, Kapoor TM. hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division. Curr Biol 2002; 12: 2055-2059.
-
(2002)
Curr Biol
, vol.12
, pp. 2055-2059
-
-
Garrett, S.1
Auer, K.2
Compton, D.A.3
Kapoor, T.M.4
-
25
-
-
0013057087
-
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
-
Ditchfied C et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol 2003; 161: 267-280.
-
(2003)
J Cell Biol
, vol.161
, pp. 267-280
-
-
Ditchfied, C.1
-
26
-
-
0038746733
-
The small molecule Hesperadin reveals a role for Aurora B in correctng kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
-
Hauf S et al. The small molecule Hesperadin reveals a role for Aurora B in correctng kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 2003; 161: 281-294.
-
(2003)
J Cell Biol
, vol.161
, pp. 281-294
-
-
Hauf, S.1
-
28
-
-
10744225982
-
CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function
-
Kunitoku N et al. CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. Dev Cel 2003; 5: 853-864.
-
(2003)
Dev Cel
, vol.5
, pp. 853-864
-
-
Kunitoku, N.1
-
30
-
-
0037586498
-
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
-
Anand S, Penrhyn-Lowe S, Venkitaraman AR. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 2003; 3: 51-62.
-
(2003)
Cancer Cell
, vol.3
, pp. 51-62
-
-
Anand, S.1
Penrhyn-Lowe, S.2
Venkitaraman, A.R.3
-
31
-
-
9944220985
-
Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models
-
Zhang D et al. Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models. Oncogene 2004; 23: 8720-8730.
-
(2004)
Oncogene
, vol.23
, pp. 8720-8730
-
-
Zhang, D.1
-
32
-
-
0034213929
-
Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin proteasome pathway
-
Honda K et al. Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin proteasome pathway. Oncogene 2000; 19: 2812-2819.
-
(2000)
Oncogene
, vol.19
, pp. 2812-2819
-
-
Honda, K.1
-
33
-
-
12244301635
-
The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A
-
Castro A et al. The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A. EMBO Rep 2002; 3: 1209-1214.
-
(2002)
EMBO Rep
, vol.3
, pp. 1209-1214
-
-
Castro, A.1
-
34
-
-
0032100685
-
A homologue of Drosophilla aurora kinase is oncogenic and amplified in human colorectal cancers
-
Bischoff JR et al. A homologue of Drosophilla aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 1998; 17: 3052-3065.
-
(1998)
EMBO J
, vol.17
, pp. 3052-3065
-
-
Bischoff, J.R.1
-
35
-
-
0030962953
-
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines
-
Sen S, Zhou H, White RA. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 1997; 14: 2195-2200.
-
(1997)
Oncogene
, vol.14
, pp. 2195-2200
-
-
Sen, S.1
Zhou, H.2
White, R.A.3
-
36
-
-
0037099531
-
Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis
-
Goepfert TM et al. Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res 2002; 62: 4115-4122.
-
(2002)
Cancer Res
, vol.62
, pp. 4115-4122
-
-
Goepfert, T.M.1
-
37
-
-
1642361744
-
Overexpression and amplification of Aurora-A in hepatocellular carcinoma
-
Jeng YM, Peng SY, Lin CY, Hsu HC. Overexpression and amplification of Aurora-A in hepatocellular carcinoma. Clin Cancer Res 2004; 10: 2065-2071.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2065-2071
-
-
Jeng, Y.M.1
Peng, S.Y.2
Lin, C.Y.3
Hsu, H.C.4
-
38
-
-
0037009435
-
Suppression of the STK1 5 oncogenic activity requires a transactivation-independent p53 function
-
Chen SS, Chang PC, Cheng YW et al. Suppression of the STK1 5 oncogenic activity requires a transactivation-independent p53 function. EMBO J 2002; 21: 4491-4499.
-
(2002)
EMBO J
, vol.21
, pp. 4491-4499
-
-
Chen, S.S.1
Chang, P.C.2
Cheng, Y.W.3
-
39
-
-
9144251019
-
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
-
Katayama H et al. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nature Genet 2004; 36: 55-62.
-
(2004)
Nature Genet
, vol.36
, pp. 55-62
-
-
Katayama, H.1
-
40
-
-
10644227569
-
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem
-
doi: 10. 1074/jbc,M406802200
-
Liu Q et al. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem 2004 doi: 10. 1074/jbc,M406802200.
-
(2004)
-
-
Liu, Q.1
-
41
-
-
0345304925
-
AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer
-
Jiang Y, Zhang Y, Lees E, Seghezzi W. AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer. Oncogene 2003; 22: 8293-8301.
-
(2003)
Oncogene
, vol.22
, pp. 8293-8301
-
-
Jiang, Y.1
Zhang, Y.2
Lees, E.3
Seghezzi, W.4
-
42
-
-
25444456359
-
The in vitro and in vivo effects of JNJ-7706621: A dual inhibitor of cyclin-dependent kinases and aurora kinases
-
Emanuel S, Rugg CA, Gruninger RH et al. The in vitro and in vivo effects of JNJ-7706621: A dual inhibitor of cyclin-dependent kinases and aurora kinases. Cancer Res 2005; 65(19): 9038-9046.
-
(2005)
Cancer Res
, vol.65
, Issue.19
, pp. 9038-9046
-
-
Emanuel, S.1
Rugg, C.A.2
Gruninger, R.H.3
-
43
-
-
23044510618
-
Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling
-
Godl K, Gruss OJ, Eickhoff J et al. Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling. Cancer Res 2005; 65(15): 6919-6926.
-
(2005)
Cancer Res
, vol.65
, Issue.15
, pp. 6919-6926
-
-
Godl, K.1
Gruss, O.J.2
Eickhoff, J.3
-
44
-
-
2342639645
-
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
-
Harrington EA et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo, Nat Med 2004; 10: 262-267.
-
(2004)
Nat Med
, vol.10
, pp. 262-267
-
-
Harrington, E.A.1
-
45
-
-
0037373258
-
G1 tetraploidy checkpoint and the suppression of tumorigenesis
-
Margolis RL, Lohez OD, Andreassen PR. G1 tetraploidy checkpoint and the suppression of tumorigenesis. J Cell Biochem 2003; 88: 673-683.
-
(2003)
J Cell Biochem
, vol.88
, pp. 673-683
-
-
Margolis, R.L.1
Lohez, O.D.2
Andreassen, P.R.3
|