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Volumn 24, Issue 11, 2007, Pages 1181-1186

A new era for Type 2 diabetes genetics

Author keywords

Genome wide association; Type 2 diabetes

Indexed keywords

INSULIN;

EID: 35448987054     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2007.02274.x     Document Type: Review
Times cited : (28)

References (33)
  • 1
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls
    • Wellcome Trust Case Control Consortium.
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls. Nature 2007 447 : 661 678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 2
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007 316 : 1336 1341.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3    Frayling, T.M.4    Elliott, K.S.5    Lango, H.6
  • 3
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research.
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007 316 : 1331 1336.
    • (2007) Science , vol.316 , pp. 1331-1336
  • 4
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007 316 : 1341 1345.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3    Willer, C.J.4    Li, Y.5    Duren, W.L.6
  • 5
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007 445 : 828 830.
    • (2007) Nature , vol.445 , pp. 828-830
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3    Dina, C.4    Shen, L.5    Serre, D.6
  • 8
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with increased risk of Type 2 diabetes
    • Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with increased risk of Type 2 diabetes. Diabetes 2003 52 : 568 572.
    • (2003) Diabetes , vol.52 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3    Turner, M.J.4    Knight, B.A.5    Hitman, G.6
  • 9
    • 33845939675 scopus 로고    scopus 로고
    • TCF7L2: The biggest story in diabetes genetics since HLA?
    • Zeggini E, McCarthy MI. TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia 2007 50 : 1 4.
    • (2007) Diabetologia , vol.50 , pp. 1-4
    • Zeggini, E.1    McCarthy, M.I.2
  • 10
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International HapMap Consortium.
    • International HapMap Consortium. A haplotype map of the human genome. Nature 2005 437 : 1299 1320.
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 12
    • 30044434823 scopus 로고    scopus 로고
    • MicroRNAs: 'ribo-regulators' of glucose homeostasis
    • Gauthier BR, Wollheim CB. MicroRNAs: 'ribo-regulators' of glucose homeostasis. Nat Med 2006 12 : 36 38.
    • (2006) Nat Med , vol.12 , pp. 36-38
    • Gauthier, B.R.1    Wollheim, C.B.2
  • 13
    • 33745279056 scopus 로고    scopus 로고
    • Evaluating coverage of genome-wide association studies
    • Barrett JC, Cardon LR. Evaluating coverage of genome-wide association studies. Nat Genet 2006 38 : 659 662.
    • (2006) Nat Genet , vol.38 , pp. 659-662
    • Barrett, J.C.1    Cardon, L.R.2
  • 14
    • 33745279392 scopus 로고    scopus 로고
    • Evaluating and improving power in whole-genome association studies using fixed marker sets
    • Pe'er I, de Bakker PI, Maller J, Yelensky R, Altshuler D, Daly MJ. Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat Genet 2006 38 : 663 667.
    • (2006) Nat Genet , vol.38 , pp. 663-667
    • Pe'Er, I.1    De Bakker, P.I.2    Maller, J.3    Yelensky, R.4    Altshuler, D.5    Daly, M.J.6
  • 15
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007 316 : 889 894.
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3    Zeggini, E.4    Freathy, R.M.5    Lindgren, C.M.6
  • 16
    • 12444282662 scopus 로고    scopus 로고
    • Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility
    • Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M et al. Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility. Diabetes 2003 52 : 1300 1305.
    • (2003) Diabetes , vol.52 , pp. 1300-1305
    • Groves, C.J.1    Wiltshire, S.2    Smedley, D.3    Owen, K.R.4    Frayling, T.M.5    Walker, M.6
  • 17
    • 0038659900 scopus 로고    scopus 로고
    • Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study
    • Karamohamed S, Demissie S, Volcjak J, Liu C, Heard-Costa N, Liu J et al. Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. Diabetes 2003 52 : 1562 1567.
    • (2003) Diabetes , vol.52 , pp. 1562-1567
    • Karamohamed, S.1    Demissie, S.2    Volcjak, J.3    Liu, C.4    Heard-Costa, N.5    Liu, J.6
  • 18
    • 33644772571 scopus 로고    scopus 로고
    • High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4206 people
    • Florez JC, Wiltshire S, Agapakis CM, Burtt NP, de Bakker PI, Almgren P et al. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4206 people. Diabetes 2006 55 : 128 135.
    • (2006) Diabetes , vol.55 , pp. 128-135
    • Florez, J.C.1    Wiltshire, S.2    Agapakis, C.M.3    Burtt, N.P.4    De Bakker, P.I.5    Almgren, P.6
  • 19
    • 13244291649 scopus 로고    scopus 로고
    • Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex
    • Foley AC, Mercola M. Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. Genes Dev 2005 19 : 387 396.
    • (2005) Genes Dev , vol.19 , pp. 387-396
    • Foley, A.C.1    Mercola, M.2
  • 20
    • 1342263517 scopus 로고    scopus 로고
    • Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    • Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 2004 131 : 797 806.
    • (2004) Development , vol.131 , pp. 797-806
    • Bort, R.1    Martinez-Barbera, J.P.2    Beddington, R.S.3    Zaret, K.S.4
  • 21
    • 35449001954 scopus 로고    scopus 로고
    • Common variants of the novel type 2 diabetes genes, CDKAL1 and HHEX/IDE, are associated with decreased pancreatic β-cell function
    • the RISC Consortium*et al. in press.
    • Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, the RISC Consortium et al. Common variants of the novel type 2 diabetes genes, CDKAL1 and HHEX/IDE, are associated with decreased pancreatic β-cell function. Diabetes 2007 in press.
    • (2007) Diabetes
    • Pascoe, L.1    Tura, A.2    Patel, S.K.3    Ibrahim, I.M.4    Ferrannini, E.5
  • 25
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
    • Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP et al. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet 1999 22 : 44 52.
    • (1999) Nat Genet , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5    Reddy, E.P.6
  • 26
    • 0347383875 scopus 로고    scopus 로고
    • Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice
    • Mettus RV, Rane SG. Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice. Oncogene 2003 22 : 8413 8421.
    • (2003) Oncogene , vol.22 , pp. 8413-8421
    • Mettus, R.V.1    Rane, S.G.2
  • 27
    • 2442699174 scopus 로고    scopus 로고
    • Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes
    • Marzo N, Mora C, Fabregat ME, Martín J, Usac EF, Franco C et al. Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes. Diabetologia 2004 47 : 686 694.
    • (2004) Diabetologia , vol.47 , pp. 686-694
    • Marzo, N.1    Mora, C.2    Fabregat, M.E.3    Martín, J.4    Usac, E.F.5    Franco, C.6
  • 30
    • 33749389928 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity
    • Ubeda M, Rukstalis JM, Habener JF. Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. J Biol Chem 2006 281 : 28858 28864.
    • (2006) J Biol Chem , vol.281 , pp. 28858-28864
    • Ubeda, M.1    Rukstalis, J.M.2    Habener, J.F.3
  • 32
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007 39 : 724 726.
    • (2007) Nat Genet , vol.39 , pp. 724-726
    • Dina, C.1    Meyre, D.2    Gallina, S.3    Durand, E.4    Korner, A.5    Jacobson, P.6
  • 33
    • 33750876203 scopus 로고    scopus 로고
    • Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
    • Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, Zeggini E et al. Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 2006 3 : e374.
    • (2006) PLoS Med , vol.3
    • Weedon, M.N.1    McCarthy, M.I.2    Hitman, G.3    Walker, M.4    Groves, C.J.5    Zeggini, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.