Biphenyl amides and isosteres as MCH R1 antagonists

Current Topics in Medicinal Chemistry

Volumn 7, Issue 15, 2007, Pages 1455-1470

  Hertzog, Donald L ^a   Witty, David R ^b  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

MCH; MCH R1; MCH R1 antagonist; Melanin concentrating hormone; Obesity

Indexed keywords

2 AMINO 1H BENZIMIDAZOLE DERIVATIVE; 2,3 DIHYDRO 1,4 BENZODIOXIN DERIVATIVE; 3,4 DIHYDRO 1,4 BENZOXAZINE DERIVATIVE; AMIDE; ANTIOBESITY AGENT; BENZIMIDAZOLE DERIVATIVE; BENZOXAZINE DERIVATIVE; BIPHENYL AMIDE DERIVATIVE; DIOXIN; GW 803430; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; PHTHALIMIDE DERIVATIVE; PYRIMIDINONE DERIVATIVE; QUINOLINE DERIVATIVE; SIBUTRAMINE; SULFONAMIDE; UNCLASSIFIED DRUG;

BODY WEIGHT; DISEASE MODEL; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG INDUSTRY; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; FEEDING; HIGH THROUGHPUT SCREENING; IC 50; LOW DRUG DOSE; NONHUMAN; OBESITY; REVIEW; STRUCTURE ACTIVITY RELATION; TRANSGENIC ANIMAL;

AMIDES; ANIMALS; BIPHENYL COMPOUNDS; HUMANS; MODELS, MOLECULAR; QUINOLINES; RECEPTORS, PITUITARY HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35448945709     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607782194743     Document Type: Review

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