Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility

Diabetes

Volumn 52, Issue 5, 2003, Pages 1300-1305

  Groves, Christopher J ^a,b   Wiltshire, Steven ^b,c   Smedley, Damian ^c   Owen, Katherine R ^d   Frayling, Timothy M ^d   Walker, Mark ^e   Hitman, Graham A ^f   Levy, Jonathan C ^a   O'Rahilly, Stephen ^g   Menzel, Stephan ^b   Hattersley, Andrew T ^d   McCarthy, Mark I ^a,b,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d PENINSULA MEDICAL SCHOOL   (United Kingdom)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULINASE;

ADULT; ARTICLE; CHROMOSOME 10Q; CONTROLLED STUDY; FEMALE; GENE MAPPING; GENE MUTATION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHROMOSOMES, ARTIFICIAL, BACTERIAL; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE; HAPLOTYPES; HOMEOSTASIS; HUMANS; INSULYSIN; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SEQUENCE ALIGNMENT;

EID: 12444282662     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.5.1300     Document Type: Article

References (25)

1. Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M, O'Rahilly S, Frayling TM, Bell JI, Lathrop GM, Bennett A, Dhillon R, Fletcher C, Groves CJ, Jones E, Prestwich P, Simecek N, Subba Rao PV, Wishart M, Foxon R, Howell S, Smedley D, Cardon LR, Menzel S, McCarthy MI: A genome-wide scan for loci predisposing to type 2 diabetes in a U.K. population (The Diabetes (U.K.) Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet 69:553-569, 2001
2. Ghosh S, Watanabe RM, Valle TT, Hauser ER, Magnuson VL, Langefeld CD, Ally DS, Mohlke KL, Silander K, Kohtamaki K, Chines P, Balow Jr J, Birznieks G, Chang J, Eldridge W, Erdos MR, Karanjawala ZE, Knapp JI, Kudelko K, Martin C, Morales-Mena A, Musick A, Musick T, Pfahl C, Porter R, Rayman JB, Rha D, Segal L, Shapiro S, Sharaf R, Shurtleff B, So A, Tannenbaum J, Te C, Tovar J, Unni A, Welch C, Whiten R, Witt A, Blaschak-Harvan J, Douglas JA, Duren WL, Epstein MP, Fingerlin TE, Kaleta HS, Langer EM, Li C, McEachin RC, Stringham HM, Trager E, White PP, Eriksson J, Toivanen L, Vidgren G, Nylund SJ, Tuomilehto-Wolf E, Ross EH, Demirchyan E, Hagopian WA, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M: The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet 67:1174-1185, 2000
3. 1c in a community-based sample of Caucasian pedigrees: the Framingham Offspring Study. Diabetes 51:833-840, 2002
4. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP: Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 64:1127-1140, 1999
5. Vionnet N, Hani EH, Dupont S, Gallina S, Francke S, Dotte S, De Matos F, Durand E, Lepêtre F, Lecouer C, Gallina P, Zekiri L, Dina C, Froguel P: Genomewide search for type 2 diabetes-susceptibility genes in French Whites: evidence for a novel susceptibility locus for early onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 67:1470-1480, 2000
6. Galli J, Li LS, Glaser A, Östenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H: Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 12:31-37, 1996
7. Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau MT, Portha B, James MR, Penicaud L, Lathrop M, Ktorza A: Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 12:38-43, 1996
8. Galli J, Fakhrai-Rad H, Kamel A, Marcus C, Norgren S, Luthman H: Pathophysiological and genetic characterization of the major diabetes locus in GK rats. Diabetes 48:2463-2470, 1999
9. Kaisaki PJ, Rouard M, Danoy PA, Wallis RH, Collins SC, Rice M, Levy ER, Lathrop M, Bihoreau MT, Gauguier D: Detailed comparative gene map of rat chromosome 1 with mouse and human genomes and physical mapping of an evolutionary chromosomal breakpoint. Genomics 64:32-43, 2000
10. Fakhrai-Rad H, Nikoshkov A, Kamel A, Fernström M, Zierath JR, Norgren S, Luthman H, Galli J: Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Hum Mol Genet 9:2149-2158, 2000
11. Duckworth WC, Bennett RG, Hamel FG: Insulin degradation: progress and potential. Endocr Rev 19:608-624, 1998
12. Kurochkin IV: Insulin-degrading enzyme: embarking on amyloid destruction. Trends Biochem Sci 26:421-425, 2001
13. Authier F, Posner BI, Bergeron JJM: Insulin-degrading enzyme. Clin Invest Med 19:149-160, 1996
14. Seta KA, Roth RA: Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signalling. Biochem Biophys Res Commun 231:167-171, 1997
15. Jones CN, Pei D, Staris P, Polonsky KS, Chen YD, Reaven GM: Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals. J Clin Endocrinol Metab 82:1834-1838, 1997
16. Misbin RI, Almira EC, Cleman MW: Insulin degradation in serum of a patient with apparent insulin resistance. J Clin Endocrinol Metab 52:177-180, 1981
17. Abraham R, Myers A, DeVrieze FW, Hamshere MV, Thomas HM, Marshall H, Compton D, Spurlock G, Turic D, Hoogendoorn B, Kwon JM, Petersen RC, Tangalos E, Norton J, Morris JC, Bullock R, Liolitsa D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen MJ, Jones L: Substantial linkage disequilibrium across the insulin degrading enzyme locus but no association with late-onset Alzheimer's disease. Hum Genet 109:646-652, 2001
18. Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TM, Mashima H, Schwarz PEH, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI: Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26:163-175, 2000
19. Sun L, Cox NJ, McPeek MS: A statistical method for identification of polymorphisms that explain a linkage results. Am J Hum Genet 70:399-411, 2002
20. Li C, Scott LJ, Boehnke M: Allele-sharing linkage analysis on subsets of families stratified based on an associated allele (Abstract). Am J Hum Genet 71 (Suppl.):574, 2002
21. Farook VS, Hanson RL, Wolford JK, Bogardus C, Prochazka M: Molecular analysis of KCNJ10 on 1q as a candidate gene for type 2 diabetes in Pima Indians. Diabetes 51:3342-3346, 2002
22. Frayling TM, Walker M, McCarthy MI, Evans JC, Ayres S, Allen LI, Ellard S, Lynn S, Turner RC, O'Rahilly S, Hitman GA, Hattersley AT: Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes. Diabetes 48:2475-2479, 1999
23. Minton J, Hattersley AT, Owen KR, McCarthy MI, Walker M, Barrett T, Frayling TM: Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes 51:1287-1290, 2002
24. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D: The structure of haplotype blocks in the human genome. Science 296:2225-2229, 2002
25. Zhao JH, Curtis D, Sham PC: Model-free analysis and permutation test for allelic association. Hum Hered 50:133-139, 2000