The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys

Experimental Neurology

Volumn 178, Issue 2, 2002, Pages 236-242

  Eberling, Jamie L ^a,b   Pivirotto, Phillip ^c   Bringas, John ^c   Steiner, Joseph P ^d   Kordower, Jeffrey H ^e   Chu, Yaping ^e   Emborg, Marina E ^e   Bankiewicz, Krzysztof S ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GUILFORD PHARMACEUTICALS INC   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Dopamine transporter; GPI 1046; Immunophilin; MPTP; Parkinson's disease; Regeneration; SPECT

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; IMMUNOPHILIN; IODINE 123;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DISEASE MODEL; DOPAMINERGIC NERVE CELL; HISTOLOGY; MONKEY; NERVE REGENERATION; NONHUMAN; OUTCOMES RESEARCH; PARKINSON DISEASE; POSTOPERATIVE CARE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPECIES DIFFERENTIATION;

EID: 0036939396     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.8023     Document Type: Article

References (26)

1. Bloom, F. E., W. G. Young, E. A. Nimchinsky, P. R. Hof, and J. H. Morrison. 1997. Neuronal vulnerability and informatics in human disease. In Progress in Neuroinformatics Research, Vol. 1, Neuroinformatics - An Overview of the Human Brain Project (S. H. K. a. M. F. Huerts, Ed.), pp. 83-123. Earlbaum, Mahwah, NJ.
2. Cavalieri, B. 1966. Geometria degli Indivisible. Unione Ti-pografico Editrice, Torino.
3. Coggeshall, R. E. 1992. A consideration of neuronal counting methods. Trends Neurosci. 15: 9-13.
4. Eberling, J. L., K. S. Bankiewicz, P. Pivirotto, J. Bringas, K. Chen, D. P. Nowotnik, J. P. Steiner, T. F. Budinger, and W. J. Jagust. 1999. Dopamine transporter loss and clinical changes in MPTP-lesioned primates. Brain Res. 832: 184-187.
5. Eberling, J. L., W. J. Jagust, S. Taylor, J. Bringas, P. Pivirotto, H. F. VanBrocklin, and K. S. Bankiewicz, 1998. A novel MPTP primate model of Parkinson's disease: Neurochemical and clinical changes. Brain Res. 805: 259-262.
6. Emborg, M., S. Ma, E. J. Mufson, A. I. Levey, M. Taylor, D. Brown, J. Holden, and J. H. Kordower. 1998. Age-related decline in nigral neuronal function correlate with motor impairments in rhesus monkeys. J. Comp. Neurol. 401: 253-265.
7. Emborg, M. E., P. Shin, B. Roitberg, J. G. Sramek, Y. Chu, G. T. Stebbins, J. S. Hamilton, P. D. Suzdak, J. P. Steiner, and J. H. Kordower. 2001. Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys. Exp. Neurol. 168: 171-182.
8. Gundersen, H. J. G., P. Bagger, T. F. Bendtsen, S. M. Evans, L. Korbo, N. Marcussen, A. Moller, J. Nielsen, J. R. Nyengaard, B. Pakkenberg, F. B. Sorensen, A. Vesterby, and M. J. West. 1988. The new stereological tools: Dissector, fractionator, nucleator and point sampled intercepts and their use in pathologic research and diagnosis. Acta Pathol. Microbiol. Scand. 96: 857-881.
9. Harper, S., J. Bilsland, L. Young, L. Bristow, S. Boyce, G. Mason, M. Rigby, L. Hewson, D. Smith, R. O'Donnell, D. O'Connor, R. G. Hill, D. Evans, C. Swain, B. Williams, and F. Hefti. 1999. Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo. Neuroscience 88: 257-267.
10. Kaufman, M. J., and B. K. Madras. 1991. Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum. Synpapse 9: 43-49.
11. Kordower, J. H., M. S. Fiandaca, M. F. D. Notter, J. T. Hansen, and D. M. Gash. 1990. NGF-like trophic support from peripheral nerve for grafted rhesus adrenal chromaffin cells. J. Neurosurg. 73: 418-428.
12. Kordower, J. H., T. B. Freeman, B. J. Snow, F. J. G. Vingerhoets, E. J. Mufson, P. R. Sanberg, R. A. Hauser, D. A. Smith, G. M. Nauert, D. P. Perl, and C. W. Olanow. 1995. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N. Engl. J. Med. 332: 1118-1124.
13. 123I]β-CIT binding to dopamine transporters in healthy human subjects. J. Cereb. Blood Flow Metab. 14: 982-994.
14. Lyons, W. E., E. B. George, T. M. Dawson, J. P. Steiner, and S. H. Snyder. 1994. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells in sensory ganglia. Proc. Natl. Acad. Sci. USA 91: 3191-3195.
15. Ma, S. Y., Y. Collan, M. Roytta, J. O. Rinne, and U. K. Rinne. 1995. Cell counts in the substantia nigra: A comparison of single section counts and dissector counts in patients with Parkinson's disease and in controls. Neuropathol. Appl. Neurobiol. 21: 10-17.
16. Muller T., J. Farahati, W. Kuhn, E. G. Eising, H. Przuntek, C. Reiners, and H. H. Coenen. 1998. [123I]beta-CIT SPECT visualizes dopamine transporter loss in de novo parkinsonian patients. Eur. Neurol. 39: 44-48.
17. Neumeyer, J. L., S. Y. Wang, R. A. Milius, R. M. Baldwin, Y. Zea-Ponce, P. B. Hoffer, E. Sybirska, M. al-Tikriti, D. S. Charney, R. T. Malison, et al. 1991. [123I]-2 Beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: High-affinity SPECT radiotracer of monoamine reuptake sites in brain. J. Med. Chem. 34: 3144-3146.
18. Pakkenberg, B., M. Miller, H. J. G. Gundersen, A. M. Dam, and H. Pakkenberg. 1991. The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinsonis disease estimated with an unbiased stereological method. J. Neurol. Neurosurg. Psychiatry 54: 30-33.
19. Rinne, J. O., J. T. Kuikka, K. A. Bergstrom, and U. K. Rinne. 1995. Striatal dopamine transporter in different disability stages of Parkinson's disease studied with [123I]β-CIT SPECT. Parkinsonism Related Disorders 1: 47-51.
20. Ross, D. T., H. Guo, P. Howorth, Y. Chen, G. S. Hamilton, and J. P. Steiner. 2001. The small molecule FKBP ligand GPI 1046 induces partial striatal reinnervation after intranigral 6-hydroxydopamine lesion in rats. Neurosci. Lett. 297: 113-116.
21. Seibyl, J. P., K. L. Marek, D. Quinlan, K. Sheff, S. Zoghbi, Y. Zea-Ponce, R. M. Baldwin, B. Fussell, E. O. Smith, D. S. Charney, P. B. Hoffer, and R. B. Innis. 1995. Decreased single-photon emission computed tomographic [123I]β-CIT striatal uptake correlates with symptom severity in Parkinson's disease. Ann. Neurol. 38: 589-598.
22. Steiner, J. P., G. S. Hamilton, D. T. Ross, H. L. Valentine, H. Guo, M. A. Connolly, S. Liang, C. Ramsey, J. H. Li, W. Huang, et al. 1997. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc. Natl. Acad. Sci. USA 94: 2019-2024.
23. Szabo, J., and W. M. Cowan. 1984. A stereotaxic atlas of the brain of the cynomolgus monkey (Macaca fascicularis). J. Comp. Neurol. 222: 265-300.
24. Vermeulen, R. J., E. C. Wolters, G. Tissingh, J. Booij, A. G. Janssen, J. Habraken, E. Sokole-Busemann, J. C. Stoof, and E. A. Van Royen. 1995. Evaluation of [123I] beta-CIT binding with SPECT in controls, early and late Parkinson's disease. Nucl. Med. Biol. 22: 985-991.
25. West, M. J., K. Ostergaard, O. A. Andreassen, and B. Finsen. 1996. Estimation of the number of somatostatin neurons in the striatum: An in situ hybridization study using the optical fractionator method. J. Comp. Neurol. 370: 11-22.
26. Winter, C., J. Schenkel, E. Bürger, C. Eickmeier, M. Zimmermann, and T. Herdegen. 2000. The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle. Neuroscience 95: 753-762.