Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity

Journal of Biological Chemistry

Volumn 281, Issue 39, 2006, Pages 28858-28864

  Ubeda, Mariano ^a,b   Rukstalis, J Michael ^a,b,c   Habener, Joel F ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASES; GENE EXPRESSION; NEURONAL DYSFUNCTION; PANCREATIC BETA CELLS;

BIOASSAY; CELL CULTURE; DISEASES; GENETIC ENGINEERING; GLUCOSE; INSULIN; NEUROLOGY; PATHOLOGY;

ENZYME KINETICS;

CYCLIN DEPENDENT KINASE 5; GLUCOSE; INSULIN; MYC PROTEIN; ROSCOVITINE; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CANCER CELL CULTURE; CELL FRACTIONATION; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DNA BINDING; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; IN VITRO STUDY; LONG TERM EXPOSURE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TRANSPORT; RAT; REPORTER GENE; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE 5; CYTOPLASM; DIABETES MELLITUS, TYPE 2; ENZYME INHIBITORS; GLUCOSE; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; RATS; RNA, SMALL INTERFERING; TIME FACTORS; TRANS-ACTIVATORS;

EID: 33749389928     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604690200     Document Type: Article

References (25)

1. Ubeda, M., Kemp, D. M., and Habener, J. F. (2004) Endocrinology 145, 3023-3031
2. Park, B. H., Rho, H. W., Park, J. W., Cho, C. G., Kim, J. S., Chung, H. T., and Kim, H. R. (1995) Biochem. Biophys. Res. Commun. 210, 1-6
3. Srinivasan, S., Bernal-Mizrachi, E., Ohsugi, M., and Permutt, M. A. (2002) Am. J. Physiol. 283, E784-E793
4. Sharma, A., Olson, L. K., Robertson, R. P., and Stein, R. (1995) Mol. Endocrinol. 9, 1127-1134
5. Olson, L. K., Sharma, A., Peshavaria, M., Wright, C. V., Towle, H. C., Rodertson, R. P., and Stein, R. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9127-9131
6. Leahy, J. L., Cooper, H. E., Deal, D. A., and Weir, G. C. (1986) J. Clin. Investig. 77, 908-915
7. Kaiser, N., Leibowitz, G., and Nesher, R. (2003) J. Pediatr. Endocrinol. Metab. 16, 5-22
8. Tsai, L. H., Lee, M. S., and Cruz, J. (2004) Biochim. Biophys. Acta 1697, 137-142
9. Cruz, J. C., and Tsai, L. H. (2004) Trends Mol. Med. 10, 452-458
10. Lim, A. C., and Qi, R. Z. (2003) J. Alzheimer's Dis. 5, 329-335
11. Olson, L. K., Qian, J., and Poitout, V. (1998) Mol. Endocrinol. 12, 207-219
12. Kawamori, D., Kajimoto, Y., Kaneto, H., Umayahara, Y., Fujitani, Y., Miyatsuka, T., Watada, H., Leibiger, I. B., Yamasaki, Y., and Hori, M. (2003) Diabetes 52, 2896-2904
13. Harmon, J. S., Stein, R., and Robertson, R. P. (2005) J. Biol. Chem. 280, 11107-11113
14. Seufert, J., Weir, G. C., and Habener, J. F. (1998) J. Clin. Investig. 101, 2528-2539
15. Lu, M., Seufert, J., and Habener, J. F. (1997) J. Biol. Chem. 272, 28349-28359
16. Ubeda, M., Wang, X. Z., Zinszner, H., Wu, I., Habener, J. F., and Ron, D. (1996) Mol. Cell Biol. 16, 1479-1489
17. Habener, J. F. (2002) Drug News Perspect. 15, 491-497
18. Harmon, J. S., Tanaka, Y., Olson, L. K., and Robertson, R. P. (1998) Diabetes 47, 900-904
19. Poitout, V., Olson, L. K., and Robertson, R. P. (1996) J. Clin. Investig. 97, 1041-1046
20. Tokuyama, Y., Sturis, J., DePaoli, A. M., Takeda, J., Stoffel, M., Tang, J., Sun, X., Polonsky, K. S., and Bell, G. I. (1995) Diabetes 44, 1447-1457
21. Zangen, D. H., Bonner-Weir, S., Lee, C. H., Latimer, J. B., Miller, C. P., Habener, J. F., and Weir, G. C. (1997) Diabetes 46, 258-264
22. Nguyen, M. D., and Julien, J. P. (2003) NeuroSignals 12, 215-220
23. Kajimoto, Y., and Kaneto, H. (2004) Ann. N. Y. Acad. Sci. 1011, 168-176
24. Strocchi, P., Pession, A., and Dozza, B. (2003) J. Cell Biochem. 88, 758-765
25. Otth, C., Mendoza-Naranjo, A., Mujica, L., Zambrano, A., Concha, I. I., and Maccioni, R. B. (2003) Neuroreport 14, 2403-2409