Synthesis and antiviral activity of novel acyclic nucleosides: Discovery of a cyclopropyl nucleoside with potent inhibitory activity against herpesviruses

Journal of Medicinal Chemistry

Volumn 41, Issue 8, 1998, Pages 1284-1298

  Sekiyama, Takaaki ^a   Hatsuya, Satoshi ^a   Tanaka, Yasuhiro ^a   Uchiyama, Mamoru ^a   Ono, Nobukazu ^a   Iwayama, Satoshi ^a   Oikawa, Miki ^a   Suzuki, Katsuya ^a   Okunishi, Masahiko ^a   Tsuji, Takashi ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

9 [[1',2' BIS(HYDROXYMETHYL)CYCLOPROPAN 1' YL]METHYL]GUANINE; ACICLOVIR; ANTIVIRUS AGENT; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG CONFORMATION; DRUG POTENCY; DRUG SPECIFICITY; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; NONHUMAN; STRUCTURE ACTIVITY RELATION; VARICELLA ZOSTER VIRUS; VIRUS INHIBITION;

ACYCLOVIR; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; CELL LINE; DRUG EVALUATION, PRECLINICAL; GUANINE; HERPESVIRUS 1, HUMAN; HERPESVIRUS 3, HUMAN; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; PHOSPHORYLATION; PLAQUE ASSAY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE KINASE;

EID: 15444359037     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9705869     Document Type: Article

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