Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 19, 2005, Pages 4174-4179

  Vasudevan, Anil ^a   LaMarche, Matthew J ^b   Blackburn, Christopher ^b   Che, Jennifer Lee ^b   Luchaco Cullis, Courtney A ^b   Lai, Sujen ^b   Marsilje, Thomas H ^b   Patane, Michael A ^b   Souers, Andrew J ^a   Wodka, Derek ^a   Geddes, Bradley ^b   Chen, Sumiao ^b   Brodjian, Seven ^a   Falls, Doug H ^a   Dayton, Brian D ^a   Bush, Eugene ^a   Brune, Michael ^a   Shapiro, Robin D ^a   Marsh, Kennan C ^a   Hernandez, Lisa E ^a   Sham, Hing L ^a   Collins, Christine A ^a   Kym, Philip R ^a   more..

^a ABBOTT LABORATORIES   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Benzamides; MCH; Melanin concentrating hormone; Nicotinamides; Obesity

Indexed keywords

BENZAMIDE DERIVATIVE; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE; NICOTINAMIDE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; IC 50; MOUSE; NONHUMAN; OBESITY;

ANIMALS; ANTHRANILIC ACIDS; BENZAMIDES; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED STRAINS; NIACINAMIDE; PHARMACOKINETICS; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 23944453917     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.06.089     Document Type: Article

References (19)

1. J.C. Bittencourt, F. Presse, C. Arias, C. Peto, J. Vaughan, J.L. Nahon, W. Vale, and P.E. Sawchenko J. Comp. Neurol. 319 1992 218
2. G. Skofitsch, D.M. Jacobowitz, and N. Zamir Brain Res. Bull. 15 1985 635
3. D. Qu, D.S. Ludwig, S. Gammeltoft, M. Piper, M.A. Pelleymounter, M.J. Cullen, W.F. Mathes, R. Przypek, R. Kanarek, and E. Maratos-Flier Nature 380 1996 243
4. D.J. Marsh, D.T. Weingarth, D.E. Novi, H.Y. Chen, M.E. Trumbauer, A.S. Chen, X. Guan, M.M. Jiang, Y. Feng, R.E. Camacho, Z. Shen, E.G. Frazier, H. Yu, J.M. Metzger, S.J. Kuca, L.P. Shearman, S. Gopal-Truter, D.J. MacNeil, A.M. Strack, D.E. MacIntyre, P.L.H.T. Vander, and S. Qian Proc. Natl. Acad. Sci. USA 99 5 2002 3240
5. Y. Chen, C. Hu, C. Hsu, Q. Zhang, C. Bi, M. Asnicar, H.M. Hsiung, N. Fox, L.J. Slieker, D.D. Yang, M.L. Heiman, and Y. Shi Endocrinology 143 7 2002 2469
6. S. Takekawa, A. Asami, Y. Ishihara, J. Terauchi, K. Kato, Y. Shimomura, M. Mori, H. Murakoshi, K. Kato, N. Suzuki, O. Nishimura, and M. Fujino Eur. J. Pharmacol. 438 2002 129
7. B. Borowsky, M.M. Durkin, K. Ogozalek, M.R. Marzabadi, J. DeLeon, B. Lagu, R. Heurich, H. Lichtblau, Z. Shaposhnik, I. Daniewska, T.P. Blackburn, T.A. Branchek, C. Gerald, P.J. Vaysse, and C. Forray Nat. Med. 8 2002 779
8. C.A. Collins, and P.R. Kym Curr. Opin. Invest. Drugs 4 4 2003 386
9. A. Browning Expert Opin. Ther. Patents 14 3 2004 313
10. A.J. Carpenter, and D.L. Hertzog Expert Opin. Ther. Patents 12 11 2002 1639
11. E. Bush, T. Fey, R. Dickinson, R. Shapiro, V. Knourek-Segel, B. Droz, C. McDowell, P. Jacobson, M. Nuss, A. Souers, R. Iyengar, P. Kym, C. Collins, and M. Brune Obesity Res. 12 S 2004 A14
12. Blackburn, C.; Lai, S.; Lee, J. G.; Maguire, M.; Patane, M. A.; LaMarche, M. J.; Cullis, C. A.; Brown, J.; Vasudevan, A.; Freeman, J. C.; Mulhern, M. M.; Lynch, J. K.; Gao, J.; Wodka, D.; Souers, A. J.; Iyengar, R. WO2003106452.
13. Kym, P. R.; Iyengar, R.; Souers, A. J.; Lynch, J. K.; Judd, A. S.; Gao, J.; Freeman, J.; Mulhern, M.; Zhao, G.; Vasudevan, A.; Wodka, D.; Blackburn, C.; Brown, J.; Che, J. L.; Cullis, C.; Lai, S.; LaMarche, M. J.; Marsilje, T.; Roses, J.; Sells, T.; Geddes, B.; Govek, E.; Patane, M.; Fry, D.; Dayton, B. D.; Brodjian, S.; Falls, D.; Brune, M.; Bush, E.; Shapiro, R.; Knourek-Segel, V.; Fey, T.; McDowell, C.; Reinhart, G. A.; Preusser, L. C.; Marsh, K.; Hernandez, L.; Sham, H. L.; Collins, C. A. J. Med. Chem. [in review].
14. A. Vasudevan, M.K. Verzal, D. Wodka, A. Souers, C. Blackburn, L.C. Che, S. Lai, S. Brodjian, D. Falls, B. Dayton, E. Govek, T. Daniels, B. Geddes, K.C. Marsh, L.E. Hernandez, C.A. Collins, and P.R. Kym Bioorg. Med. Chem. Lett. 15 2005 3412
15. A.J. Souers, D. Wodka, J. Gao, J.C. Lewis, A. Vasudevan, R. Gentles, S. Brodjian, B. Dayton, C.A. Ogiela, D. Fry, L.E. Hernandez, K.C. Marsh, C.A. Collins, and P.R. Kym Bioorg. Med. Chem. Lett. 14 19 2004 4873
16. A.J. Souers, J. Gao, M. Brune, E. Bush, D. Wodka, A. Vasudevan, A.S. Judd, M. Mulhern, S. Brodjian, B. Dayton, R. Shapiro, L.E. Hernandez, K.C. Marsh, H.L. Sham, C.A. Collins, and P.R. Kym J. Med. Chem. 48 2005 1318
17. D.E. Clark J. Pharm. Sci. 88 8 1999 815
18. 3CN were purchased from Argonaut Technologies (www.argotech.com).
19. K. Sjogren, N. Hellberg, Y.M. Bohlooly, L. Savendahl, M.S. Johansson, T. Berglindh, I. Bosaeus, and C. Ohlsson J. Nutr. 131 11 2001 2963