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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 17, 2005, Pages 3853-3856

Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1

(12) Kanuma, Kosuke a Omodera, Katsunori a Nishiguchi, Mariko a Funakoshi, Takeo a Chaki, Shigeyuki a Semple, Graeme b Tran, Thuy Anh b Kramer, Bryan b Hsu, Debbie b Casper, Martin b Thomsen, Bill b Sekiguchi, Yoshinori a

a TAISHO PHARMACEUTICAL CO LTD (Japan)

b ARENA PHARMACEUTICALS (United States)

Author keywords

ATC0175; MCH R1 antagonists; Melanin concentrating hormone receptor 1 antagonists

Indexed keywords

ATC 0175; CHLORIDE; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE; N [4 [[4 (DIMETHYLAMINO)QUINAZOLIN 2 YL]AMINO]CYCLOHEXYL] 3,4 DIFLUOROBENZAMIDE; PHENYL GROUP; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

HUMANS; INHIBITORY CONCENTRATION 50; QUINAZOLINES; RADIOLIGAND ASSAY; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 23244461591 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.05.121 Document Type: Article

Times cited : (34)

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