Biochemical and structural characterization of (South)- methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells

Journal of Biological Chemistry

Volumn 279, Issue 31, 2004, Pages 32832-32838

  Schelling, Pierre ^a,d   Claus, Michael T ^b   Johner, Regula ^a   Marquez, Victor E ^c   Schulz, Georg E ^b   Scapozza, Leonardo ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

^c NATIONAL CANCER INSTITUTE   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC CONVERTERS; CELLS; DRUG THERAPY; ENZYMES; METHANE; PLASTICITY; SUBSTRATES; TOXIC MATERIALS;

METHANOCARBATHYMIDINE; STRUCTURAL CHARACTERIZATIONS; TRANSFECTED CELLS;

BIOCHEMISTRY;

CARBOCYCLIC THYMIDINE; GANCICLOVIR; HUMAN CYTOSOLIC THYMIDINE KINASE ISOENZYME 1; ISOENZYME; MENADIONE; NORTH METHANOCARBATHYMIDINE; PRODRUG; SOUTH METHANOCARBATHYMIDINE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IC 50; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA; PRIORITY JOURNAL; SARCOMA CELL;

ANTIVIRAL AGENTS; BINDING SITES; CELL DIVISION; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; GANCICLOVIR; HERPESVIRUS 1, HUMAN; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; OSTEOSARCOMA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; THYMIDINE; THYMIDINE KINASE; TIME FACTORS; TRANSFECTION;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 3543041813     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313343200     Document Type: Article

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