Comparative in-vivo genotoxicity of antiviral nucleoside analogues; penciclovir, acyclovir, ganciclovir and the xanthine analogue, caffeine, in the mouse bone marrow micronucleus assay

Mutation Research - Genetic Toxicology

Volumn 369, Issue 1, 1996, Pages 65-74

  Haynes, P ^a   Lambert, T R ^a   Mitchell, I D G ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Acyclovir; Caffeine; Ganciclovir; In vivo; Micronucleus test; Penciclovir

Indexed keywords

ACICLOVIR; CAFFEINE; GANCICLOVIR; NUCLEOSIDE ANALOG; PENCICLOVIR; XANTHINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENOTOXICITY; IN VIVO STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0029956994     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(96)90049-X     Document Type: Article

References (30)

1. Aeschbacher, H.U., H. Meier and E. Jaccaud (1986) The effect of caffeine in the in vivo SCE and micronucleus mutagenicity tests. Mutation Res., 174, 53-58.
2. Anderson, D., C. R. Richardson and P.J. Davies (1981) The genetic potential of bases and nucleosides, Mutation Res., 91, 265-272.
3. Ashby, J., H. Tinwell, D. Gulati and J.A. Heddle (1990) Overview of the study in relation to protocol design for the rodent bone-marrow micronucleus assay, Mutation Res., 234, 223-248.
4. Bechhofer, R.E. and C.W. Dunnett (1988) Percentage points of multivariate student t-distributions, in: Institute of Mathematical Statistics (Ed.), Selected Tables in Mathematical Statistics, Vol. 11, American Mathematical Society, Providence, Rhode Island, USA, pp. 1-319.
5. Boyd, M.R., S. Safrin and E.R. Kern (1993) Penciclovir: a review of its spectrum of activity, selectivity and cross-resistance pattern, Antiviral Chem. Chemother., 4 (Suppl. 1), 3-11.
6. Brusick, D., B. Myhr, S. Galloway, J. Rundell, D.R. Jagannath and S. Tarka (1986) Genotoxicity of theobromine in a series of short-term assays. Mutation Res., 169, 105-114.
7. Clive, D., N.T. Turner, J. Hozier, A.G. Batson and W.E. Tucker Jr. (1983) Preclinical Toxicology Studies with Acyclovir: Genetic Toxicology Tests, Fund. Applied Toxicol., 3, 587-602.
8. Conover, W.J. and R.L. Iman (1981) Rank transformations as a bridge between parametric and nonparametric statistics, Am. Statistician, 35(3), 124-133.
9. CSGMT (Collaborative study group for the micronucleus test) (1990) Single versus multiple dosing in the micronucleus test: The summary of the fourth collaborative by CSGMT/JEMMS.MMS, Mutation Res., 234, 205-222.
10. Draper, N.R. and H. Smith (1981) Time trends in data, in: Applied Regression Analysis, 2nd Edn., John Wiley & Sons Inc., New York, Chapter 5.4, pp. 250-257.
11. Dunnett, C.W. (1955) A multiple comparison procedure for comparing several treatments with a control, Am. Statistical Assoc. J., 50, 1096-1121.
12. Elion, G.B. (1993) Acyclovir: Discovery, mechanism of action, and selectivity, J. Med. Virol., Suppl., 1, 2-6.
13. Faulds, D. and R.C. Heel (1990) Ganciclovir: A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections, Drugs, 39(4), 597-638.
14. Iman, R.L. (1974) A power study of a rank transform for the two-way classification model when interaction may be present. Can. J. Statistics, Sect. C 2(2), 227-239.
15. McCann, J., E. Choi, E. Yamasaki and B.N. Ames (1975) Detection of carcinogens as mutagens in the Salmonella/microsome test; assay of 300 chemicals, Proc. Natl. Acad. Sci. USA, 72(12), 5135-5139.
16. Palu, G., F. Bevilacqua, M.A. Biasolo, C. Parolin, M. Tognon, M.G. Romanelli and G.A. Melono (1989) Acyclovir resistance in herpes simplex virus type 1: biochemical and functional studies on the thymidine kinase of the highly resistant R100 strain, Virus Res., 13, 303-318.
17. Physicians' Desk Reference (1995a), 48th Edn., Medical Economics Data Production Company, Montvale, NJ 07645-1742, USA, pp. 831-834.
18. Physicians' Desk Reference (1995b), 48th Edn., Medical Economics Data Production Company, Montvale, NJ 07645-1742, USA, pp. 2471-2475.
19. Pue, M., A. and L. Z. Benet (1993) Pharmacokinetics of famciclovir in man, Antiviral Chem. Chemother., 4, Suppl., 1, 47-55.
20. Richold, M., A. Chandley, J. Ashby, D.G. Gatehouse, J. Bootman and L. Henderson (1990) In vivo cytogenetics assays, in: D.J. Kirkland (Ed.), Basic Mutagenicity Test: UKEMS Recommended Procedures, Cambridge University Press, Cambridge, pp. 115-141.
21. Schmid, W. (1975) The micronucleus test. Mutation Res., 31, 9-15.
22. Shobukhov, V.M. and V.V. Yurchenko (1988) The cytogenetic effect of 9-(2- hydroxyethoxymethyl)guanine, Biull. Eksp. Biol. Med., 105, 591-593.
23. Smee, D.F., R. Boehme, M. Chernow, B.P. Binko and T.R Matthews (1985) Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxylmethyl)guanine and acyclovir in Herpes Simplex Virus - infected and uninfected cells, Biochem. Pharmacol., 34(7), 1049-1056.
24. Sullivan, V., C.L. Talarico, S.C. Stanat, M. Davis, D.M. Coen and K.K. Biron (1992) A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells, Nature, 358, 162-164.
25. Sutou, S., M. Kondo and Y. Mitsui (1990) Effects of multiple dosing of phenacetin in the micronucleus test, Mutation Res., 234, 183-186.
26. Vere Hodge, R.A. and R.M. Perkins (1989) Mode of action of 9-(4-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells. Antimicrob. Agents Chemother., 33(2), 223-229.
27. Vere Hodge, R.A. and Y.C. Cheng (1993) The mode of action of penciclovir, Antiviral Chem. Chemother., 4 (Suppl. 1), 13-24.
28. Waters, M.D., H.B. Bergman and N. Nesnow (1988) The genetic toxicology of Gene-Tox non-carcinogens, Mutation Res., 205, 139-182.
29. Weinstein, D., I. Mauer and H. M. Solomon (1972) The effect of caffeine on chromosomes of human lymphocytes in-vivo and in-vitro studies, Mutation Res., 16, 391-399.
30. Yamazaki, Z. and I. Tagaya (1980) Anti-viral effects of atropine and caffeine, J. Gen. Virol., 50, 429-431.