Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo

Neuroscience

Volumn 88, Issue 1, 1999, Pages 257-267

  Harper, S ^a   Bilsland, J ^a   Young, L ^a   Bristow, L ^a   Boyce, S ^a   Mason, G ^a   Rigby, M ^a   Hewson, L ^a   Smith, D ^a   O'Donnell, R ^a   O'Connor, D ^a   Hill, R G ^a   Evans, D ^a   Swain, C ^a   Williams, B ^a   Hefti, F ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

6 hydroxydopamine; Immunophilin; Neurite outgrowth; Neurotrophic; Sciatic nerve

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; 3 (3 PYRIDYL) 1 PROPYL (2) 1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLATE; IMMUNOPHILIN; NERVE GROWTH FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; LIGAND BINDING; NERVE FIBER GROWTH; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CHICK EMBRYO; EMBRYO; GANGLIA, SPINAL; MALE; MICROINJECTIONS; NERVE CRUSH; NERVE REGENERATION; NEURITES; NEURONS; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; OXIDOPAMINE; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SUBSTANTIA NIGRA;

EID: 0032889368     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00221-8     Document Type: Article

References (36)

1. Atkinson K., Biggs J., Darveniza P., Concannon A., Dodds A. Cyclosporine associated central nervous system toxicity after allogenic bone marrow transplants. New Engl. J. Med. 310:1984;527.
2. Bierer B. E., Somers P. K., Wandless T. J., Burakoff S. J., Schreiber S. L. Probing immunosuppressive action with a nonnatural immunophilin ligand. Science. 250:1990;556-559.
3. Boyce S., Mason G., Carlson E., Pearce D., Hill R. G. and Rupniak N. M. J. (1997) rhIGF-1 and GPI-1046, but not SR57746A, enhance functional recovery after sciatic nerve crush injury in mice. (Submitted to Expl. Neurol.).
4. Bram R. J., Hung D. T., Martin P. K., Shreiber S. L., Crabtree G. R. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Molec. Cell Biol. 13:1993;4760-4769.
5. Brown E. J., Albers M. W., Shin T. B., Ichikawa K., Keith C. T., Lane W. S., Schreiber S. L. A mammalian protein targeted by G1 arresting rapamycin-receptor complex. Nature. 369:1994;756-758.
6. 2+ flux. Cell. 83:1995;463-472.
7. Dawson T. M., Steiner J. P., Dawson V. L., Dinerman J. L., Uhl G. R., Snider S. H. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc. natn. Acad. Sci. U.S.A. 90:1993;9808-9812.
8. Dawson T. M., Steiner J. P., Lyons W. E., Fotuhi M., Blue M., Snider S. H. The immunophilins, FK506 and cyclophilin are discretely localized in the brain: relationship to calcineurin. Neuroscience. 62:1994;569-580.
9. Dumont F. J., Staruch M. J., Koprak S. L., Siekierka J. J., Lin C. S., Harrison R., Sewell T., Kindt V. M., Beattie T. R., Wyvratt M., Sigal N. H. The immunosuppressive and toxic effects of FK506 are mechanistically related: pharmacology of a novel antagonist of FK506 and rapamycin. J. exp. Med. 176:1992;751-760.
10. Freskgard P. O., Bergenhem N., Jonsson B. H., Svensson M., Carlsson U. Isomerase and chaperone activity of prolyl isomerase in the folding of carbonic anhydrase. Science. 258:1992;466-468.
11. Gold B. G., Katoh K., Storm-Dickerson T. The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J. Neurosci. 15:1995;7509-7516.
12. Gold B. G., Zeleny-Pooley M., Wang M-S., Chaturvedi P., Armistead D. M. A non-immunosuppressant FKBP-12 ligand increases nerve regeneration. Expl Neurol. 147:1997;269-278.
13. Goldner F. M., Patrick J. W. Neuronal localization of the cyclophilin A protein in the adult rat brain. J. comp. Neurol. 372:1996;283-293.
14. Handschumacher R. E., Harding M. W., Rice J., Drugge R. J., Speicer D. W. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 226:1984;544-547.
15. Helekar S. A., Char D., Neff S., Patrick J. Prolyl isomerase requirement for the expression of functional homo-oligomeric ligand gated ion channels. Neuron. 12:1994;179-189.
16. Jayaraman T., Brillantes A. M., Timerman A. P., Fleischer S., Erdjument-Bromage H., Tempst P., Marks A. R. FK506 binding protein associated with the calcium release channel (ryanadine receptor). J. biol. Chem. 267:1992;9474-9477.
17. Kay J. E. Structure-function relationships in the FK506-binding protein family of peptidylprolyl cis-trans isomerases. Biochem. J. 314:1996;361-385.
18. Laird J. M. A., Mason G. S., Thomas K. A., Hargreaves R. J., Hill R. G. Acidic fibroblast growth factor stimulates motor and sensory axon regeneration after sciatic nerve crush in the rat. Neuroscience. 65:1995;209-216.
19. Lodish H. F., Kong N. Cyclosporin A inhibits an initial step in the folding of transferrin within the endoplasmic reticulum. J. biol. Chem. 266:1991;14835-14838.
20. Lyons W. E., George E. B., Dawson T. M., Steiner J. P., Snider S. H. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc. natn. Acad. Sci. U.S.A. 91:1994;3191-3195.
21. Lyons W. E., Steiner J. P., Snider S. H., Dawson T. M. Neuronal regeneration enhances the expression of the immunophilin FKBP-12. J. Neurosci. 15:1995;2985.
22. Maki N., Sekiguchi F., Nishimaki J., Miwa K., Hayano T., Takashi N., Suzuki M. Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin. Proc. natn. Acad. Sci. U.S.A. 87:1990;5440-5443.
23. Michel P. P., Dandapani B. K., Sanchez-Ramos J., Efange S., Pressman B. C., Hefti F. Toxic effects of potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium on cultured rat dopaminergic neurons. J. Pharmac. exp. Ther. 248:1989;842-850.
24. Michel P. P., Dandapani B. K., Knusel B., Sanchez-Ramos J., Hefti F. Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility. J. Neurochem. 54:1990;1102-1109.
25. Near S. L., Whalen L. R., Miller J. A., Ishii D. N. Insulin-like growth factor-II stimulates motor nerve regeneration. Proc. natn. Acad. Sci. U.S.A. 89:1992;11716-11720.
26. Paxinos G. and Watson C. (1982) The Rat Brain in Stereotaxic Coordinates. Academic, New York.
27. Ryffel B., Woerly G., Greiner B., Haendler B., Mihatsck M. J., Foxwell B. M. J. Distribution of the cyclosporine binding protein cyclophilin in human tissues. Immunology. 72:1991;399-404.
28. Sharkey J., Butcher S. P. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature. 371:1994;336-339.
29. Steiner J. P., Dawson T. M., Fotuhi M., Glatt C. E., Snowman A. M., Cohen N., Snyder S. H. High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature. 358:1992;584-587.
30. Steiner J. P., Hamilton G. S., Ross D. T., Valentine H. L., Guo H., Connolly M. A., Liang S., Ramsey C., Li J-H. J., Huang W., Howorth P., Soni R., Fuller M., Sauer H., Nowotnik A. C., Suzdak P. D. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc. natn. Acad. Sci. U.S.A. 94:1997;2019-2024.
31. Steiner J. P., Connolly M. A., Valentine H. L., Hamilton G. S., Dawson T. M., Hester L., Snyder S. H. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nature Med. 3:1997;421-428.
32. Steinmann B., Bruckner P., Superti-Furga A. Cyclosporin A slows collagen triple helix formation in vivo: indirect evidence for a physiologic role of peptidyl-prolyl cis-trans isomerase. J. biol. Chem. 266:1991;1299-1303.
33. Ventimiglia R., Jones B. E., Moller A. A quantitative method for morphometric analysis in neuronal cell culture: unbiased estimation of neuron area and number of branch points. J. Neurosci. Meth. 57:1995;63-66.
34. Wang T., Donahoe P. K., Zervos A. S. Specific interaction of Type I receptors of the TGF-β family with the immunophilin FKBP-12. Science. 265:1994;674-676.
35. Wang T., Li B.-Y., Danielson P. D., Shah P., Rockwell S., Manganaro T., Donahoe P. K. The immunophilin FKBP12 functions as a common inhibitor of the TGFβ family type I receptor. Cell. 86:1996;435-444.
36. Wijdicks E. F. M., Wiesner R. H., Dahlke L. J., Krom R. A. F. FK506-induced neurotoxicity in liver transplantation. Ann. Neurol. 35:1994;498-501.