Evaluating coverage of genome-wide association studies

Nature Genetics

Volumn 38, Issue 6, 2006, Pages 659-662

  Barrett, Jeffrey C ^a   Cardon, Lon R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CALCULATION; EVALUATION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC MARKER; GENOME; GENOTYPE; HIGH THROUGHPUT SCREENING; HUMAN; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

CASE-CONTROL STUDIES; GENOME, HUMAN; HAPLOTYPES; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 33745279056     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1801     Document Type: Article

References (19)

1. Altshuler, D. et al. A haplotype map of the human genome. Nature 437, 1299-1320 (2005).
2. Hinds, D.A. et al. Whole-genome patterns of common DNA variation in three human populations. Science 307, 1072-1079 (2005).
3. Wang, W.Y., Barratt, B.J., Clayton, D.G. & Todd, J.A. Genome-wide association studies: theoretical and practical concerns. Nat. Rev. Genet. 6, 109-118 (2005).
4. Hirschhorn, J.N. & Daly, M.J. Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6, 95-108 (2005).
5. Palmer, L.J. & Cardon, L.R. Shaking the tree: mapping complex disease genes with linkage disequilibrium. Lancet 366, 1223-1234 (2005).
6. Botstein, D. & Risch, N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat. Genet. 33 (Suppl.), 228-237 (2003).
7. Neale, B.M. & Sham, P.C. The future of association studies: gene-based analysis and replication. Am. J. Hum. Genet. 75, 353-362 (2004).
8. Clayton, D.G. et al. Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat. Genet. 37, 1243-1246 (2005).
9. de Bakker, P.I. et al. Efficiency and power in genetic association studies. Nat. Genet. 37, 1217-1223 (2005).
10. Dong, S. et al. Flexible use of high-density oligonucleotide arrays for single-nucleotide polymorphism discovery and validation. Genome Res. 11, 1418-1424 (2001).
11. Carlson, C.S. et al. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am. J. Hum. Genet. 74, 106-120 (2004).
12. Ke, X. et al. A comparison of tagging methods and their tagging space. Hum. Mol. Genet. 14, 2757-2767 (2005).
13. Pritchard, J.K. & Przeworski, M. Linkage disequilibrium in humans: models and data. Am. J. Hum. Genet. 69, 1-14 (2001).
14. Jorgenson, E. & Witte, J.S. Coverage and power in genomewide association studies. Am. J. Hum. Genet. 78, 884-888 (2006).
15. Daly, M. et al. Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat. Genet. advance online publication 21 May 2006 (doi:10.1038/ngXXXX).
16. Klein, R.J. et al. Complement factor H polymorphism in age-related macular degeneration. Science 308, 385-389 (2005).
17. Rieder, M.J. et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N. Engl. J. Med. 352, 2285-2293 (2005).
18. Hardenbol, P. et al. Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay. Genome Res. 15, 269-275 (2005).
19. Barrett, J.C., Fry, B., Maller, J. & Daly, M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 (2005).